{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:17:33Z","timestamp":1790709453895,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016981","name":"Necmettin Erbakan University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016981","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Since the outbreak of the Syrian civil war in 2011, the population of Arab refugees in Turkey has rapidly increased. While cystic fibrosis (CF) is believed to be rare among Arabs, recent studies suggest it is underdiagnosed. This study aims to present the demographic, clinical, and genetic characteristics of CF patients among Arab refugees in Turkey. Additionally, a comparison is made between the findings in the National CF Registry 2021 in Turkey (NCFRT) and the refugee CF patient group. The study included refugee patients between the ages of 0 and 18\u00a0years who were diagnosed with CF and received ongoing care at pediatric pulmonology centers from March 2011 to March 2021. The study examined demographic information, age at diagnosis, age of diagnosis of patients through CF newborn screening (NBS), presenting symptoms, CF transmembrane conductance regulator\u00a0(CFTR) mutation test results, sputum culture results, weight, height, and body mass index (BMI) z score. Their results were compared with the NCFRT results. The study included 14 pediatric pulmonology centers and 87 patients, consisting of 46 (52.9%) boys and 41 (47.1%) girls. All of the patients were Arab refugees, with 80 (92%) being Syrian. All the patients were diagnosed in Turkey. The median age at diagnosis of patients was 22.33 (interquartile range, 1\u2013258) months. The median age of diagnosis of patients through NBS was 4.2 (interquartile range, 1\u201312) months. The median age of older patients, who were unable to be included in the NBS program, was 32.3 (interquartile range, 3\u2013258) months. Parental consanguinity was observed in 52 (59.7%) patients. The mutation that was most frequently found was F508del, which accounted for 22.2% of the cases. It was present in 20 patients, constituting 32 out of the total 144 alleles. There was a large number of genetic variations. CFTR genotyping could not be conducted for 12 patients. These patients had high sweat tests, and their genetic mutations could not be determined due to a lack of data. Compared to NCFRT, refugee patients were diagnosed later, and long-term follow-up of refugee CF patients had significantly worse nutritional status and pseudomonas colonization.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>\u00a0 Conclusion<\/jats:italic>\n                    : Although refugee CF patients have equal access to NBS programs and CF medications as well as Turkish patients, the median age at diagnosis of patients, the median age of diagnosis of patients through NBS, their nutritional status, and Pseudomonas colonization were significantly worse than Turkish patients, which may be related to the difficulties of living in another country and poor living conditions. The high genetic heterogeneity and rare mutations detected in the refugee patient group compared to Turkish patients. Well-programmed NBS programs, thorough genetic studies, and the enhancement of living conditions for refugee patients in the countries they relocate to can have several advantages such as early detection and improved prognosis.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 Children who have chronic diseases are the group that is most affected by wars.<\/jats:italic>\n                              <jats:italic>\u2022 The outcome gets better with early diagnosis and treatment in patients with Cystic Fibrosis (CF).<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 Through the implementation of a newborn screening program, which has never been done in Syria previously, refugee patients, the majority of whom are Syrians were diagnosed with cystic fibrosis within a duration of 4 months.<\/jats:italic>\n                              <jats:italic>\u2022 Despite equal access to the newborn screening program and CF medications for both Turkish patients and refugee patients, the challenges of living in a foreign country have an impact on refugees.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-024-05431-8","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T05:02:54Z","timestamp":1706072574000},"page":"1831-1838","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of refugee patients with cystic fibrosis and their counterpart children from Turkey during the war"],"prefix":"10.1007","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-7904","authenticated-orcid":false,"given":"Asl\u0131 \u0130mran","family":"Y\u0131lmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-902X","authenticated-orcid":false,"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-4999","authenticated-orcid":false,"given":"Tu\u011fba \u015ei\u015fmanlar","family":"Ey\u00fcbo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6226-0340","authenticated-orcid":false,"given":"Melih","family":"Hang\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-8910","authenticated-orcid":false,"given":"Ay\u015fe Ayz\u0131t","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-3936","authenticated-orcid":false,"given":"Haluk","family":"\u00c7oku\u011fra\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-8535","authenticated-orcid":false,"given":"Elif","family":"Ar\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Keskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-6577","authenticated-orcid":false,"given":"Ali","family":"Ersoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-918X","authenticated-orcid":false,"given":"Mehmet","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-8361","authenticated-orcid":false,"given":"Beste","family":"\u00d6zsezen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4380-7643","authenticated-orcid":false,"given":"G\u00f6k\u00e7en","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-927X","authenticated-orcid":false,"given":"\u00d6m\u00fcr","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saniye","family":"Girit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9801-3181","authenticated-orcid":false,"given":"Sinem Can","family":"Oksay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"G\u00f6kdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-8871","authenticated-orcid":false,"given":"B\u00fclent","family":"Karada\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velat","family":"\u015een","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9577-8445","authenticated-orcid":false,"given":"Hasan","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-5704","authenticated-orcid":false,"given":"Merve Nur","family":"Tekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-8517","authenticated-orcid":false,"given":"Ay\u015fe Tana","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"5431_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4274\/jpea.2023.209","volume":"4","author":"A Koca Yozgat","year":"2023","unstructured":"Koca Yozgat A, \u00d6zy\u00f6r\u00fck D, Emir S, Demir A, Yazal Erdem A, Aker CB, G\u00fczelk\u00fc\u00e7\u00fck Z, Yaman Bajin \u0130, Ka\u00e7ar D, Yaral\u0131 N et al (2023) Evaluation of leukemia and solid tumors in refugee children in Turkey: a tertiary center experience. J Pediatr Acad 4:62\u201366. https:\/\/doi.org\/10.4274\/jpea.2023.209","journal-title":"J Pediatr Acad"},{"key":"5431_CR2","unstructured":"UNCHR. United Nations High Commissioner for Refugees, The UN Refugee Agency.\u00a0https:\/\/www.unhcr.org\/. Accessed Jul 2022"},{"key":"5431_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00467-021-05046-3","volume":"37","author":"A Balat","year":"2022","unstructured":"Balat A, Kilic BD, Aksu B, Kara MA, Buyukcelik M, Agbas A, Eroglu FK, Gungor T, Alaygut D, Yildiz N et al (2022) Kidney disease profile and encountered problems during follow-up in Syrian refugee children: a multicenter retrospective study. Pediatr Nephrol 37:393\u2013402. https:\/\/doi.org\/10.1007\/s00467-021-05046-3","journal-title":"Pediatr Nephrol"},{"key":"5431_CR4","first-page":"109","volume":"11","author":"MA Kara","year":"2017","unstructured":"Kara MA, Kilic BD, Col N, Ozcelik AA, Buyukcelik M, Balat A (2017) Kidney disease profile of Syrian refugee children. Iran J Kidney Dis 11:109\u2013114","journal-title":"Iran J Kidney Dis"},{"key":"5431_CR5","unstructured":"National CF Registry in Turkey (NCFRT) (2021) report-2.pdf. https:\/\/www.kistikfibrozisturkiye.org\/wpcontent\/uploads\/2022\/11. Accessed Nov 2022"},{"key":"5431_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00296-020-04534-3","volume":"40","author":"\u015eG Karada\u011f","year":"2020","unstructured":"Karada\u011f \u015eG, S\u00f6nmez HE, Demir F, \u00c7akan M, \u00d6zt\u00fcrk K, Tanatar A, \u00c7akmak F, S\u00f6zeri B, Aktay AN (2020) Rheumatic diseases in Syrian refugee children: a retrospective multicentric study in Turkey. Rheumatol Int 40:583\u2013589. https:\/\/doi.org\/10.1007\/s00296-020-04534-3","journal-title":"Rheumatol Int"},{"key":"5431_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.yapd.2019.04.003","volume":"66","author":"ALH Kroening","year":"2019","unstructured":"Kroening ALH, Dawson-Hahn E (2019) Health considerations for immigrant and refugee children. Adv Pediatr 66:87\u2013110. https:\/\/doi.org\/10.1016\/j.yapd.2019.04.003","journal-title":"Adv Pediatr"},{"key":"5431_CR8","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","volume":"181S","author":"PM Farrell","year":"2017","unstructured":"Farrell PM, White TB, Ren CL, Hempstead SE, Accurso F, Derichs N, Howenstine M, McColley SA, Rock M, Rosenfeld M et al (2017) Diagnosis of cystic fibrosis: consensus guidelines from the cystic fibrosis foundation. J Pediatr 181S:S4\u2013S15. https:\/\/doi.org\/10.1016\/j.jpeds.2016.09.064","journal-title":"J Pediatr"},{"key":"5431_CR9","doi-asserted-by":"publisher","unstructured":"Rosenstein BJ, Cutting GR (1998) The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel. J Pediatr 132:589\u2013595. https:\/\/doi.org\/10.1016\/s0022-3476(98)70344-0","DOI":"10.1016\/s0022-3476(98)70344-0"},{"key":"5431_CR10","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/apa.15155","volume":"109","author":"K De Boeck","year":"2020","unstructured":"De Boeck K (2020) Cystic fibrosis in the year 2020: a disease with a new face. Acta Paediatr 109:893\u2013899. https:\/\/doi.org\/10.1111\/apa.15155","journal-title":"Acta Paediatr"},{"key":"5431_CR11","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.4103\/jfmpc.jfmpc_1168_19","volume":"9","author":"AA Asseri","year":"2020","unstructured":"Asseri AA (2020) Cystic fibrosis knowledge and practice among primary care physicians in southwest region, Saudi Arabia. J Family Med Prim Care 9:1354\u20131361. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1168_19","journal-title":"J Family Med Prim Care"},{"key":"5431_CR12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/resp.13437","volume":"24","author":"D Al-Sadeq","year":"2019","unstructured":"Al-Sadeq D, Abunada T, Dalloul R, Fahad S, Taleb S, Aljassim K, Al Hamed FA, Zayed H (2019) Spectrum of mutations of cystic fibrosis in the 22 Arab countries: a systematic review. Respirology 24:127\u2013136. https:\/\/doi.org\/10.1111\/resp.13437","journal-title":"Respirology"},{"key":"5431_CR13","doi-asserted-by":"publisher","unstructured":"Ko\u00e7 I (2022) Change in the prevalence of consanguineous marriages in Turkey and identification of resistant groups: analysis according to marriage generations from the 2018 Turkey Demographic and Health Survey. Turk J Pub Health 20:423\u2013438. https:\/\/doi.org\/10.20518\/tjph.1114922","DOI":"10.20518\/tjph.1114922"},{"key":"5431_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ijpam.2015.05.006","volume":"2","author":"H Banjar","year":"2015","unstructured":"Banjar H, Angyalosi G (2015) The road for survival improvement of cystic fibrosis patients in Arab countries. Int J Pediatr Adolesc Med 2:47\u201358. https:\/\/doi.org\/10.1016\/j.ijpam.2015.05.006","journal-title":"Int J Pediatr Adolesc Med"},{"key":"5431_CR15","unstructured":"Arab Genomic Studies, C (2015) Centre for Arab genomic studies a division of Sheikh Hamdan award for medical sciences. Retrieved from http:\/\/www.cags.org.ae\/pdf\/219700.pdf.\u00a0Accessed Nov 2018"},{"issue":"Pt 1","key":"5431_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2020.104628","volume":"119","author":"E Sahin","year":"2021","unstructured":"Sahin E, Dagli TE, Acarturk C, Sahin DF (2021) Vulnerabilities of Syrian refugee children in Turkey and actions taken for prevention and management in terms of health and wellbeing. Child Abuse Negl 119(Pt 1):104628. https:\/\/doi.org\/10.1016\/j.chiabu.2020.104628","journal-title":"Child Abuse Negl"},{"key":"5431_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.5455\/medarh.2019.73.118-120","volume":"73","author":"B Al-Abadi","year":"2019","unstructured":"Al-Abadi B, Al-Hiary M, Khasawneh R, Al-Momani A, Bani-Salameh A, Al-Saeidat S, Al-Khlaifat A, Aboalsondos O (2019) Cystic fibrosis gene mutation frequency among a group of suspected children in King Hussein Medical Center. Med Arch 73:118\u2013120. https:\/\/doi.org\/10.5455\/medarh.2019.73.118-120","journal-title":"Med Arch"},{"key":"5431_CR18","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s004390050505","volume":"100","author":"M Desgeorges","year":"1997","unstructured":"Desgeorges M, M\u00e9garban\u00e9 A, Guittard C, Carles S, Loiselet J, Demaille J, Claustres M (1997) Cystic fibrosis in Lebanon: distribution of CFTR mutations among Arab communities. Hum Genet 100:279\u2013283. https:\/\/doi.org\/10.1007\/s004390050505","journal-title":"Hum Genet"},{"key":"5431_CR19","doi-asserted-by":"publisher","unstructured":"Laufer-Cahana A, Lerer I, Sagi M, Rachmilewitz-Minei T, Zamir C, Rivlin JR, Abeliovich D (1999) Cystic fibrosis mutations in Israeli Arab patients. Hum Mutat 14:543. https:\/\/doi.org\/10.1002\/(SICI)1098-1004(199912)14:6%3c543::AID-HUMU16%3e3.0.CO;2-V","DOI":"10.1002\/(SICI)1098-1004(199912)14:6%3c543::AID-HUMU16%3e3.0.CO;2-V"},{"key":"5431_CR20","doi-asserted-by":"publisher","first-page":"664","DOI":"10.4314\/ahs.v18i3.24","volume":"18","author":"K Boussetta","year":"2018","unstructured":"Boussetta K, Khalsi F, Bahri Y, Belhadj I, Tinsa F, Messaoud TB, Hamouda S (2018) Cystic fibrosis in Tunisian children: a review of 32 children. Afr Health Sci 18:664\u2013670. https:\/\/doi.org\/10.4314\/ahs.v18i3.24","journal-title":"Afr Health Sci"},{"key":"5431_CR21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.23736\/S0026-4946.17.04280-3","volume":"70","author":"RA Jarjour","year":"2018","unstructured":"Jarjour RA, Al-Berrawi S, Ammar S, Majdalawi R (2018) Spectrum of cystic fibrosis mutations in Syrian patients. Minerva Pediatr 70:159\u2013164. https:\/\/doi.org\/10.23736\/S0026-4946.17.04280-3","journal-title":"Minerva Pediatr"},{"key":"5431_CR22","doi-asserted-by":"crossref","unstructured":"Al-Baba and Zetoune (2021) A retrospective study of cases diagnosed with cystic fibrosis at a single care center in Syria. Egypt J Med Hum Genet 22:5","DOI":"10.1186\/s43042-021-00178-5"},{"key":"5431_CR23","unstructured":"Zolin A, Orenti A, Jung A, van Rens J et al (2023) ECFSPR Annual Report 2021"},{"key":"5431_CR24","doi-asserted-by":"publisher","unstructured":"Estivill X, Bancells C, Ramos C (1997) Geographic distribution and regional origin of 272 cystic fibrosis mutations in European populations. The Biomed CF Mutation Analysis Consortium. Hum Mutat 10:135\u2013154. https:\/\/doi.org\/10.1002\/(SICI)1098-1004(1997)10:2<135::AID-HUMU6>3.0.CO;2-J","DOI":"10.1002\/(SICI)1098-1004(1997)10:2<135::AID-HUMU6>3.0.CO;2-J"},{"key":"5431_CR25","unstructured":"The clinical and functional translation of CFTR (CFTR2) available at http:\/\/cftr2.org"},{"key":"5431_CR26","unstructured":"Karimi N, Alibakhshi R, Almasi S (2018) CFTR mutation analysis in Western Iran: identification of two novel mutations. J Reprod Infertil 19:3\u20139. PMID: 29850441; PMCID: PMC5960049"},{"key":"5431_CR27","doi-asserted-by":"publisher","unstructured":"Frossard PM, Girodon E, Dawson KP, Ghanem N, Plassa F, Lestringant GG, Goossens M (1998) Identification of cystic fibrosis mutations in the United Arab Emirates. Mutations in brief no. 133. Hum Mutat 11:412\u2013413. https:\/\/doi.org\/10.1002\/(SICI)1098-1004(1998)11:5<412::AID-HUMU15>3.0.CO;2-O","DOI":"10.1002\/(SICI)1098-1004(1998)11:5<412::AID-HUMU15>3.0.CO;2-O"},{"key":"5431_CR28","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1093\/tropej\/48.6.348","volume":"48","author":"H Eskandarani","year":"2002","unstructured":"Eskandarani H (2002) Cysticfibrosis transmembrane regulator genemutations in Bahrain. J Trop Pediatr 48:348\u2013350","journal-title":"J Trop Pediatr"},{"key":"5431_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1080\/02724936.2000.11748135","volume":"20","author":"AA Wahab","year":"2000","unstructured":"Wahab AA, Dawod S, Thani GA (2000) Cystic fibrosis in a large kindred family in Qatar. Ann Trop Paediatr 20:203\u2013207","journal-title":"Ann Trop Paediatr"},{"key":"5431_CR30","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s004310051277","volume":"159","author":"M Kambouris","year":"2000","unstructured":"Kambouris M, Banjar H, Moggari I, Nazer H, Al-Hamed M, Meyer B (2000) Identification of novel mutations in Arabs with cystic fibrosis and their impact on the cystic fibrosis transmembrane regulator mutation detection rate in Arab populations. Eur J Pediatr 159:303\u2013309","journal-title":"Eur J Pediatr"},{"key":"5431_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/458653","volume":"2015","author":"O Essawi","year":"2015","unstructured":"Essawi O, Farraj M, De Leeneer K, Steyaert W, De Pauw K, De Paepe A, Claes K, Essawi T, Coucke PJ (2015) Next generation sequencing to determine the cystic fibrosis mutation spectrum in Palestinian population. Dis Markers 2015:458653. https:\/\/doi.org\/10.1155\/2015\/458653","journal-title":"Dis Markers"},{"key":"5431_CR32","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33337","volume":"15","author":"N Francis","year":"2023","unstructured":"Francis N, Yavuz S, Elnazir B (2023) Beyond the local basic panel: full CFTR gene analysis identifies novel CF mutation missed on standard testing in an Arabic child. Cureus 15:e33337. https:\/\/doi.org\/10.7759\/cureus.33337","journal-title":"Cureus"},{"key":"5431_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.645","volume":"7","author":"RDS Martins","year":"2019","unstructured":"Martins RDS, Campos Junior M, Dos Santos MA, Marques Zembrzuski V, da Fonseca ACP, Abreu GM, Cabello PH, de Cabello GMK (2019) Identification of a novel large deletion and other copy number variations in the CFTR gene in patients with cystic fibrosis from a multiethnic population. Mol Genet Genomic Med 7:e00645. https:\/\/doi.org\/10.1002\/mgg3.645","journal-title":"Mol Genet Genomic Med"},{"key":"5431_CR34","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00431-018-3141-y","volume":"177","author":"A Baauw","year":"2018","unstructured":"Baauw A, Rosiek S, Slattery B, Chinapaw M, van Hensbroek MB, van Goudoever JB, Kist-van HJ (2018) Pediatrician-experienced barriers in the medical care for refugee children in the Netherlands. Eur J Pediatr 177:995\u20131002. https:\/\/doi.org\/10.1007\/s00431-018-3141-y","journal-title":"Eur J Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05431-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05431-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05431-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:13:15Z","timestamp":1712567595000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05431-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["5431"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05431-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3564095\/v1","asserted-by":"object"}]},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"assertion":[{"value":"5 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approved by Necmettin Erbakan University Faculty of Medicine Ethics Committee ((2021\/3502).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}