{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:41:53Z","timestamp":1777736513617,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-024-05473-y","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T04:02:18Z","timestamp":1709265738000},"page":"2311-2324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial"],"prefix":"10.1007","volume":"183","author":[{"given":"Oleg Yu","family":"Tyrsin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry Yu","family":"Tyrsin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniil G.","family":"Nemenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey S.","family":"Ruzov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera E.","family":"Odintsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav I.","family":"Koshechkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"D`Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"5473_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpeds.2016.04.008","volume":"177","author":"ML Lewis","year":"2016","unstructured":"Lewis ML, Palsson OS, Whitehead WE, van Tilburg MAL (2016) Prevalence of functional gastrointestinal disorders in children and adolescents. J Pediatr 177:39\u201343.e3. https:\/\/doi.org\/10.1016\/j.jpeds.2016.04.008","journal-title":"J Pediatr"},{"issue":"21","key":"5473_CR2","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.3390\/jcm10215087","volume":"10","author":"A Vernon-Roberts","year":"2021","unstructured":"Vernon-Roberts A, Alexander I, Day AS (2021) Systematic review of pediatric functional gastrointestinal disorders (Rome IV criteria). J Clin Med 10(21):5087. https:\/\/doi.org\/10.3390\/jcm10215087","journal-title":"J Clin Med"},{"issue":"5","key":"5473_CR3","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","volume":"17","author":"F Backhed","year":"2015","unstructured":"Backhed F, Roswall J, Peng Y et al (2015) Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17(5):690\u2013703. https:\/\/doi.org\/10.1016\/j.chom.2015.04.004","journal-title":"Cell Host Microbe"},{"issue":"343","key":"5473_CR4","doi-asserted-by":"publisher","first-page":"343ra82","DOI":"10.1126\/scitranslmed.aad0917","volume":"8","author":"M Yassour","year":"2016","unstructured":"Yassour M, Vatanen T, Siljander H et al (2016) Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci Transl Med 8(343):343ra82. https:\/\/doi.org\/10.1126\/scitranslmed.aad0917","journal-title":"Sci Transl Med."},{"issue":"7","key":"5473_CR5","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1371\/journal.pbio.0050177","volume":"5","author":"C Palmer","year":"2007","unstructured":"Palmer C, Bik EM, DiGiulio DB et al (2007) Development of the human infant intestinal microbiota. PLoS Biol 5(7):e177. https:\/\/doi.org\/10.1371\/journal.pbio.0050177","journal-title":"PLoS Biol."},{"key":"5473_CR6","doi-asserted-by":"publisher","first-page":"26050","DOI":"10.3402\/mehd.v26.26050","volume":"26","author":"JM Rodr\u00edguez","year":"2015","unstructured":"Rodr\u00edguez JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, Avershina E, Rudi K, Narbad A, Jenmalm MC, Marchesi JR, Collado MC (2015) The composition of the gut microbiota throughout life, with an emphasis on early life. Microb Ecol Health Dis 26:26050. https:\/\/doi.org\/10.3402\/mehd.v26.26050. PMID: 25651996; PMCID: PMC4315782","journal-title":"Microb Ecol Health Dis"},{"issue":"2","key":"5473_CR7","doi-asserted-by":"publisher","first-page":"561S","DOI":"10.3945\/ajcn.112.038893","volume":"98","author":"R Oozeer","year":"2013","unstructured":"Oozeer R, van Limpt K, Ludwig T et al (2013) Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides. Am J Clin Nutr 98(2):561S\u2013571S. https:\/\/doi.org\/10.3945\/ajcn.112.038893. Epub 2013 Jul 3","journal-title":"Am J Clin Nutr."},{"issue":"9","key":"5473_CR8","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1128\/AEM.00342-14","volume":"80","author":"A Bergstrom","year":"2014","unstructured":"Bergstrom A, Skov TH, Bahl MI et al (2014) Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol 80(9):2889\u20132900. https:\/\/doi.org\/10.1128\/AEM.00342-14","journal-title":"Appl Environ Microbiol."},{"issue":"7","key":"5473_CR9","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1399-3038.2012.01328.x","volume":"23","author":"IH Ismail","year":"2012","unstructured":"Ismail IH, Oppedisano F, Joseph SJ et al (2012) Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infants. Pediatr Allergy Immunol 23(7):674\u2013681. https:\/\/doi.org\/10.1111\/j.1399-3038.2012.01328.x. Epub 2012 Jul 26","journal-title":"Pediatr Allergy Immunol"},{"issue":"2","key":"5473_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.chom.2015.01.001","volume":"17","author":"AD Kostic","year":"2015","unstructured":"Kostic AD, Gevers D, Siljander H et al (2015) The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe 17(2):260\u2013273. https:\/\/doi.org\/10.1016\/j.chom.2015.01.001","journal-title":"Cell Host Microbe"},{"issue":"1","key":"5473_CR11","doi-asserted-by":"publisher","first-page":"e02419","DOI":"10.1128\/mBio.02419-14","volume":"6","author":"S Dogra","year":"2015","unstructured":"Dogra S, Sakwinska O, Soh SE et al (2015) Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio 6(1):e02419\u201314. https:\/\/doi.org\/10.1128\/mBio.02419-14","journal-title":"MBio"},{"issue":"2","key":"5473_CR12","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1542\/peds.2005-2824","volume":"118","author":"J Penders","year":"2006","unstructured":"Penders J, Thijs C, Vink C et al (2006) Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118(2):511\u2013521. https:\/\/doi.org\/10.1542\/peds.2005-2824","journal-title":"Pediatrics"},{"key":"5473_CR13","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3389\/fmicb.2014.00494","volume":"5","author":"N Voreades","year":"2014","unstructured":"Voreades N, Kozil A, Weir TL (2014) Diet and the development of the human intestinal microbiome. Front Microbiol 5:494. https:\/\/doi.org\/10.3389\/fmicb.2014.00494. eCollection 2014","journal-title":"Front Microbiol"},{"issue":"Suppl 1","key":"5473_CR14","doi-asserted-by":"publisher","first-page":"4578","DOI":"10.1073\/pnas.1000081107","volume":"108","author":"JE Koenig","year":"2011","unstructured":"Koenig JE, Spor A, Scalfone N et al (2011) Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA 108(Suppl 1):4578\u20134585. https:\/\/doi.org\/10.1073\/pnas.1000081107. Epub 2010 Jul 28","journal-title":"Proc Natl Acad Sci USA"},{"key":"5473_CR15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-food-022811-101120","volume":"3","author":"PA Scholtens","year":"2012","unstructured":"Scholtens PA, Oozeer R, Martin R et al (2012) The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol 3:425\u2013447. https:\/\/doi.org\/10.1146\/annurev-food-022811-101120. Epub 2012 Jan 3","journal-title":"Annu Rev Food Sci Technol"},{"issue":"7728","key":"5473_CR16","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-018-0617-x","volume":"562","author":"CJ Stewart","year":"2018","unstructured":"Stewart CJ, Ajami NJ, O\u2019Brien JL et al (2018) Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 562(7728):583\u2013588. https:\/\/doi.org\/10.1038\/s41586-018-0617-x","journal-title":"Nature"},{"issue":"4","key":"5473_CR17","doi-asserted-by":"publisher","first-page":"e00036","DOI":"10.1128\/MMBR.00036-17","volume":"81","author":"C Milani","year":"2017","unstructured":"Milani C, Duranti S, Bottacini F et al (2017) The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev. 81(4):e00036\u201317. https:\/\/doi.org\/10.1128\/MMBR.00036-17","journal-title":"Microbiol Mol Biol Rev."},{"issue":"3","key":"5473_CR18","doi-asserted-by":"publisher","first-page":"e562","DOI":"10.1136\/bmj.g2107","volume":"134","author":"V Sung","year":"2014","unstructured":"Sung V, Hiscock H, Tang ML et al (2014) Treating infant colic with the probiotic Lactobacillus reuteri: double-blind, placebo-controlled randomized trial. Pediatrics. 134(3):e562\u20139. https:\/\/doi.org\/10.1136\/bmj.g2107","journal-title":"Pediatrics."},{"issue":"3","key":"5473_CR19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1001\/jamapediatrics.2013.4367","volume":"168","author":"F Indrio","year":"2014","unstructured":"Indrio F, Di Mauro A, Riezzo G et al (2014) Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr 168(3):228\u201333. https:\/\/doi.org\/10.1001\/jamapediatrics.2013.4367","journal-title":"JAMA Pediatr."},{"issue":"1","key":"5473_CR20","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1542\/peds.2006-1222","volume":"119","author":"F Savino","year":"2007","unstructured":"Savino F, Pelle E, Palumeri E et al (2007) Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics 119(1):e124\u201330. https:\/\/doi.org\/10.1542\/peds.2006-1222","journal-title":"Pediatrics"},{"issue":"3","key":"5473_CR21","doi-asserted-by":"publisher","first-page":"e526","DOI":"10.1542\/peds.2010-0433","volume":"126","author":"F Savino","year":"2010","unstructured":"Savino F, Cordisco L et al (2010) Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 126(3):e526\u2013e533. https:\/\/doi.org\/10.1542\/peds.2010-0433","journal-title":"Pediatrics"},{"issue":"1","key":"5473_CR22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpeds.2014.09.020","volume":"166","author":"K Chau","year":"2015","unstructured":"Chau K, Lau E, Greenberg S et al (2015) Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr 166(1):74\u20138. https:\/\/doi.org\/10.1016\/j.jpeds.2014.09.020","journal-title":"J Pediatr"},{"issue":"1","key":"5473_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2017-1811","volume":"141","author":"V Sung","year":"2018","unstructured":"Sung V, D\u2019Amico F, Cabana MD et al (2018) Lactobacillus reuteri to treat infant colic: a meta-analysis. Pediatrics 141(1):1\u201310. https:\/\/doi.org\/10.1542\/peds.2017-1811","journal-title":"Pediatrics."},{"issue":"51","key":"5473_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1097\/MD.0000000000009375","volume":"96","author":"P Guti\u00e9rrez-Castrell\u00f3n","year":"2017","unstructured":"Guti\u00e9rrez-Castrell\u00f3n P, Indrio F, Bolio-Galvis A, Jim\u00e9nez-Guti\u00e9rrez C, Jimenez-Escobar I, L\u00f3pez-Vel\u00e1zquez G (2017) Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network metaanalysis. Medicine (Baltimore) 96(51):375. https:\/\/doi.org\/10.1097\/MD.0000000000009375. Erratum in: Medicine (Baltimore). 2018 Jan;97(4):e9730. PMID: 29390535; PMCID: PMC5758237","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"5473_CR25","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1097\/MPG.0000000000001340","volume":"64","author":"A Partty","year":"2017","unstructured":"Partty A, Kalliomaki M, Salminen S et al (2017) Infantile colic is associated with low-grade systemic inflammation. J Pediatr Gastroenterol Nutr 64(5):691\u20135. https:\/\/doi.org\/10.1097\/MPG.0000000000001340","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"5473_CR26","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","volume":"340","author":"Schulz KF, Altman DG, Moher D; CONSORT Group","year":"2010","unstructured":"Schulz KF, Altman DG, Moher D; CONSORT Group (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 340:c332. https:\/\/doi.org\/10.1136\/bmj.c332. PMID: 20332509; PMCID: PMC2844940","journal-title":"BMJ"},{"key":"5473_CR27","volume-title":"Designing Clinical Research","author":"SB Hulley","year":"2013","unstructured":"Hulley SB, Cummings SR, Browner WS, Grady DG, Newman TB (2013) Designing clinical research, 4th edn. Lippincott Williams and Wilkins, Philadelphia, PA. ISBN 9781608318049","edition":"4"},{"key":"5473_CR28","doi-asserted-by":"publisher","unstructured":"Chow S-C, Shao J, Wang H, Lokhnygina Y (2017) Sample size calculations in clinical research, 3rd ed. Chapman and Hall\/CRC, New York. https:\/\/doi.org\/10.1201\/9781315183084.\u00a0eBook ISBN 9781315183084","DOI":"10.1201\/9781315183084"},{"key":"5473_CR29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1442-9993.2001.01070.pp.x","volume":"26","author":"MJ Anderson","year":"2001","unstructured":"Anderson MJ (2001) A new method for non-parametric multivariate analysis of variance. Austral Ecol 26:32\u201346. https:\/\/doi.org\/10.1111\/j.1442-9993.2001.01070.pp.x","journal-title":"Austral Ecol"},{"key":"5473_CR30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13040-018-0187-3","volume":"11","author":"D Efimova","year":"2018","unstructured":"Efimova D, Tyakht A, Popenko A, Vasilyev A, Altukhov I, Dovidchenko N et al (2018) Knomics-Biota system for exploratory analysis of human gut microbiota data. BioData Min 11:25","journal-title":"BioData Min"},{"key":"5473_CR31","doi-asserted-by":"publisher","unstructured":"Odintsova VE, Klimenko NS, Tyakht AV (2022) Approximation of a microbiome composition shift by a change in a single balance between two groups of Taxa. mSystems 7(3):e0015522. https:\/\/doi.org\/10.1128\/msystems.00155-22. Epub 2022 May 9. PMID: 35532211; PMCID: PMC9239069","DOI":"10.1128\/msystems.00155-22"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05473-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05473-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05473-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:24:09Z","timestamp":1713745449000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05473-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["5473"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05473-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3268650\/v1","asserted-by":"object"}]},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"16 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research was conducted in accordance with the Declaration of Helsinki (Fortaleza, 2013) and ICH guideline for good clinical practice E6(R2).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}