{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:10:44Z","timestamp":1740107444023,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"internal funding from Ente Ospedaliero Cantonale for junior researchers"},{"DOI":"10.13039\/100030993","name":"Universit\u00e0 della Svizzera italiana","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030993","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study is to evaluate the intracellular and extracellular volume before and after anesthesia in order to ascertain their variations and determine the potential utility of this information in optimizing intraoperative fluid administration practices.\u00a0A bioimpedance spectroscopy device (body composition monitor, BCM) was used to measure total body fluid volume, extracellular volume, and intracellular volume. BCM measurements were performed before and after general anesthesia in unselected healthy children and adolescents visiting the Pediatric Institute of Southern Switzerland for low-risk surgical procedures hydrated with an isotonic solution.\u00a0In 100 children and adolescents aged 7.0 (4.8\u201311) years (median and interquartile range), the average total body water increased perioperatively with a delta value of 182 (0\u2013383) mL\/m<jats:sup>2<\/jats:sup> from pre- to postoperatively, as well as the extracellular water content, which had a similar increase with a delta value of 169 (19\u2013307) mL\/m<jats:sup>2<\/jats:sup>. The changes in total body water and extracellular water content significantly correlated with the amount of fluids administered. The intracellular water content did not significantly change.\u00a0<\/jats:p><jats:p><jats:italic>\u00a0 Conclusion<\/jats:italic>:\u00a0Intraoperative administration of isotonic solutions results in a significant fluid accumulation in low-risk schoolchildren during general anesthesia. The results suggest that children without major health problems undergoing short procedures do not need any perioperative intravenous fluid therapy, because they are allowed to take clear fluids up to 1\u00a0h prior anesthesia. In future studies, the use of BCM measurements has the potential to be valuable in guiding intraoperative fluid therapy.<\/jats:p><jats:p><jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Most children who undergo common surgical interventions or investigations requiring anesthesia are nowadays hydrated at a rate of 1700\u00a0mL\/m<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup><jats:italic>\/day with an isotonic solution.<\/jats:italic><jats:italic>\u2022 The use bioimpedance spectroscopy for the assessment of fluid status in healthy children has already been successfully validated.<\/jats:italic><jats:italic>\u2022 The bioimpedance spectroscopy is already currently widely used in various nephrological settings to calculate fluid overload and determine patient\u2019s optimal fluid status.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Routine intraoperative fluid administration results in a significant fluid accumulation during general anesthesia in low-risk surgical procedures.<\/jats:italic><jats:italic>\u2022 This observation might be relevant for children and adolescents with conditions predisposing to fluid retention.<\/jats:italic><jats:italic>\u2022 In future studies, the use of BCM measurements has the potential to be valuable in guiding intraoperative fluid therapy.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-024-05490-x","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T16:02:11Z","timestamp":1708963331000},"page":"2251-2256","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fluids and body composition during anesthesia in children and adolescents: A pilot study"],"prefix":"10.1007","volume":"183","author":[{"given":"C\u00e9line","family":"Betti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Busi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Mendoza-Sagaon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo D.","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"5490_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1542\/peds.19.5.823","volume":"19","author":"MA Holliday","year":"1957","unstructured":"Holliday MA, Segar WE (1957) The maintenance need for water in parenteral fluid therapy. 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