{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:40:32Z","timestamp":1721641232736},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-024-05614-3","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:02:31Z","timestamp":1716444151000},"page":"3471-3478","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Viral load in hospitalized infants with respiratory syncytial virus bronchiolitis: a three-way comparative analysis"],"prefix":"10.1007","volume":"183","author":[{"given":"Inbal","family":"Golan- Tripto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Danino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"De Waal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Akel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yotam","family":"Dizitzer- Hillel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher","family":"Tal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Langman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviv","family":"Goldbart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"5614_CR1","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1067\/mpd.2000.110531","volume":"137","author":"TG Boyce","year":"2000","unstructured":"Boyce TG, Mellen BG, Mitchel EF Jr, Wright PF, Griffin MR (2000) Rates of hospitalization for respiratory syncytial virus infection among children in medicaid. J Pediatr 137:865\u2013870","journal-title":"J Pediatr"},{"key":"5614_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0022-3476(95)70547-3","volume":"126","author":"EE Wang","year":"1995","unstructured":"Wang EE, Law BJ, Stephens D (1995) Pediatric investigators collaborative Ne2rk on infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J Pediatr 126:212\u2013219","journal-title":"J Pediatr"},{"key":"5614_CR3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1056\/NEJMoa0804877","volume":"360","author":"CB Hall","year":"2009","unstructured":"Hall CB, Weinberg GA, Iwane MK et al (2009) The burden of respiratory syncytial virus infection in young children. N Engl J Med 360:588\u2013598","journal-title":"N Engl J Med"},{"key":"5614_CR4","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","volume":"375","author":"H Nair","year":"2010","unstructured":"Nair H, Nokes DJ, Gessner BD et al (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375:1545\u20131555","journal-title":"Lancet"},{"key":"5614_CR5","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1128\/JCM.43.5.2356-2362.2005","volume":"43","author":"SM Perkins","year":"2005","unstructured":"Perkins SM, Webb DL, Torrance SA et al (2005) Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus. J Clin Microbiol 43:2356\u20132362","journal-title":"J Clin Microbiol"},{"key":"5614_CR6","doi-asserted-by":"publisher","first-page":"e615","DOI":"10.1542\/peds.2008-0691","volume":"122","author":"SB Lambert","year":"2008","unstructured":"Lambert SB, Whiley DM, O\u2019Neill NT et al Comparing nose-throat swabs and nasopharyngeal aspirates collected from children with symptoms for respiratory virus identification using real-time polymerase chain reaction. Pediatrics 2008;122;e615","journal-title":"Pediatrics"},{"key":"5614_CR7","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/infdis\/jir494","volume":"204","author":"CM El Saleeby","year":"2011","unstructured":"El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, Devincenzo JP (2011) Respirator syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 204:996\u20131002","journal-title":"J Infect Dis"},{"issue":"1","key":"5614_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/v10010018","volume":"10","author":"L de Waal","year":"2018","unstructured":"de Waal L, Smits SL, Veldhuis Kroeze EJB, van Amerongen G, Pohl MO, Osterhaus AD, M. E, Stittelaar KJ (2018) Transmission of human respiratory syncytial virus in the immunocompromised ferret model. Viruses 10(1):18","journal-title":"Viruses"},{"issue":"6","key":"5614_CR9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3390\/v8060168","volume":"8","author":"KJ Stittelaar","year":"2016","unstructured":"Stittelaar KJ, de Waal L, van Amerongen G, Veldhuis Kroeze EJ, Fraaij PL, van Baalen CA, van Kampen JJ, van der Vries E, Osterhaus AD, de Swart RL (2016) Ferrets as a novel animal model for studying human respiratory syncytial virus infections in immunocompetent and immunocompromised hosts. Viruses 8(6):168","journal-title":"Viruses"},{"issue":"6","key":"5614_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/ppul.24007","volume":"53","author":"I Golan-Tripto","year":"2018","unstructured":"Golan-Tripto I, Goldbart A, Akel KH, Dizitzer Y, Novack V, Tal A (2018) Modified Tal Score: validated score for prediction of bronchiolitis severity. Ped Pulmo 53(6):796\u2013801","journal-title":"Ped Pulmo"},{"key":"5614_CR11","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1056\/NEJMoa1401184","volume":"371","author":"JP DeVincenzo","year":"2014","unstructured":"DeVincenzo JP et al (2014) Oral GS-5806 activity in a respiratory syncytial virus challenge study. N Engl J Med 371:711\u2013722","journal-title":"N Engl J Med"},{"issue":"4","key":"5614_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/INF.0b013e318282603a","volume":"32","author":"HS Jafri","year":"2013","unstructured":"Jafri HS, Wu X, Makari D, Henrickson KJ (2013) Distribution of respiratory syncytial virus subtypes A and B among infants presenting to the emergency department with lower respiratory tract infection or apnea. Pediatr Infect Dis J 32(4):335\u201340","journal-title":"Pediatr Infect Dis J"},{"issue":"8","key":"5614_CR13","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1093\/infdis\/jix150","volume":"215","author":"RS Thwaites","year":"2017","unstructured":"Thwaites RS, Ito K, Chingono JMS, Coates M, Jarvis HC, Tunstall T, Anderson-Dring L, Cass L, Rapeport G, Openshaw PJ, Nadel S, Hansel TT (2017) Nasosorption as a minimally invasive sampling procedure: mucosal viral load and inflammation in primary RSV bronchiolitis. J Infect Dis 215(8):1240\u20131244","journal-title":"J Infect Dis"},{"key":"5614_CR14","doi-asserted-by":"publisher","first-page":"e0169805","DOI":"10.1371\/journal.pone.0169805","volume":"12","author":"SP Jochems","year":"2017","unstructured":"Jochems SP, Piddock K, Rylance J et al (2017) Novel analysis of immune cells from nasal microbiopsy demonstrates reliable, reproducible data for immune populations, and superior cytokine detection compared to nasal wash. PLoS ONE 12:e0169805","journal-title":"PLoS ONE"},{"key":"5614_CR15","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1086\/339822","volume":"185","author":"PF Wright","year":"2002","unstructured":"Wright PF, Gruber WC, Peters M, Reed G, Zhu Y, Robinson F, Coleman-Dockery S, Graham BS (2002) Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J Infect Dis 185:1011\u20131018","journal-title":"J Infect Dis"},{"key":"5614_CR16","doi-asserted-by":"publisher","first-page":"113947","DOI":"10.1016\/j.jviromet.2020.113947","volume":"285","author":"L Garnett","year":"2020","unstructured":"Garnett L, Bello A, Tran KN, Audet J, Leung A, Schiffman Z, Griffin BD, Tailor N, Kobasa D, Strong JE (2020) Comparison analysis of different swabs and transport mediums suitable for SARS-CoV-2 testing following shortages. J Virol Methods 285:113947","journal-title":"J Virol Methods"},{"issue":"2","key":"5614_CR17","doi-asserted-by":"publisher","first-page":"102872","DOI":"10.1016\/j.amjoto.2020.102872","volume":"42","author":"V Bidkar","year":"2021","unstructured":"Bidkar V, Selvaraj K, Mishra M, Shete V, Sajjanar A (2021 Mar-Apr) A comparison of swab types on sample adequacy, suspects comfort and provider preference in COVID-19. Am J Otolaryngol 42(2):102872","journal-title":"Am J Otolaryngol"},{"key":"5614_CR18","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1164\/rccm.200210-1148OC","volume":"168","author":"JP Legg","year":"2003","unstructured":"Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO (2003) Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 168:633\u2013639","journal-title":"Am J Respir Crit Care Med"},{"key":"5614_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00006454-200002000-00006","volume":"19","author":"S Buckingham","year":"2000","unstructured":"Buckingham S, Bush A, DeVincenzo J (2000) Nasal quantity of respiratory syncytial virus correlates with disease severity in hospitalized infants. Pediatr Infect Dis J 19:113\u2013117","journal-title":"Pediatr Infect Dis J"},{"key":"5614_CR20","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/infdis\/jiu658","volume":"211","author":"K Hasegawa","year":"2015","unstructured":"Hasegawa K, Jartti T, Mansbach JM et al (2015) Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis 211:1550\u20131559","journal-title":"J Infect Dis"},{"key":"5614_CR21","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1086\/430008","volume":"191","author":"JP DeVincenzo","year":"2005","unstructured":"DeVincenzo JP, El Saleeby CM, Bush AJ (2005) Respiratory syncytial virus load predicts disease severity in previously healthy infants. J Infect Dis 191:1861\u20131868","journal-title":"J Infect Dis"},{"key":"5614_CR22","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/jmv.21771","volume":"82","author":"M Houben","year":"2010","unstructured":"Houben M, Coenjaerts F, Rossen J, Belderbos M, Hofland R, Kimpen J, Bont L (2010) Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community. J Med Virol 82:1266\u20131271","journal-title":"J Med Virol"},{"issue":"11","key":"5614_CR23","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.3390\/pathogens10111515","volume":"10","author":"MF Flynn","year":"2021","unstructured":"Flynn MF, Kelly M, Dooley JSG (2021) Nasopharyngeal swabs vs. nasal aspirates for respiratory virus detection: a systematic review. Pathogens 10(11):1515","journal-title":"Pathogens"},{"issue":"11","key":"5614_CR24","first-page":"1987","volume":"11","author":"T Todsen","year":"2021","unstructured":"Todsen T, Bohr A, Hovgaard LH, Ei\u00f0 RC, Benfield T, Svendsen MBS, Kirkby N, Konge L, von Buchwald C, Melchiors J, Tolsgaard M (2021) Valid and reliable assessment of upper respiratory. Valid and reliable assessment of upper respiratory tract specimen collection skills during the COVID-19 pandemic 11(11):1987","journal-title":"Valid and reliable assessment of upper respiratory tract specimen collection skills during the COVID-19 pandemic"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05614-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:19:28Z","timestamp":1721639968000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05614-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":24,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["5614"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05614-3","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"17 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the declaration of Helsinki and was approved by the Institutional Ethics Committee (Soroka University Medical Center, No. 268-14).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the parents of all participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Competing interests"}}]}}