{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:19:15Z","timestamp":1781119155227,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-024-05638-9","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T04:02:00Z","timestamp":1717992120000},"page":"3749-3756","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chemotherapy-induced neuropathy and pain in pediatric oncology patients: impact of combination therapies"],"prefix":"10.1007","volume":"183","author":[{"given":"Delia","family":"Soriano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisella","family":"Santos Chocler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Alejandra","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-5105","authenticated-orcid":false,"given":"Mar\u00eda Florencia","family":"Coronel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"5638_CR1","doi-asserted-by":"publisher","unstructured":"Triarico S, Romano A, Attin\u00e0 G, et al (2021) Vincristine-induced peripheral neuropathy (VIPN) in pediatric tumors: mechanisms, risk factors, strategies of prevention and treatment. Int J Mol Sci 22:. https:\/\/doi.org\/10.3390\/IJMS22084112","DOI":"10.3390\/IJMS22084112"},{"key":"5638_CR2","doi-asserted-by":"publisher","unstructured":"Bo L, Wang Y, Li Y, et al (2023) The battlefield of chemotherapy in pediatric cancers. Cancers (Basel) 15:. https:\/\/doi.org\/10.3390\/CANCERS15071963","DOI":"10.3390\/CANCERS15071963"},{"key":"5638_CR3","doi-asserted-by":"publisher","unstructured":"Tay N, Laakso EL, Schweitzer D, et al (2022) Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients. Front Mol Biosci 9:. https:\/\/doi.org\/10.3389\/FMOLB.2022.1015746","DOI":"10.3389\/FMOLB.2022.1015746"},{"key":"5638_CR4","doi-asserted-by":"publisher","unstructured":"\u0160kubn\u00edk J, Pavl\u00ed\u010dkov\u00e1 VS, Ruml T, Rimpelov\u00e1 S (2021) Vincristine in combination therapy of cancer: emerging trends in clinics. Biology (Basel) 10(9):849. https:\/\/doi.org\/10.3390\/biology10090849","DOI":"10.3390\/biology10090849"},{"key":"5638_CR5","doi-asserted-by":"publisher","first-page":"100420","DOI":"10.1016\/J.CTARC.2021.100420","volume":"28","author":"EM Lavoie-Smith","year":"2021","unstructured":"Lavoie-Smith EM, Kuisell C, Cho Y et al (2021) Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: a systematic review. Cancer Treat Res Commun 28:100420. https:\/\/doi.org\/10.1016\/J.CTARC.2021.100420","journal-title":"Cancer Treat Res Commun"},{"key":"5638_CR6","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/PBC.23039","volume":"57","author":"DL Anghelescu","year":"2011","unstructured":"Anghelescu DL, Faughnan LG, Jeha S et al (2011) Neuropathic pain during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 57:1147\u20131153. https:\/\/doi.org\/10.1002\/PBC.23039","journal-title":"Pediatr Blood Cancer"},{"key":"5638_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/S12098-009-0254-3","volume":"77","author":"S Gomber","year":"2010","unstructured":"Gomber S, Dewan P, Chhonker D (2010) Vincristine induced neurotoxicity in cancer patients. Indian J Pediatr 77:97\u2013100. https:\/\/doi.org\/10.1007\/S12098-009-0254-3","journal-title":"Indian J Pediatr"},{"key":"5638_CR8","doi-asserted-by":"publisher","unstructured":"Was H, Borkowska A, Bagues A, et al (2022) Mechanisms of chemotherapy-induced neurotoxicity. Front Pharmacol 13:. https:\/\/doi.org\/10.3389\/FPHAR.2022.750507","DOI":"10.3389\/FPHAR.2022.750507"},{"key":"5638_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/J.BLRE.2014.09.012","volume":"29","author":"RS Magge","year":"2015","unstructured":"Magge RS, DeAngelis LM (2015) The double-edged sword: neurotoxicity of chemotherapy. Blood Rev 29:93\u2013100. https:\/\/doi.org\/10.1016\/J.BLRE.2014.09.012","journal-title":"Blood Rev"},{"key":"5638_CR10","doi-asserted-by":"publisher","unstructured":"Walker SM (2020) Neuropathic pain in children: steps towards improved recognition and management. EBioMedicine 62:103124. https:\/\/doi.org\/10.1016\/j.ebiom.2020.103124","DOI":"10.1016\/j.ebiom.2020.103124"},{"key":"5638_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/jns.12114","volume":"20","author":"EM Lavoie Smith","year":"2015","unstructured":"Lavoie Smith EM, Li L, Chiang C et al (2015) Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia. J Peripher Nerv Syst 20:37\u201346. https:\/\/doi.org\/10.1111\/jns.12114","journal-title":"J Peripher Nerv Syst"},{"key":"5638_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/pch\/pxac048","volume":"27","author":"ED Trottier","year":"2022","unstructured":"Trottier ED, Ali S, Dor\u00e9-Bergeron M-J, Chauvin-Kimoff L (2022) Best practices in pain assessment and management for children. Paediatr Child Health 27:429\u2013437. https:\/\/doi.org\/10.1093\/pch\/pxac048","journal-title":"Paediatr Child Health"},{"key":"5638_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/J.PAIN.0000000000001377","volume":"160","author":"KA Birnie","year":"2019","unstructured":"Birnie KA, Hundert AS, Lalloo C et al (2019) Recommendations for selection of self-report pain intensity measures in children and adolescents: a systematic review and quality assessment of measurement properties. Pain 160:5\u201318. https:\/\/doi.org\/10.1097\/J.PAIN.0000000000001377","journal-title":"Pain"},{"key":"5638_CR14","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/pbc.22882","volume":"57","author":"B Langholz","year":"2011","unstructured":"Langholz B, Skolnik JM, Barrett JS et al (2011) Dactinomycin and vincristine toxicity in the treatment of childhood cancer: a retrospective study from the Children\u2019s Oncology Group. Pediatric Blood Cancer 57:252\u2013257. https:\/\/doi.org\/10.1002\/pbc.22882","journal-title":"Pediatric Blood Cancer"},{"key":"5638_CR15","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1001\/JAMANEUROL.2018.0963","volume":"75","author":"T Kandula","year":"2018","unstructured":"Kandula T, Farrar MA, Cohn RJ et al (2018) Chemotherapy-induced peripheral neuropathy in long-term survivors of childhood cancer: clinical, neurophysiological, functional, and patient-reported outcomes. JAMA Neurol 75:980\u2013988. https:\/\/doi.org\/10.1001\/JAMANEUROL.2018.0963","journal-title":"JAMA Neurol"},{"key":"5638_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/08880018.2019.1677832","volume":"37","author":"N Nama","year":"2020","unstructured":"Nama N, Barker MK, Kwan C et al (2020) Vincristine-induced peripheral neurotoxicity: a prospective cohort. Pediatr Hematol Oncol 37:15\u201328. https:\/\/doi.org\/10.1080\/08880018.2019.1677832","journal-title":"Pediatr Hematol Oncol"},{"key":"5638_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.clinph.2023.08.002","volume":"154","author":"T Li","year":"2023","unstructured":"Li T, Kandula T, Cohn RJ et al (2023) Prospective assessment of vincristine-induced peripheral neuropathy in paediatric acute lymphoblastic leukemia. Clin Neurophysiol 154:157\u2013168. https:\/\/doi.org\/10.1016\/j.clinph.2023.08.002","journal-title":"Clin Neurophysiol"},{"key":"5638_CR18","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S2352-4642(18)30236-0","volume":"2","author":"KL Bjornard","year":"2018","unstructured":"Bjornard KL, Gilchrist LS, Inaba H et al (2018) Peripheral neuropathy in children and adolescents treated for cancer. Lancet Child Adolesc Health 2:744. https:\/\/doi.org\/10.1016\/S2352-4642(18)30236-0","journal-title":"Lancet Child Adolesc Health"},{"key":"5638_CR19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/J.CRITREVONC.2017.04.004","volume":"114","author":"ME van de Velde","year":"2017","unstructured":"van de Velde ME, Kaspers GL, Abbink FCH et al (2017) Vincristine-induced peripheral neuropathy in children with cancer: a systematic review. Crit Rev Oncol Hematol 114:114\u2013130. https:\/\/doi.org\/10.1016\/J.CRITREVONC.2017.04.004","journal-title":"Crit Rev Oncol Hematol"},{"key":"5638_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s40272-018-00324-4","volume":"21","author":"DL Anghelescu","year":"2019","unstructured":"Anghelescu DL, Tesney JM (2019) Neuropathic pain in pediatric oncology: a clinical decision algorithm. Pediatr Drugs 21:59\u201370. https:\/\/doi.org\/10.1007\/s40272-018-00324-4","journal-title":"Pediatr Drugs"},{"key":"5638_CR21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jpainsymman.2019.08.005","volume":"59","author":"KL Marcus","year":"2020","unstructured":"Marcus KL, Santos G, Ciapponi A et al (2020) Impact of specialized pediatric palliative care: a systematic review. J Pain Symptom Manage 59:339-364.e10","journal-title":"J Pain Symptom Manage"},{"key":"5638_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5546\/aap.2018.eng.62","volume":"116","author":"MLY Puleio","year":"2018","unstructured":"Puleio MLY, G\u00f3mez KV, Majdalani A et al (2018) Tratamiento opioide del dolor mixto en pacientes pedi\u00e1tricos asistidos por el equipo de Cuidados Paliativos. Cinco an\u00f5s de experiencia. Arch Argent Pediatr 116:62\u201365. https:\/\/doi.org\/10.5546\/aap.2018.eng.62","journal-title":"Arch Argent Pediatr"},{"key":"5638_CR23","doi-asserted-by":"publisher","unstructured":"Grisold W, Cavaletti G, Windebank AJ (2012) Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol 14:. https:\/\/doi.org\/10.1093\/neuonc\/nos203","DOI":"10.1093\/neuonc\/nos203"},{"key":"5638_CR24","doi-asserted-by":"publisher","unstructured":"Jordan B, Margulies A, Cardoso F, et al (2020) Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMOeEONSeEANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up 5 behalf of the ESMO Guidelines Committee * , the EONS Education Working Group * and the EANO Guideline Committee. 10:. https:\/\/doi.org\/10.1016\/j.annonc.2020.07.003","DOI":"10.1016\/j.annonc.2020.07.003"},{"key":"5638_CR25","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/PBC.26204","volume":"64","author":"LS Gilchrist","year":"2017","unstructured":"Gilchrist LS, Tanner LR, Ness KK (2017) Short-term recovery of chemotherapy-induced peripheral neuropathy after treatment for pediatric non-CNS cancer. Pediatr Blood Cancer 64:180\u2013187. https:\/\/doi.org\/10.1002\/PBC.26204","journal-title":"Pediatr Blood Cancer"},{"key":"5638_CR26","doi-asserted-by":"publisher","first-page":"e637","DOI":"10.1097\/MPH.0000000000001604","volume":"42","author":"TJ Sajdyk","year":"2020","unstructured":"Sajdyk TJ, Boyle FA, Foran KS et al (2020) Obesity as a potential risk factor for vincristine-induced peripheral neuropathy. J Pediatr Hematol Oncol 42:e637\u2013e640. https:\/\/doi.org\/10.1097\/MPH.0000000000001604","journal-title":"J Pediatr Hematol Oncol"},{"key":"5638_CR27","doi-asserted-by":"publisher","unstructured":"Yang QY, Hu YH, Guo HL et al (2021) Vincristine-induced peripheral neuropathy in childhood acute lymphoblastic leukemia: genetic variation as a potential risk factor. Front Pharmacol 12:771487. https:\/\/doi.org\/10.3389\/fphar.2021.771487","DOI":"10.3389\/fphar.2021.771487"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05638-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05638-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05638-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T21:04:40Z","timestamp":1723583080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05638-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["5638"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05638-9","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"3 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was evaluated and approved by the Review Board on Ethics in Research from the School of Biomedical Sciences, Austral University (protocol #22\u201316). Confidentiality principles established by the Declaration of Helsinki were respected, and endorsement was obtained from the clinical institution to access the data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"This is an observational study. The Review Board on Ethics in Research from the School of Biomedical Sciences, Austral University (protocol #22\u201316) has confirmed that no consent to participate is required, since the medical records were kept anonymous.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}