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In addition, individuals with achondroplasia face significant medical, functional, and psychosocial challenges throughout their lives. This study assessed associated morbidities in patients with achondroplasia at a single center in Turkey. In this study, the clinical findings and associated morbidities of a group of patients with achondroplasia (n\u2009=\u200968) with clinical multidisciplinary follow-up at a single center between the years 2005\u20132023 are evaluated retrospectively. A total of 68 patients, 30 male (44.1%) and 38 female (55.9%), were evaluated. In the majority (84.2%) of patients, shortness of extremities was detected in the prenatal period at an average of 28.7 gestational weeks (\u00b1\u20093.6 SDS) with the aid of ultrasonography. More than half (n\u2009=\u200934\/63, 54%) of the patients had a father of advanced paternal age (\u2265\u200935\u00a0years). Among the complications, respiratory system manifestations, including obstructive sleep apnea (70%), ear-nose-throat manifestations including adenoid hypertrophy (56.6%) and otitis media (54.7%), neurological manifestations due to foramen magnum stenosis (53.2%), and skeletal manifestations including scoliosis (28.8%), are represented among the most common. The mortality rate was 7.3% (n\u2009=\u20095\/68).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : This study not only represents the first retrospective analysis of the associated morbidities of patients with achondroplasia from a single center in Turkey but also will provide a reference point for future studies.\n                  <\/jats:p>","DOI":"10.1007\/s00431-024-05643-y","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T14:01:43Z","timestamp":1718460103000},"page":"3819-3829","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Review of patients with achondroplasia: a single-center's experience with follow-up and associated morbidities"],"prefix":"10.1007","volume":"183","author":[{"given":"Merve","family":"So\u011fukp\u0131nar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem \u00dcrel","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclen Eda","family":"Utine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmas Nazl\u0131","family":"G\u00f6n\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Alev","family":"\u00d6z\u00f6n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin \u00d6zlem","family":"\u015eim\u015fek-Kiper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"issue":"18","key":"5643_CR1","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1002\/ajmg.a.32485","volume":"146A","author":"DK Waller","year":"2008","unstructured":"Waller DK, Correa A, Vo TM, Wang Y, Hobbs C, Langlois PH et al (2008) The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. 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The patient\u2019s parents have given their informed consent to publish this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of ethics"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}