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A prospective cohort study started in 2001\u20132004 and followed up 166 children hospitalised for bronchiolitis in early infancy. At 16\u201320\u00a0years of age, 76 cases and 41 population-based controls without a history of bronchiolitis participated in the current study. Clinical asthma, presumptive symptoms and HRQoL data were collected with a structured questionnaire and the St. Georges Respiratory Questionnaire (SGRQ). Flow-volume spirometry was measured before and after bronchodilator administration. Asthma was present in 21.1% of cases in the post-bronchiolitis cohort compared to 9.8% in the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.21). Also, 35.5% of cases and 19.5% of controls reported dyspnea during the last 12\u00a0months (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). In addition, total SGRQ scores were higher in the bronchiolitis group (4.26) than in the control group (1.67,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) referring to a reduced health-related quality of life.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Viral bronchiolitis in early infancy was associated with increased respiratory symptoms and lower health-related quality of life at age 16\u201320\u00a0years.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is known:<\/jats:bold>\n                              \u2022 The prevalence of asthma at the school age and adolescence is increased after hospitalisation required bronchiolitis in infancy compared to those without hospitalisation due to bronchiolitis.\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is new:<\/jats:bold>\n                              \u2022 Viral bronchiolitis requiring hospitalisation in early infancy was associated with increased respiratory symptoms, such as dyspnoea, and lower health-related quality of life at age 16\u201320 years in a prospectively followed post-bronchiolitis cohort.\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-024-05754-6","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T04:05:26Z","timestamp":1725941126000},"page":"4877-4883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asthma and health-related quality of life at 16\u201320\u00a0years of age in a prospectively followed post-bronchiolitis cohort"],"prefix":"10.1007","volume":"183","author":[{"given":"Sonja","family":"Laitinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-7602","authenticated-orcid":false,"given":"Eero","family":"Lauhkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna","family":"Saarikallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"Riikonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninni","family":"Ker\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-8615","authenticated-orcid":false,"given":"Paula","family":"Heikkil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"issue":"9532","key":"5754_CR1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0140-6736(06)69077-6","volume":"368","author":"RL Smyth","year":"2006","unstructured":"Smyth RL, Openshaw PJ (2006) Bronchiolitis. 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The study was approved by the Ethics Committee of the Tampere University Hospital District (R19070).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all study subjects over 18\u00a0years old and from the parents before enrolling the children in infancy and during all control visits, including the current control visit, if the study subjects were under 18\u00a0years old.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}