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This study aimed to evaluate bone biomarkers and microarchitecture using high resolution peripheral quantitative computed tomography (HR-pQCT) at the time of KTx and 6\u00a0months thereafter and to compare these results with those of matched healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study presented the single-center subgroup of patients aged between 10 and 18\u00a0years included in the prospective \u201cBone Microarchitecture in the Transplant Patient\u201d study (TRANSOS-NCT02729142). Patients undergoing a first KTx were matched (1:2) with HC from the \u201cVitamin D, Bones, Nutritional and Cardiovascular Status\u201d cohort (VITADOS) on sex, pubertal stage, and age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At a median (interquartile range, IQR) age of 15 [13; 16] years, 19 patients (6 girls, 7 pre-emptive KTx, 7 steroid-sparing immunosuppressive strategies) underwent a first KTx, with a median [IQR] parathyroid hormone level of 1.9 [1.4; 2.9] the upper limit of normal (ULN). Higher total and trabecular bone densities, along with superior trabecular microarchitecture, were observed at KTx compared to HC. Six months post-KTx, patients had significantly impaired trabecular parameters at the radius, while results were not significantly different at the weight-bearing tibia, neither cortical parameters at both sites. Six months post-KTx, 6 (32%) patients still present with metabolic acidosis, 10 (53%) persistent hyperparathyroidism (always\u2009&lt;\u20092 ULN), and 5 (26%) elevated FGF23 levels; 11 (58%) received phosphate supplementation.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Conclusions<\/jats:italic>\n                      : Bone density and microarchitecture at the time of KTx were superior compared to HC, but radial trabecular bone microarchitecture impairment observed 6\u00a0months post-KTx may reflect subtle albeit present post-KTx CKD-MBD.\n                      <jats:table-wrap>\n                        <jats:table>\n                          <jats:tbody>\n                            <jats:tr>\n                              <jats:td align=\"left\">\n                                <jats:bold>What is Known?<\/jats:bold>\n                                \u2022\n                                <jats:italic>Mineral bone disorder associated with chronic kidney disease (CKD-MBD) frequently persists after kidney transplantation (KTx) and is associated with morbidity. However, biochemical parameters and dual X-ray absorptiometry (DXA) are poor predictors of the underlying bone disease.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                            <jats:tr>\n                              <jats:td align=\"left\">\n                                <jats:bold>What is new?<\/jats:bold>\n                                \u2022\n                                <jats:italic>The present study on 19 adolescent KTx recipients with adequate CKD-MBD control at the time of KTx reveals no significant bone disease compared to matched healthy controls. Microarchitecture impairment observes 6\u00a0months post-KTx may reflect subtle, albeit present, post-KTx CKD-MBD.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                          <\/jats:tbody>\n                        <\/jats:table>\n                      <\/jats:table-wrap>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00431-024-05777-z","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T18:02:04Z","timestamp":1728496924000},"page":"5303-5312","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in bone density and microarchitecture in adolescents undergoing a first kidney transplantation: a prospective study"],"prefix":"10.1007","volume":"183","author":[{"given":"Aur\u00e9lie","family":"De Mul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure Sellier","family":"Leclerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphanie","family":"Ginhoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e8ne","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Confavreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Aurelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Portefaix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"5777_CR1","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1097\/01.TP.0000092524.75807.84","volume":"76","author":"SM Bartosh","year":"2003","unstructured":"Bartosh SM, Leverson G, Robillard D, Sollinger HW (2003) Long-term outcomes in pediatric renal transplant recipients who survive into adulthood. 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