{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:42:49Z","timestamp":1791477769693,"version":"4.3.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["No. SZXK00036"],"award-info":[{"award-number":["No. SZXK00036"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["No. SZXK00036"],"award-info":[{"award-number":["No. SZXK00036"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["No. SZXK00036"],"award-info":[{"award-number":["No. SZXK00036"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["No. SZXK00036"],"award-info":[{"award-number":["No. SZXK00036"]}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["No. SZXK00036"],"award-info":[{"award-number":["No. SZXK00036"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201612003"],"award-info":[{"award-number":["SZSM201612003"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201612003"],"award-info":[{"award-number":["SZSM201612003"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong High-level Hospital Construction Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-024-05896-7","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:25:57Z","timestamp":1734654357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Detection of circulating tumor cells using a microfluidic chip for diagnostics and therapeutic prediction in mediastinal neuroblastoma"],"prefix":"10.1007","volume":"184","author":[{"given":"Yuanxiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianhua","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxing","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengnan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaican","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"5896_CR1","doi-asserted-by":"crossref","unstructured":"Stiller CA, Parkin DM (1992) International variations in the incidence of neuroblastoma. International Journal of Cancer 52:538-543","DOI":"10.1002\/ijc.2910520407"},{"key":"5896_CR2","doi-asserted-by":"crossref","unstructured":"Schwab M, Westermann F, Hero B, Berthold F (2003) Neuroblastoma: biology and molecular and chromosomal pathology. The Lancet Oncology 4:472-480","DOI":"10.1016\/S1470-2045(03)01166-5"},{"key":"5896_CR3","doi-asserted-by":"crossref","unstructured":"Cheung N, Dyer M (2013) Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nature reviews Cancer 13:397-411","DOI":"10.1038\/nrc3526"},{"key":"5896_CR4","doi-asserted-by":"crossref","unstructured":"Matthay K, Maris J, Schleiermacher G, Nakagawara A, Mackall C, Diller L, Weiss W (2016) Neuroblastoma. Nature reviews Disease primers 2:16078","DOI":"10.1038\/nrdp.2016.78"},{"key":"5896_CR5","doi-asserted-by":"crossref","unstructured":"Maris J, Hogarty M, Bagatell R, Cohn S (2007) Neuroblastoma. Lancet (London, England) 369:2106-2120","DOI":"10.1016\/S0140-6736(07)60983-0"},{"key":"5896_CR6","doi-asserted-by":"crossref","unstructured":"Suita S, Tajiri T, Sera Y, Takamatsu H, Mizote H, Ohgami H, Kurosaki N, Hara T, Okamura J, Miyazaki S, Sugimoto T, Kawakami K, Tsuneyoshi M, Tasaka H, Yano H, Akiyama H, Ikeda K (2000) The characteristics of mediastinal neuroblastoma. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery [et al] = Zeitschrift fur Kinderchirurgie 10:353-359","DOI":"10.1055\/s-2000-12064"},{"key":"5896_CR7","doi-asserted-by":"crossref","unstructured":"Choi JH, Ro JY (2022) Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: pathology review and diagnostic approach. Seminars in Diagnostic Pathology 39:120-130","DOI":"10.1053\/j.semdp.2021.06.007"},{"key":"5896_CR8","doi-asserted-by":"crossref","unstructured":"Swift CC, Eklund MJ, Kraveka JM, Alazraki AL (2018) Updates in diagnosis, management, and treatment of neuroblastoma. RadioGraphics 38:566-580","DOI":"10.1148\/rg.2018170132"},{"key":"5896_CR9","doi-asserted-by":"crossref","unstructured":"Qiu B, Matthay K (2022) Advancing therapy for neuroblastoma. Nature reviews Clinical oncology 19:515-533","DOI":"10.1038\/s41571-022-00643-z"},{"key":"5896_CR10","doi-asserted-by":"crossref","unstructured":"Hao J, Sang J, Xu X, Bao A (2023) Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma. World journal of surgical oncology 21:251","DOI":"10.1186\/s12957-023-03131-5"},{"key":"5896_CR11","doi-asserted-by":"crossref","unstructured":"Georgantzi K, Sk\u00f6ldenberg EG, Stridsberg M, Kogner P, Jakobson \u00c5, Janson ET, Christofferson RHB (2018) Chromogranin A and neuron-specific enolase in neuroblastoma: correlation to stage and prognostic factors. Pediatric Hematology and Oncology 35:156-165","DOI":"10.1080\/08880018.2018.1464087"},{"key":"5896_CR12","doi-asserted-by":"crossref","unstructured":"Wang X, Wang L, Su Y, Yue Z, Xing T, Zhao W, Zhao Q, Duan C, Huang C, Zhang D, Jin M, Cheng X, Chen S, Liu Y, Ma X (2018) Plasma cell-free DNA quantification is highly correlated to tumor burden in children with neuroblastoma. Cancer Medicine 7:3022-3030","DOI":"10.1002\/cam4.1586"},{"key":"5896_CR13","doi-asserted-by":"crossref","unstructured":"Yang R, Zheng S, Dong R (2023) Circulating tumor cells in neuroblastoma: current status and future perspectives. Cancer medicine 12:7-19","DOI":"10.1002\/cam4.4893"},{"key":"5896_CR14","doi-asserted-by":"crossref","unstructured":"Pantel K, Alix-Panabi\u00e8res C (2019) Liquid biopsy and minimal residual disease \u2014 latest advances and implications for cure. Nature Reviews Clinical Oncology 16:409-424","DOI":"10.1038\/s41571-019-0187-3"},{"key":"5896_CR15","doi-asserted-by":"crossref","unstructured":"Labib M, Kelley S (2021) Circulating tumor cell profiling for precision oncology. Molecular oncology 15:1622-1646","DOI":"10.1002\/1878-0261.12901"},{"key":"5896_CR16","doi-asserted-by":"crossref","unstructured":"Monclair T, Brodeur GM, Ambros PF, Brisse HJ, Cecchetto G, Holmes K, Kaneko M, London WB, Matthay KK, Nuchtern JG, von Schweinitz D, Simon T, Cohn SL, Pearson AD (2009) The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol 27:298-303","DOI":"10.1200\/JCO.2008.16.6876"},{"key":"5896_CR17","doi-asserted-by":"crossref","unstructured":"Kushner B, Cheung N, LaQuaglia M, Ambros P, Ambros I, Bonilla M, Ladanyi M, Gerald W (1996) International neuroblastoma staging system stage 1 neuroblastoma: a prospective study and literature review. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 14:2174-2180","DOI":"10.1200\/JCO.1996.14.7.2174"},{"key":"5896_CR18","doi-asserted-by":"crossref","unstructured":"Wang LL, Teshiba R, Ikegaki N, Tang XX, Naranjo A, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR (2015) Augmented expression of MYC and\/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children\u2019s Oncology Group study. British Journal of Cancer 113:57-63","DOI":"10.1038\/bjc.2015.188"},{"key":"5896_CR19","doi-asserted-by":"crossref","unstructured":"Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T, Chareonsirisuthigul T, Phornsarayuth P, Klinkulab N, Jinawath N, Chiangjong W, Anurathapan U, Pattanapanyasat K, Hongeng S, Chutipongtanate S (2022) Extracellular vesicle-based method for detecting MYCN amplification status of pediatric neuroblastoma. Cancers (Basel) 14","DOI":"10.3390\/cancers14112627"},{"key":"5896_CR20","doi-asserted-by":"crossref","unstructured":"Campbell K, Gastier-Foster JM, Mann M, Naranjo AH, Dubois SG (2017) Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group. Cancer 123","DOI":"10.1002\/cncr.30873"},{"key":"5896_CR21","unstructured":"R AT (1869) A case of cancer in which cells similar to those in the tumours were seen in the blood after death. The Medical Journal of Australia:146-147"},{"key":"5896_CR22","doi-asserted-by":"crossref","unstructured":"Rack B, Schindlbeck C, J\u00fcckstock J, Andergassen U, Hepp P, Zwingers T, Friedl T, Lorenz R, Tesch H, Fasching P, Fehm T, Schneeweiss A, Lichtenegger W, Beckmann M, Friese K, Pantel K, Janni W (2014) Circulating tumor cells predict survival in early average-to-high risk breast cancer patients. Journal of the National Cancer Institute 106","DOI":"10.1093\/jnci\/dju066"},{"key":"5896_CR23","doi-asserted-by":"crossref","unstructured":"Aceto N, Bardia A, Miyamoto David\u00a0T, Donaldson Maria\u00a0C, Wittner Ben\u00a0S, Spencer Joel\u00a0A, Yu M, Pely A, Engstrom A, Zhu H, Brannigan Brian\u00a0W, Kapur R, Stott Shannon\u00a0L, Shioda T, Ramaswamy S, Ting David\u00a0T, Lin Charles\u00a0P, Toner M, Haber Daniel\u00a0A, Maheswaran S (2014) Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell 158:1110-1122","DOI":"10.1016\/j.cell.2014.07.013"},{"key":"5896_CR24","doi-asserted-by":"crossref","unstructured":"Vilalta M, Rafat M, Giaccia AJ, Graves EE (2014) Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell reports 8:402-409","DOI":"10.1016\/j.celrep.2014.06.011"},{"key":"5896_CR25","doi-asserted-by":"crossref","unstructured":"Pierga J, Bidard F, Mathiot C, Brain E, Delaloge S, Giachetti S, de Cremoux P, Salmon R, Vincent-Salomon A, Marty M (2008) Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clinical cancer research: an official journal of the American Association for Cancer Research 14:7004-7010","DOI":"10.1158\/1078-0432.CCR-08-0030"},{"key":"5896_CR26","doi-asserted-by":"crossref","unstructured":"Papadaki MA, Koutsopoulos AV, Tsoulfas PG, Lagoudaki E, Agelaki S (2020) Clinical relevance of immune checkpoints on circulating tumor cells in breast cancer. Cancers 12:376","DOI":"10.3390\/cancers12020376"},{"key":"5896_CR27","doi-asserted-by":"crossref","unstructured":"Andre F, Ismaila N, Allison K, Barlow W, Collyar D, Damodaran S, Henry N, Jhaveri K, Kalinsky K, Kuderer N, Litvak A, Mayer E, Pusztai L, Raab R, Wolff A, Stearns V (2022) Biomarkers for adjuvant endocrine and chemotherapy in early-stage breast cancer: ASCO guideline update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40:1816-1837","DOI":"10.1200\/JCO.22.00069"},{"key":"5896_CR28","doi-asserted-by":"crossref","unstructured":"Tamminga M, de Wit S, Hiltermann T, Timens W, Schuuring E, Terstappen L, Groen H (2019) Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors. Journal for immunotherapy of cancer 7:173","DOI":"10.1186\/s40425-019-0649-2"},{"key":"5896_CR29","doi-asserted-by":"crossref","unstructured":"Zhu H, Liu Y, Feng Y, Zhang L, Zhang T, Dong G, Xing P, Wang H, Shi Y, Hu X (2021) Circulating tumor cells (CTCs)\/circulating tumor endothelial cells (CTECs) and their subtypes in small cell lung cancer: Predictors for response and prognosis. Thoracic cancer 12:2749-2757","DOI":"10.1111\/1759-7714.14120"},{"key":"5896_CR30","doi-asserted-by":"crossref","unstructured":"Moon S, Kim J, Kim S, Kim S, Kwon H, Bae J, Lee S, Lee H, Choi M, Jeon B, Jeong B, Lee K, Kim H, Kim J, Um S (2020) Clinical utility of combined circulating tumor cell and circulating tumor DNA assays for diagnosis of primary lung cancer. Anticancer research 40:3435-3444","DOI":"10.21873\/anticanres.14329"},{"key":"5896_CR31","doi-asserted-by":"crossref","unstructured":"Kanayama M, Kuwata T, Mori M, Nemoto Y, Nishizawa N, Oyama R, Matsumiya H, Taira A, Shinohara S, Takenaka M, Yoneda K, Kuroda K, Ohnaga T, Tanaka F (2022) Prognostic impact of circulating tumor cells detected with the microfluidic \u201cuniversal CTC-chip\u201d for primary lung cancer. Cancer science 113:1028-1037","DOI":"10.1111\/cas.15255"},{"key":"5896_CR32","doi-asserted-by":"crossref","unstructured":"Biller L, Schrag D (2021) Diagnosis and treatment of metastatic colorectal cancer: a review. JAMA 325:669-685","DOI":"10.1001\/jama.2021.0106"},{"key":"5896_CR33","doi-asserted-by":"crossref","unstructured":"Li M, Wu S, Zhuang C, Shi C, Gu L, Wang P, Guo F, Wang Y, Liu Z (2023) Metabolomic analysis of circulating tumor cells derived liver metastasis of colorectal cancer. Heliyon 9","DOI":"10.1016\/j.heliyon.2022.e12515"},{"key":"5896_CR34","doi-asserted-by":"crossref","unstructured":"Ring A, Nguyen-Str\u00e4uli BD, Wicki A, Aceto N (2022) Biology, vulnerabilities and clinical applications of circulating tumour cells. Nature Reviews Cancer","DOI":"10.1038\/s41568-022-00536-4"},{"key":"5896_CR35","doi-asserted-by":"crossref","unstructured":"Ahn J, Teng P, Chen P, Posadas E, Tseng H, Lu S, Yang J (2021) Detection of circulating tumor cells and their implications as a biomarker for diagnosis, prognostication, and therapeutic monitoring in hepatocellular carcinoma. Hepatology (Baltimore, Md) 73:422-436","DOI":"10.1002\/hep.31165"},{"key":"5896_CR36","doi-asserted-by":"crossref","unstructured":"Palmela Leit\u00e3o T, Miranda M, Polido J, Morais J, Corredeira P, Alves P, Oliveira T, Pereira E Silva R, Fernandes R, Ferreira J, Palma Reis J, Lopes T, Costa L (2021) Circulating tumor cell detection methods in renal cell carcinoma: a systematic review. Critical reviews in oncology\/hematology 161:103331","DOI":"10.1016\/j.critrevonc.2021.103331"},{"key":"5896_CR37","unstructured":"Xiangqi, Liu, Zhenzhen, Zhang, Binbin, Yijie, Zheng, Chao, Baihui, Shan (2018) Circulating tumor cells detection in neuroblastoma patients by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. Ebiomedicine"},{"key":"5896_CR38","doi-asserted-by":"crossref","unstructured":"Liu Z, Huang Y, Liang W, Bai J, Feng H, Fang Z, Tian G, Zhu Y, Zhang H, Wang Y, Liu A, Chen Y (2021) Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells. Lab on a chip 21:2881-2891","DOI":"10.1039\/D1LC00360G"},{"key":"5896_CR39","doi-asserted-by":"crossref","unstructured":"Zeineldin M, Patel A, Dyer M (2022) Neuroblastoma: when differentiation goes awry. Neuron 110:2916-2928","DOI":"10.1016\/j.neuron.2022.07.012"},{"key":"5896_CR40","doi-asserted-by":"crossref","unstructured":"Zafar A, Wang W, Liu G, Wang X, Xian W, McKeon F, Foster J, Zhou J, Zhang R (2021) Molecular targeting therapies for neuroblastoma: progress and challenges. Medicinal research reviews 41:961-1021","DOI":"10.1002\/med.21750"},{"key":"5896_CR41","doi-asserted-by":"crossref","unstructured":"Yue Z, Gao C, Xing T, Zhao W, Duan C, Wang X, Jin M, Su Y (2023) Combined analysis of PHOX2B at two time points and its value for further risk stratification in high-risk neuroblastoma. Pediatric blood & cancer 70:e30261","DOI":"10.1002\/pbc.30261"},{"key":"5896_CR42","doi-asserted-by":"crossref","unstructured":"Cangemi G, Reggiardo G, Barco S, Barbagallo L, Conte M, D'Angelo P, Bianchi M, Favre C, Galleni B, Melioli G, Haupt R, Garaventa A, Corrias MV (2012) Prognostic value of ferritin, neuron-specific enolase, lactate dehydrogenase, and urinary and plasmatic catecholamine metabolites in children with neuroblastoma. OncoTargets and therapy 5:417-423","DOI":"10.2147\/OTT.S36366"},{"key":"5896_CR43","doi-asserted-by":"crossref","unstructured":"Zeltzer P, Parma A, Dalton A, Siegel S, Marangos P, Sather H, Hammond D, Seeger R (1983) Raised neuron-specific enolase in serum of children with metastatic neuroblastoma: a report from the Children\u2019s Cancer Study Group. The Lancet 322:361-363","DOI":"10.1016\/S0140-6736(83)90342-2"},{"key":"5896_CR44","doi-asserted-by":"crossref","unstructured":"Tsuchida Y, Honna T, Iwanaka T, Saeki M, Taguchi N, Kaneko T, Koide R, Tsunematsu Y, Shimizu K-i, Makino S-i, Hashizume K, Nakajo T (1987) Serial determination of serum neuron-specific enolase in patients with neuroblastoma and other pediatric tumors. Journal of Pediatric Surgery 22:419-424","DOI":"10.1016\/S0022-3468(87)80261-0"},{"key":"5896_CR45","doi-asserted-by":"crossref","unstructured":"Merugu S, Chen L, Gavens E, Gabra H, Brougham M, Makin G, Ng A, Murphy D, Gabriel A, Robinson M, Wright J, Burchill S, Humphreys A, Bown N, Jamieson D, Tweddle D (2020) Detection of circulating and disseminated neuroblastoma cells using the ImageStream flow cytometer for use as predictive and pharmacodynamic biomarkers. Clinical cancer research: an official journal of the American Association for Cancer Research 26:122-134","DOI":"10.1158\/1078-0432.CCR-19-0656"},{"key":"5896_CR46","doi-asserted-by":"crossref","unstructured":"Batth I, Dao L, Satelli A, Mitra A, Yi S, Noh H, Li H, Brownlee Z, Zhou S, Bond J, Wang J, Gill J, Sholler G, Li S (2020) Cell surface vimentin-positive circulating tumor cell-based relapse prediction in a long-term longitudinal study of postremission neuroblastoma patients. International journal of cancer 147:3550-3559","DOI":"10.1002\/ijc.33140"},{"key":"5896_CR47","doi-asserted-by":"crossref","unstructured":"Uemura S, Ishida T, Thwin K, Yamamoto N, Tamura A, Kishimoto K, Hasegawa D, Kosaka Y, Nino N, Lin K, Takafuji S, Mori T, Iijima K, Nishimura N (2019) Dynamics of minimal residual disease in neuroblastoma patients. Frontiers in oncology 9:455","DOI":"10.3389\/fonc.2019.00455"},{"key":"5896_CR48","doi-asserted-by":"crossref","unstructured":"Yang D-d, Liu C, Gao J, Hu Q-j, Liang Y, Liu J (2023) Association of image-defined risk factors with clinical features, tumor biology, and outcomes in neuroblastoma: a single-center retrospective study. European Journal of Pediatrics 182:2189-2196","DOI":"10.1007\/s00431-023-04899-0"},{"key":"5896_CR49","doi-asserted-by":"crossref","unstructured":"Kojima M, Harada T, Fukazawa T, Kurihara S, Touge R, Saeki I, Takahashi S, Hiyama E (2023) Single-cell next-generation sequencing of circulating tumor cells in patients with neuroblastoma. Cancer science 114:1616-1624","DOI":"10.1111\/cas.15707"},{"key":"5896_CR50","doi-asserted-by":"crossref","unstructured":"Jansky S, Sharma A, K\u00f6rber V, Quintero A, Toprak U, Wecht E, Gartlgruber M, Greco A, Chomsky E, Gr\u00fcnewald T, Henrich K, Tanay A, Herrmann C, H\u00f6fer T, Westermann F (2021) Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma. Nature genetics 53:683-693","DOI":"10.1038\/s41588-021-00806-1"},{"key":"5896_CR51","doi-asserted-by":"crossref","unstructured":"Fetahu I, Esser-Skala W, Dnyansagar R, Sindelar S, Rifatbegovic F, Bileck A, Skos L, Bozsaky E, Lazic D, Shaw L, T\u00f6tzl M, Tarlungeanu D, Bernkopf M, Rados M, Weninger W, Tomazou E, Bock C, Gerner C, Ladenstein R, Farlik M, Fortelny N, Taschner-Mandl S (2023) Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis. Nature communications 14:3620","DOI":"10.1038\/s41467-023-39210-0"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05896-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05896-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05896-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T03:46:30Z","timestamp":1737690390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05896-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["5896"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05896-7","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for the research was granted by the Shenzhen Children\u2019s Hospital Ethics Committee. All patients consented to donate samples to this study. The study was performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Due to ethical considerations, proposals for access deidentified individual participant data underlying the reported results should be send to caican@smu.edu.cn and will be appropriately recorded. The study protocols are provided as Supplementary file1 with the online version of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"93"}}