{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:22:29Z","timestamp":1767903749474,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-024-05961-1","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T20:28:08Z","timestamp":1738009688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of azithromycin combined with fluticasone propionate aerosol inhalation on immune function in children with chronic cough caused by Mycoplasma pneumoniae infection"],"prefix":"10.1007","volume":"184","author":[{"given":"Xin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"11","key":"5961_CR1","first-page":"e31572","volume":"14","author":"AL Campos","year":"2022","unstructured":"Campos AL, Goncalves FMF, Costa M et al (2022) Mycoplasma pneumoniae infection with cavitated lung lesions: a case report. Cureus 14(11):e31572","journal-title":"Cureus"},{"key":"5961_CR2","doi-asserted-by":"publisher","first-page":"558941","DOI":"10.3389\/fped.2020.558941","volume":"8","author":"CO Marginean","year":"2020","unstructured":"Marginean CO, Melit LE, Simu I et al (2020) The association between Mycoplasma pneumoniae and Chlamydia pneumoniae, a life-threatening condition in small children-a case report and a review of the literature. Front Pediatr 8:558941","journal-title":"Front Pediatr"},{"key":"5961_CR3","doi-asserted-by":"publisher","first-page":"803842","DOI":"10.3389\/fmolb.2022.803842","volume":"9","author":"M Liang","year":"2022","unstructured":"Liang M, Meng Y, Wang X et al (2022) The effectiveness of wogonin on treating cough mice with Mycoplasma pneumoniae infection. Front Mol Biosci 9:803842","journal-title":"Front Mol Biosci"},{"issue":"7","key":"5961_CR4","doi-asserted-by":"publisher","first-page":"e0254405","DOI":"10.1371\/journal.pone.0254405","volume":"16","author":"Y Peng","year":"2021","unstructured":"Peng Y, Chen Z, Li Y et al (2021) Shuanghuanglian oral preparations combined with azithromycin for treatment of Mycoplasma pneumoniae pneumonia in Asian children: a systematic review and meta-analysis of randomized controlled trials. PLoS One 16(7):e0254405","journal-title":"PLoS One"},{"issue":"6","key":"5961_CR5","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.24953\/turkjped.2022.545","volume":"64","author":"M Ocak","year":"2022","unstructured":"Ocak M, Oz FN, Cinar HG et al (2022) Clinical and radiologic manifestations of Mycoplasma pneumoniae infection in children. Turk J Pediatr 64(6):1031\u20131040","journal-title":"Turk J Pediatr"},{"key":"5961_CR6","doi-asserted-by":"publisher","first-page":"735093","DOI":"10.3389\/fped.2021.735093","volume":"9","author":"H Zhong","year":"2021","unstructured":"Zhong H, Yin R, Zhao R et al (2021) Analysis of clinical characteristics and risk factors of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia. Front Pediatr 9:735093","journal-title":"Front Pediatr"},{"issue":"2","key":"5961_CR7","first-page":"105","volume":"14","author":"FM Sanchez-Vargas","year":"2008","unstructured":"Sanchez-Vargas FM, Gomez-Duarte OG (2008) Mycoplasma pneumoniae-an emerging extra-pulmonary pathogen. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis 14(2):105\u2013117","journal-title":"Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis"},{"issue":"42","key":"5961_CR8","doi-asserted-by":"publisher","first-page":"e27585","DOI":"10.1097\/MD.0000000000027585","volume":"100","author":"H Pei","year":"2021","unstructured":"Pei H, Ma Y, Wang L et al (2021) Effects of Shenfu injection on inflammatory factors and immune function in children with Mycoplasma pneumoniae: a protocol for a double-blind, randomized controlled trial. Medicine 100(42):e27585","journal-title":"Medicine"},{"key":"5961_CR9","doi-asserted-by":"publisher","first-page":"974","DOI":"10.3389\/fmicb.2016.00974","volume":"7","author":"S Pereyre","year":"2016","unstructured":"Pereyre S, Goret J, Bebear C (2016) Mycoplasma pneumoniae: current knowledge on macrolide resistance and treatment. Front Microbiol 7:974","journal-title":"Front Microbiol"},{"key":"5961_CR10","unstructured":"Fraser SD, Thackray-Nocera S, Shepherd M et al (2020) Azithromycin for sarcoidosis cough: an open-label exploratory clinical trial. ERJ open research 6(4). conduct of the study. Conflict of interest: S. Thackray-Nocera has nothing to disclose. Conflict of interest: M. Shepherd has nothing to disclose. Conflict of interest: R. Flockton has nothing to disclose. Conflict of interest: C. Wright has nothing to disclose. Conflict of interest: W. Sheedy has nothing to disclose. Conflict of interest: K. Brindle has nothing to disclose. Conflict of interest: A.H. Morice has nothing to disclose. Conflict of interest: P.M. Kaye reports grants from SarcoidosisUK during the conduct of the study. Conflict of interest: M.G. Crooks reports grants from SarcoidosisUK during the conduct of the study. Conflict of interest: S.P. Hart reports grants from SarcoidosisUK during the conduct of the study."},{"issue":"4(Special)","key":"5961_CR11","first-page":"1649","volume":"31","author":"J Wang","year":"2018","unstructured":"Wang J, Yang C (2018) Clinical effect of sequential therapy with azithromycin in children mycoplasma pneumoniae pneumonia. Pakistan J Pharm Sci 31(4(Special)):1649\u201352","journal-title":"Pakistan J Pharm Sci"},{"issue":"12","key":"5961_CR12","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1513\/AnnalsATS.202103-266OC","volume":"18","author":"SA Guler","year":"2021","unstructured":"Guler SA, Clarenbach C, Brutsche M et al (2021) Azithromycin for the treatment of chronic cough in idiopathic pulmonary fibrosis: a randomized controlled crossover trial. Ann Am Thorac Soc 18(12):2018\u20132026","journal-title":"Ann Am Thorac Soc"},{"issue":"4","key":"5961_CR13","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.21037\/apm-20-119","volume":"9","author":"J Zhou","year":"2020","unstructured":"Zhou J, Yi F, Xu Z et al (2020) The efficacy and safety of azithromycin in chronic respiratory diseases related cough. Ann Palliat Med 9(4):1488\u20131496","journal-title":"Ann Palliat Med"},{"issue":"1","key":"5961_CR14","doi-asserted-by":"publisher","first-page":"e0191951","DOI":"10.1371\/journal.pone.0191951","volume":"13","author":"D Yang","year":"2018","unstructured":"Yang D, Chen L, Chen Z (2018) The timing of azithromycin treatment is not associated with the clinical prognosis of childhood Mycoplasma pneumoniae pneumonia in high macrolide-resistant prevalence settings. PLoS One 13(1):e0191951","journal-title":"PLoS One"},{"issue":"1","key":"5961_CR15","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1080\/22221751.2022.2078228","volume":"11","author":"X Wang","year":"2022","unstructured":"Wang X, Li M, Luo M et al (2022) Mycoplasma pneumoniae triggers pneumonia epidemic in autumn and winter in Beijing: a multicentre, population-based epidemiological study between 2015 and 2020. Emerg Microbes Infect 11(1):1508\u20131517","journal-title":"Emerg Microbes Infect"},{"key":"5961_CR16","doi-asserted-by":"publisher","first-page":"1181402","DOI":"10.3389\/fcimb.2023.1181402","volume":"13","author":"TT Jiang","year":"2023","unstructured":"Jiang TT, Sun L, Wang TY et al (2023) The clinical significance of macrolide resistance in pediatric Mycoplasma pneumoniae infection during COVID-19 pandemic. Front Cell Infect Microbiol 13:1181402","journal-title":"Front Cell Infect Microbiol"},{"issue":"3(Special)","key":"5961_CR17","first-page":"1001","volume":"36","author":"J Liu","year":"2023","unstructured":"Liu J, Yang J, Du S et al (2023) Clinical efficacy and safety of fluticasone\/salmeterol inhalation powder combined with huaiqihuang granules in the treatment of children with cough variant asthma. Pakistan J Pharm Sci 36(3(Special)):1001\u20137","journal-title":"Pakistan J Pharm Sci"},{"issue":"7","key":"5961_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1139\/cjpp-2018-0569","volume":"97","author":"V Sutariya","year":"2019","unstructured":"Sutariya V, Kelly SJ, Weigel RG et al (2019) Nanoparticle drug delivery characterization for fluticasone propionate and in vitro testing (1). Can J Physiol Pharmacol 97(7):675\u2013684","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"5961_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2174\/15748863113089990038","volume":"8","author":"P Muley","year":"2013","unstructured":"Muley P, Shah M, Muley A (2013) Safety of inhaled fluticasone propionate therapy for pediatric asthma - a systematic review. Curr Drug Saf 8(3):186\u2013194","journal-title":"Curr Drug Saf"},{"key":"5961_CR20","doi-asserted-by":"publisher","first-page":"175346661877792","DOI":"10.1177\/1753466618777924","volume":"12","author":"A Ploszczuk","year":"2018","unstructured":"Ploszczuk A, Bosheva M, Spooner K et al (2018) Efficacy and safety of fluticasone propionate\/formoterol fumarate in pediatric asthma patients: a randomized controlled trial. Ther Adv Respir Dis 12:1753466618777924","journal-title":"Ther Adv Respir Dis"},{"issue":"3","key":"5961_CR21","first-page":"1800","volume":"18","author":"H Shi","year":"2019","unstructured":"Shi H, Lan L, Lv X et al (2019) Effect of pidotimod combined with azithromycin on children with mycoplasma pneumonia and the expression levels of IL-10 and G-CSF in serum. Exp Ther Med 18(3):1800\u20131806","journal-title":"Exp Ther Med"},{"issue":"20","key":"5961_CR22","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.21037\/atm-22-4304","volume":"10","author":"YT Lv","year":"2022","unstructured":"Lv YT, Sun XJ, Chen Y et al (2022) Epidemic characteristics of Mycoplasma pneumoniae infection: a retrospective analysis of a single center in Suzhou from 2014 to 2020. Ann Transl Med 10(20):1123","journal-title":"Ann Transl Med"},{"issue":"5","key":"5961_CR23","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3345\/kjp.2015.58.5.172","volume":"58","author":"EK Kim","year":"2015","unstructured":"Kim EK, Youn YS, Rhim JW et al (2015) Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years. Korean J Pediatr 58(5):172\u2013177","journal-title":"Korean J Pediatr"},{"issue":"3","key":"5961_CR24","first-page":"179","volume":"116","author":"E Kassisse","year":"2018","unstructured":"Kassisse E, Garcia H, Prada L et al (2018) Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation. Arch Argent Pediatr 116(3):179\u2013185","journal-title":"Arch Argent Pediatr"},{"key":"5961_CR25","first-page":"3120138","volume":"2017","author":"D Du","year":"2017","unstructured":"Du D, Liao S, Wu Y et al (2017) Serological analysis and drug resistance of Chlamydia pneumoniae and Mycoplasma pneumoniae in 4500 healthy subjects in Shenzhen. China BioMed Res Int 2017:3120138","journal-title":"China BioMed Res Int"},{"issue":"4","key":"5961_CR26","doi-asserted-by":"publisher","first-page":"300060520911263","DOI":"10.1177\/0300060520911263","volume":"48","author":"S Lu","year":"2020","unstructured":"Lu S, Liu J, Cai Z et al (2020) Bronchial casts associated with Mycoplasma pneumoniae pneumonia in children. J Int Med Res 48(4):300060520911263","journal-title":"J Int Med Res"},{"issue":"1 Pt 1","key":"5961_CR27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jfma.2020.08.018","volume":"120","author":"KL Lee","year":"2021","unstructured":"Lee KL, Lee CM, Yang TL et al (2021) Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010\u20132019. J Formos Med Assoc = Taiwan yi zhi 120(1 Pt 1):281\u201391","journal-title":"J Formos Med Assoc = Taiwan yi zhi"},{"issue":"1","key":"5961_CR28","doi-asserted-by":"publisher","first-page":"e0127521","DOI":"10.1128\/AAC.01275-21","volume":"66","author":"SD Crane","year":"2022","unstructured":"Crane SD, Banerjee SK, Pechous RD (2022) Treatment with fluticasone propionate increases antibiotic efficacy during treatment of late-stage primary pneumonic plague. Antimicrob Agents Chemother 66(1):e0127521","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"5961_CR29","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1067\/mpd.2001.114474","volume":"138","author":"RT Brouillette","year":"2001","unstructured":"Brouillette RT, Manoukian JJ, Ducharme FM et al (2001) Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea. J Pediatr 138(6):838\u2013844","journal-title":"J Pediatr"},{"key":"5961_CR30","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.2147\/JIR.S321656","volume":"14","author":"Q Zhao","year":"2021","unstructured":"Zhao Q, Zhang T, Zhu B et al (2021) Increasing age affected polymorphonuclear neutrophils in prognosis of mycoplasma pneumoniae pneumonia. J Inflamm Res 14:3933\u20133943","journal-title":"J Inflamm Res"},{"key":"5961_CR31","first-page":"e923449","volume":"26","author":"HL Jin","year":"2020","unstructured":"Jin HL, Zhan L, Mei SF et al (2020) Serum cytokines and FeNO in school-aged children with Mycoplasma pneumoniae pneumonia. Med Sci Monit Int Med J Exp Clin Res 26:e923449","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"issue":"1","key":"5961_CR32","doi-asserted-by":"publisher","first-page":"e00471","DOI":"10.1128\/CVI.00471-16","volume":"24","author":"WJ Lee","year":"2017","unstructured":"Lee WJ, Huang EY, Tsai CM et al (2017) Role of serum Mycoplasma pneumoniae IgA, IgM, and IgG in the diagnosis of Mycoplasma pneumoniae-related pneumonia in school-age children and adolescents. Clin Vaccine Immunol CVI 24(1):e00471-16","journal-title":"Clin Vaccine Immunol CVI"},{"issue":"1","key":"5961_CR33","first-page":"202","volume":"15","author":"Y Ni","year":"2023","unstructured":"Ni Y, Fang M, Jiang J et al (2023) Effect of azithromycin combined with ambroxol in children with Mycoplasma pneumoniae pneumonia. Am J Transl Res 15(1):202\u2013212","journal-title":"Am J Transl Res"},{"issue":"13","key":"5961_CR34","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.2165\/11202210-000000000-00000","volume":"69","author":"K McKeage","year":"2009","unstructured":"McKeage K, Keam SJ (2009) Salmeterol\/fluticasone propionate: a review of its use in asthma. Drugs 69(13):1799\u20131828","journal-title":"Drugs"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05961-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-024-05961-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-024-05961-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T03:04:56Z","timestamp":1739934296000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-024-05961-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["5961"],"URL":"https:\/\/doi.org\/10.1007\/s00431-024-05961-1","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]},"assertion":[{"value":"6 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by South Hospital of Ganzhou People\u2019s Hospital\u2019s ethical committee (approval number: 20190112), and conformed to the Helsinki Declaration. Patients\u2019 family members or guardians provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"155"}}