{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:56:46Z","timestamp":1754153806980,"version":"3.41.2"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Desbuquois dysplasia (DBQD) is a rare autosomal recessive chondrodysplasia characterized by distinct skeletal abnormalities and multisystem involvement. Cardiac manifestations, such as aortic root dilatation and mitral valve prolapse, have also been reported, likely due to impaired proteoglycan production. This study aims to enhance the understanding of clinical management and cardiac implications in patients with DBQD, contributing to the broader knowledge of this rare condition. This research was conducted at Hacettepe University \u0130hsan Do\u011framac\u0131 Children\u2019s Hospital, a tertiary reference center for all pediatric subspecialties. A single-center, descriptive, retrospective cohort study was performed. Demographic characteristics, genetic mutations, echocardiographic findings, and measurements of patients with Desbuquois dysplasia were documented. A total of nine patients, including five females (55%) were included in the study. The median age of the patients was 11\u00a0years (range 3.6\u201323.6\u00a0years), the median body weight was 15\u00a0kg (6\u201364\u00a0kg), and the median height was 94\u00a0cm (63\u2013130\u00a0cm). The median follow-up period was 7.7\u00a0years (range 2.9\u201315.4\u00a0years). All patients had homozygous or compound heterozygous pathogenic variants in the CANT1 gene. The most common cardiac findings included mitral valve prolapse (seven patients, 77%), ascending aortic dilatation (seven patients, 77%), aortic root enlargement (six patients, 66%), small atrial septal defect (ASD) (five patients, 55%), bicuspid aortic valve (two patients, 22%), and ventricular septal defect (VSD) (one patient, 11%). Additionally, coronary-cameral fistula, a rare finding in the general population, was observed in one patient. The median individual <jats:italic>Z<\/jats:italic> scores for the sinus valsalva (SVS) in patients with aortic dilatation were 4.9 (range 2.7\u20137.5), while the median <jats:italic>Z<\/jats:italic> score in the ascending aorta was 5 (range 2.3\u20138.5). <jats:italic>Conclusion<\/jats:italic>: Aortic root and ascending aorta dilatation as well as mitral valve prolapse are frequently observed in patients with DBQD. ASD, VSD, and bicuspid aorta are less common. Aortopathy develops early and can progress to a severe stage. Early detection of cardiac abnormalities and timely initiation of medical treatment may significantly improve the long-term prognosis of the disease.\n<jats:table-wrap>\n              <jats:table>\n                <jats:tbody>\n                  <jats:tr>\n                    <jats:td align=\"left\" colspan=\"2\">\n                      <jats:bold>What is Known:<\/jats:bold>\n                      <jats:italic>\u2022 Desbuquois dysplasia (DBQD) is a rare autosomal recessive chondrodysplasia characterized by distinct skeletal abnormalities and multisystem involvement. Cardiac manifestations, such as aortic root dilatation and mitral valve prolapse, have also been reported, likely due to impaired proteoglycan production.<\/jats:italic>\n                    <\/jats:td>\n                  <\/jats:tr>\n                  <jats:tr>\n                    <jats:td align=\"left\" colspan=\"2\">\n                      <jats:bold>What is New:<\/jats:bold>\n                      <jats:italic>\u2022 The most frequently observed findings include aortic root and ascending aortic dilatation as well as mitral valve prolapse. Aortopathy develops early and can progress to severe disease. Early detection of cardiac abnormalities and timely initiation of medical treatment may significantly improve long-term prognosis.<\/jats:italic>\n                    <\/jats:td>\n                  <\/jats:tr>\n                <\/jats:tbody>\n              <\/jats:table>\n            <\/jats:table-wrap>\n          <\/jats:p>","DOI":"10.1007\/s00431-025-06231-4","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:00:24Z","timestamp":1748966424000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Desbuquois dysplasia and cardiovascular complications: a retrospective cohort study"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-2002","authenticated-orcid":false,"given":"Musa","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-9946","authenticated-orcid":false,"given":"Merve Tanr\u0131sever","family":"T\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-3236","authenticated-orcid":false,"given":"Gizem \u00dcrel","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-5542","authenticated-orcid":false,"given":"G\u00fclen Eda","family":"\u00dctine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-0568","authenticated-orcid":false,"given":"\u0130lker","family":"Ertu\u011frul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-8399","authenticated-orcid":false,"given":"Ebru","family":"Aypar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7680-8183","authenticated-orcid":false,"given":"Tevfik","family":"Karag\u00f6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-8835","authenticated-orcid":false,"given":"Dursun","family":"Alehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-7766","authenticated-orcid":false,"given":"Pelin \u00d6zlem \u015eim\u015fek","family":"Kiper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-3977","authenticated-orcid":false,"given":"Hayrettin Hakan","family":"Aykan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"LeMerrer M, Young ID, Stanescu V, Maroteaux Des P (1991) \u201cDesbuquois syndrome\u201d. 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