{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:22:35Z","timestamp":1783200155731,"version":"3.54.6"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Health Holland Erasmus MC-TKI-LSH PPP","award":["EMCLSH23046"],"award-info":[{"award-number":["EMCLSH23046"]}]},{"name":"Health Holland Erasmus MC-TKI-LSH PPP","award":["EMCLSH23046"],"award-info":[{"award-number":["EMCLSH23046"]}]},{"name":"Health Holland Erasmus MC-TKI-LSH PPP","award":["EMCLSH23046"],"award-info":[{"award-number":["EMCLSH23046"]}]},{"name":"Bilihome B.V."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>This pilot study aimed to assess the effectiveness and safety of the first wearable phototherapy device in (near-)term neonates with unconjugated hyperbilirubinaemia. This prospective single-arm intervention pilot study was conducted in the Erasmus MC Sophia Children\u2019s Hospital maternity ward and the Primary Care Birth Centre Sophia in Rotterdam, the Netherlands. Twelve (near-)term neonates with hyperbilirubinaemia requiring treatment, according to the Dutch national hyperbilirubinaemia guideline, were treated with wearable phototherapy. Results were compared to a matched historical cohort of neonates treated with BiliSoft. Effective and safe treatment was\u00a0defined by (1) the ability to discontinue phototherapy within 48\u00a0h after initiation and (2) no adverse events that necessitate switching to a conventional phototherapy device, as indicated by an independent expert. Twelve neonates were included, with a median gestational age of 38.5\u00a0weeks (IQR 37.9\u201339.2) and a median postnatal age of 77\u00a0h (IQR 58\u201387). In ten neonates (83%), phototherapy was successfully completed within 48\u00a0h, with a median phototherapy duration of 23\u00a0h (IQR 22.5\u201330.3) and a median TSB reduction rate of 1.8\u00a0\u00b5mol\/L\/h (IQR 2.3\u20131.1). These findings were similar in the control group. Two neonates were switched to conventional intensive phototherapy due to the ongoing rise of bilirubin levels despite wearable phototherapy treatment. No safety issues were recorded. Parents and healthcare providers reported positive experiences, highlighting benefits such as mobility and increased parental autonomy.<\/jats:p>\n          <jats:p>\n            <jats:italic>Conclusion<\/jats:italic>: This pilot study provides data to indicate that wearable phototherapy is effective and safe in reducing bilirubin levels in the majority of (near-)term neonates with hyperbilirubinaemia.\n<jats:table-wrap>\n              <jats:table>\n                <jats:tbody>\n                  <jats:tr>\n                    <jats:td colspan=\"2\">\n                      <jats:bold>What Is Known:<\/jats:bold>\n                      <jats:italic>\u2022 Home phototherapy for neonatal hyperbilirubinaemia is\u00a0generally regarded as a safe and effective alternative to in-hospital phototherapy.<\/jats:italic>\n                      <jats:italic>\u2022 The current fibreoptic phototherapy devices have limitations that hinder their optimal use in the home setting.<\/jats:italic>\n                      <jats:bold>What Is New:<\/jats:bold>\n                      <jats:italic>\u2022 Wearable phototherapy is effective and safe in reducing bilirubin levels in the majority of (near-)term neonates with hyperbilirubinaemia.<\/jats:italic>\n                    <\/jats:td>\n                  <\/jats:tr>\n                <\/jats:tbody>\n              <\/jats:table>\n            <\/jats:table-wrap>\n          <\/jats:p>","DOI":"10.1007\/s00431-025-06239-w","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:20:39Z","timestamp":1749450039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["First in-human pilot study of wearable phototherapy for neonatal hyperbilirubinaemia"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0275-6771","authenticated-orcid":false,"given":"Jessie","family":"Spaan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper V.","family":"Been","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanera","family":"Wall\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin K. M.","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine H. L.","family":"Wagenaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian V.","family":"Hulzebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthe A. M.","family":"van der Geest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"issue":"8","key":"6239_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","volume":"2","author":"BO Olusanya","year":"2018","unstructured":"Olusanya BO, Kaplan M, Hansen TWR (2018) Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health 2(8):610\u2013620","journal-title":"Lancet Child Adolesc Health"},{"key":"6239_CR2","doi-asserted-by":"crossref","unstructured":"Battersby C, Michaelides S, Upton M, Rennie JM (2017) Jaundice Working Group of the Atain programme lbtPStiNHSI. Term admissions to neonatal units in England: a role for transitional care? A retrospective cohort study. BMJ Open 7(5):e016050","DOI":"10.1136\/bmjopen-2017-016050"},{"issue":"5","key":"6239_CR3","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s00431-021-03932-4","volume":"180","author":"M Pettersson","year":"2021","unstructured":"Pettersson M, Eriksson M, Albinsson E, Ohlin A (2021) Home phototherapy for hyperbilirubinemia in term neonates-an unblinded multicentre randomized controlled trial. Eur J Pediatr 180(5):1603\u20131610","journal-title":"Eur J Pediatr"},{"issue":"8","key":"6239_CR4","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1007\/s00431-022-04461-4","volume":"181","author":"SS Coquery","year":"2022","unstructured":"Coquery SS, Georges A, Cortey A, Floch C, Avran D, Gatbois E et al (2022) Discharge of newborns with risk factors of severe hyperbilirubinemia: description of a hospital at home-based care monitoring and phototherapy. Eur J Pediatr 181(8):3075\u20133084","journal-title":"Eur J Pediatr"},{"issue":"1","key":"6239_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13052-024-01613-0","volume":"50","author":"R Li","year":"2024","unstructured":"Li R, Li T, Yan X, Feng J, Yu Z, Chen C (2024) Efficacy of home phototherapy versus inpatient phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis. Ital J Pediatr 50(1):37","journal-title":"Ital J Pediatr"},{"issue":"1","key":"6239_CR6","doi-asserted-by":"publisher","first-page":"10727","DOI":"10.1038\/s41598-023-37684-y","volume":"13","author":"M Pettersson","year":"2023","unstructured":"Pettersson M, Ryen L, Eriksson M, Ohlin A (2023) The cost-effectiveness of home phototherapy for hyperbilirubinemia in neonates: results from a randomized controlled trial. Sci Rep 13(1):10727","journal-title":"Sci Rep"},{"issue":"4","key":"6239_CR7","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/13674935221082404","volume":"27","author":"M Pettersson","year":"2023","unstructured":"Pettersson M, Eriksson M, Blomberg K (2023) Parental experiences of home phototherapy for neonatal hyperbilirubinemia. J Child Health Care 27(4):562\u2013573","journal-title":"J Child Health Care"},{"issue":"1","key":"6239_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jnn.2018.09.001","volume":"25","author":"MMM Namnabati","year":"2019","unstructured":"Namnabati MMM, Sardari S (2019) The effect of home-based phototherapy on parental stress in mothers of infants with neonatal jaundice. J Neonatal Nurs 25(1):37\u201340","journal-title":"J Neonatal Nurs"},{"issue":"7","key":"6239_CR9","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/jpc.15925","volume":"58","author":"M Khajehei","year":"2022","unstructured":"Khajehei M, Gidaszewski B, Maheshwari R, McGee TM (2022) Clinical outcomes and cost-effectiveness of large-scale midwifery-led, paediatrician-overseen home phototherapy and neonatal jaundice surveillance: a retrospective cohort study. 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[Dutch Paediatric Society] Nederlandse Vereniging voor Kindergeneeskunde 2023"},{"key":"6239_CR14","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1542\/peds.114.1.297","volume":"114","author":"American Academy of Pediatrics","year":"2004","unstructured":"American Academy of Pediatrics (2004) Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114:297\u2013316","journal-title":"Pediatrics"},{"issue":"4","key":"6239_CR15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028270","volume":"9","author":"BAM van der Geest","year":"2019","unstructured":"van der Geest BAM, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF et al (2019) Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol. 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J Neonatal Nurs 29(3):568\u2013574","journal-title":"J Neonatal Nurs"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06239-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06239-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06239-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T19:03:15Z","timestamp":1757185395000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06239-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["6239"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06239-w","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"8 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was partly funded by Bilihome B.V., as part of a requirement for the Health Holland Erasmus MC-TKI-LSH PPP grant. The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"407"}}