{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:06:33Z","timestamp":1791439593490,"version":"4.3.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06248-9","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T03:17:22Z","timestamp":1749871042000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prophylactic hydrocortisone and the risk of sepsis in neonates born extremely preterm"],"prefix":"10.1007","volume":"184","author":[{"given":"Olivier","family":"Baud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lehert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PREMILOC study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Biran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Rideau Batista-Novais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Farnoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Soud\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Maury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lebail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duksha","family":"Ramful","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Samperiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Beuch\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Guimard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"El Moussawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Boileau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Castela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Nicaise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Vialet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Andrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Debillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Zupan-Simunek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasinirina","family":"Razafimahefa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Coursol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00efd","family":"Merbouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bolot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Kana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Guichoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Brissaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Thiriez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickael","family":"Pomedio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Morville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Marret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guillois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9n\u00e9ric","family":"Alexandre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Le Bou\u00ebdec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Leboucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Simeoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lacroze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Litzler-Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Zana-Ta\u00efeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Henri","family":"Jarreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Renolleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Meau-Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Cambonie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Bourmaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"6248_CR1","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","volume":"390","author":"AL Shane","year":"2017","unstructured":"Shane AL, Sanchez PJ, Stoll BJ (2017) Neonatal sepsis. Lancet 390:1770\u20131780","journal-title":"Lancet"},{"key":"6248_CR2","doi-asserted-by":"crossref","unstructured":"El Manouni El Hassani S et al (2019) Risk factors for late-onset sepsis in preterm infants: a multicenter case-control study. Neonatology 116:42\u201351","DOI":"10.1159\/000497781"},{"key":"6248_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1001\/jama.2021.23580","volume":"327","author":"EF Bell","year":"2022","unstructured":"Bell EF et al (2022) Mortality, in-hospital morbidity, care practices, and 2-year outcomes for extremely preterm infants in the US, 2013\u20132018. JAMA 327:248\u2013263","journal-title":"JAMA"},{"key":"6248_CR4","doi-asserted-by":"crossref","unstructured":"Kaplan HC, Lannon C, Walsh MC, Donovan EF, Ohio Perinatal Quality C (2011) Ohio Statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics 127:427\u2013435","DOI":"10.1542\/peds.2010-2141"},{"key":"6248_CR5","doi-asserted-by":"crossref","unstructured":"Shaffer ML et al (2019) Effect of prophylaxis for early adrenal insufficiency using low-dose hydrocortisone in very preterm infants: an individual patient data meta-analysis. J Pediatr 207:136\u2013142 e135","DOI":"10.1016\/j.jpeds.2018.10.004"},{"key":"6248_CR6","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/s00431-019-03398-5","volume":"178","author":"IP Morris","year":"2019","unstructured":"Morris IP, Goel N, Chakraborty M (2019) Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis. Eur J Pediatr 178:1171\u20131184","journal-title":"Eur J Pediatr"},{"key":"6248_CR7","doi-asserted-by":"crossref","unstructured":"van de Loo M et al (2024) Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews. Cochrane Database Syst Rev 4:CD013271","DOI":"10.1002\/14651858.CD013271.pub2"},{"key":"6248_CR8","doi-asserted-by":"publisher","first-page":"1170842","DOI":"10.3389\/fphar.2023.1170842","volume":"14","author":"S Iacobelli","year":"2023","unstructured":"Iacobelli S et al (2023) Postnatal corticosteroid exposure in very preterm infants: a French cohort study. Front Pharmacol 14:1170842","journal-title":"Front Pharmacol"},{"key":"6248_CR9","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/S0140-6736(16)00202-6","volume":"387","author":"O Baud","year":"2016","unstructured":"Baud O et al (2016) Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial. Lancet 387:1827\u20131836","journal-title":"Lancet"},{"issue":"7","key":"6248_CR10","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/dmcn.15470","volume":"65","author":"C Trousson","year":"2022","unstructured":"Trousson C, Toumazi A, Bourmaud A, Biran V, Baud O (2022) Neurocognitive outcomes at age 5 years after prophylactic hydrocortisone in infants born extremely preterm. Dev Med Child Neurol 65(7):926\u2013932","journal-title":"Dev Med Child Neurol"},{"key":"6248_CR11","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1001\/jama.2017.2692","volume":"317","author":"O Baud","year":"2017","unstructured":"Baud O et al (2017) Association between early low-dose hydrocortisone therapy in extremely preterm neonates and neurodevelopmental outcomes at 2 years of age. JAMA 317:1329\u20131337","journal-title":"JAMA"},{"key":"6248_CR12","doi-asserted-by":"publisher","first-page":"105630","DOI":"10.1016\/j.earlhumdev.2022.105630","volume":"171","author":"A Briscoe","year":"2022","unstructured":"Briscoe A, Piyasena C, Meau-Petit V (2022) Tolerance of hydrocortisone prophylaxis administration in extreme preterm neonates: experience of a single UK level III neonatal unit. Early Hum Dev 171:105630","journal-title":"Early Hum Dev"},{"key":"6248_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1136\/archdischild-2023-325913","volume":"109","author":"M de Souza","year":"2024","unstructured":"de Souza M et al (2024) Effects of prophylactic hydrocortisone in a tertiary Canadian NICU. Arch Dis Child Fetal Neonatal Ed 109:342","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"6248_CR14","doi-asserted-by":"crossref","unstructured":"Shah SD et al (2024) Prophylactic early low-dose hydrocortisone and survival without bronchopulmonary dysplasia among extremely preterm infants born at 22\u201327 weeks\u2019 gestation. J Perinatol\u00a0\u00a044(7):947\u2013952","DOI":"10.1038\/s41372-024-01923-5"},{"key":"6248_CR15","doi-asserted-by":"crossref","unstructured":"Petrishka-Lozenska M et al (2025) Association between early postnatal hydrocortisone and retinopathy of prematurity in extremely preterm infants. Neonatology\u00a0122(3):329\u2013338","DOI":"10.1159\/000543659"},{"key":"6248_CR16","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/S0140-6736(16)31611-7","volume":"388","author":"O Baud","year":"2016","unstructured":"Baud O, Alberti C, Mohamed D, Watterberg K (2016) Low-dose hydrocortisone in extremely preterm infants - authors\u2019 reply. Lancet 388:1158\u20131159","journal-title":"Lancet"},{"key":"6248_CR17","doi-asserted-by":"crossref","unstructured":"Baud O et al (2018) Two-year neurodevelopmental outcomes of extremely preterm infants treated with early hydrocortisone: treatment effect according to gestational age at birth. Arch Dis Child Fetal Neonatal Ed\u00a0104(1):F30\u2013F35","DOI":"10.1136\/archdischild-2017-313756"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06248-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06248-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T19:27:47Z","timestamp":1757186867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06248-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,14]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["6248"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06248-9","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,14]]},"assertion":[{"value":"1 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors thank Aguettant Pharma for a provided unconditional grant. This financial sponsor had no implication in study design, data collection, analysis, decision to publish or preparation of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"419"}}