{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:55:42Z","timestamp":1790121342546,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06305-3","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T07:06:00Z","timestamp":1751439960000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["PEN-FAST in pediatrics: a reliable tool for penicillin allergy assessment?"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-8055","authenticated-orcid":false,"given":"Funda Aytekin","family":"G\u00fcvenir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-0352","authenticated-orcid":false,"given":"Zeynep \u015eeng\u00fcl","family":"Emeksiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-7192","authenticated-orcid":false,"given":"G\u00f6khan","family":"Y\u00f6r\u00fcs\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-0056","authenticated-orcid":false,"given":"Asl\u0131 Kuzu","family":"Ku\u015fakl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8540-3751","authenticated-orcid":false,"given":"Kezban \u0130pek","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-7330","authenticated-orcid":false,"given":"Ahmet","family":"Selmano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3241-2005","authenticated-orcid":false,"given":"Emine Dibek","family":"M\u0131s\u0131rl\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"6305_CR1","unstructured":"Centers for Disease Control and Prevention(CDC) (2017) Antibiotic use in the United States, 2017: progress and opportunities. Atlanta, GA: US Department of Health and Human Services"},{"issue":"9","key":"6305_CR2","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1111\/all.12881","volume":"71","author":"L Zhou","year":"2016","unstructured":"Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW (2016) Drug allergies documented in electronic health records of a large healthcare system. Allergy 71(9):1305\u20131313. https:\/\/doi.org\/10.1111\/all.12881","journal-title":"Allergy"},{"issue":"1","key":"6305_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1001\/jama.2017.6510","volume":"318","author":"JA Trubiano","year":"2017","unstructured":"Trubiano JA, Adkinson NF, Phillips EJ (2017) Penicillin allergy is not necessarily forever. JAMA 318(1):82\u201383. https:\/\/doi.org\/10.1001\/jama.2017.6510","journal-title":"JAMA"},{"key":"6305_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11882-014-0476-y","volume":"14","author":"E Macy","year":"2014","unstructured":"Macy E (2014) Penicillin and beta-lactam allergy: epidemiology and diagnosis. Curr Allergy Asthma Rep 14:1\u20137. https:\/\/doi.org\/10.1007\/s11882-014-0476-y","journal-title":"Curr Allergy Asthma Rep"},{"key":"6305_CR5","doi-asserted-by":"publisher","unstructured":"American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asthma & Immunology, Joint Council of Allergy, Asthma & Immunology, Joint Task Force on Practice Parameters (2010) Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol 105(4):259\u2013273. https:\/\/doi.org\/10.1016\/j.anai.2010.08.002","DOI":"10.1016\/j.anai.2010.08.002"},{"issue":"6","key":"6305_CR6","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/jac\/dkw008","volume":"71","author":"JA Trubiano","year":"2016","unstructured":"Trubiano JA, Chen C, Cheng A, Grayson ML, Slavin MA, Thursky KA (2016) Antimicrobial allergy \u2018labels\u2019 drive inappropriate antimicrobial prescribing: lessons for stewardship. J Antimicrob Chemother 71(6):1715\u20131722. https:\/\/doi.org\/10.1093\/jac\/dkw008","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"6305_CR7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/bcp.13830","volume":"85","author":"R Moran","year":"2019","unstructured":"Moran R, Devchand M, Smibert O, Trubiano JA (2019) Antibiotic allergy labels in hospitalized and critically ill adults: a review of current impacts of inaccurate labelling. Br J Clin Pharmacol 85(3):492\u2013500. https:\/\/doi.org\/10.1111\/bcp.13830","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"6305_CR8","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/all.14122","volume":"75","author":"A Romano","year":"2020","unstructured":"Romano A, Atanaskovic-Markovic M, Barbaud A, Bircher AJ, Brockow K, Caubet JC, Celik G, Cernadas J, Chiriac AM, Demoly P et al (2020) Towards a more precise diagnosis of hypersensitivity to beta-lactams An EAACI position paper. Allergy 75(6):1300\u20131315. https:\/\/doi.org\/10.1111\/all.14122","journal-title":"Allergy"},{"issue":"8","key":"6305_CR9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1001\/jamainternmed.2023.1572","volume":"183","author":"C Su","year":"2023","unstructured":"Su C, Belmont A, Liao J, Kuster JK, Trubiano JA, Kwah JH (2023) Evaluating the PEN-FAST clinical decision-making tool to enhance penicillin allergy delabeling. JAMA Intern Med 183(8):883\u2013885. https:\/\/doi.org\/10.1001\/jamainternmed.2023.1572","journal-title":"JAMA Intern Med"},{"issue":"4","key":"6305_CR10","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/all.12350","volume":"69","author":"P Demoly","year":"2014","unstructured":"Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W et al (2014) International consensus on drug allergy. Allergy 69(4):420\u2013437. https:\/\/doi.org\/10.1111\/all.12350","journal-title":"Allergy"},{"issue":"10","key":"6305_CR11","doi-asserted-by":"publisher","first-page":"100472","DOI":"10.1016\/j.waojou.2020.100472","volume":"13","author":"V Cardona","year":"2020","unstructured":"Cardona V, Ansotegui IJ, Ebisawa M, El-Gamal Y, Rivas MF, Fineman S, Senna G, Sheikh A, Tanno LK, Thongh B et al (2020) World Allergy Organization anaphylaxis guidance 2020. World Allergy Organ J 13(10):100472. https:\/\/doi.org\/10.1016\/j.waojou.2020.100472","journal-title":"World Allergy Organ J"},{"key":"6305_CR12","doi-asserted-by":"publisher","unstructured":"Muraro A, Worm M, Alviani C, Cardona V, DunnGalvin A, Garvey LH, Riggioni C, de Silva D, Angier E, Arasi S, et al .European Academy of Allergy and Clinical Immunology, Food Allergy, Anaphylaxis Guidelines Group (2022) EAACI guidelines: anaphylaxis (2021 update).\u00a0Allergy 77(2), 357\u2013377. https:\/\/doi.org\/10.1111\/all.15032","DOI":"10.1111\/all.15032"},{"issue":"1","key":"6305_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","volume":"57","author":"K Brockow","year":"2002","unstructured":"Brockow K, Romano A, Blanca M, Ring J, Pichler W, Demoly P (2002) General considerations for skin test procedures in the diagnosis of drug hypersensitivity. Allergy 57(1):45\u201351","journal-title":"Allergy"},{"issue":"12","key":"6305_CR14","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1111\/j.1398-9995.2006.01136.x","volume":"61","author":"K Turjanmaa","year":"2006","unstructured":"Turjanmaa K, Darsow U, Niggemann B, Ranc\u00e9 F, Vanto T, Werfel T (2006) EAACI\/GA2LEN position paper: present status of the atopy patch test. Allergy 61(12):1377\u20131384. https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01136.x","journal-title":"Allergy"},{"issue":"4","key":"6305_CR15","first-page":"287","volume":"50","author":"DS Wilkinson","year":"1970","unstructured":"Wilkinson DS, Fregert S, Magnusson B, Bandmann HJ, Calnan CD, Cronin E, Hjorth N, Maibach HJ, Malalten KE, Meneghini CL et al (1970) Terminology of contact dermatitis. Acta Derm Venereol 50(4):287\u2013292","journal-title":"Acta Derm Venereol"},{"issue":"9","key":"6305_CR16","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","volume":"58","author":"W Aberer","year":"2003","unstructured":"Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J, Brockow K, Pichler WJ, Demoly P (2003) Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy 58(9):854\u2013863. https:\/\/doi.org\/10.1034\/j.1398-9995.2003.00279.x","journal-title":"Allergy"},{"issue":"5","key":"6305_CR17","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1001\/jamainternmed.2020.0403","volume":"180","author":"JA Trubiano","year":"2020","unstructured":"Trubiano JA, Vogrin S, Chua KY, Bourke J, Yun J, Douglas A, Stone CA, Yu R, Groenendijk L, Holmes NE et al (2020) Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med 180(5):745\u2013752. https:\/\/doi.org\/10.1001\/jamainternmed.2020.0403","journal-title":"JAMA Intern Med"},{"issue":"1","key":"6305_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.anai.2021.07.005","volume":"128","author":"A Piotin","year":"2022","unstructured":"Piotin A, Godet J, Trubiano JA, Grandbastien M, Gu\u00e9nard-Bilbault L, de Blay F, Metz-Favre C (2022) Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule. Ann Allergy Asthma Immunol 128(1):27\u201332. https:\/\/doi.org\/10.1016\/j.anai.2021.07.005","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"9","key":"6305_CR19","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1001\/jamainternmed.2023.2986","volume":"183","author":"AM Copaescu","year":"2023","unstructured":"Copaescu AM, Vogrin S, James F, Chua KY, Rose MT, De Luca J, Waldron J, Awad A, Godsell J, Mitri E et al (2023) Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial. JAMA Intern Med 183(9):944\u2013952. https:\/\/doi.org\/10.1001\/jamainternmed.2023.2986","journal-title":"JAMA Intern Med"},{"key":"6305_CR20","doi-asserted-by":"publisher","first-page":"1302567","DOI":"10.3389\/falgy.2023.1302567","volume":"4","author":"J Castagna","year":"2023","unstructured":"Castagna J, Chasset F, Autegarden JE, Le Thai C, Amsler E, Barbaud A, Soria A (2023) Assessing delayed penicillin hypersensitivity using the PENFAST+ score. Front Allergy 4:1302567. https:\/\/doi.org\/10.3389\/falgy.2023.1302567","journal-title":"Front Allergy"},{"key":"6305_CR21","doi-asserted-by":"publisher","first-page":"1439698","DOI":"10.3389\/falgy.2024.1439698","volume":"5","author":"A Hanniet","year":"2024","unstructured":"Hanniet A, Puyraveau M, Castelain F, Pelletier F, Aubin F (2024) Efficacy of the PEN-FAST score in a French cohort of patients with reported allergy to penicillins. Front Allergy 5:1439698. https:\/\/doi.org\/10.3389\/falgy.2024.1439698","journal-title":"Front Allergy"},{"issue":"9","key":"6305_CR22","doi-asserted-by":"publisher","first-page":"e2233703","DOI":"10.1001\/jamanetworkopen.2022.33703","volume":"5","author":"AM Copaescu","year":"2022","unstructured":"Copaescu AM, Vogrin S, Shand G, Ben-Shoshan M, Trubiano JA (2022) Validation of the PEN-FAST score in a pediatric population. JAMA Netw Open 5(9):e2233703. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.33703","journal-title":"JAMA Netw Open"},{"issue":"6","key":"6305_CR23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/archdischild-2014-306280","volume":"100","author":"T Marrs","year":"2015","unstructured":"Marrs T, Fox AT, Lack G, Du Toit G (2015) The diagnosis and management of antibiotic allergy in children: systematic review to inform a contemporary approach. Arch Dis Child 100(6):583\u2013588. https:\/\/doi.org\/10.1136\/archdischild-2014-306280","journal-title":"Arch Dis Child"},{"issue":"6","key":"6305_CR24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1080\/00325481.2016.1191319","volume":"128","author":"F Harandian","year":"2016","unstructured":"Harandian F, Pham D, Ben-Shoshan M (2016) Positive penicillin allergy testing results: a systematic review and meta-analysis of papers published from 2010 through 2015. Postgrad Med 128(6):557\u2013562. https:\/\/doi.org\/10.1080\/00325481.2016.1191319","journal-title":"Postgrad Med"},{"issue":"2","key":"6305_CR25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/all.12774","volume":"71","author":"E Gomes","year":"2016","unstructured":"Gomes E, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, Ott H, Atanaskovic-Markovic M, Kidon M, Caubet JC et al (2016) Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy 71(2):149\u2013161. https:\/\/doi.org\/10.1111\/all.12774","journal-title":"Allergy"},{"issue":"5","key":"6305_CR26","doi-asserted-by":"publisher","first-page":"e20172497","DOI":"10.1542\/peds.2017-2497","volume":"141","author":"AE Norton","year":"2018","unstructured":"Norton AE, Konvinse K, Phillips EJ, Broyles AD (2018) Antibiotic allergy in pediatrics. Pediatrics 141(5):e20172497. https:\/\/doi.org\/10.1542\/peds.2017-2497","journal-title":"Pediatrics"},{"key":"6305_CR27","doi-asserted-by":"publisher","first-page":"k2400","DOI":"10.1136\/bmj.k2400","volume":"361","author":"KG Blumenthal","year":"2018","unstructured":"Blumenthal KG, Lu N, Zhang Y, Li Y, Walensky RP, Choi HK (2018) Risk of meticillin-resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ 361:k2400. https:\/\/doi.org\/10.1136\/bmj.k2400","journal-title":"BMJ"},{"issue":"10167","key":"6305_CR28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0140-6736(18)32218-9","volume":"393","author":"KG Blumenthal","year":"2019","unstructured":"Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ (2019) Antibiotic allergy. Lancet 393(10167):183\u2013198. https:\/\/doi.org\/10.1016\/S0140-6736(18)32218-9","journal-title":"Lancet"},{"issue":"2","key":"6305_CR29","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/pai.12047","volume":"24","author":"M Erko\u00e7o\u011flu","year":"2013","unstructured":"Erko\u00e7o\u011flu M, Kaya A, Civelek E, \u00d6zcan C, \u00c7ak\u0131r B, Akan A, Toyran M, Ginis T, Kocaba\u015f CN (2013) Prevalence of confirmed immediate-type drug hypersensitivity reactions among school children. Pediatr Allergy Immunol 24(2):160\u2013167. https:\/\/doi.org\/10.1111\/pai.12047","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"6305_CR30","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1365-2222.2007.02870.x","volume":"38","author":"E Rebelo Gomes","year":"2008","unstructured":"Rebelo Gomes E, Fonseca J, Araujo L, Demoly P (2008) Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy 38(1):191\u2013198. https:\/\/doi.org\/10.1111\/j.1365-2222.2007.02870.x","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"6305_CR31","doi-asserted-by":"publisher","first-page":"e12008","DOI":"10.1002\/clt2.12008","volume":"11","author":"A Cardoso-Fernandes","year":"2021","unstructured":"Cardoso-Fernandes A, Blumenthal KG, Chiriac AM, Tarrio I, Afonso-Jo\u00e3o D, Delgado L, Fonseca JA, Azevedo LF, Sousa-Pinto B (2021) Frequency of severe reactions following penicillin drug provocation tests: a Bayesian meta-analysis. Clin Transl Allergy 11(4):e12008. https:\/\/doi.org\/10.1002\/clt2.12008","journal-title":"Clin Transl Allergy"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06305-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06305-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06305-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:27:05Z","timestamp":1757204825000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06305-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["6305"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06305-3","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"463"}}