{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:58:29Z","timestamp":1777895909945,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82401838"],"award-info":[{"award-number":["No. 82401838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"crossref","award":["CSTB2023NSCQ-BHX0042"],"award-info":[{"award-number":["CSTB2023NSCQ-BHX0042"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06328-w","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:37:19Z","timestamp":1753425439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of pertussis vaccination on PT-IgG levels and clinical characteristics in 3\u201312-month-old infants with acute pertussis"],"prefix":"10.1007","volume":"184","author":[{"given":"Yuanyuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"6328_CR1","unstructured":"World Health Organization (2018) WHO vaccine-preventable diseases: monitoring system. 2018 Global Summary. Available at:\u00a0http:\/\/apps.who.int\/immunization_monitoring\/globalsummary\/countries?countrycriteria%5Bcountry%5D%5B%5D=CHN&commit=OK.\u00a0Accessed 31 Jan 2019"},{"key":"6328_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.coi.2019.03.006","volume":"59","author":"P Kapil","year":"2019","unstructured":"Kapil P, Merkel TJ (2019) Pertussis vaccines and protective immunity. Curr Opin Immunol 59:72\u201378","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"6328_CR3","doi-asserted-by":"publisher","first-page":"645.e1","DOI":"10.1016\/j.cmi.2019.10.001","volume":"26","author":"L Subissi","year":"2020","unstructured":"Subissi L, Rodeghiero C, Martini H, Litzroth A, Huygen K, Leroux-Roels G et al (2020) Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects. Clin Microbiol Infect 26(5):645.e1-645.e8","journal-title":"Clin Microbiol Infect"},{"key":"6328_CR4","unstructured":"Cherry JD, Heininger U (2003) Text book of pediatric infectious diseases[M] .5th Edit, America:Saunders 1588\u20131608."},{"issue":"3","key":"6328_CR5","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1086\/315318","volume":"181","author":"J Taranger","year":"2000","unstructured":"Taranger J, Trollfors B, Lagerg\u00e5rd T, Sundh V, Bryla DA, Schneerson R et al (2000) Correlation between pertussis toxin IgG antibodies in postvaccination sera and subsequent protection against pertussis. J Infect Dis 181(3):1010\u20131013","journal-title":"J Infect Dis"},{"issue":"2","key":"6328_CR6","doi-asserted-by":"publisher","first-page":"250.e1","DOI":"10.1016\/j.cmi.2018.04.013","volume":"25","author":"S Son","year":"2019","unstructured":"Son S, Thamlikitkul V, Chokephaibulkit K, Perera J, Jayatilleke K, Hsueh PR et al (2019) Prospective multinational serosurveillance study of Bordetella pertussis infection among 10- to 18-year-old Asian children and adolescents. Clin Microbiol Infect 25(2):250.e1-250.e7","journal-title":"Clin Microbiol Infect"},{"issue":"16","key":"6328_CR7","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1016\/j.vaccine.2020.02.080","volume":"38","author":"P J\u00f5gi","year":"2020","unstructured":"J\u00f5gi P, Soeorg H, Oona M, Kaart T, Toompere K, Maskina T et al (2020) Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults. Vaccine 38(16):3196\u20133200","journal-title":"Vaccine"},{"issue":"11","key":"6328_CR8","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s00247-017-3944-4","volume":"47","author":"S Andronikou","year":"2017","unstructured":"Andronikou S, Lambert E, Halton J, Hilder L, Crumley I, Lyttle MD et al (2017) Guidelines for the use of chest radiographs in community-acquired pneumonia in children and adolescents. Pediatr Radiol 47(11):1405\u20131411","journal-title":"Pediatr Radiol"},{"issue":"10","key":"6328_CR9","first-page":"1232","volume":"11","author":"B Panetti","year":"2024","unstructured":"Panetti B, Bucci I, Di Ludovico A, Pellegrino GM, Di Filippo P, Di Pillo S et al (2024) Acute respiratory failure in children: a clinical update on diagnosis. Children (Basel) 11(10):1232","journal-title":"Children (Basel)"},{"key":"6328_CR10","unstructured":"WHO: immunization, vaccines and biologicals: pertussis. 25 July 2019 2019. https:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/vpd\/surveillance_type\/passive\/pertussis\/en\/. Last Accessed 2019"},{"issue":"12","key":"6328_CR11","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.vaccine.2021.02.032","volume":"39","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Pan J, Chen M, Zhang T, Li J, Lu L (2021) Seroepidemiology of pertussis in China: a population-based, cross-sectional study. Vaccine 39(12):1687\u20131692","journal-title":"Vaccine"},{"issue":"8","key":"6328_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3390\/toxins13080508","volume":"13","author":"AM Barkoff","year":"2021","unstructured":"Barkoff AM, Knuutila A, Mertsola J, He Q (2021) Evaluation of anti-PT antibody response after pertussis vaccination and infection: the importance of both quantity and quality. Toxins (Basel) 13(8):508","journal-title":"Toxins (Basel)"},{"key":"6328_CR13","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1093\/infdis\/jit639","volume":"209","author":"EL Hewlett","year":"2014","unstructured":"Hewlett EL, Burns DL, Cotter PA, Harvill ET, Merkel TJ, Quinn CP et al (2014) Pertussis pathogenesis\u2013what we know and what we don\u2019t know. J Infect Dis 209:982\u2013985","journal-title":"J Infect Dis"},{"key":"6328_CR14","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nrmicro3235","volume":"12","author":"JA Melvin","year":"2014","unstructured":"Melvin JA, Scheller EV, Miller JF, Cotter PA (2014) Bordetella pertussis pathogenesis: current and future challenges. Nat Rev Microbiol 12:274\u2013288","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"6328_CR15","doi-asserted-by":"publisher","first-page":"ftw087","DOI":"10.1093\/femspd\/ftw087","volume":"74","author":"NH Carbonetti","year":"2016","unstructured":"Carbonetti NH (2016) Pertussis leukocytosis: mechanisms, clinical relevance and treatment. Pathog Dis. 74(7):ftw087","journal-title":"Pathog Dis."},{"key":"6328_CR16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1086\/589753","volume":"47","author":"CD Paddock","year":"2008","unstructured":"Paddock CD, Sanden GN, Cherry JD, Gal AA, Langston C, Tatti KM et al (2008) Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Clin Infect Dis 47:328\u2013338","journal-title":"Clin Infect Dis"},{"issue":"4","key":"6328_CR17","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/PCC.0b013e31828a70fe","volume":"14","author":"JT Berger","year":"2013","unstructured":"Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R et al (2013) Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med 14(4):356\u2013365","journal-title":"Pediatr Crit Care Med"},{"issue":"7","key":"6328_CR18","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1093\/cid\/civ472","volume":"61","author":"K Winter","year":"2015","unstructured":"Winter K, Zipprich J, Harriman K, Murray EL, Gornbein J, Hammer SJ et al (2015) Risk factors associated with infant deaths from pertussis: a case-control study. Clin Infect Dis 61(7):1099\u20131106","journal-title":"Clin Infect Dis"},{"issue":"17","key":"6328_CR19","doi-asserted-by":"publisher","first-page":"e0549","DOI":"10.1097\/MD.0000000000010549","volume":"97","author":"SF Tian","year":"2018","unstructured":"Tian SF, Wang HM, Deng JK (2018) Fatal malignant pertussis with hyperleukocytosis in a Chinese infant: a case report and literature review. Medicine (Baltimore) 97(17):e0549","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"6328_CR20","doi-asserted-by":"publisher","first-page":"ftv081","DOI":"10.1093\/femspd\/ftv081","volume":"73","author":"JC Eby","year":"2015","unstructured":"Eby JC, Hoffman CL, Gonyar LA, Hewlett EL (2015) Review of the neutrophil response to Bordetella pertussis infection. Pathog Dis 73(9):ftv081","journal-title":"Pathog Dis"},{"issue":"11","key":"6328_CR21","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1128\/IAI.00895-08","volume":"76","author":"C Andreasen","year":"2008","unstructured":"Andreasen C, Carbonetti NH (2008) Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice. Infect Immun 76(11):5139\u20135148","journal-title":"Infect Immun"},{"issue":"4","key":"6328_CR22","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1128\/IAI.01578-06","volume":"75","author":"NH Carbonetti","year":"2007","unstructured":"Carbonetti NH, Artamonova GV, Van Rooijen N, Ayala VI (2007) Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. Infect Immun 75(4):1713\u20131720","journal-title":"Infect Immun"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06328-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06328-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06328-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:02:30Z","timestamp":1758049350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06328-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["6328"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06328-w","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study received ethics approval at the Ethics Committee of the Children\u2019s Hospital Affiliated to Chongqing Medical University and adhered to the principles of the Helsinki Declaration. Ethical approval was obtained, and informed consent was waived as the study was retrospective and used anonymized routine clinical data only. PT-IgG testing was performed once at hospital admission as part of the standard diagnostic workup for pertussis. The timing of antibody response was inferred based on the interval between symptom onset and the date of hospital admission. No additional blood samples were collected for research purposes. All patients, regardless of vaccination status, underwent the same clinical assessment and diagnostic procedures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"501"}}