{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:23:15Z","timestamp":1786980195207,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The purpose of this study is to investigate long-term morbidity (physical, psychosocial, neurocognitive, quality of life (QoL)) in critical care patients with multisystem inflammatory syndrome in children (MIS-C). This prospective study examined MIS-C critical care admissions (May 2020\u2013March 2022). Outcomes were determined by semi-structured interview, functional assessment scores, self- and parent-reported questionnaires, and extensive neurocognitive testing at 3 and 24\u00a0months after pediatric intensive care unit (PICU) admission. There was no control group, but general population norm data was used. Thirty-six MIS-C PICU admissions were included (median [IQR] age 10.1 [7.9\u201313.6] years, 72% male). Median [IQR] PICU stay was 3\u00a0days [2\u20134] and all survived; 81% (29\/36) attended 24\u00a0months follow-up. Functional assessment scores were favorable in most. Forty-five percent reported\u2009\u2265\u20091 functional complaint (e.g., fatigue (23%) or exercise intolerance (17%)). Fourteen percent had not resumed full-time school, and grade adjustments were necessary in 10%. Psychosocial, neurocognitive, and QoL outcomes were comparable to the general population except for visual memory and sustained attention.<\/jats:p>\n                    <jats:p>\n                      <jats:italic>Conclusions<\/jats:italic>\n                      : Repeated, multidimensional validated neuropsychological testing in MIS-C PICU patients was comparable to the norm population, except for visual memory and sustained attention. Functional assessment scores were mostly favorable. However, self-reported complaints remained prevalent (45%) and school participation was not possible in 14%. This discrepancy (validated vs. self-reported outcome measures) underlines the need for standardized physical testing and age- and community-matched control groups to establish an association with disease-related factors, especially during unique social circumstances. Overall, structured PICU longitudinal follow-up identifies specific domains for rehabilitation to address morbidity and enhance social participation.\n                      <jats:table-wrap>\n                        <jats:table>\n                          <jats:tbody>\n                            <jats:tr>\n                              <jats:td align=\"left\" colspan=\"2\">\n                                <jats:bold>What is Known:<\/jats:bold>\n                                <jats:italic>\u2022 MIS-C is a multi organ inflammatory response to a SARS-CoV-2 infection with varying severity ranging from subclinical to critical illness.<\/jats:italic>\n                                <jats:italic>\u2022 The retention of knowledge from this training is a point of concern for parents.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                            <jats:tr>\n                              <jats:td align=\"left\" colspan=\"2\">\n                                <jats:bold>What is New:<\/jats:bold>\n                                <jats:italic>\u2022 Multidimensional, longitudinal outcome of MIS-C critical care survivors showed validated functional scores and repeated neuropsychological outcomes comparable to the norm, with the exception of visual memory and sustained attention. Self-reported complaints remained prevalent (45%).<\/jats:italic>\n                                <jats:italic>\u2022 Longitudinal, multidisciplinary follow-up programs are crucial for (novel) disease trajectory understanding and individualized rehabilitation programs.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                          <\/jats:tbody>\n                        <\/jats:table>\n                      <\/jats:table-wrap>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00431-025-06396-y","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:43:36Z","timestamp":1757907816000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal functional and neuropsychological 2-year follow-up after intensive care admission for multisystem inflammatory syndrome in children"],"prefix":"10.1007","volume":"184","author":[{"given":"Naomi","family":"Ketharanathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne M. 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