{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:15:58Z","timestamp":1788336958150,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007950","name":"Tanta University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007950","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the correlation between serum Golgi protein-73 (GP-73) and the degree of hepatic fibrosis in children with autoimmune liver diseases. This case\u2013control study included 100 children. Group A involved 50 children with autoimmune hepatitis (AIH), aged 2\u201317\u00a0years (mean 11.3\u2009\u00b1\u20092.7\u00a0years), while Group B included 50 age- and sex-matched healthy controls. All participants underwent clinical assessment, abdominal ultrasonography, laboratory investigations, and measurement of serum GP-73 using enzyme-linked immunosorbent assay. Children with AIH had significantly higher serum GP-73 levels than controls (median 110.7\u00a0ng\/L vs. 21.3\u00a0ng\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). GP-73 levels showed a strong positive correlation with both the histological activity index (r\u2009=\u20090.879,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and the stage of fibrosis (r\u2009=\u20090.647, p\u2009&lt;\u20090.001). At a cutoff level\u2009&gt;\u200949\u00a0ng\/L, GP-73 distinguished AIH cases with 100% sensitivity and 100% specificity. For identifying severe fibrosis, a cutoff\u2009&gt;\u2009124.6\u00a0ng\/L yielded 100% sensitivity and 91.7% specificity (area under the ROC curve\u2009=\u20090.995,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    :\u00a0Serum GP-73 levels are significantly elevated in children with autoimmune hepatitis and correlate strongly with both histological grading and staging. GP-73 may serve as a reliable non-invasive marker for assessing disease severity and guiding clinical management in pediatric autoimmune liver diseases.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Non-invasive biomarkers for assessing liver fibrosis in children with autoimmune hepatitis are still limited, and liver biopsy remains the gold standard despite its risks.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Serum GP-73 is significantly elevated in pediatric AIH, strongly correlates with fibrosis severity, and may serve as a reliable non-invasive biomarker.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-025-06428-7","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:44:05Z","timestamp":1756932245000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum golgi protein-73 (GP-73) in children with autoimmune hepatitis"],"prefix":"10.1007","volume":"184","author":[{"given":"Marwa Sabry","family":"Rizk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola Galal Ali","family":"Behairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amera Mohamed Abdel Salam","family":"Dawood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Atef","family":"Khashaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa El","family":"Gendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa Farouk","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"6428_CR1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/diagnostics14040382","volume":"14","author":"LA Mercado","year":"2024","unstructured":"Mercado LA, Gil-Lopez F, Chirila RM, Harnois DM (2024) Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview. 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