{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:38:21Z","timestamp":1762846701255,"version":"build-2065373602"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06497-8","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:32:39Z","timestamp":1759959159000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ectodermal dysplasias and isolated ectodermal anomalies: expanding the clinical and molecular spectrum in a cohort of 36 patients"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3814-564X","authenticated-orcid":false,"given":"Ay\u015fe Burcu","family":"Do\u011fan Ar\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-8970","authenticated-orcid":false,"given":"Ayberk","family":"T\u00fcrky\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-9910","authenticated-orcid":false,"given":"Abdulkerim","family":"Kolk\u0131ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-9792","authenticated-orcid":false,"given":"Elifcan","family":"Ta\u015fdelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-1809","authenticated-orcid":false,"given":"Esra","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"6497_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61045","author":"JT Wright","year":"2019","unstructured":"Wright JT et al (2019) Ectodermal dysplasias: classification and organization by phenotype, genotype and molecular pathway. Am J Med Genet A. https:\/\/doi.org\/10.1002\/ajmg.a.61045","journal-title":"Am J Med Genet A"},{"key":"6497_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-3-031-31978-5_15","volume":"1423","author":"C Yapijakis","year":"2023","unstructured":"Yapijakis C, Douka A, Gintoni I, Agiannitopoulos K, Vlachakis D, Chrousos GP (2023) Clinical and molecular genetic analysis of cases with ectodermal dysplasia. Adv Exp Med Biol 1423:181\u2013186. https:\/\/doi.org\/10.1007\/978-3-031-31978-5_15","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"6497_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/IJD.14048","volume":"57","author":"J Reyes-Reali","year":"2018","unstructured":"Reyes-Reali J, Mendoza-Ramos MI, Garrido-Guerrero E, M\u00e9ndez-Catal\u00e1 CF, M\u00e9ndez-Cruz AR, Pozo-Molina G (2018) Hypohidrotic ectodermal dysplasia: clinical and molecular review. Int J Dermatol 57(8):965\u2013972. https:\/\/doi.org\/10.1111\/IJD.14048","journal-title":"Int J Dermatol"},{"key":"6497_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/GENES13061056","author":"EA Rabie","year":"2022","unstructured":"Rabie EA et al (2022) Confirmation of a phenotypic entity for TSPEAR variants in Egyptian ectodermal dysplasia patients and role of ethnicity. Genes. https:\/\/doi.org\/10.3390\/GENES13061056","journal-title":"Genes"},{"key":"6497_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/GENES13122327","author":"N Peschel","year":"2022","unstructured":"Peschel N et al (2022) Molecular pathway-based classification of ectodermal dysplasias: first five-yearly update. Genes. https:\/\/doi.org\/10.3390\/GENES13122327","journal-title":"Genes"},{"issue":"3","key":"6497_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4103\/IDOJ.IDOJ_599_23","volume":"15","author":"A Dev","year":"2024","unstructured":"Dev A, Malhi K, Mahajan R (2024) Ectodermal dysplasia \u2013 an overview and update. Indian Dermatol Online J 15(3):405\u2013414. https:\/\/doi.org\/10.4103\/IDOJ.IDOJ_599_23","journal-title":"Indian Dermatol Online J"},{"key":"6497_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/GENES12091389","author":"HA Ahmed","year":"2021","unstructured":"Ahmed HA et al (2021) Gene mutations of the three ectodysplasin pathway key players (EDA, EDAR, and EDARADD) account for more than 60% of Egyptian ectodermal dysplasia: a report of seven novel mutations. Genes. https:\/\/doi.org\/10.3390\/GENES12091389","journal-title":"Genes"},{"key":"6497_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30","author":"S Richards","year":"2015","unstructured":"Richards S et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. https:\/\/doi.org\/10.1038\/gim.2015.30","journal-title":"Genet Med"},{"issue":"4","key":"6497_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000499325","volume":"157","author":"Y G\u00fcven","year":"2019","unstructured":"G\u00fcven Y et al (2019) Turkish ectodermal dysplasia cohort: from phenotype to genotype in 17 families. Cytogenet Genome Res 157(4):189\u2013196. https:\/\/doi.org\/10.1159\/000499325","journal-title":"Cytogenet Genome Res"},{"issue":"4","key":"6497_CR10","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1002\/AJMG.A.61493","volume":"182","author":"GM Anbouba","year":"2020","unstructured":"Anbouba GM, Carmany EP, Natoli JL (2020) The characterization of hypodontia, hypohidrosis, and hypotrichosis associated with X-linked hypohidrotic ectodermal dysplasia: a systematic review. Am J Med Genet A 182(4):831\u2013841. https:\/\/doi.org\/10.1002\/AJMG.A.61493","journal-title":"Am J Med Genet A"},{"key":"6497_CR11","unstructured":"Wright JT, Grange DK, Fete M (2025) Hypohidrotic Ectodermal Dysplasia,\u201d GeneReviews\u00ae. Available:  https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1112\/. Accessed 29 June 2025"},{"key":"6497_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/S13023-019-1288-X","author":"S Wohlfart","year":"2020","unstructured":"Wohlfart S et al (2020) Natural history of X-linked hypohidrotic ectodermal dysplasia: a 5-year follow-up study. Orphanet J Rare Dis. https:\/\/doi.org\/10.1186\/S13023-019-1288-X","journal-title":"Orphanet J Rare Dis"},{"key":"6497_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS12102300","author":"H Liu","year":"2022","unstructured":"Liu H et al (2022) Rare X-linked hypohidrotic ectodermal dysplasia in females associated with Ectodysplasin-A variants and the X-chromosome inactivation pattern. Diagnostics. https:\/\/doi.org\/10.3390\/DIAGNOSTICS12102300","journal-title":"Diagnostics"},{"key":"6497_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2023.100186","author":"A Jackson","year":"2023","unstructured":"Jackson A et al (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. Hum Genet Genomics Adv. https:\/\/doi.org\/10.1016\/j.xhgg.2023.100186","journal-title":"Hum Genet Genomics Adv"},{"key":"6497_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIFF.2025.100838","author":"EL Benard","year":"2025","unstructured":"Benard EL, Hammerschmidt M (2025) The fundamentals of WNT10A. Differentiation. https:\/\/doi.org\/10.1016\/J.DIFF.2025.100838","journal-title":"Differentiation"},{"issue":"7","key":"6497_CR16","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/S00784-018-2731-4","volume":"23","author":"G Ruiz-Heiland","year":"2019","unstructured":"Ruiz-Heiland G, Lenz S, Bock N, Ruf S (2019) Prevalence of WNT10A gene mutations in non-syndromic oligodontia. Clin Oral Investig 23(7):3103\u20133113. https:\/\/doi.org\/10.1007\/S00784-018-2731-4","journal-title":"Clin Oral Investig"},{"key":"6497_CR17","doi-asserted-by":"publisher","DOI":"10.1159\/000545293","author":"LE Prieto","year":"2025","unstructured":"Prieto LE, Vasquez-Forero DM, Pachajoa H (2025) The first Colombian patient with CDH3 -related hypotrichosis with juvenile macular dystrophy. Ski Appendage Disord. https:\/\/doi.org\/10.1159\/000545293","journal-title":"Ski Appendage Disord"},{"key":"6497_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-019-09675-w","author":"F Nasser","year":"2019","unstructured":"Nasser F, Mulahasanovic L, Alkhateeb M, Biskup S, Stingl K, Zrenner E (2019) Hypotrichosis with cone-rod dystrophy in a patient with cadherin 3 (CDH3) mutation. Doc Ophthalmol. https:\/\/doi.org\/10.1007\/s10633-019-09675-w","journal-title":"Doc Ophthalmol"},{"issue":"8","key":"6497_CR19","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1002\/ajmg.a.62347","volume":"185","author":"B Bowles","year":"2021","unstructured":"Bowles B et al (2021) Tspear variants are primarily associated with ectodermal dysplasia and tooth agenesis but not hearing loss: a novel cohort study. Am J Med Genet A 185(8):2417\u20132433. https:\/\/doi.org\/10.1002\/ajmg.a.62347","journal-title":"Am J Med Genet A"},{"issue":"5","key":"6497_CR20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/1346-8138.14257","volume":"45","author":"Y Mizukami","year":"2018","unstructured":"Mizukami Y, Hayashi R, Tsuruta D, Shimomura Y, Sugawara K (2018) Novel splice site mutation in the LIPH gene in a patient with autosomal recessive woolly hair\/hypotrichosis: case report and published work review. J Dermatol 45(5):613\u2013617. https:\/\/doi.org\/10.1111\/1346-8138.14257","journal-title":"J Dermatol"},{"issue":"4","key":"6497_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/NRENDO.2017.166","volume":"14","author":"F Brioude","year":"2018","unstructured":"Brioude F et al (2018) Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement. Nat Rev Endocrinol 14(4):229\u2013249. https:\/\/doi.org\/10.1038\/NRENDO.2017.166","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"6497_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/15513815.2024.2337639","volume":"43","author":"S Collier","year":"2024","unstructured":"Collier S, Wasilewska EM, Craver R (2024) Novel autopsy findings in premature infant with beckwith-wiedemann syndrome uniparental disomy: multifocal developmental dysplastic chrondromatous lesions and cortical neuronal heterotopias. Fetal Pediatr Pathol 43(3):257\u2013265. https:\/\/doi.org\/10.1080\/15513815.2024.2337639","journal-title":"Fetal Pediatr Pathol"},{"key":"6497_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/FMED.2024.1374222","author":"S Minakawa","year":"2024","unstructured":"Minakawa S et al (2024) Case report: exploring autosomal recessive woolly hair: genetic and scanning electron microscopic perspectives on a Japanese patient. Front Med. https:\/\/doi.org\/10.3389\/FMED.2024.1374222","journal-title":"Front Med"},{"issue":"12","key":"6497_CR24","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1111\/1346-8138.15581","volume":"47","author":"H Lv","year":"2020","unstructured":"Lv H, Li M, Cheng R (2020) Novel small-insertion mutation in the LIPH gene in a patient with autosomal recessive woolly hair\/hypotrichosis. J Dermatol 47(12):1445\u20131449. https:\/\/doi.org\/10.1111\/1346-8138.15581","journal-title":"J Dermatol"},{"issue":"8","key":"6497_CR25","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/IJD.14480","volume":"58","author":"GM Khan","year":"2019","unstructured":"Khan GM et al (2019) Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair\/hypotrichosis phenotype in five Pakistani families. Int J Dermatol 58(8):946\u2013952. https:\/\/doi.org\/10.1111\/IJD.14480","journal-title":"Int J Dermatol"},{"issue":"9","key":"6497_CR26","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1111\/IJD.13109","volume":"55","author":"S Mehmood","year":"2016","unstructured":"Mehmood S et al (2016) Disease causing homozygous variants in the human hairless gene. Int J Dermatol 55(9):977\u2013981. https:\/\/doi.org\/10.1111\/IJD.13109","journal-title":"Int J Dermatol"},{"issue":"6","key":"6497_CR27","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.18502\/IJPH.V50I6.6429","volume":"50","author":"H Heidary","year":"2021","unstructured":"Heidary H, Mardi A, Mousavi SM, Khazaie G, Golab F (2021) Hairless gene nonsense mutations in alopecia universalis: A case report. Iran J Public Health 50(6):1275\u20131279. https:\/\/doi.org\/10.18502\/IJPH.V50I6.6429","journal-title":"Iran J Public Health"},{"key":"6497_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17349","author":"K Ullah","year":"2024","unstructured":"Ullah K et al (2024) Novel pathogenic variants in HR underlie atrichia with papular lesions in a cohort of 10 families. J Dermatol. https:\/\/doi.org\/10.1111\/1346-8138.17349","journal-title":"J Dermatol"},{"key":"6497_CR29","doi-asserted-by":"publisher","unstructured":"Wang J, Malloy PJ, Feldman D (2007) Interactions of the vitamin D receptor with the corepressor hairless: analysis of hairless mutants in atrichia with papular lesions. J Biol Chem 282(35).  https:\/\/doi.org\/10.1074\/jbc.M702939200","DOI":"10.1074\/jbc.M702939200"},{"key":"6497_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45040194","author":"A Ortiz-Ram\u00edrez","year":"2023","unstructured":"Ortiz-Ram\u00edrez A et al (2023) HR gene variants identified in Mexican patients with alopecia areata. Curr Issues Mol Biol. https:\/\/doi.org\/10.3390\/cimb45040194","journal-title":"Curr Issues Mol Biol"},{"issue":"3","key":"6497_CR31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/CGE.14265","volume":"103","author":"X Wang","year":"2023","unstructured":"Wang X et al (2023) Loss-of-function mutations in CST6 cause dry skin, desquamation and abnormal keratosis without hypotrichosis. Clin Genet 103(3):301\u2013309. https:\/\/doi.org\/10.1111\/CGE.14265","journal-title":"Clin Genet"},{"issue":"7","key":"6497_CR32","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/S41436-018-0355-3","volume":"21","author":"EHJ van den Bogaard","year":"2019","unstructured":"van den Bogaard EHJ et al (2019) Deficiency of the human cysteine protease inhibitor cystatin M\/E causes hypotrichosis and dry skin. Genet Med 21(7):1559\u20131567. https:\/\/doi.org\/10.1038\/S41436-018-0355-3","journal-title":"Genet Med"},{"issue":"5","key":"6497_CR33","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1111\/bjd.14973","volume":"176","author":"ML Lovgren","year":"2017","unstructured":"Lovgren ML et al (2017) Mutations in desmoglein 1 cause diverse inherited palmoplantar keratoderma phenotypes: implications for genetic screening. Br J Dermatol 176(5):1345\u20131350. https:\/\/doi.org\/10.1111\/bjd.14973","journal-title":"Br J Dermatol"},{"key":"6497_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/CCR3.8881","author":"K Koschitzki","year":"2024","unstructured":"Koschitzki K et al (2024) Hereditary epidermolytic palmoplantar keratosis due to a novel desmoglein-1 mutation: a case report. Clin Case Rep. https:\/\/doi.org\/10.1002\/CCR3.8881","journal-title":"Clin Case Rep"},{"issue":"no. 5","key":"6497_CR35","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.jid.2019.06.154","volume":"140","author":"S Duchatelet","year":"2020","unstructured":"Duchatelet S et al (2020) A TP63 mutation causes prominent alopecia with mild ectodermal dysplasia. J Invest Dermatol 140(5):1103-1106.e4. https:\/\/doi.org\/10.1016\/j.jid.2019.06.154","journal-title":"J Invest Dermatol"},{"issue":"1","key":"6497_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/S41439-022-00186-W","volume":"9","author":"A Hori","year":"2022","unstructured":"Hori A, Migita O, Isogawa N, Takada F, Hata K (2022) A novel TP63 variant in a patient with ankyloblepharon-ectodermal defect\u2013cleft lip\/palate syndrome and Rapp-Hodgkin syndrome-like ectodermal dysplasia. Hum Genome Var 9(1):17. https:\/\/doi.org\/10.1038\/S41439-022-00186-W","journal-title":"Hum Genome Var"},{"issue":"10","key":"6497_CR37","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1111\/EXD.14045","volume":"28","author":"A Maillard","year":"2019","unstructured":"Maillard A et al (2019) P63-related disorders: dermatological characteristics in 22 patients. Exp Dermatol 28(10):1190\u20131195. https:\/\/doi.org\/10.1111\/EXD.14045","journal-title":"Exp Dermatol"},{"key":"6497_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/S13052-021-01152-Y","author":"G Serra","year":"2021","unstructured":"Serra G et al (2021) Novel missense mutation of the TP63 gene in a newborn with Hay-Wells\/ankyloblepharon-ectodermal defects-Cleft lip\/palate (AEC) syndrome: clinical report and follow-up. Ital J Pediatr. https:\/\/doi.org\/10.1186\/S13052-021-01152-Y","journal-title":"Ital J Pediatr"},{"issue":"12","key":"6497_CR39","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1002\/ajmg.a.34335","volume":"155","author":"V Serra","year":"2011","unstructured":"Serra V, Castori M, Paradisi M, Bui L, Melino G, Terrinoni A (2011) Functional characterization of a novel TP63 mutation in a family with overlapping features of Rapp-Hodgkin\/AEC\/ADULT syndromes. Am J Med Genet A 155(12):3104\u20133109. https:\/\/doi.org\/10.1002\/ajmg.a.34335","journal-title":"Am J Med Genet A"},{"key":"6497_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/S13023-019-1251-X","author":"MC Mart\u00ednez-Romero","year":"2019","unstructured":"Mart\u00ednez-Romero MC et al (2019) EDA, EDAR, EDARADD and WNT10A allelic variants in patients with ectodermal derivative impairment in the Spanish population. Orphanet J Rare Dis. https:\/\/doi.org\/10.1186\/S13023-019-1251-X","journal-title":"Orphanet J Rare Dis"},{"key":"6497_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.183","author":"BL Griggs","year":"2009","unstructured":"Griggs BL, Ladd S, Decker A, DuPont BR, Asamoah A, Srivastava AK (2009) Identification of ectodysplasin-A receptor gene deletion at 2q12.2 and a potential autosomal MR locus. Eur J Hum Genet. https:\/\/doi.org\/10.1038\/ejhg.2008.183","journal-title":"Eur J Hum Genet"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06497-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06497-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06497-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:34:56Z","timestamp":1762846496000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06497-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":41,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6497"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06497-8","relation":{},"ISSN":["1432-1076"],"issn-type":[{"type":"electronic","value":"1432-1076"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"3 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the University of Health Sciences, Ankara Bilkent City Hospital Clinical Research Ethics Committee under number TABED 1\u201324-255.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent for the publication of clinical details and images was obtained from all patients or their legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"667"}}