{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:51:09Z","timestamp":1790823069082,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073062"],"award-info":[{"award-number":["82073062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06498-7","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:40:51Z","timestamp":1759923651000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic factors and treatment outcomes of hepatoblastoma in children: a SEER database analysis"],"prefix":"10.1007","volume":"184","author":[{"given":"Xiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"issue":"2","key":"6498_CR1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1053\/j.semdp.2016.12.015","volume":"34","author":"D Sharma","year":"2017","unstructured":"Sharma D, Subbarao G, Saxena R (2017) Hepatoblastoma. Semin Diagn Pathol 34(2):192\u2013200","journal-title":"Semin Diagn Pathol"},{"issue":"1","key":"6498_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-019-0411-7","volume":"39","author":"J Feng","year":"2019","unstructured":"Feng J, Polychronidis G, Heger U (2019) Incidence trends and survival prediction of hepatoblastoma in children: a population-based study. Cancer Commun 39(1):62","journal-title":"Cancer Commun"},{"issue":"2","key":"6498_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.30699\/ijp.2023.1972340.3005","volume":"18","author":"GV Patil Okaly","year":"2023","unstructured":"Patil Okaly GV, Prakash A, Akshatha C et al (2023) A clinicopathological study with risk-stratified staging of pediatric hepatoblastoma: a 5-year experience from a tertiary cancer center. Iran J Pathol 18(2):165\u2013172","journal-title":"Iran J Pathol"},{"issue":"4","key":"6498_CR4","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1002\/cam4.5300","volume":"12","author":"M Honda","year":"2023","unstructured":"Honda M, Uchida K, Irie T et al (2023) Recent advances in surgical strategies and liver transplantation for hepatoblastoma. Cancer Med 12(4):3909\u20133918","journal-title":"Cancer Med"},{"issue":"3","key":"6498_CR5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1097\/MCG.0000000000000833","volume":"52","author":"F Nautsch","year":"2018","unstructured":"Nautsch F, Ludwig JM, Xing M et al (2018) Racial disparities and sociodemographic differences in incidence and survival among pediatric patients in the United States with primary liver cancer: a Surveillance, Epidemiology, and End Results (SEER) population study. J Clin Gastroenterol 52(3):262\u2013267","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"6498_CR6","first-page":"69","volume":"34","author":"P Li","year":"2023","unstructured":"Li P, Kong Y, Guo J et al (2023) Incidence and trends of hepatic cancer among children and adolescents in the United States from 2000 to 2017: evidence from the Surveillance, Epidemiology, and End Results registry data. Cancer Causes Control 34(1):69\u201379","journal-title":"Cancer Causes Control"},{"issue":"11","key":"6498_CR7","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1016\/j.radcr.2022.08.025","volume":"17","author":"V Barragan","year":"2022","unstructured":"Barragan V, Escudero MC, Jimenez IC et al (2022) Bone metastases in hepatoblastoma, an unusual presentation. Case report and review of the literature. Radiol Case Rep 17(11):4272\u20134275","journal-title":"Radiol Case Rep"},{"issue":"1","key":"6498_CR8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/bjs.9681","volume":"102","author":"R Venkatramani","year":"2015","unstructured":"Venkatramani R, Stein JE, Sapra A (2015) Effect of neoadjuvant chemotherapy on resectability of stage III and IV hepatoblastoma. Br J Surg 102(1):108\u2013113","journal-title":"Br J Surg"},{"issue":"2","key":"6498_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00247-006-0361-5","volume":"37","author":"DJ Roebuck","year":"2007","unstructured":"Roebuck DJ, Aronson D, Clapuyt P et al (2007) 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group. Pediatr Radiol 37(2):123\u2013132 (quiz 249\u201350)","journal-title":"Pediatr Radiol"},{"key":"6498_CR10","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejca.2015.09.023","volume":"52","author":"P Czauderna","year":"2016","unstructured":"Czauderna P, Haeberle B, Hiyama E (2016) The children\u2019s hepatic tumors international collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur J Cancer 52:92\u2013101","journal-title":"Eur J Cancer"},{"issue":"21","key":"6498_CR11","first-page":"10553","volume":"27","author":"YB Lin","year":"2023","unstructured":"Lin YB, Huang SH, Liu S (2023) 2 years is a reasonable age cut-off level for prognostic assessment of children with hepatoblastoma. Eur Rev Med Pharmacol Sci 27(21):10553\u201310562","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"6498_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S1470-2045(16)30598-8","volume":"18","author":"RL Meyers","year":"2017","unstructured":"Meyers RL, Maibach R, Hiyama E (2017) Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children\u2019s Hepatic Tumors International Collaboration. Lancet Oncol 18(1):122\u2013131","journal-title":"Lancet Oncol"},{"key":"6498_CR13","doi-asserted-by":"crossref","unstructured":"Kahla JA, Siegel DA, Dai S et al (2022) Incidence and 5-year survival of children and adolescents with hepatob lastoma in the United States. Pediatr Blood Cancer 69(10):e29763","DOI":"10.1002\/pbc.29763"},{"issue":"1","key":"6498_CR14","volume":"10","author":"WQ Che","year":"2023","unstructured":"Che WQ, Li YJ, Tsang CK (2023) How to use the surveillance, epidemiology, and end results (SEER) data: research design and methodology. Mil Med Res 10(1):50","journal-title":"Mil Med Res"},{"issue":"4","key":"6498_CR15","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","volume":"16","author":"VP Balachandran","year":"2015","unstructured":"Balachandran VP, Gonen M, Smith JJ et al (2015) Nomograms in oncology: more than meets the eye. Lancet Oncol 16(4):e173\u2013e180","journal-title":"Lancet Oncol"},{"issue":"2","key":"6498_CR16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.21037\/tcr-23-1786","volume":"13","author":"W Chen","year":"2024","unstructured":"Chen W, Zhang L, Zhang B et al (2024) Development and validation of nomogram-based models for personalized survival assessment in pediatric hepatoblastoma patients. Transl Cancer Res 13(2):699\u2013713","journal-title":"Transl Cancer Res"},{"issue":"7","key":"6498_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7111","volume":"13","author":"J Luo","year":"2024","unstructured":"Luo J, Hu J, Mulati Y et al (2024) Developing and validating a nomogram for penile cancer survival: a comprehensive study based on SEER and Chinese data. Cancer Med 13(7):e7111","journal-title":"Cancer Med"},{"issue":"6","key":"6498_CR18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s10147-013-0616-8","volume":"18","author":"K Watanabe","year":"2013","unstructured":"Watanabe K (2013) Current chemotherapeutic approaches for hepatoblastoma. Int J Clin Oncol 18(6):955\u2013961","journal-title":"Int J Clin Oncol"},{"issue":"24","key":"6498_CR19","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1200\/JCO.2010.29.3837","volume":"29","author":"MH Malogolowkin","year":"2011","unstructured":"Malogolowkin MH, Katzenstein HM, Meyers RL (2011) Complete surgical resection is curative for children with hepatoblastoma with pure fetal histology: a report from the children\u2019s oncology group. J Clin Oncol 29(24):3301\u20133306","journal-title":"J Clin Oncol"},{"issue":"1","key":"6498_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/pbc.10376","volume":"42","author":"JB Otte","year":"2004","unstructured":"Otte JB, Pritchard J, Aronson DC (2004) Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer 42(1):74\u201383","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"6498_CR21","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/1093526619875228","volume":"23","author":"S Ranganathan","year":"2020","unstructured":"Ranganathan S, Lopez-Terrada D, Alaggio R (2020) Hepatoblastoma and pediatric hepatocellular carcinoma: an update. Pediatr Dev Pathol 23(2):79\u201395","journal-title":"Pediatr Dev Pathol"},{"issue":"6","key":"6498_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2019.150856","volume":"28","author":"CM Lake","year":"2019","unstructured":"Lake CM, Tiao GM, Bondoc AJ (2019) Surgical management of locally-advanced and metastatic hepatoblastoma. Semin Pediatr Surg 28(6):150856","journal-title":"Semin Pediatr Surg"},{"issue":"12","key":"6498_CR23","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.jpedsurg.2017.08.031","volume":"52","author":"T Hishiki","year":"2017","unstructured":"Hishiki T, Watanabe K, Ida K et al (2017) The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: results from the JPLT-2 study. J Pediatr Surg 52(12):2051\u20132055","journal-title":"J Pediatr Surg"},{"issue":"1","key":"6498_CR24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/MOP.0000000000000046","volume":"26","author":"P Czauderna","year":"2014","unstructured":"Czauderna P, Lopez-Terrada D, Hiyama E et al (2014) Hepatoblastoma state of the art: pathology, genetics, risk stratification, and chemotherapy. Curr Opin Pediatr 26(1):19\u201328","journal-title":"Curr Opin Pediatr"},{"issue":"3","key":"6498_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2021.151164","volume":"37","author":"LA Linder","year":"2021","unstructured":"Linder LA, Ameringer S, Stegenga K et al (2021) A person-centered approach to symptom assessment and management for children and adolescents receiving cancer treatment. Semin Oncol Nurs 37(3):151164","journal-title":"Semin Oncol Nurs"},{"issue":"11","key":"6498_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28594","volume":"67","author":"S Kahana-Edwin","year":"2020","unstructured":"Kahana-Edwin S, McCowage G, Cain L (2020) Exploration of CTNNB1 ctDNA as a putative biomarker for hepatoblastoma. Pediatr Blood Cancer 67(11):e28594","journal-title":"Pediatr Blood Cancer"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06498-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06498-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06498-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:35:11Z","timestamp":1762846511000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06498-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6498"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06498-7","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"20 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies directly involving human subjects, as it is a study based on pre-existing data from the SEER database.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"666"}}