{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:22:02Z","timestamp":1772119322017,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-025-06533-7","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T03:38:01Z","timestamp":1760413081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linking IgE-mediated CMPA to functional gastrointestinal disorders"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7561-0485","authenticated-orcid":false,"given":"Nur Kevser","family":"\u00d6zyurt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-7867","authenticated-orcid":false,"given":"Merve","family":"Ki\u015fio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-8168","authenticated-orcid":false,"given":"Burcu","family":"G\u00fcven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-4679","authenticated-orcid":false,"given":"Nalan","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-932X","authenticated-orcid":false,"given":"Faz\u0131l","family":"Orhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"6533_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2024.100888","author":"A Bognanni","year":"2024","unstructured":"Bognanni A, Fiocchi A, Arasi S, Chu DK, Ansotegui I, Assa\u2019ad AH, Bahna SL, Berni Canani R, Bozzola M, Dahdah L, Dupont C, Dziechciarz P, Ebisawa M, Firmino RT, Chu A, Galli E, Horvath A, Kamenwa R, Lack G, Li H, Martelli A, Nowak-W\u0119grzyn A, Papadopoulos NG, Pawankar R, Roldan Y, Said M, S\u00e1nchez-Borges M, Shamir R, Spergel JM, Szajewska H, Terracciano L, Vandenplas Y, Venter C, Waffenschmidt S, Waserman S, Warner A, Wong GWK, Sch\u00fcnemann HJ, Brozek JL (2024) World Allergy Organization (WAO) diagnosis and rationale for action against cow\u2019s milk allergy (DRACMA) guideline update - XII - recommendations on milk formula supplements with and without probiotics for infants and toddlers with CMA. World Allergy Organ J. https:\/\/doi.org\/10.1016\/j.waojou.2024.100888","journal-title":"World Allergy Organ J"},{"issue":"1","key":"6533_CR2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","volume":"141","author":"SH Sicherer","year":"2018","unstructured":"Sicherer SH, Sampson HA (2018) Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol 141(1):41\u201358","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"6533_CR3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.iac.2011.11.008","volume":"32","author":"KJ Allen","year":"2012","unstructured":"Allen KJ, Koplin JJ (2012) The epidemiology of IgE-mediated food allergy and anaphylaxis. Immunol Allergy Clin North Am 32(1):35\u201350","journal-title":"Immunol Allergy Clin North Am"},{"key":"6533_CR4","doi-asserted-by":"crossref","unstructured":"Borrelli, Osvaldo, et al. Neuroimmune interaction and anorectal motility in children with food allergy-related chronic constipation.\u00a0Official journal of the American College of Gastroenterology| ACG, 2009, 104.2: 454\u2013463.Licari A, Votto M, D\u2019Auria E, Castagnoli R, Caimmi SME, Marseglia GL. Eosinophilic gastrointestinal diseases in children: a practical review. Curr Pediatr Rev. 2020; 16(2):106\u2013114.","DOI":"10.2174\/157339631566619102215443"},{"issue":"2","key":"6533_CR5","doi-asserted-by":"publisher","first-page":"106","DOI":"10.2174\/18756336MTAxdNzcpx","volume":"16","author":"A Licari","year":"2020","unstructured":"Licari A, Votto M, D\u2019Auria E, Castagnoli R, Caimmi SME, Marseglia GL (2020) Eosinophilic gastrointestinal diseases in children: a practical review. Curr Pediatr Rev 16(2):106\u2013114","journal-title":"Curr Pediatr Rev"},{"key":"6533_CR6","volume-title":"Investigation of gastrointestinal symptoms in children aged 4\u201310 years diagnosed with cow\u2019s milk protein allergy [thesis]","author":"O Erel","year":"2022","unstructured":"Erel O (2022) Investigation of gastrointestinal symptoms in children aged 4\u201310 years diagnosed with cow\u2019s milk protein allergy [thesis]. Dokuz Eyl\u00fcl University, \u0130zmir"},{"issue":"2","key":"6533_CR7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/MPG.0b013e3181e85b55","volume":"52","author":"M Saps","year":"2011","unstructured":"Saps M, Lu P, Bonilla S (2011) Cow\u2019s-milk allergy is a risk factor for the development of FGIDs in children. J Pediatr Gastroenterol Nutr 52(2):166\u2013169","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6533_CR8","doi-asserted-by":"crossref","unstructured":"Di Nardo, Giovanni, et al. Allergic proctocolitis is a risk factor for functional gastrointestinal disorders in children.\u00a0The Journal of Pediatrics, 2018, 195: 128\u2013133. e1.","DOI":"10.1016\/j.jpeds.2017.10.073"},{"key":"6533_CR9","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.3390\/nu10111716","volume":"10","author":"L Pensabene","year":"2018","unstructured":"Pensabene L, Salvatore S, D\u2019auria E, Parisi F, Concolino D, Borrelli O et al (2018) Cow\u2019s milk protein allergy in infancy: a risk factor for functional gastrointestinal disorders in children? Nutrients 10:1716","journal-title":"Nutrients"},{"issue":"1","key":"6533_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S0022-3476(95)70496-5","volume":"126","author":"G Iacono","year":"1995","unstructured":"Iacono G, Carroccio A, Cavataio F, Montalto G, Cantarero MD, Notarbartolo A (1995) Chronic constipation as a symptom of cow milk allergy. J Pediatr 126(1):34\u201339","journal-title":"J Pediatr"},{"issue":"1","key":"6533_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/00365520410009401","volume":"40","author":"A Carroccio","year":"2005","unstructured":"Carroccio A, Scalici C, Maresi E, DiPrima L, Cavataio F, Noto D et al (2005) Chronic constipation and food intolerance: a model of proctitis causing constipation. Scand J Gastroenterol 40(1):33\u201342","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"6533_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/jpn3.12410","volume":"80","author":"M Marget","year":"2025","unstructured":"Marget M, Baker C, O\u2019Connell I, Shreffler WG, Yuan Q, Martin VM (2025) Prospective association between food protein-induced allergic proctocolitis in infancy and constipation after age 3. J Pediatr Gastroenterol Nutr 80(1):108\u2013112","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"11","key":"6533_CR13","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.cgh.2011.07.030","volume":"9","author":"A Carroccio","year":"2011","unstructured":"Carroccio A, Brusca I, Mansueto P, Soresi M, D\u2019alcamo A, Ambrosiano G et al (2011) Fecal assays detect hypersensitivity to cow\u2019s milk protein and gluten in adults with irritable bowel syndrome. Clin Gastroenterol Hepatol 9(11):965\u2013971","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11\u201312","key":"6533_CR14","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/apt.12965","volume":"40","author":"O Ol\u00e9n","year":"2014","unstructured":"Ol\u00e9n O, Neuman A, Koopmann B, Ludvigsson JF, Ballardini N, Westman M et al (2014) Allergy-related diseases and recurrent abdominal pain during childhood \u2013 a birth cohort study. Aliment Pharmacol Ther 40(11\u201312):1349\u20131358","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"6533_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/MPG.0000000000001219","volume":"64","author":"TK Tan","year":"2017","unstructured":"Tan TK, Chen AC, Lin CL, Shen TC, Li TC, Wei CC (2017) Preschoolers with allergic diseases have an increased risk of irritable bowel syndrome when reaching school age. J Pediatr Gastroenterol Nutr 64(1):26\u201330","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7","key":"6533_CR16","first-page":"1","volume":"3","author":"M Henstr\u00f6m","year":"2016","unstructured":"Henstr\u00f6m M, D\u2019Amato M (2016) Genetics of irritable bowel syndrome. Mol Cell Pediatr 3(7):1\u20135","journal-title":"Mol Cell Pediatr"},{"issue":"1","key":"6533_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.gtc.2010.12.011","volume":"40","author":"YA Saito","year":"2011","unstructured":"Saito YA (2011) The role of genetics in IBS. Gastroenterol Clin North Am 40(1):45\u201367","journal-title":"Gastroenterol Clin North Am"},{"issue":"1","key":"6533_CR18","first-page":"59","volume":"32","author":"AM Ravelli","year":"2001","unstructured":"Ravelli AM, Tobanelli P, Volpi S, Ugazio AG (2001) Vomiting and gastric motility in infants with cow\u2019s milk allergy. J Pediatr Gastroenterol Nutr 32(1):59\u201364","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"6533_CR19","volume-title":"Evaluation of the effect of eliminating cow\u2019s milk and dairy products on dyspepsia in patients with functional dyspepsia [thesis]","author":"A Akp\u0131nar","year":"2021","unstructured":"Akp\u0131nar A (2021) Evaluation of the effect of eliminating cow\u2019s milk and dairy products on dyspepsia in patients with functional dyspepsia [thesis]. Bezm-i Alem Vak\u0131f University, \u0130stanbul"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06533-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-025-06533-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-025-06533-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:35:14Z","timestamp":1762846514000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-025-06533-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["6533"],"URL":"https:\/\/doi.org\/10.1007\/s00431-025-06533-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7092977\/v1","asserted-by":"object"}]},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the principles of the Declaration of Helsinki. The study was approved by Karadeniz Technical University Scientific Research Ethics Committee (Approval No.: 24237859-611).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"688"}}