{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:30:41Z","timestamp":1768512641545,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007950","name":"Tanta University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007950","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This research investigated the efficacy of intravenous vitamin C administration in septic, mechanically ventilated (MV) full-term neonates following surgical interventions. This double-blinded randomized controlled trial included 50 full-term neonates who required mechanical ventilation and developed confirmed sepsis after surgery. Neonates were randomly assigned to receive either standard sepsis management with placebo (No Vitamin C group) or standard protocol with vitamin C infusion, administered as a 0.5\u00a0g\/kg loading dose followed by a maintenance dose of 0.5\u00a0g\/kg\/h over 6\u00a0h, continued for 7 to 10\u00a0days (Vitamin C group). Respiratory rate and peak inspiratory pressure were significantly lower at 24\u00a0h, 72\u00a0h, and 120\u00a0h in the Vitamin C group than in the No Vitamin C group. FiO\u2082 requirements were significantly reduced at 72\u00a0h and 120\u00a0h in the Vitamin C group. SpO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    did not change across groups at baseline and 24\u00a0h but were considerably higher in the Vitamin C group at 72\u00a0h and 120\u00a0h. Duration of MV (4.44\u2009\u00b1\u20091.23 vs. 5.64\u2009\u00b1\u20092.2\u00a0days,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021) and inotropic support needs (40% vs. 76%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) were significantly lower in the Vitamin C group. There were no statistically significant differences in mortality rates or the duration of hospitalization, including stays at neonatal intensive care units (NICU) or the hospital.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Vitamin C infusion significantly improved respiratory parameters and reduced the duration of MV and inotropic support requirements in septic neonates following surgery, though it did not significantly affect the NICU or hospital length of stay or mortality.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Trial registration<\/jats:italic>\n                    : registered on ClinicalTrials.gov (ID: NCT06780345) (date: 17\/1\/2025).\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>In neonatal intensive care units (NICU), neonatal sepsis continues to be a major cause of death and morbidity.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Vitamin C has become a possible therapeutic intervention given its many pathways in sepsis control.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Vitamin C infusion significantly improved respiratory parameters and reduced the duration of MV and inotropic support requirements in septic neonates following surgery, though it did not significantly affect the NICU or hospital length of stay or mortality.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-025-06625-4","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:42:50Z","timestamp":1764376970000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-1424","authenticated-orcid":false,"given":"Asmaa Mahmoud","family":"Elmesiry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Rabie","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Mohamed","family":"Elshimy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany Mohamed","family":"Abotaleb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"6625_CR1","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","volume":"390","author":"AL Shane","year":"2017","unstructured":"Shane AL, S\u00e1nchez PJ, Stoll BJ (2017) Neonatal sepsis. 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The trial was approved by the institutional ethics committee (approval ID: 36264PR117\/2\/23), was done in accordance with the Declaration of Helsinki, and was registered on ClinicalTrials.gov (ID: NCT06780345) (date: 17\/1\/2025).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participating neonates\u2019 parents or legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"806"}}