{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:01:57Z","timestamp":1777982517454,"version":"3.51.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009583","name":"Morinaga Foundation For Health and Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Congenital heart disease (CHD) is frequently associated with extracardiac abnormalities that can significantly affect prognosis and management. Although abdominal ultrasound is a readily available and noninvasive tool, detailed observational studies on comprehensive screening for neonates with CHD remain lacking. We aimed to evaluate the prevalence of significant abdominal abnormalities detected during early comprehensive ultrasound screening in neonates with CHD. This single-center, retrospective case series included neonates admitted to a tertiary neonatal intensive care unit (NICU) between April 2021 and May 2024 who underwent screening within 14\u00a0days of birth. We compared the proportion of neonates with significant abnormalities and the number of abnormalities per patient between those with and without chromosomal abnormalities or malformation syndromes. Among 59 neonates, significant abnormalities were identified in 29 (49.2%). The most common were hydronephrosis (13.6%), hepatomegaly (10.2%), and intestinal malrotation (8.5%). The proportion of significant abnormalities did not differ significantly between the groups with and without chromosomal abnormalities or malformation syndromes (66.7% vs. 39.5%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.06). However, the number of abnormalities per patient was significantly higher in the former group (1.38 vs. 0.61,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.03).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Early comprehensive abdominal ultrasound screening in hospitalized neonates with CHD revealed significant abnormalities in 49.2% of cases. This screening may improve systemic management of patients with CHD, including perioperative care, and facilitate individualized treatment of CHD\u2012with or without chromosomal or malformation syndromes\u2012by enhancing phenotype characterization.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u30fb\n                              <jats:italic>Congenital heart disease (CHD) is frequently associated with extracardiac abnormalities that can affect prognosis and management.<\/jats:italic>\n                              \u30fb\n                              <jats:italic>Detailed observational studies on comprehensive abdominal ultrasound screening for neonates with CHD remain lacking.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u30fb\n                              <jats:italic>Early comprehensive abdominal ultrasound screening in hospitalized neonates with CHD revealed significant abnormalities in 49.2%.<\/jats:italic>\n                              \u30fb\n                              <jats:italic>While abnormalities were more frequent in neonates with chromosomal or malformation syndromes, 39.5% of non-syndromic neonates had significant abnormalities; the screening improves systemic management and individualized treatment.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-026-06772-2","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:12:23Z","timestamp":1770012743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of extracardiac abnormalities by early comprehensive abdominal ultrasound screening in neonates with congenital heart disease"],"prefix":"10.1007","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-6739","authenticated-orcid":false,"given":"Takashi","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"6772_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248894","volume":"16","author":"CS Chang","year":"2021","unstructured":"Chang CS, Hong SY, Kim SY, Kim YM, Sung JH, Choi SJ, Oh SY, Roh CR, Song J, Huh J et al (2021) Prevalence of associated extracardiac anomalies in prenatally diagnosed congenital heart diseases. 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Approval was granted by the Ethics Committee of University of Tsukuba Hospital (R06-122).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The requirement for informed consent was waived by the Ethics Committee of the University of Tsukuba Hospital because the study involved the retrospective analysis of existing de-identified data. Instead, an opt-out method was employed, and study information was disclosed on the hospital website to provide participants or their guardians the opportunity to decline inclusion.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}