{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:01:06Z","timestamp":1780124466115,"version":"3.54.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-026-06921-7","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:45:25Z","timestamp":1776239125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["7-days versus 14-days antibiotic therapy in uncomplicated culture proven neonatal sepsis: a randomized control assessor-blinded trial"],"prefix":"10.1007","volume":"185","author":[{"given":"Ayushie","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phalguni","family":"Padhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"6921_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315:801\u2013810","journal-title":"JAMA"},{"issue":"10258","key":"6921_CR2","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","volume":"396","author":"GBD 2019 Diseases and Injuries Collaborators","year":"2020","unstructured":"GBD 2019 Diseases and Injuries Collaborators (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396(10258):1204\u20131222","journal-title":"Lancet"},{"key":"6921_CR3","doi-asserted-by":"crossref","unstructured":"Fleischmann C, Reichert F, Cassini A, Horner R, Harder T, Markwart R, Tr\u00f6ndle M, Savova Y, Kissoon N, Schlattmann P, Reinhart K (2021) Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis. Arch Dis Child 106(8):745\u2013752","DOI":"10.1136\/archdischild-2020-320217"},{"key":"6921_CR4","unstructured":"Bang AT, Bang RA, Baitule S et al ( 2001) Burden of morbidities and the unmet need for health care in rural neonates\u2014a prospective observational study in Gadchiroli, India Indian Pediatr. 38:952\u2013965"},{"issue":"12","key":"6921_CR5","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/apa.12764","volume":"103","author":"SE Bakhuizen","year":"2014","unstructured":"Bakhuizen SE, De Haan TR, Teune MJ, van Wassenaer\u2010Leemhuis AG, Van Der Heyden JL, Van Der Ham DP, Mol BW (2014) Meta\u2010analysis shows that infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications. Acta Paediatr 103(12):1211\u20131218","journal-title":"Acta Paediatr"},{"key":"6921_CR6","doi-asserted-by":"crossref","unstructured":"Esaiassen E, Fjalstad JW, Juvet LK, van den Anker JN, Klingenberg C (2017) Antibiotic exposure in neonates and early adverse outcomes: a systematic review and meta-analysis. J Antimicrob Chemother 72(7):1858\u20131870","DOI":"10.1093\/jac\/dkx088"},{"issue":"15","key":"6921_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.544460","volume":"8","author":"S Shekhar","year":"2020","unstructured":"Shekhar S, Petersen FC (2020) The dark side of antibiotics: adverse effects on the infant immune defense against infection. Front Pediatr 8(15):544460","journal-title":"Front Pediatr"},{"issue":"7","key":"6921_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00431-025-06271-w","volume":"184","author":"P Soni","year":"2025","unstructured":"Soni P, Matoria R, Nagalli MM (2025Jun 24) Antibiotic strategies for neonatal sepsis: navigating efficacy and emerging resistance patterns. Eur J Pediatr 184(7):439","journal-title":"Eur J Pediatr"},{"key":"6921_CR9","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1001\/jamapediatrics.2014.1539","volume":"168","author":"LC Bailey","year":"2014","unstructured":"Bailey LC, Forrest CB, Zhang P et al (2014) Association of antibiotics in infancy with early childhood obesity. JAMA Pediatr 168:1063\u20131069","journal-title":"JAMA Pediatr"},{"key":"6921_CR10","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/pai.12153","volume":"24","author":"L Hoskin-Parr","year":"2013","unstructured":"Hoskin-Parr L, Teyhan A, Blocker A et al (2013) Antibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5\u2009yr: a dose-dependent relationship. Pediatr Allergy Immunol 24:762\u201371","journal-title":"Pediatr Allergy Immunol"},{"key":"6921_CR11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3886","volume":"130","author":"MP Kronman","year":"2012","unstructured":"Kronman MP, Zaoutis TE, Haynes K et al (2012) Antibiotic exposure and IBD development among children: a population-based cohort study. Pediatrics 130:e794\u2013803","journal-title":"Pediatrics"},{"issue":"11","key":"6921_CR12","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/jpc.16647","volume":"60","author":"P Singh","year":"2024","unstructured":"Singh P, Priyadarshi M, Chaurasia S, Basu S (2024) Efficacy of short\u2010course antibiotics for culture\u2010positive neonatal sepsis: a systematic review and meta\u2010analysis. J Paediatr Child Health 60(11):630\u2013639","journal-title":"J Paediatr Child Health"},{"key":"6921_CR13","doi-asserted-by":"crossref","unstructured":"Dutta S, Nangia S, Jajoo M, Sundaram M, Kumar M, Shivanna N, Gathwala G, Nesargi S, Jain S, Kumar P, Saili A et al (2025) Seven-day versus 14-day antibiotic course for culture-proven neonatal sepsis: a multicentre randomised non-inferiority trial in a low and middle-income country. Archives of Disease in Childhood-Fetal and Neonatal Edition","DOI":"10.1136\/archdischild-2024-328232"},{"key":"6921_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/archdischild-2015-308255","volume":"101","author":"N Spyridis","year":"2016","unstructured":"Spyridis N, Syridou G, Goossens H et al (2016) Variation in paediatric hospital antibiotic guidelines in Europe. Arch Dis Child 101:72\u201376","journal-title":"Arch Dis Child"},{"key":"6921_CR15","doi-asserted-by":"crossref","unstructured":"Chowdhary G, Dutta S, Narang A et al (2006) Randomized controlled trial of 7-day vs. 14-day antibiotics for neonatal sepsis. J trop pediatr 52(6):427\u201332","DOI":"10.1093\/tropej\/fml054"},{"issue":"1","key":"6921_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13312-011-0019-8","volume":"48","author":"SS Saini","year":"2011","unstructured":"Saini SS, Dutta S, Ray P, Narang A (2011) Short course versus 7-day course of intravenous antibiotics for probable neonatal septicemia: a pilot, open-label, randomized controlled trial. Indian Pediatr 48(1):19\u201324","journal-title":"Indian Pediatr"},{"key":"6921_CR17","doi-asserted-by":"crossref","unstructured":"Islam K, Khatun N, Das K, Paul S, Ghosh T, Nayek K et al (2023) Ten-vs. 14-day antibiotic therapy for culture-positive neonatal sepsis. J Trop Pediatr 69(6):fmad036","DOI":"10.1093\/tropej\/fmad036"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-06921-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-06921-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-06921-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T06:02:04Z","timestamp":1780120924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-06921-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["6921"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-06921-7","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"11 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The research received approval from the Institutional Ethics Committee of our institute\u2014Institute Ethics Committee\u2014All India Institute of Medical Sciences, Raipur, Chhattisgarh, India (Registration No. ECR\/1261\/Inst\/CTl2015\/RR-21). Letter no. \u2013 2409\/IEC-AIIMSRPR\/2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participant\u2019s parents\/legal guardian included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The individual patient\u2019s identity has not been revealed anywhere in the manuscript. The parents\/legal guardians were informed about the possibility of publication of their ward\u2019s data without revealing their individual identities.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"268"}}