{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:40:20Z","timestamp":1793144420222,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012533","name":"Minia University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012533","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phenylketonuria (PKU) is a hereditary metabolic disorder. It is characterized by the accumulation of phenylalanine (Phe) metabolites in the brain and body. These metabolites can harm brain function, especially cognition, if they are not reduced by following a Phe-restricted diet early in life. Despite early treatment with a Phe-restricted diet, many neuro-psychiatric disorders are still reported in adults with PKU. The aim of this study is to assess depression in children with PKU. The study included 76 children aged 8\u201315\u00a0years. They were divided into late-diagnosed, early-diagnosed, and healthy control groups. Participants completed the Birelson depression scale and Peds QL 4.0 to measure health-related quality of life. Phe levels were measured at testing and averaged from the previous year. Children with PKU have higher depression scores than healthy controls. Late-diagnosed children have higher depression scores than early-diagnosed children (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Early-diagnosed children differ from controls only in reduced activity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Late-diagnosed children show more loss of energy (85.7%), irritability (78.6%), and suicidal thoughts (21.4%).\u00a0Quality of life is lower in children with PKU compared to controls, either regarding the total score or all domains. Quality of life is negatively correlated to Phe levels and depression scores (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2009\u2212\u20090.32 and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u2009\u2212\u20090.51, respectively) while positively correlated to IQ levels (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.74).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    :\u00a0Children with PKU show more depression and lower quality of life. These effects may be linked to diagnosis timing, long term Phe control, and IQ. Depression is more pronounced in late-diagnosed children than in early-diagnosed ones.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Patients with PKU are at increased risk of psychiatric disorders.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Poor metabolic control (elevated Phe levels) is associated with lower IQ and QoL in PKU patients.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Children with PKU have higher levels of depressive symptoms, especially in late-diagnosed children, who develophigher rates of suicidal thoughts.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Diagnosis timing, phe levels, depression severity, and IQ together strongly predict QoL (explaining up to 61% ofvariance).<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-026-06933-3","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:26:12Z","timestamp":1776932772000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of depression on quality of life in PKU children"],"prefix":"10.1007","volume":"185","author":[{"given":"Ibtehal Saad","family":"Abuelela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihan Mohamed","family":"Bebars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Ibrahim","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Samir","family":"Refaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"6933_CR1","unstructured":"Abdelaziz AE, Fahim M, Samy S, Abu Elsood H, Afifi S, Khafagy H, Abd El Fattah M, Elgunidy N, Kandeel A. 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