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This study aimed to examine parent\u2013clinician concordance in perceived severity, to investigate its association with parental emotional distress at baseline and six months after communication, and to explore the interdependence between perceived severity and perceived control within parental dyads. A total of. 171 mothers and 168 fathers reported parental distress and completed the Impact of Event Scale\u2013Revised and the Emotion Thermometers. Perceived severity and control were measured using single-item Likert scales reflecting subjective appraisals at the time of disclosure. For 147 parents (74 mothers and 73 fathers), a clinician-rated severity score was available. An Actor\u2013Partner Interdependence Model with indistinguishable dyads was applied to 115 parental couples. Most parents (61.9%) rated their child\u2019s condition as more severe than the clinician. At baseline, higher parental severity ratings relative to clinicians were associated with higher distress and post-traumatic symptoms. No differences were observed at 6\u00a0months. Higher perceived severity in one parent was associated with lower perceived control in the partner (\u03b2\u2009= \u2212\u20090.207,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.004).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Differences between parental and clinician perceptions of severity are common following positive ENBS communication and are associated with elevated early parental distress. Psychosocial support may benefit from adopting a dyadic perspective, acknowledging that each parent\u2019s appraisal of the situation can shape the partner\u2019s adjustment.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\" colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Receiving communication of positivity at the ENBS can be highly stressful for parents.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Parents\u2019 perceptions of disease severity play an important role in their psychological adjustment.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\" colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Parent\u2013clinician misalignment in perceived severity is frequent after positive ENBS communication and is associated with higher early parental distress.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Parental perceptions of severity and control show significant dyadic interdependence within couples, high lighting parental adjustment as a relational process.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-026-06983-7","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:26:58Z","timestamp":1777415218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perceived severity and parental distress after positive expanded newborn screening: parent\u2013clinician concordance and dyadic processes"],"prefix":"10.1007","volume":"185","author":[{"given":"Marco","family":"Bani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Gasperini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Crescitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Menni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tagliaferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Cefalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Banderali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Marchisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Balduzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Strepparava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"2","key":"6983_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns11020032","volume":"11","author":"SA Sandelowsky","year":"2025","unstructured":"Sandelowsky SA, McEwen A, Russell J, Boggs K, Junek R, Ellaway C, Selvanathan A, Farrar MA, Bhattacharya K (2025) An explorative qualitative study of the role of a genetic counsellor to parents receiving a diagnosis after a positive newborn bloodspot screening. 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