{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:55:18Z","timestamp":1781769318340,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-026-07035-w","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:12:55Z","timestamp":1778490775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rate and timing to clinical remission in celiac children on a gluten-free diet"],"prefix":"10.1007","volume":"185","author":[{"given":"Francesca","family":"Sbravati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Arsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"De Palo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Del Bono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Brintazzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Labriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Alvisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"issue":"6","key":"7035_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","volume":"16","author":"P Singh","year":"2018","unstructured":"Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH et al (2018) Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol 16(6):823-836.e2. https:\/\/doi.org\/10.1016\/j.cgh.2017.06.037","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10344","key":"7035_CR2","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/S0140-6736(22)00794-2","volume":"399","author":"C Catassi","year":"2022","unstructured":"Catassi C, Verdu EF, Bai JC, Lionetti E (2022) Coeliac disease. Lancet 399(10344):2413\u20132426. https:\/\/doi.org\/10.1016\/S0140-6736(22)00794-2","journal-title":"Lancet"},{"key":"7035_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01183-5","author":"M Pedretti","year":"2021","unstructured":"Pedretti M, Sbravati F, Allegri D, Labriola F, Lombardo V, Spisni E et al (2021) Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center. Ital J Pediatr. https:\/\/doi.org\/10.1186\/s13052-021-01183-5","journal-title":"Ital J Pediatr"},{"issue":"3","key":"7035_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/MPG.0000000000003540","volume":"75","author":"ML Mearin","year":"2022","unstructured":"Mearin ML, Agardh D, Antunes H, Al-Toma A, Auricchio R, Castillejo G et al (2022) ESPGHAN position paper on management and follow-up of children and adolescents with celiac disease. J Pediatr Gastroenterol Nutr 75(3):369\u201386. https:\/\/doi.org\/10.1097\/MPG.0000000000003540","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"7035_CR5","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"S Husby","year":"2012","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 IR, Mearin ML, Phillips A, Shamir R et al (2012) European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 54(1):136\u201360. https:\/\/doi.org\/10.1097\/MPG.0b013e31821a23d0","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"7035_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","volume":"70","author":"S Husby","year":"2020","unstructured":"Husby S, Koletzko S, Korponay-Szab\u00f3 I, Kurppa K, Mearin ML, Ribes-Koninckx C et al (2020) European Society Paediatric Gastroenterology, Hepatology and Nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr 70(1):141\u2013156. https:\/\/doi.org\/10.1097\/MPG.0000000000002497","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"7035_CR7","unstructured":"World Health Organization (2024) Guideline on haemoglobin cutoffs to define anaemia in individuals and populations. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK602181\/"},{"key":"7035_CR8","volume-title":"Preventing and controlling iron deficiency anaemia through primary health care. A guide for health administrators and programme managers","author":"EM DeMaeyer","year":"1989","unstructured":"DeMaeyer EM, Dallman P, Gurney JM, Hallberg L, Sood SK, Srikantia SG (1989) Preventing and controlling iron deficiency anaemia through primary health care. A guide for health administrators and programme managers. World Health Organization, Geneva"},{"issue":"10","key":"7035_CR9","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","volume":"11","author":"G Oberhuber","year":"1999","unstructured":"Oberhuber G, Granditsch G, Vogelsang H (1999) The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 11(10):1185\u201394. https:\/\/doi.org\/10.1097\/00042737-199910000-00019","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"10","key":"7035_CR10","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1017\/S0007114511007367","volume":"108","author":"F Biagi","year":"2012","unstructured":"Biagi F, Bianchi PI, Marchese A, Trotta L, Vattiato C, Balduzzi D et al (2012) A score that verifies adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life. Br J Nutr 108(10):1884\u20138. https:\/\/doi.org\/10.1017\/S0007114511007367","journal-title":"Br J Nutr"},{"issue":"6","key":"7035_CR11","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s00431-021-03939-x","volume":"180","author":"M Kori","year":"2021","unstructured":"Kori M, Goldstein S, Hofi L, Topf-Olivestone C (2021) Adherence to gluten-free diet and follow-up of pediatric celiac disease patients, during childhood and after transition to adult care. Eur J Pediatr 180(6):1817\u20131823. https:\/\/doi.org\/10.1007\/s00431-021-03939-x","journal-title":"Eur J Pediatr"},{"issue":"13","key":"7035_CR12","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3748\/wjg.v27.i13.1311","volume":"27","author":"G Veeraraghavan","year":"2021","unstructured":"Veeraraghavan G, Therrien A, Degroote M, McKeown A, Mitchell PD, Silvester JA et al (2021) Non-responsive celiac disease in children on a gluten free diet. World J Gastroenterol 27(13):1311\u201320. https:\/\/doi.org\/10.3748\/wjg.v27.i13.1311","journal-title":"World J Gastroenterol"},{"issue":"1","key":"7035_CR13","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/MPG.0000000000001634","volume":"66","author":"N Sansotta","year":"2018","unstructured":"Sansotta N, Amirikian K, Guandalini S, Jericho H (2018) Celiac disease symptom resolution: effectiveness of the gluten-free diet. J Pediatr Gastroenterol Nutr 66(1):48\u201352. https:\/\/doi.org\/10.1097\/MPG.0000000000001634","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"12","key":"7035_CR14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50217","volume":"15","author":"A Mouslih","year":"2023","unstructured":"Mouslih A, El Rhazi K, Bahra N, Lakhdar Idrissi M, Hida M (2023) Gluten-free diet compliance in children with celiac disease and its effect on clinical symptoms: a retrospective cohort study. Cureus 15(12). https:\/\/doi.org\/10.7759\/cureus.50217","journal-title":"Cureus"},{"issue":"7","key":"7035_CR15","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/j.1365-2036.2011.04787.x","volume":"34","author":"R Turco","year":"2011","unstructured":"Turco R, Boccia G, Miele E, Giannetti E, Buonavolont\u00e0 R, Quitadamo P et al (2011) The association of coeliac disease in childhood with functional gastrointestinal disorders: a prospective study in patients fulfilling Rome III criteria. Aliment Pharmacol Ther 34(7):783\u20139. https:\/\/doi.org\/10.1111\/j.1365-2036.2011.04787.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"12","key":"7035_CR16","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1016\/j.cgh.2020.09.001","volume":"19","author":"F Cristofori","year":"2021","unstructured":"Cristofori F, Tripaldi M, Lorusso G, Indrio F, Rutigliano V, Piscitelli D et al (2021) Functional abdominal pain disorders and constipation in children on gluten-free diet. Clin Gastroenterol Hepatol 19(12):2551\u20138. https:\/\/doi.org\/10.1016\/j.cgh.2020.09.001","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"46","key":"7035_CR17","doi-asserted-by":"publisher","first-page":"6589","DOI":"10.3748\/wjg.v28.i46.6589","volume":"28","author":"FF Nastro","year":"2022","unstructured":"Nastro FF, Serra MR, Cenni S, Pacella D, Martinelli M, Miele E et al (2022) Prevalence of functional gastrointestinal disorders in children with celiac disease on different types of gluten-free diets. World J Gastroenterol 28(46):6589\u201398. https:\/\/doi.org\/10.3748\/wjg.v28.i46.6589","journal-title":"World J Gastroenterol"},{"issue":"3","key":"7035_CR18","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1002\/jpn3.70316","volume":"82","author":"A Almallouhi","year":"2026","unstructured":"Almallouhi A, Sadek M, Absah I (2026) Clinical outcome of constipation as the presenting symptom in children with celiac disease. J Pediatr Gastroenterol Nutr 82(3):734\u2013740. https:\/\/doi.org\/10.1002\/jpn3.70316","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"7035_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1365-277X.2005.00607.x","volume":"18","author":"T Thompson","year":"2005","unstructured":"Thompson T, Dennis M, Higgins LA, Lee AR, Sharrett MK (2005) Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods? J Hum Nutr Diet 18(3):163\u2013169. https:\/\/doi.org\/10.1111\/j.1365-277X.2005.00607.x","journal-title":"J Hum Nutr Diet"},{"issue":"1","key":"7035_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0606-0","volume":"20","author":"A Sue","year":"2018","unstructured":"Sue A, Dehlsen K, Ooi CY (2018) Paediatric patients with coeliac disease on a gluten-free diet: nutritional adequacy and macro- and micronutrient imbalances. Curr Gastroenterol Rep 20(1). https:\/\/doi.org\/10.1007\/s11894-018-0606-0","journal-title":"Curr Gastroenterol Rep"},{"issue":"4","key":"7035_CR21","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/ajcn\/79.4.669","volume":"79","author":"JA Murray","year":"2004","unstructured":"Murray JA, Watson T, Clearman B, Mitros F (2004) Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr 79(4):669\u2013673. https:\/\/doi.org\/10.1093\/ajcn\/79.4.669","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"7035_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/MPG.0000000000001420","volume":"65","author":"H Jericho","year":"2017","unstructured":"Jericho H, Sansotta N, Guandalini S (2017) Extraintestinal manifestations of celiac disease: effectiveness of the gluten-free diet. J Pediatr Gastroenterol Nutr 65(1):75\u201379. https:\/\/doi.org\/10.1097\/MPG.0000000000001420","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"7035_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1182\/blood-2006-07-031104","volume":"109","author":"TR Halfdanarson","year":"2007","unstructured":"Halfdanarson TR, Litzow MR, Murray JA (2007) Hematologic manifestations of celiac disease. Blood 109(2):412\u2013421. https:\/\/doi.org\/10.1182\/blood-2006-07-031104","journal-title":"Blood"},{"issue":"1","key":"7035_CR24","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/MPG.0000000000001221","volume":"64","author":"T Rajalahti","year":"2017","unstructured":"Rajalahti T, Repo M, Kivel\u00e4 L, Huhtala H, M\u00e4ki M, Kaukinen K et al (2017) Anemia in pediatric celiac disease: association with clinical and histological features and response to gluten-free diet. J Pediatr Gastroenterol Nutr 64(1):e1-6. https:\/\/doi.org\/10.1097\/MPG.0000000000001221","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"3","key":"7035_CR25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3906\/sag-1402-169","volume":"45","author":"F \u00c7atal","year":"2015","unstructured":"\u00c7atal F, Topal E, Ermi\u015ftekin H, Yildirim Acar N, Sinano\u011flu MS, Karabiber H et al (2015) The hematologic manifestations of pediatric celiac disease at the time of diagnosis and efficiency of gluten-free diet. Turk J Med Sci 45(3):663\u2013667","journal-title":"Turk J Med Sci"},{"issue":"10","key":"7035_CR26","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1007\/s10620-008-0596-0","volume":"54","author":"S Aydogdu","year":"2009","unstructured":"Aydogdu S, Midyat L, Cakir M, Tumgor G, Yuksekkaya HA, Baran M et al (2009) Long-term effect of gluten-free diet on growth velocity in Turkish children with celiac disease. Dig Dis Sci 54(10):2183\u20137. https:\/\/doi.org\/10.1007\/s10620-008-0596-0","journal-title":"Dig Dis Sci"},{"issue":"1\u20132","key":"7035_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1515\/jpem.2011.360","volume":"25","author":"A Zung","year":"2012","unstructured":"Zung A, Kori M (2012) Lack of association between seroconversion and catch-up growth in children with celiac disease. J Pediatr Endocrinol Metab 25(1\u20132):131\u2013137. https:\/\/doi.org\/10.1515\/jpem.2011.360","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"Suppl 1","key":"7035_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000064771","volume":"58","author":"B Boersma","year":"2002","unstructured":"Boersma B, Houwen RH, Blum WF, van Doorn J, Wit JM (2002) Catch-up growth and endocrine changes in childhood celiac disease. Endocrine changes during catch-up growth. Horm Res 58(Suppl 1):57\u201365. https:\/\/doi.org\/10.1159\/000064771","journal-title":"Horm Res"},{"issue":"5","key":"7035_CR29","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s00431-024-05477-8","volume":"183","author":"A Krauthammer","year":"2024","unstructured":"Krauthammer A, Guz-Mark A, Zevit N, Waisbourd-Zinman O, Silbermintz A, Mozer-Glassberg Y et al (2024) A significant increase in anthropometric indices during long-term follow-up of pediatric patients with celiac disease, with no endocrine disorders. Eur J Pediatr 183(5):2173\u201382. https:\/\/doi.org\/10.1007\/s00431-024-05477-8","journal-title":"Eur J Pediatr"},{"issue":"3","key":"7035_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.dld.2021.06.026","volume":"54","author":"F Sbravati","year":"2022","unstructured":"Sbravati F, Cosentino A, Lenzi J, Fiorentino M, Ambrosi F, Salerno A et al (2022) Antitissue transglutaminase antibodies\u2019 normalization after starting a gluten-free diet in a large population of celiac children-a real-life experience. Dig Liver Dis 54(3):336\u201342. https:\/\/doi.org\/10.1016\/j.dld.2021.06.026","journal-title":"Dig Liver Dis"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07035-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-07035-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07035-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:34:12Z","timestamp":1781768052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-07035-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["7035"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-07035-w","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"22 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present manuscript has been approved by the Central Emilia Wide Area EthicalCommittee of the Emilia-Romagna Region (CE-AVEC).The research was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent for participation was obtained from parents or legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent for publication was obtained from parents or legal guardians.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"374"}}