{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:05:53Z","timestamp":1784286353996,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"Abstract<\/jats:title>\n \n Short stature homeobox\u2010containing (\n SHOX)<\/jats:italic>\n -gene haploinsufficiency causes short stature both in isolated\n SHOX<\/jats:italic>\n deficiency and in Turner syndrome (TS), yet head-to-head data on growth-hormone (GH) outcomes remain scarce. We therefore compared growth response and near-final height (NFH) after GH therapy between girls with\n SHOX<\/jats:italic>\n deficiency and those with TS. Single-centre retrospective cohort study. In this single-centre retrospective cohort, we reviewed 44 pre-pubertal girls who received daily GH (mean 0.045\u00a0mg\/kg\/day) between 2015 and 2024 and subsequently reached NFH (bone age\u2009\u2265\u200914 y; height velocity\u2009<\u20092\u00a0cm\/year). Ten had molecularly confirmed\n SHOX<\/jats:italic>\n deficiency and 34 had karyotype-proven TS. Baseline auxology, annual height velocity, pubertal timing, treatment duration, NFH standard-deviation score (SDS) and total height SDS gain were analysed. Mean chronological and bone ages at GH initiation were similar (10.7\u2009\u00b1\u20091.9 vs 10.4\n \u2009\u00b1\u2009<\/jats:bold>\n 2.7\u00a0years). Baseline height SDS was lower in TS (\u20133.51\u2009\u00b1\u20091.0) than in\n SHOX<\/jats:italic>\n (\n \u2013<\/jats:bold>\n 2.66\u2009\u00b1\u20090.8). First-year growth velocity was higher in\n SHOX<\/jats:italic>\n (8.55\u2009\u00b1\u20091.4\u00a0cm\/year) than TS (6.72\u2009\u00b1\u20091.9\u00a0cm\/year;\n p<\/jats:italic>\n \u2009=\u20090.01). Puberty began earlier in\n SHOX<\/jats:italic>\n (11.6\u2009\u00b1\u20091.3\u00a0years) than TS (13.7\u2009\u00b1\u20091.5\u00a0years;\n p<\/jats:italic>\n \u2009<\u20090.01), and GH exposure was shorter (2.00\u2009\u00b1\u20090.4 vs 4.38\u2009\u00b1\u20092.3;\n p<\/jats:italic>\n \u2009<\u20090.01). Observed NFH-SDS was similar between groups (\n SHOX<\/jats:italic>\n \u2009\u2212\u20092.46\u2009\u00b1\u20091.2 vs TS\u2009\u2212\u20092.47\u2009\u00b1\u20091.0). Unadjusted height-SDS gain was greater in TS (1.04\u2009\u00b1\u20090.1 vs 0.20\u2009\u00b1\u20090.2\n ;<\/jats:bold>\n p<\/jats:italic>\n \u2009=\u20090.04). In exploratory ANCOVA models adjusting for baseline age, baseline height SDS, and GH treatment duration\n ,<\/jats:bold>\n adjusted height-SDS gain did not differ significantly between groups.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n :\u00a0TS was associated with a greater unadjusted height-SDS gain, whereas\n SHOX<\/jats:italic>\n deficiency was characterized by earlier puberty and shorter GH exposure. Although observed NFH-SDS was similar, these findings highlight how differences in pubertal timing and treatment duration may influence growth outcomes in routine clinical practice and should be interpreted as reflecting real-world growth trajectories rather than intrinsic biological responsiveness to GH therapy.\n \n \n \n \n \n What is Known:<\/jats:bold>\n \u2022\u00a0\n Growth hormone therapy is an established treatment for short stature in both\u00a0<\/jats:italic>\n SHOX\u00a0<\/jats:italic>\n deficiency and Turner syndrome.<\/jats:italic>\n \u2022\u00a0\n Treatment response is influenced by several factors, including age at treatment initiation and pubertal development.<\/jats:italic>\n <\/jats:td>\n <\/jats:tr>\n \n \n What is New:<\/jats:bold>\n \u2022\u00a0\n This study provides a real-world comparison of growth hormone treatment outcomes in girls with\u00a0<\/jats:italic>\n SHOX\u00a0<\/jats:italic>\n deficiency\u00a0<\/jats:italic>\n and Turner syndrome.<\/jats:italic>\n \u2022\u00a0\n Spontaneous pubertal progression in\u00a0<\/jats:italic>\n SHOX<\/jats:italic>\n \u00a0\n deficiency versus medically induced puberty in Turner syndrome may\u00a0<\/jats:italic>\n substantially influence the duration of the therapeutic growth window and the observed growth response.<\/jats:italic>\n <\/jats:td>\n <\/jats:tr>\n <\/jats:tbody>\n <\/jats:table>\n <\/jats:table-wrap>\n <\/jats:p>","DOI":"10.1007\/s00431-026-07135-7","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:15:21Z","timestamp":1780625721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study"],"prefix":"10.1007","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-5828","authenticated-orcid":false,"given":"Mehmet Ali","family":"Oktay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-3955","authenticated-orcid":false,"given":"Esra","family":"D\u00f6\u011fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-4952","authenticated-orcid":false,"given":"Aylin K\u0131l\u0131n\u00e7","family":"U\u011furlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-243X","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Kayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-8018","authenticated-orcid":false,"given":"Meral Yirmibe\u015f","family":"Karao\u011fuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-2605","authenticated-orcid":false,"given":"Mahmut Orhun","family":"\u00c7amurdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-414X","authenticated-orcid":false,"given":"Aysun","family":"Bideci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"5","key":"7135_CR1","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1530\/EJE-15-0451","volume":"173","author":"SH Donze","year":"2015","unstructured":"Donze SH, Meijer C, Kant S, Zandwijken G, van der Hout A, van Spaendonk R et al (2015) The growth response to GH treatment is greater in patients with SHOX enhancer deletions compared to SHOX defects. 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