{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:10:10Z","timestamp":1790518210538,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-026-07168-y","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:46:12Z","timestamp":1781325972000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a multiplex respiratory PCR panel on antibiotic stewardship in hospitalized pediatric pneumonia: a randomized clinical trial"],"prefix":"10.1007","volume":"185","author":[{"given":"Jiande","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhulin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruike","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"7168_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ccm.2011.05.011","volume":"32","author":"TM File Jr","year":"2011","unstructured":"File TM Jr (2011) New diagnostic tests for pneumonia: what is their role in clinical practice? Clin Chest Med 32:417\u2013430","journal-title":"Clin Chest Med"},{"key":"7168_CR2","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1093\/cid\/ciaa508","volume":"71","author":"KE Hanson","year":"2020","unstructured":"Hanson KE, Azar MM, Banerjee R, Chou A, Colgrove RC, Ginocchio CC, Hayden MK, Holodiny M, Jain S, Koo S, Levy J, Timbrook TT, Caliendo AM (2020) Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the IDSA\u2019s Diagnostics Committee. Clin Infect Dis 71:2744\u20132751","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"7168_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.37201\/req\/s01.03.2022","volume":"35","author":"A Burillo","year":"2022","unstructured":"Burillo A, Candel FJ, Canut-Blasco A (2022) Value of syndromic panels in the management of severe community-acquired pneumonia. Rev Esp Quimioter 35(Suppl 1):15\u201320","journal-title":"Rev Esp Quimioter"},{"key":"7168_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026047","volume":"6","author":"MA Poritz","year":"2011","unstructured":"Poritz MA, Blaschke AJ, Byington CL, Allen L, Nilsson K, Jones DE, Thatcher SA, Robbins T, Lingenfelter B, Amiott E, Herbener A, Daly J, Dobrowolski SF, Teng DH, Ririe KM (2011) FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection. PLoS ONE 6:e26047","journal-title":"PLoS ONE"},{"key":"7168_CR5","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.cmi.2019.06.012","volume":"25","author":"D Shengchen","year":"2019","unstructured":"Shengchen D, Gu X, Fan G, Sun R, Wang Y, Yu D, Li H, Zhou F, Xiong Z, Lu B, Zhu G, Cao B (2019) Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial. Clin Microbiol Infect 25:1415\u20131421","journal-title":"Clin Microbiol Infect"},{"key":"7168_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004314","volume":"20","author":"MB Cartuliares","year":"2023","unstructured":"Cartuliares MB, Rosenvinge FS, Mogensen CB, Skovsted TA, Andersen SL, \u00d8stergaard C, Pedersen AK, Skj\u00f8t-Arkil H (2023) Evaluation of point-of-care multiplex polymerase chain reaction in guiding antibiotic treatment of patients acutely admitted with suspected community-acquired pneumonia in Denmark: a multicentre randomised controlled trial. PLoS Med 20:e1004314","journal-title":"PLoS Med"},{"key":"7168_CR7","doi-asserted-by":"publisher","first-page":"778808","DOI":"10.3389\/fcimb.2021.778808","volume":"11","author":"N Shen","year":"2021","unstructured":"Shen N, Zhou Y, Zhou Y, Luo L, Chen W, Wang J, Zhao R, Xie L, Cao Q, Tao Y, Mo X (2021) Evaluation of molecular point-of-care testing for respiratory pathogens in children with respiratory infections: a retrospective case-control study. Front Cell Infect Microbiol 11:778808","journal-title":"Front Cell Infect Microbiol"},{"key":"7168_CR8","doi-asserted-by":"crossref","unstructured":"Tiew WT, Chen YC, Hsiao HL, Chen CL, Chen CJ, Chiu CH (2023) Impact of multiplex polymerase chain reaction syndromic panel on antibiotic use among hospitalized children with respiratory tract illness during COVID-19 pandemic.\u00a0J Microbiol Immunol Infect Wei mian yu gan ran za zhi 56:688\u2013694","DOI":"10.1016\/j.jmii.2023.01.009"},{"key":"7168_CR9","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23203","volume":"34","author":"AT Reischl","year":"2020","unstructured":"Reischl AT, Schreiner D, Poplawska K, Kidszun A, Zepp F, Gr\u00f6ndahl B, Gehring S (2020) The clinical impact of PCR-based point-of-care diagnostic in respiratory tract infections in children. J Clin Lab Anal 34:e23203","journal-title":"J Clin Lab Anal"},{"key":"7168_CR10","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/jpids\/piae014","volume":"13","author":"AS Plattner","year":"2024","unstructured":"Plattner AS, Lockowitz CR, Dumm R, Banerjee R, Newland JG, Same RG (2024) Practice versus potential: the impact of the BioFire FilmArray Pneumonia Panel on antibiotic use in children. J Pediatric Infect Dis Soc 13:196\u2013202","journal-title":"J Pediatric Infect Dis Soc"},{"key":"7168_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.cmi.2024.08.001","volume":"31","author":"A Cantais","year":"2025","unstructured":"Cantais A, Pillet S, Rigaill J, Angoulvant F, Gras-Le-Guen C, Cros P, Thuiller C, Molly C, Tripodi L, Desbree A, Annino N, Verhoeven P, Carricajo A, Bourlet T, Chapelle C, Claudet I, Garcin A, Izopet J, Mory O, Pozzetto B (2025) Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community-acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study. Clin Microbiol Infect 31:64\u201370","journal-title":"Clin Microbiol Infect"},{"key":"7168_CR12","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.16162","volume":"5","author":"S Mattila","year":"2022","unstructured":"Mattila S, Paalanne N, Honkila M, Pokka T, Tapiainen T (2022) Effect of point-of-care testing for respiratory pathogens on antibiotic use in children: a randomized clinical trial. JAMA Netw Open 5:e2216162","journal-title":"JAMA Netw Open"},{"key":"7168_CR13","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1056\/NEJMoa1405870","volume":"372","author":"S Jain","year":"2015","unstructured":"Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, Stockmann C et al (2015) Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med 372:835\u2013845","journal-title":"N Engl J Med"},{"key":"7168_CR14","unstructured":"National Health Commission of the People\u2019s Republic of China, State Administration of Traditional Chinese Medicine (2019) Guideline for diagnosis and treatment of community-acquired pneumonia in children (2019 version). Chin J Clin Infect Dis 12:6\u201313"},{"key":"7168_CR15","first-page":"983","volume":"33","author":"Experts Group of Pediatric Respiratory Endoscopy, Talent Exchange Service Center of National Health Commission","year":"2018","unstructured":"Experts Group of Pediatric Respiratory Endoscopy, Talent Exchange Service Center of National Health Commission, Endoscopy Committee, Pediatric Section of Chinese Medical Doctor Association, Pediatric Respiratory Endoscopy Committee, Endoscopists Section of Chinese Medical Doctor Association, Pediatric Interventional Respirology Group, Maternal and Pediatric Minimally Invasive Section of Chinese Maternal and Child Health Association, Bronchoscopy Collaboration Subgroup of Respirology Group, Pediatric Section of Chinese Medical Association (2018) Guideline of pediatric flexible bronchoscopy in China (2018 version). Zhongguo Shi Yong Lin Chuang Er Ke Za Zhi 33:983\u2013989","journal-title":"Zhongguo Shi Yong Lin Chuang Er Ke Za Zhi"},{"key":"7168_CR16","doi-asserted-by":"crossref","unstructured":"Chen J, Ji F, Yin Y, Yuan S (2021) Time to Mycoplasma pneumoniae RNA clearance for wheezy vs. non-wheezy young children with community-acquired pneumonia.\u00a0J Trop Pediatr\u00a067:fmaa109","DOI":"10.1093\/tropej\/fmaa109"},{"key":"7168_CR17","unstructured":"National Health Commission of the People\u2019s Republic of China. Operating procedures of blood culture for clinical microbiology laboratory. [EB\/OL]. https:\/\/www.nhc.gov.cn\/wjw\/s9492\/201710\/f5612af688db482193a08b15e3091a29\/files\/1739781577054_27804.pdf. Accessed 17 Oct 2017"},{"key":"7168_CR18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/thx.2007.086785","volume":"63","author":"R Men\u00e9ndez","year":"2008","unstructured":"Men\u00e9ndez R, Cavalcanti M, Reyes S, Mensa J, Martinez R, Marcos MA, Filella X, Niederman M, Torres A (2008) Markers of treatment failure in hospitalised community acquired pneumonia. Thorax 63:447\u2013452","journal-title":"Thorax"},{"key":"7168_CR19","unstructured":"National Health Commission of the People\u2019s Republic of China. Notice of the General Office of the National Health Commission on the issuance of clinical pathways for relevant diseases (2019 Edition). [EB\/OL].https:\/\/www.nhc.gov.cn\/yzygj\/c100068\/202001\/30af17cccf9e4d5f98ac030a1249e636.shtml. Accessed 29 Dec 2019"},{"key":"7168_CR20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jcv.2018.09.009","volume":"108","author":"M Echavarr\u00eda","year":"2018","unstructured":"Echavarr\u00eda M, Marcone DN, Querci M, Seoane A, Ypas M, Videla C, O\u2019Farrell C, Vidaurreta S, Ekstrom J, Carballal G (2018) Clinical impact of rapid molecular detection of respiratory pathogens in patients with acute respiratory infection. J Clin Virol 108:90\u201395","journal-title":"J Clin Virol"},{"key":"7168_CR21","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s12879-025-10732-w","volume":"25","author":"R Rasti","year":"2025","unstructured":"Rasti R, Kumbakumba E, Nanjebe D, Mlotshwa P, Nassejje M, Mzee J, Businge S, Akankwasa G, Nyehangane D, Gantelius J, Boum Y 2nd, M\u00e5rtensson A, Mwanga-Amumpaire J, Alfv\u00e9n T, Gaudenzi G (2025) Clinical utility of the FilmArray\u00ae meningitis\/encephalitis panel in children with suspected central nervous system infection in a low-resource setting - a prospective study in Southwestern Uganda. BMC Infect Dis 25:396","journal-title":"BMC Infect Dis"},{"key":"7168_CR22","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s15010-023-02144-2","volume":"52","author":"J Gong","year":"2024","unstructured":"Gong J, Yang J, Liu L, Chen X, Yang G, He Y, Sun R (2024) Evaluation and clinical practice of pathogens and antimicrobial resistance genes of BioFire FilmArray Pneumonia Panel in lower respiratory tract infections. Infection 52:545\u2013555","journal-title":"Infection"},{"key":"7168_CR23","doi-asserted-by":"crossref","unstructured":"Buchan BW, Windham S, Balada-Llasat JM, Leber A, Harrington A, Relich R, Murphy C et al (2020) Practical comparison of the BioFire FilmArray Pneumonia Panel to routine diagnostic methods and potential impact on antimicrobial stewardship in adult hospitalized patients with lower respiratory tract infections. J Clin Microbiol 58:e00135\u201320","DOI":"10.1128\/JCM.00135-20"},{"key":"7168_CR24","doi-asserted-by":"crossref","unstructured":"Webber DM, Wallace MA, Burnham CA, Anderson NW (2020) Evaluation of the BioFire FilmArray Pneumonia Panel for detection of viral and bacterial pathogens in lower respiratory tract specimens in the setting of a tertiary care academic medical center. J Clin Microbiol 58:e00343\u201320","DOI":"10.1128\/JCM.00343-20"},{"key":"7168_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12941-022-00512-8","volume":"21","author":"K Kosai","year":"2022","unstructured":"Kosai K, Akamatsu N, Ota K, Mitsumoto-Kaseida F, Sakamoto K, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K (2022) BioFire FilmArray Pneumonia Panel enhances detection of pathogens and antimicrobial resistance in lower respiratory tract specimens. Ann Clin Microbiol Antimicrob 21:24","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"2","key":"7168_CR26","doi-asserted-by":"publisher","first-page":"106683","DOI":"10.1016\/j.jinf.2026.106683","volume":"92","author":"E Gim\u00e9nez","year":"2026","unstructured":"Gim\u00e9nez E, Clari M, Albert E, Carbonell N, Navarro D (2026) Performance of the BIOFIRE\u00ae Filmarray Pneumonia Plus Panel for quantifiable bacterial targets compared to semiquantitative culture methods: a systematic review and meta-analysis. J Infect 92:106683","journal-title":"J Infect"},{"key":"7168_CR27","doi-asserted-by":"crossref","unstructured":"Lee SH, Ruan SY, Pan SC, Lee TF, Chien JY, Hsueh PR (2019) Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units. J Microbiol Immunol Infect Wei mian yu gan ran za zhi 52:920\u2013928","DOI":"10.1016\/j.jmii.2019.10.009"},{"key":"7168_CR28","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1186\/s13054-020-03114-y","volume":"24","author":"C Monard","year":"2020","unstructured":"Monard C, Pehlivan J, Auger G, Alviset S, Tran Dinh A, Duquaire P, Gastli N, d\u2019Humi\u00e8res C, Maamar A, Boibieux A, Baldeyrou M, Loubinoux J, Dauwalder O, Cattoir V, Armand-Lef\u00e8vre L, Kern\u00e9is S (2020) Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia. Crit Care (London, England) 24:434","journal-title":"Crit Care (London, England)"},{"key":"7168_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00000441-200108000-00002","volume":"322","author":"C Lawrence","year":"2001","unstructured":"Lawrence C, Tuma R, Guha S, Michael H, Lowy FD, Shuter J (2001) Multiple antibiotic changes during the first 72 hours of hospitalization. Am J Med Sci 322:61\u201367","journal-title":"Am J Med Sci"},{"key":"7168_CR30","doi-asserted-by":"crossref","unstructured":"Tanzarella ES, Cutuli SL, Lombardi G, Cammarota F, Caroli A, Franchini E, Sancho Ferrando E, Grieco DL, Antonelli M, De Pascale G (2024) Antimicrobial de-escalation in critically ill patients. Antibiotics (Basel, Switzerland) 13:375","DOI":"10.3390\/antibiotics13040375"},{"key":"7168_CR31","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0002-9343(89)80697-7","volume":"87","author":"JH Kim","year":"1989","unstructured":"Kim JH, Gallis HA (1989) Observations on spiraling empiricism: its causes, allure, and perils, with particular reference to antibiotic therapy. Am J Med 87:201\u2013206","journal-title":"Am J Med"},{"key":"7168_CR32","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1186\/s12879-017-2784-z","volume":"17","author":"D Andrews","year":"2017","unstructured":"Andrews D, Chetty Y, Cooper BS, Virk M, Glass SK, Letters A, Kelly PA, Sudhanva M, Jeyaratnam D (2017) Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use. BMC Infect Dis 17:671","journal-title":"BMC Infect Dis"},{"key":"7168_CR33","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0830","volume":"7","author":"DL Markussen","year":"2024","unstructured":"Markussen DL, Serigstad S, Ritz C, Knoop ST, Ebbesen MH, Faurholt-Jepsen D, Heggelund L, van Werkhoven CH, Clark TW, Bj\u00f8rneklett RO, Kommedal \u00d8, Ulvestad E, Grewal HMS (2024) Diagnostic stewardship in community-acquired pneumonia with syndromic molecular testing: a randomized clinical trial. JAMA Netw Open 7:e240830","journal-title":"JAMA Netw Open"},{"key":"7168_CR34","doi-asserted-by":"crossref","unstructured":"Nicholson KG, Abrams KR, Batham S, Medina MJ, Warren FC, Barer M, Bermingham A, Clark TW, Latimer N, Fraser M, Perera N, Rajakumar K, Zambon M (2014) Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18- to 64-year-olds. Health Technol Assess (Winchester, England) 18:1\u2013274,vii-viii","DOI":"10.3310\/hta18360"},{"issue":"12","key":"7168_CR35","doi-asserted-by":"publisher","first-page":"100928","DOI":"10.1016\/S2666-5247(24)00170-8","volume":"5","author":"A Virk","year":"2024","unstructured":"Virk A, Strasburg AP, Kies KD, Donadio AD, Mandrekar J, Harmsen WS, Stevens RW, Estes LL, Tande AJ, Challener DW, Osmon DR, Fida M, Vergidis P, Suh GA, Wilson JW, Rajapakse NS, Borah BJ, Dholakia R, Reed KA, Hines LM, Schuetz AN, Patel R (2024) Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial. Lancet Microbe 5:100928","journal-title":"Lancet Microbe"},{"key":"7168_CR36","doi-asserted-by":"crossref","unstructured":"Simon V, Floda D, Gleason C, Gonzalez-Reiche AS, Paniz-Mondolfi AE, Sordillo EM, Palese P, van Bakel H (2026) The pandemic gap of respiratory viruses during the COVID-19 pandemic. mBio 17:e0337625","DOI":"10.1128\/mbio.03376-25"},{"key":"7168_CR37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S2213-2600(17)30120-0","volume":"5","author":"NJ Brendish","year":"2017","unstructured":"Brendish NJ, Malachira AK, Armstrong L, Houghton R, Aitken S, Nyimbili E, Ewings S, Lillie PJ, Clark TW (2017) Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial. Lancet Respir Med 5:401\u2013411","journal-title":"Lancet Respir Med"},{"key":"7168_CR38","unstructured":"National People\u2019s Congress of the People\u2019s Republic of China. Physicians Law of the People\u2019s Republic of China. [EB\/OL]. http:\/\/www.npc.gov.cn\/npc\/c2\/c30834\/202108\/t20210820_313104.html. Accessed 17 Aug 2021"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07168-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-07168-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07168-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:26:22Z","timestamp":1784283982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-07168-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["7168"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-07168-y","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]},"assertion":[{"value":"14 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the parents or legal guardians of any participant.","order":2,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"497"}}