{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:23:09Z","timestamp":1792264989147,"version":"4.4.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-026-07201-0","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:33:04Z","timestamp":1782365584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urine leukocyte count demonstrates limited diagnostic accuracy for complicated appendicitis in children: a retrospective cohort study"],"prefix":"10.1007","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-6595","authenticated-orcid":false,"given":"Sabri","family":"Cansaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutlay","family":"G\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubilay","family":"P\u0131\u00e7aklar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Erdede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia G\u00f6n\u00fcl Sezer","family":"Yamanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"3","key":"7201_CR1","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/MOP.0000000000001472","volume":"37","author":"AS Ching","year":"2025","unstructured":"Ching AS, Bauman A, Carney MM (2025) Current approaches to diagnosing acute appendicitis: pitfalls and progress. Curr Opin Pediatr 37(3):250\u2013256. https:\/\/doi.org\/10.1097\/MOP.0000000000001472","journal-title":"Curr Opin Pediatr"},{"issue":"1","key":"7201_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0335-2","volume":"43","author":"HH Almaramhy","year":"2017","unstructured":"Almaramhy HH (2017) Acute appendicitis in young children less than 5 years: a review. Ital J Pediatr 43(1):92. https:\/\/doi.org\/10.1186\/s13052-017-0335-2","journal-title":"Ital J Pediatr"},{"issue":"3","key":"7201_CR3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4274\/jpr.galenos.2019.62582","volume":"7","author":"Y T\u00fcrkmeno\u011flu","year":"2020","unstructured":"T\u00fcrkmeno\u011flu Y, Ka\u00e7ar A, Duras E, K\u00f6k S, G\u00f6z\u00fcb\u00fcy\u00fck AA, Arat C (2020) The role of Alvarado and pediatric appendicitis score in acute appendicitis in children. J Pediatr Res 7(3):192\u2013198. https:\/\/doi.org\/10.4274\/jpr.galenos.2019.62582","journal-title":"J Pediatr Res"},{"key":"7201_CR4","doi-asserted-by":"publisher","unstructured":"Yang J, Liu C, He Y, Cai Z (2019) Laboratory markers in the prediction of acute perforated appendicitis in children. Emerg Med Int 4. https:\/\/doi.org\/10.1155\/2019\/4608053","DOI":"10.1155\/2019\/4608053"},{"issue":"8","key":"7201_CR5","doi-asserted-by":"publisher","first-page":"e2122248","DOI":"10.1001\/jamanetworkopen.2021.22248","volume":"4","author":"KA Michelson","year":"2021","unstructured":"Michelson KA, Reeves SD, Grubenhoff JA, Cruz AT, Chaudhari PP, Dart AH, Finkelstein JA, Bachur RG (2021) Clinical features and preventability of delayed diagnosis of pediatric appendicitis. JAMA Netw Open 4(8):e2122248. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.22248","journal-title":"JAMA Netw Open"},{"issue":"11","key":"7201_CR6","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.ajem.2013.06.027","volume":"31","author":"CY Chen","year":"2013","unstructured":"Chen CY, Zhao LL, Lin YR, Wu KH, Wu HP (2013) Different urinalysis appearances in children with simple and perforated appendicitis. Am J Emerg Med 31(11):1560\u20131563. https:\/\/doi.org\/10.1016\/j.ajem.2013.06.027","journal-title":"Am J Emerg Med"},{"issue":"8","key":"7201_CR7","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00383-016-3918-x","volume":"32","author":"M Sal\u00f6","year":"2016","unstructured":"Sal\u00f6 M, Roth B, Stenstr\u00f6m P, Arnbj\u00f6rnsson E, Ohlsson B (2016) Urinary biomarkers in pediatric appendicitis. Pediatr Surg Int 32(8):795\u2013804. https:\/\/doi.org\/10.1007\/s00383-016-3918-x","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"7201_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1553-2712.2011.01251.x","volume":"19","author":"AB Kharbanda","year":"2012","unstructured":"Kharbanda AB, Rai AJ, Cosme Y, Liu K, Dayan PS (2012) Novel serum and urine markers for pediatric appendicitis. Acad Emerg Med 19(1):56\u201362. https:\/\/doi.org\/10.1111\/j.1553-2712.2011.01251.x","journal-title":"Acad Emerg Med"},{"key":"7201_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.2147\/PHMT.S155302","volume":"9","author":"EC Howell","year":"2018","unstructured":"Howell EC, Dubina ED, Lee SL (2018) Perforation risk in pediatric appendicitis: assessment and management. Pediatr Health Med Ther 9:135\u2013145. https:\/\/doi.org\/10.2147\/PHMT.S155302","journal-title":"Pediatr Health Med Ther"},{"issue":"4","key":"7201_CR10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1055\/a-2490-1156","volume":"35","author":"CM Biehl","year":"2025","unstructured":"Biehl CM, Elliver M, Gudjonsdottir J, Sal\u00f6 M (2025) Utility of urine dipstick testing in pediatric appendicitis: assessing its role in identifying complicated cases and retrocecal appendicitis. Eur J Pediatr Surg 35(4):269\u2013276. https:\/\/doi.org\/10.1055\/a-2490-1156","journal-title":"Eur J Pediatr Surg"},{"issue":"1","key":"7201_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-023-04527-1","volume":"38","author":"MA Avci","year":"2023","unstructured":"Avci MA, Akg\u00fcn C, Uyanik MS (2023) The relationship between abnormal urinalysis findings and appendicitis location. Int J Colorectal Dis 38(1):232. https:\/\/doi.org\/10.1007\/s00384-023-04527-1","journal-title":"Int J Colorectal Dis"},{"issue":"5","key":"7201_CR12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1542\/peds.2011-3375","volume":"129","author":"RG Bachur","year":"2012","unstructured":"Bachur RG, Hennelly K, Callahan MJ, Chen C, Monuteaux MC (2012) Diagnostic imaging and negative appendectomy rates in children: effects of age and gender. Pediatrics 129(5):877\u2013884. https:\/\/doi.org\/10.1542\/peds.2011-3375","journal-title":"Pediatrics"},{"issue":"1","key":"7201_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-020-00306-3","volume":"15","author":"S Di Saverio","year":"2020","unstructured":"Di Saverio S, Podda M, De Simone B et al (2020) Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg 15(1):27. https:\/\/doi.org\/10.1186\/s13017-020-00306-3","journal-title":"World J Emerg Surg"},{"issue":"7","key":"7201_CR14","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.3390\/ijms24076043","volume":"24","author":"G Tintor","year":"2023","unstructured":"Tintor G, Juki\u0107 M, \u0160upe-Domi\u0107 D, Jeron\u010di\u0107 A, Pogoreli\u0107 Z (2023) Diagnostic accuracy of leucine-rich \u03b1-2-glycoprotein 1 as a non-invasive salivary biomarker in pediatric appendicitis. Int J Mol Sci 24(7):6043. https:\/\/doi.org\/10.3390\/ijms24076043","journal-title":"Int J Mol Sci"},{"issue":"1","key":"7201_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jpedsurg.2018.10.025","volume":"54","author":"TL Yap","year":"2019","unstructured":"Yap TL, Fan JD, Chen Y, Ho MF, Choo CS, Allen J, Low Y, Jacobsen AS, Nah SA (2019) A novel noninvasive appendicitis score with a urine biomarker. J Pediatr Surg 54(1):91\u201396. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.10.025","journal-title":"J Pediatr Surg"},{"issue":"7","key":"7201_CR16","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1007\/s00431-023-04978-2","volume":"182","author":"J Arredondo Montero","year":"2023","unstructured":"Arredondo Montero J, P\u00e9rez Riveros BP, Bueso Asfura OE, Rico Jim\u00e9nez M, L\u00f3pez-Andr\u00e9s N, Mart\u00edn-Calvo N (2023) Leucine-rich alpha-2-glycoprotein as a non-invasive biomarker for pediatric acute appendicitis: a systematic review and meta-analysis. Eur J Pediatr 182(7):3033\u20133044. https:\/\/doi.org\/10.1007\/s00431-023-04978-2","journal-title":"Eur J Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-07201-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07201-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:25:34Z","timestamp":1784283934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-07201-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["7201"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-07201-0","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"7 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained from the Zeynep Kamil Maternity and Children\u2019s Diseases Health Training and Research Center Ethics Committee (Approval No: 06.03.2023\/40). The requirement for informed consent was waived due to the retrospective design of the study.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work the authors used\n                      Anthropic Claude\n                      only for language editing. After using this tool\/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the published article.","order":2,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies in the manuscript preparation process","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest relevant to this manuscript. No financial support or relationships that may pose conflicts of interest exist.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"523"}}