{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:05:23Z","timestamp":1784286323412,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To assess the feasibility and performance of ultrasound-guided midline catheters in term and preterm neonates requiring prolonged intravenous therapy without an indication for central access, and to generate hypotheses on factors influencing catheter outcomes. Single-center prospective observational cohort: 70 consecutive neonates received 2-Fr polyurethane midline catheters in a level IV NICU (March 2024\u2013November 2025). Data were analyzed descriptively; complication-free survival was estimated by Kaplan\u2013Meier, and exploratory subgroup comparisons used Fisher\u2019s exact test. Mean weight at insertion was 2582\u00a0g (range 700\u20134920), including very low-birth-weight infants. Median dwell time was 9\u00a0days (range 0\u2013176), corresponding to 1144 catheter-days. The primary composite outcome (complication-free dwell\u2009\u2265\u20097\u00a0days or elective removal before day 7) was met in 94.3% of devices. Kaplan\u2013Meier complication-free survival was 98.6% at 3\u00a0days and 81.2% at 14\u00a0days. Device-related complications occurred in 21.4%, predominantly minor and resolving after removal. Bloodstream infection and thrombosis rates were 2.62 and 0.87 per 1000 catheter-days; no thrombophlebitis occurred. Complication rates did not differ by vein diameter\u2009&lt;\u20092\u00a0mm or weight\u2009&lt;\u20091500\u00a0g, although the study was underpowered for these comparisons.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    :\u00a0In this pilot study, ultrasound-guided midline catheters were feasible in neonates, including very low-birth-weight infants and those with small-caliber veins, with predominantly minor complications. These hypothesis-generating findings require confirmation in adequately powered; comparative studies before midlines can be recommended as an alternative to central access or repeated peripheral cannulation.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Midline catheters may offer an intermediate option between peripheral and central venous access, but neonatal experience, particularly in preterm infants, is limited.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Data on the feasibility and performance of midline catheters in the NICU are scarce.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>In this single-center pilot cohort of 70 neonates, ultrasound-guided midline catheters achieved a high rate of complication-free dwell time, with predominantly minor, self-limiting complications.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Complication rates did not appear to increase in infants\u2009&lt;\u20091500\u00a0g or with veins\u2009&lt;\u20092\u00a0mm; these hypothesis-generating observations require confirmation in adequately powered studies.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-026-07218-5","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:29:01Z","timestamp":1782991741000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-guided midline catheters in the neonatal intensive care unit: a single-center pilot study"],"prefix":"10.1007","volume":"185","author":[{"given":"Lorenzo","family":"Zanetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zamunaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antuan","family":"Divisic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiammetta","family":"Della Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Salvadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Baraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-3056","authenticated-orcid":false,"given":"Luca","family":"Bonadies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"7218_CR1","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1007\/s00431-023-04984-4","volume":"182","author":"G Barone","year":"2023","unstructured":"Barone G, D\u2019Andrea V, Ancora G et al (2023) The neonatal DAV-expert algorithm: a GAVeCeLT\/GAVePed consensus for the choice of the most appropriate venous access in newborns. 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