{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:06:55Z","timestamp":1789225615674,"version":"build-2803163510"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adenotonsillectomy (ATE) has traditionally been the first-line treatment for obstructive sleep apnoea (OSA) in children. Increasing evidence suggests that many children with mild to moderate OSA may improve without surgery. This mini-review examines whether watchful waiting is a safe and effective alternative to ATE in otherwise healthy children with mild to moderate OSA.\u00a0We searched PubMed from inception to January 2026 for randomised controlled trials (RCTs) comparing ATE with watchful waiting in children aged 1\u201316 years with OSA or sleep-disordered breathing confirmed by polysomnography or a validated symptom score. Two reviewers independently screened and extracted data. Results were analysed qualitatively.\u00a0Five RCTs (seven published reports;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091287 children; mean age 6.1 years) met inclusion criteria. Spontaneous OSA resolution occurred in 44\u201355% of children managed with watchful waiting, compared with 57\u201379% following ATE. ATE produced statistically greater reductions in the apnoea\u2013hypopnoea index in four of five trials, but between-group differences were modest. The largest and most consistent effects of ATE were seen for OSA symptom scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion:\u00a0<\/jats:italic>\n                    Watchful waiting is a reasonable option for young, nonobese children with mild OSA, given the relatively high rates of spontaneous resolution. ATE remains appropriate for children with moderate to severe OSA. Shared decision-making, individualised care and close follow-up are essential when watchful waiting is chosen.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              \u2022\n                              <jats:italic>Otherwise healthy children with obstructive sleep apnoea due to adenotonsillar hyperplasia are usually managed with adenotonsillectomy.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Young, non-obese, Caucasian children with more mild obstructive sleep apnoea, however, showed a surprisingly high probability of spontaneous resolution of the disease in one study.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td align=\"left\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              \u2022\n                              <jats:italic>High rates of spontaneous resolution of obstructive sleep apnoea were observed in four independent studies, ranging from 44% to 55%.<\/jats:italic>\n                              \u2022\n                              <jats:italic>Watchful waiting for several months may, thus, be a reasonable management option in a particular low-risk group of children with obstructive sleep apnoea.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-026-07330-6","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:59:33Z","timestamp":1786654773000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is watchful waiting an alternative to adenotonsillectomy in children with mild to moderate obstructive sleep apnoea?"],"prefix":"10.1007","volume":"185","author":[{"given":"Stefan","family":"Kuhle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Poets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Urschitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"7330_CR1","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1542\/peds.2012-1671","volume":"130","author":"CL Marcus","year":"2012","unstructured":"Marcus CL, Brooks LJ, Draper KA et al (2012) Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 130:576\u2013584","journal-title":"Pediatrics"},{"key":"7330_CR2","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1093\/sleep\/29.9.1115","volume":"29","author":"DW Beebe","year":"2006","unstructured":"DW Beebe 2006 Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review Sleep 29 1115 1134","journal-title":"Sleep"},{"key":"7330_CR3","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1056\/NEJMoa1215881","volume":"368","author":"CL Marcus","year":"2013","unstructured":"CL Marcus RH Moore CL Rosen  2013 A randomized trial of adenotonsillectomy for childhood sleep apnea N Engl J Med 368 2366 2376","journal-title":"N Engl J Med"},{"key":"7330_CR4","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/resp.14050","volume":"26","author":"CT Au","year":"2021","unstructured":"Au CT, Chan KCC, Lee DLY et al (2021) Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: a randomized controlled study. Respirology 26:690\u2013699","journal-title":"Respirology"},{"key":"7330_CR5","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1001\/jamaoto.2020.0869","volume":"146","author":"J Fehrm","year":"2020","unstructured":"J Fehrm P Nerfeldt N Browaldh D Friberg 2020 Effectiveness of adenotonsillectomy vs watchful waiting in young children with mild to moderate obstructive sleep apnea: a randomized clinical trial JAMA Otolaryngol Head Neck Surg 146 647 654","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"7330_CR6","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1001\/jama.2023.22114","volume":"330","author":"S Redline","year":"2023","unstructured":"S Redline K Cook RD Chervin  2023 Adenotonsillectomy for snoring and mild sleep apnea in children: a randomized clinical trial JAMA 330 2084 2095","journal-title":"JAMA"},{"key":"7330_CR7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-1450","volume":"145","author":"KA Waters","year":"2020","unstructured":"Waters KA, Chawla J, Harris M-A et al (2020) Cognition after early tonsillectomy for mild OSA. Pediatrics 145:e20191450","journal-title":"Pediatrics"},{"key":"7330_CR8","doi-asserted-by":"publisher","first-page":"e477","DOI":"10.1542\/peds.2014-0620","volume":"135","author":"SL Garetz","year":"2015","unstructured":"SL Garetz RB Mitchell PD Parker  2015 Quality of life and obstructive sleep apnea symptoms after pediatric adenotonsillectomy Pediatrics 135 e477 e486","journal-title":"Pediatrics"},{"key":"7330_CR9","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1001\/jamaoto.2025.2831","volume":"151","author":"I Sj\u00f6lander","year":"2025","unstructured":"I Sj\u00f6lander J Fehrm A Borgstr\u00f6m P Nerfeldt D Friberg 2025 Adenotonsillectomy vs watchful waiting in pediatric mild to moderate obstructive sleep apnea: the KATE randomized clinical trial JAMA Otolaryngol Head Neck Surg 151 1038 1045","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"7330_CR10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-038588","volume":"148","author":"KA Waters","year":"2021","unstructured":"KA Waters J Chawla M-A Harris H Heussler AT Cheng RJ Black 2021 Sleep and behavior 24 months after early tonsillectomy for mild OSA: an RCT Pediatrics 148 e2020038588","journal-title":"Pediatrics"},{"key":"7330_CR11","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1378\/chest.14-2873","volume":"148","author":"RD Chervin","year":"2015","unstructured":"Chervin RD, Ellenberg SS, Hou X et al (2015) Prognosis for spontaneous resolution of OSA in children. Chest 148:1204\u20131213","journal-title":"Chest"},{"key":"7330_CR12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.5665\/sleep.1388","volume":"34","author":"S Redline","year":"2011","unstructured":"Redline S, Amin R, Beebe D et al (2011) The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. Sleep 34:1509\u20131517","journal-title":"Sleep"},{"key":"7330_CR13","volume":"1","author":"S Kuhle","year":"2020","unstructured":"Kuhle S, Hoffmann DU, Mitra S, Urschitz MS (2020) Anti-inflammatory medications for obstructive sleep apnoea in children. Cochrane Database Syst Rev 1:CD007074","journal-title":"Cochrane Database Syst Rev"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-07330-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:02:41Z","timestamp":1789225361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-07330-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":13,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["7330"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-07330-6","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"23 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval, accordance, consent to participate and consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"663"}}