{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:46:12Z","timestamp":1791924372035,"version":"4.3.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation of China"},{"name":"Joint Funds for the innovation of science and Technology\uff0cFujian province"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-026-07510-4","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:11:01Z","timestamp":1791879061000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allergic load and symptom severity in children with tic disorders: a cross-sectional study"],"prefix":"10.1007","volume":"185","author":[{"given":"Duan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"7510_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). American Psychiatric Association, DC, USA","DOI":"10.1176\/appi.books.9780890425596"},{"key":"7510_CR2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28575","volume":"14","author":"A Ramteke","year":"2022","unstructured":"Ramteke A, Lamture Y (2022) Tics and Tourette syndrome: a literature review of etiological, clinical, and pathophysiological aspects. Cureus 14:e28575. https:\/\/doi.org\/10.7759\/cureus.28575","journal-title":"Cureus"},{"key":"7510_CR3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.4414\/sanp.2023.1249714873","volume":"174","author":"A Steck","year":"2023","unstructured":"Steck A (2023) Tourette syndrome: clinical features, pathophysiology, and treatment. Swiss Arch Neurol Psychiatr Psychother 174:135. https:\/\/doi.org\/10.4414\/sanp.2023.1249714873","journal-title":"Swiss Arch Neurol Psychiatr Psychother"},{"key":"7510_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41392-023-01344-4","volume":"8","author":"J Wang","year":"2023","unstructured":"Wang J, Zhou Y, Zhang H et al (2023) Pathogenesis of allergic diseases and implications for therapeutic interventions. Signal Transduct Target Ther 8:138. https:\/\/doi.org\/10.1038\/s41392-023-01344-4","journal-title":"Signal Transduct Target Ther"},{"key":"7510_CR5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.2174\/1381612829666221121162155","volume":"29","author":"DG Ebo","year":"2023","unstructured":"Ebo DG, Beyens M, Heremans K et al (2023) Recent knowledge and insights on the mechanisms of immediate hypersensitivity and anaphylaxis: IgE\/Fc\u03b5RI- and non-IgE\/Fc\u03b5RI-dependent anaphylaxis. Curr Pharm Des 29:178\u2013184. https:\/\/doi.org\/10.2174\/1381612829666221121162155","journal-title":"Curr Pharm Des"},{"key":"7510_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.12932\/ap-230424-1843","volume":"42","author":"X Yang","year":"2024","unstructured":"Yang X, Song Z, Li S et al (2024) A real-world data analysis of distribution and inconsistency between total serum IgE and allergen-specific IgE results in clinical practice. Asian Pac J Allergy Immunol 42:325\u2013332. https:\/\/doi.org\/10.12932\/ap-230424-1843","journal-title":"Asian Pac J Allergy Immunol"},{"key":"7510_CR7","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.neubiorev.2021.12.004","volume":"132","author":"J Huang","year":"2021","unstructured":"Huang J, Li R, Li L et al (2021) The relationship between allergic diseases and tic disorders: a systematic review and meta-analysis. Neurosci Biobehav Rev 132:362\u2013377. https:\/\/doi.org\/10.1016\/j.neubiorev.2021.12.004","journal-title":"Neurosci Biobehav Rev"},{"key":"7510_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1064001","volume":"11","author":"YT Chang","year":"2023","unstructured":"Chang YT, Zhang Y, Bai Y et al (2023) The correlation between tic disorders and allergic conditions in children: a systematic review and meta-analysis of observational studies. Front Pediatr 11:1064001. https:\/\/doi.org\/10.3389\/fped.2023.1064001","journal-title":"Front Pediatr"},{"key":"7510_CR9","first-page":"119","volume":"55","author":"I Finegold","year":"1985","unstructured":"Finegold I (1985) Allergy and Tourette\u2019s syndrome. Ann Allergy 55:119\u2013121","journal-title":"Ann Allergy"},{"key":"7510_CR10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/dbp.0b013e318208f561","volume":"32","author":"YT Chang","year":"2011","unstructured":"Chang YT, Li YF, Muo CH et al (2011) Correlation of Tourette syndrome and allergic disease: nationwide population-based case-control study. J Dev Behav Pediatr 32:98\u2013102. https:\/\/doi.org\/10.1097\/dbp.0b013e318208f561","journal-title":"J Dev Behav Pediatr"},{"key":"7510_CR11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10792-019-01174-w","volume":"40","author":"L Chen","year":"2020","unstructured":"Chen L, Chen X, Ke N et al (2020) Association between allergic conjunctivitis and provisional tic disorder in children. Int Ophthalmol 40:247\u2013253. https:\/\/doi.org\/10.1007\/s10792-019-01174-w","journal-title":"Int Ophthalmol"},{"key":"7510_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04233-5","volume":"23","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li Y, Ma X et al (2023) Comparative analysis of serum total IgE levels and specific IgE levels in children aged 6 to 9 years with tic disorder and normal children. BMC Pediatr 23:399. https:\/\/doi.org\/10.1186\/s12887-023-04233-5","journal-title":"BMC Pediatr"},{"key":"7510_CR13","doi-asserted-by":"publisher","first-page":"1769483","DOI":"10.3389\/falgy.2026.1769483","volume":"7","author":"L Li","year":"2026","unstructured":"Li L, Hu W, Ren Y et al (2026) Tic disorders and allergic diseases: mechanistic links and the impact of allergy management. Front Allergy 7:1769483. https:\/\/doi.org\/10.3389\/falgy.2026.1769483","journal-title":"Front Allergy"},{"key":"7510_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.800189","volume":"12","author":"Y Tao","year":"2022","unstructured":"Tao Y, Xu P, Zhu W et al (2022) Changes of cytokines in children with tic disorder. Front Neurol 12:800189. https:\/\/doi.org\/10.3389\/fneur.2021.800189","journal-title":"Front Neurol"},{"key":"7510_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62121-z","volume":"14","author":"MO Kutuk","year":"2024","unstructured":"Kutuk MO, Tufan AE, Kilicaslan F et al (2024) Cytokine expression profiles in children and adolescents with tic disorders. Sci Rep 14:15101. https:\/\/doi.org\/10.1038\/s41598-024-62121-z","journal-title":"Sci Rep"},{"key":"7510_CR16","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1136\/jim-2021-001788","volume":"69","author":"X Liu","year":"2021","unstructured":"Liu X, Wang X, Zhang X et al (2021) Allergic diseases influence symptom severity and T lymphocyte subgroups of children with tic disorders. J Investig Med 69:1453\u20131457. https:\/\/doi.org\/10.1136\/jim-2021-001788","journal-title":"J Investig Med"},{"key":"7510_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","volume":"565","author":"M Ito","year":"2019","unstructured":"Ito M, Komai K, Mise-Omata S et al (2019) Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 565:246\u2013250. https:\/\/doi.org\/10.1038\/s41586-018-0824-5","journal-title":"Nature"},{"key":"7510_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178113","volume":"14","author":"X Wang","year":"2023","unstructured":"Wang X, Liu X, Chen L et al (2023) The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development. Front Immunol 14:1178113. https:\/\/doi.org\/10.3389\/fimmu.2023.1178113","journal-title":"Front Immunol"},{"key":"7510_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11481-025-10214-5","volume":"20","author":"Z Ke","year":"2025","unstructured":"Ke Z, Huang Y, Wang A et al (2025) Clonidine ameliorates neuroinflammation in the rat model of Tourette syndrome. J Neuroimmune Pharmacol 20:56. https:\/\/doi.org\/10.1007\/s11481-025-10214-5","journal-title":"J Neuroimmune Pharmacol"},{"key":"7510_CR20","doi-asserted-by":"publisher","unstructured":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Groups of Rhinology and Pediatrics, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association (2022) Guideline for diagnosis and treatment of pediatric allergic rhinitis (2022 revision). Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 57:392-404. https:\/\/doi.org\/10.3760\/cma.j.cn115330-20220303-00092","DOI":"10.3760\/cma.j.cn115330-20220303-00092"},{"key":"7510_CR21","unstructured":"Global Initiative for Asthma (GINA) (2023) Global strategy for asthma management and prevention. Available from: https:\/\/ginasthma.org\/2023-gina-main-report\/. Accessed 11 Oct 2026"},{"key":"7510_CR22","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1111\/all.13397","volume":"73","author":"T Zuberbier","year":"2018","unstructured":"Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B et al (2018) The EAACI\/GA2LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 73:1393\u20131414. https:\/\/doi.org\/10.1111\/all.13397","journal-title":"Allergy"},{"key":"7510_CR23","unstructured":"American Academy of Ophthalmology (2024) Conjunctivitis preferred practice pattern 2023. Available from: https:\/\/www.aao.org\/education\/preferred-practice-pattern\/conjunctivitis-ppp-2023.\u00a0Accessed 11 Oct 2026"},{"key":"7510_CR24","doi-asserted-by":"publisher","unstructured":"Chinese Society of Dermatology, China Dermatologist Association (2026) Guidelines on the diagnosis and treatment of dermatitis and eczematous diseases in China (2026 edition). Chin J Dermatol 59:97\u2013106. https:\/\/doi.org\/10.35541\/cjd.20240710","DOI":"10.35541\/cjd.20240710"},{"key":"7510_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/all.16345","volume":"80","author":"AF Santos","year":"2025","unstructured":"Santos AF, Riggioni C, Agache I et al (2025) EAACI guidelines on the management of IgE-mediated food allergy. Allergy 80:14\u201336. https:\/\/doi.org\/10.1111\/all.16345","journal-title":"Allergy"},{"key":"7510_CR26","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.jaci.2022.08.028","volume":"150","author":"DA Khan","year":"2022","unstructured":"Khan DA, Banerji A, Blumenthal KG, Phillips EJ, Solensky R, White AA et al (2022) Drug allergy: a 2022 practice parameter update. J Allergy Clin Immunol 150:1333\u20131393. https:\/\/doi.org\/10.1016\/j.jaci.2022.08.028","journal-title":"J Allergy Clin Immunol"},{"key":"7510_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.626459","volume":"12","author":"M Haas","year":"2021","unstructured":"Haas M, Jakubovski E, Fremer C et al (2021) Yale Global Tic Severity Scale (YGTSS): psychometric quality of the gold standard for tic assessment based on the large-scale EMTICS study. Front Psychiatry 12:626459. https:\/\/doi.org\/10.3389\/fpsyt.2021.626459","journal-title":"Front Psychiatry"},{"issue":"6","key":"7510_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jpsychores.2009.09.002","volume":"67","author":"MH Bloch","year":"2009","unstructured":"Bloch MH, Leckman JF (2009) Clinical course of Tourette syndrome. J Psychosom Res 67(6):497\u2013501. https:\/\/doi.org\/10.1016\/j.jpsychores.2009.09.002","journal-title":"J Psychosom Res"},{"key":"7510_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080996","volume":"8","author":"YL Tu","year":"2013","unstructured":"Tu YL, Chang SW, Tsai HJ, Chen LC, Lee WI, Hua MC, Cheng JH, Ou LS, Yeh KW, Huang JL, Yao TC (2013) Total serum IgE in a population-based study of Asian children in Taiwan: reference value and significance in the diagnosis of allergy. PLoS ONE 8:e80996. https:\/\/doi.org\/10.1371\/journal.pone.0080996","journal-title":"PLoS ONE"},{"key":"7510_CR30","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1016\/j.jaip.2023.05.022","volume":"11","author":"M Thorpe","year":"2023","unstructured":"Thorpe M, Mov\u00e9rare R, Fischer C, Lidholm J, Rudengren M, Borres MP (2023) History and utility of specific IgE cutoff levels: what is the relevance for allergy diagnosis? J Allergy Clin Immunol Pract 11:3021\u20133029. https:\/\/doi.org\/10.1016\/j.jaip.2023.05.022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"7510_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2024.102126","volume":"22","author":"JA Cortes","year":"2024","unstructured":"Cortes JA et al (2024) Combined Charlson comorbidity\/C-reactive protein index is a novel predictor in renal cell carcinoma: analysis of the International Marker Consortium for Renal Cancer (INMARC) Registry. Clin Genitourin Cancer 22:102126. https:\/\/doi.org\/10.1016\/j.clgc.2024.102126","journal-title":"Clin Genitourin Cancer"},{"key":"7510_CR32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s43168-026-00587-3","volume":"20","author":"L Liu","year":"2026","unstructured":"Liu L, Liu S, Yan J et al (2026) A three-axis serum biomarker model integrating airway neutrophilic inflammation (IL-8, MMP-9), immune exhaustion (PD-1), and subclinical myocardial injury (hs-cTnI) for predicting 90-day cardiopulmonary events. Egypt J Bronchol 20:106. https:\/\/doi.org\/10.1186\/s43168-026-00587-3","journal-title":"Egypt J Bronchol"},{"key":"7510_CR33","doi-asserted-by":"publisher","DOI":"10.18356\/9789211544701","volume-title":"Guidelines on measurement of well-being","author":"United Nations Economic Commission for Europe (UNECE)","year":"2025","unstructured":"United Nations Economic Commission for Europe (UNECE) (2025) Guidelines on measurement of well-being. United Nations Economic Commission for Europe, Geneva"},{"key":"7510_CR34","unstructured":"Land KC, Hagerty MR (2011) Statistical properties of equal-weights estimators of composite quality-of-life indices. In: Proceedings of the American Statistical Association, Section on Social Statistics, pp 304\u2013309."},{"key":"7510_CR35","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.cities.2011.12.001","volume":"29","author":"Y Jiang","year":"2012","unstructured":"Jiang Y, Shen J (2012) Weighting for what? A comparison of two weighting methods for measuring urban competitiveness. Cities 29:332\u2013339. https:\/\/doi.org\/10.1016\/j.cities.2011.12.001","journal-title":"Cities"},{"key":"7510_CR36","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3969\/j.issn.2095-8552.2022.05.033","volume":"50","author":"Y Chang","year":"2022","unstructured":"Chang Y, Li M, Li FJ et al (2022) Research on the correlation between childhood tic disorders and allergic diseases. Chin J Clin 50:610\u2013613. https:\/\/doi.org\/10.3969\/j.issn.2095-8552.2022.05.033","journal-title":"Chin J Clin"},{"key":"7510_CR37","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520973921","volume":"48","author":"LH Tsai","year":"2020","unstructured":"Tsai LH, Lin JW, Lue KH (2020) Study protocol to investigate the correlation between Tourette syndrome and allergy in children and adolescents. J Int Med Res 48:0300060520973921. https:\/\/doi.org\/10.1177\/0300060520973921","journal-title":"J Int Med Res"},{"key":"7510_CR38","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41398-020-01082-z","volume":"11","author":"F Tsetsos","year":"2021","unstructured":"Tsetsos F, Padmanabhuni SS, Alexander J et al (2021) Synaptic processes and immune-related pathways implicated in Tourette syndrome. Transl Psychiatry 11:56. https:\/\/doi.org\/10.1038\/s41398-020-01082-z","journal-title":"Transl Psychiatry"},{"key":"7510_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1360420","volume":"12","author":"P Zhang","year":"2024","unstructured":"Zhang P, Zheng Z, Sun H et al (2024) A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children. Front Pediatr 12:1360420. https:\/\/doi.org\/10.3389\/fped.2024.1360420","journal-title":"Front Pediatr"},{"key":"7510_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13052-025-01874-3","volume":"51","author":"X Wu","year":"2025","unstructured":"Wu X, Hao J, Jiang K, Wu M, Zhao X, Zhang X (2025) Neuroinflammation and pathways that contribute to Tourette syndrome. Ital J Pediatr 51:1\u201313. https:\/\/doi.org\/10.1186\/s13052-025-01874-3","journal-title":"Ital J Pediatr"},{"key":"7510_CR41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.15574\/sp.2023.136.48","volume":"8","author":"Y Marushko","year":"2023","unstructured":"Marushko Y, Halushko B, Khodakivska S (2023) Evaluation of total and specific immunoglobulin E in children with persistent allergic rhinitis and combined bronchial asthma with sensitization to house dust mite allergens. Mod Pediatr Ukraine 8:48\u201354. https:\/\/doi.org\/10.15574\/sp.2023.136.48","journal-title":"Mod Pediatr Ukraine"},{"key":"7510_CR42","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fnins.2016.00310","volume":"10","author":"S Macr\u00ec","year":"2016","unstructured":"Macr\u00ec S et al (2016) Autoimmunity, neuroinflammation and Tourette\u2019s syndrome: a systematic review of the evidence. Front Neurosci 10:310. https:\/\/doi.org\/10.3389\/fnins.2016.00310","journal-title":"Front Neurosci"},{"key":"7510_CR43","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.biopsych.2024.12.022","volume":"98","author":"Y Wang","year":"2025","unstructured":"Wang Y, Fasching L, Wu F et al (2025) Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder. Biol Psychiatry 98:260\u2013270. https:\/\/doi.org\/10.1016\/j.biopsych.2024.12.022","journal-title":"Biol Psychiatry"},{"key":"7510_CR44","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/ijms22020853","volume":"22","author":"CJ Hsu","year":"2021","unstructured":"Hsu CJ, Wong LC, Lee WT (2021) Immunological dysfunction in Tourette syndrome and related disorders. Int J Mol Sci 22:853. https:\/\/doi.org\/10.3390\/ijms22020853","journal-title":"Int J Mol Sci"},{"key":"7510_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/164_2016_127","volume":"241","author":"C Pittenger","year":"2017","unstructured":"Pittenger C (2017) Histidine decarboxylase knockout mice as a model of the pathophysiology of Tourette syndrome and related conditions. Handb Exp Pharmacol 241:189\u2013215. https:\/\/doi.org\/10.1007\/164_2016_127","journal-title":"Handb Exp Pharmacol"},{"key":"7510_CR46","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.psychres.2016.11.005","volume":"247","author":"SM Yeon","year":"2017","unstructured":"Yeon SM, Lee JH, Kang D et al (2017) A cytokine study of pediatric Tourette\u2019s disorder without obsessive compulsive disorder. Psychiatry Res 247:90\u201396. https:\/\/doi.org\/10.1016\/j.psychres.2016.11.005","journal-title":"Psychiatry Res"},{"key":"7510_CR47","doi-asserted-by":"publisher","first-page":"S4205","DOI":"10.4103\/jpbs.jpbs_1264_24","volume":"16","author":"MS Aljaid","year":"2025","unstructured":"Aljaid MS (2025) Allergic conditions and their impact on pediatric sleep: a narrative review. J Pharm Bioallied Sci 16:S4205\u2013S4209. https:\/\/doi.org\/10.4103\/jpbs.jpbs_1264_24","journal-title":"J Pharm Bioallied Sci"},{"key":"7510_CR48","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/dbp.0000000000000518","volume":"39","author":"EJ Ricketts","year":"2018","unstructured":"Ricketts EJ, Rozenman M, Choy C et al (2018) Sleep sufficiency in pediatric and adolescent Tourette\u2019s disorder: national survey of children\u2019s health. J Dev Behav Pediatr 39:72\u201376. https:\/\/doi.org\/10.1097\/dbp.0000000000000518","journal-title":"J Dev Behav Pediatr"},{"key":"7510_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137484","volume":"23","author":"A Weiglein","year":"2022","unstructured":"Weiglein A, Gaffal E, Albrecht A (2022) Probing the skin-brain axis: new vistas using mouse models. Int J Mol Sci 23:7484. https:\/\/doi.org\/10.3390\/ijms23137484","journal-title":"Int J Mol Sci"},{"key":"7510_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1458839","volume":"15","author":"X Yang","year":"2024","unstructured":"Yang X, Li S, Chen A et al (2024) Distinct IgE sensitization profiles in chronic urticaria: a comparative study with classic allergic diseases. Front Immunol 15:1458839. https:\/\/doi.org\/10.3389\/fimmu.2024.1458839","journal-title":"Front Immunol"},{"key":"7510_CR51","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1111\/j.1365-2222.2012.04009.x","volume":"42","author":"N Willumsen","year":"2012","unstructured":"Willumsen N, Holm J, Christensen LH et al (2012) The complexity of allergic patients\u2019 IgE repertoire correlates with serum concentration of allergen-specific IgE. Clin Exp Allergy 42:1227\u20131236. https:\/\/doi.org\/10.1111\/j.1365-2222.2012.04009.x","journal-title":"Clin Exp Allergy"},{"key":"7510_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100105","volume":"13","author":"K Yamamoto-Hanada","year":"2020","unstructured":"Yamamoto-Hanada K, Borres MP, \u00c5berg MK et al (2020) IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo. World Allergy Organ J 13:100105. https:\/\/doi.org\/10.1016\/j.waojou.2020.100105","journal-title":"World Allergy Organ J"},{"key":"7510_CR53","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000453034","volume":"171","author":"EK Ha","year":"2017","unstructured":"Ha EK, Baek JH, Lee SY et al (2017) Association of polysensitization, allergic multimorbidity, and allergy severity: a cross-sectional study of school children. Int Arch Allergy Immunol 171:251\u2013260. https:\/\/doi.org\/10.1159\/000453034","journal-title":"Int Arch Allergy Immunol"},{"key":"7510_CR54","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12184","volume":"12","author":"T Thomander","year":"2022","unstructured":"Thomander T, Toppila-Salmi S, Salim\u00e4ki J et al (2022) Allergic multimorbidity is associated with self-reported anaphylaxis in adults\u2014a cross-sectional questionnaire study. Clin Transl Allergy 12:e12184. https:\/\/doi.org\/10.1002\/clt2.12184","journal-title":"Clin Transl Allergy"},{"key":"7510_CR55","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1007\/s00431-026-07195-9","volume":"185","author":"J Zhao","year":"2026","unstructured":"Zhao J, Wang Z, Wang Y, Dai Q, Qu S, Ru L et al (2026) Allergy burden score and lung function impairment in children with asthma: a dose-response cross-sectional study. Eur J Pediatr 185:518. https:\/\/doi.org\/10.1007\/s00431-026-07195-9","journal-title":"Eur J Pediatr"},{"key":"7510_CR56","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13953","volume":"34","author":"CSY Ng","year":"2023","unstructured":"Ng CSY, Chan CHY, Fung YL, Chau PSY, Luk DCK, Cheng JWCH et al (2023) Impact of comorbid allergic diseases on health-related quality of life of Hong Kong schoolchildren. Pediatr Allergy Immunol 34:e13953. https:\/\/doi.org\/10.1111\/pai.13953","journal-title":"Pediatr Allergy Immunol"},{"key":"7510_CR57","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jaci.2011.12.962","volume":"129","author":"JJ Wildfire","year":"2012","unstructured":"Wildfire JJ, Gergen PJ, Sorkness CA, Mitchell HE, Calatroni A, Kattan M et al (2012) Development and validation of the Composite Asthma Severity Index\u2014an outcome measure for use in children and adolescents. J Allergy Clin Immunol 129:694\u2013701. https:\/\/doi.org\/10.1016\/j.jaci.2011.12.962","journal-title":"J Allergy Clin Immunol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07510-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-026-07510-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-026-07510-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:02:05Z","timestamp":1791921725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-026-07510-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,11]]}},"alternative-id":["7510"],"URL":"https:\/\/doi.org\/10.1007\/s00431-026-07510-4","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"9 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Fujian Children's Hospital (Approval No. 2023ETKLR11015).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from the parents or legal guardians of all individual participants included in the study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript does not contain any individual person's data in any form (including individual details, images, or videos); therefore, consent for publication is not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"837"}}