{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T04:09:20Z","timestamp":1649131760259},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2004,12,8]],"date-time":"2004-12-08T00:00:00Z","timestamp":1102464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1007\/s00432-004-0639-7","type":"journal-article","created":{"date-parts":[[2004,12,7]],"date-time":"2004-12-07T18:04:51Z","timestamp":1102442691000},"page":"323-328","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of the combined cellular survival effects of benzoquinone-ansamycins and ionizing radiation"],"prefix":"10.1007","volume":"131","author":[{"given":"Hans-Joachim","family":"Ochel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\ufffdnther","family":"Gademann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,12,8]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s002800050626","volume":"40","author":"An","year":"1997","unstructured":"An WG, Schnur RC, Neckers L, Blagosklonny MV (1997) Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity. Cancer Chemother Pharmacol 40:60?64","journal-title":"Cancer Chemother Pharmacol"},{"key":"CR2","first-page":"355","volume":"11","author":"An","year":"2000","unstructured":"An WG, Schulte TW, Neckers LM (2000) The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome. Cell Growth Differ 11:355?360","journal-title":"Cell Growth Differ"},{"key":"CR3","first-page":"82a","volume":"20","author":"Banerji","year":"2001","unstructured":"Banerji U, O?Donnell A, Scurr M, Benson C, Hanwell J, Clark S, Raynaud F, Turner A, Walton M, Workman P, Judson I (2001) Phase I trial of the heat shock protein 90 (HSP90) inhibitor 17-allylamino 17-demethoxygeldanamycin (17aag). Pharmacokinetic (PK) profile and pharmacodynamic (PD) endpoints. Proc Am Soc Clin Oncol 20:82a Abstract No. 326","journal-title":"Proc Am Soc Clin Oncol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.1073\/pnas.93.16.8379","volume":"93","author":"Blagosklonny","year":"1996","unstructured":"Blagosklonny MV, Toretsky J, Bohen S, Neckers L (1996) Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc Natl Acad Sci U S A 93:8379?8383","journal-title":"Proc Natl Acad Sci U S A"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1074\/jbc.275.5.3305","volume":"275","author":"Felts","year":"2000","unstructured":"Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (2000) The Hsp90-related protein TRAP-1 is a mitochondrial protein with distinct functional properties. J Biol Chem 275:3305?3312","journal-title":"J Biol Chem"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"23843","DOI":"10.1074\/jbc.272.38.23843","volume":"272","author":"Grenert","year":"1997","unstructured":"Grenert JP, Sullivan WP, Fadden P, Haystead TAJ, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO (1997) The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP\/ADP switch domain that regulates hsp90 conformation. J Biol Chem 272:23843?23850","journal-title":"J Biol Chem"},{"key":"CR7","first-page":"3522","volume":"44","author":"Kozlowski","year":"1984","unstructured":"Kozlowski JM, Fidler IJ, Campbell D, Xu Z, Kaighn ME, Hart IR (1984) Metastatic behaviour of human tumor cell lines grown in the nude mouse. Cancer Res 44:3522?3529","journal-title":"Cancer Res"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev.ge.22.120188.003215","volume":"22","author":"Lindquist","year":"1988","unstructured":"Lindquist S (1988) The heat-shock proteins. Annu Rev Genet 22:631?677","journal-title":"Annu Rev Genet"},{"key":"CR9","first-page":"2724","volume":"54","author":"Miller","year":"1994","unstructured":"Miller P, DiOrio C, Moyer M, Schnur RC, Bruskin A, Cullen W, Moyer JD (1994) Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins. Cancer Res 54:2724?2730","journal-title":"Cancer Res"},{"key":"CR10","first-page":"83a","volume":"20","author":"Munster","year":"2001","unstructured":"Munster PN, Tong W, Schwartz L, Larson S, Kenneson K, De La Cruz A, Rosen N, Scher H (2001) Phase I trial of 17-(allyamino)-17-demethoxygeldanamycin (17-AAG) in patients (pts) with advanced solid malignancies. Proc Am Soc Clin Oncol 20:83a Abstract No. 327","journal-title":"Proc Am Soc Clin Oncol"},{"key":"CR11","first-page":"466","volume":"25","author":"Ochel","year":"2002","unstructured":"Ochel H-J, Gademann G (2002) Heat-shock protein 90: potential involvement in the pathogenesis of malignancy and pharmacological intervention. Onkologie 25:466?473","journal-title":"Onkologie"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/mgme.1998.2774","volume":"66","author":"Ochel","year":"1999","unstructured":"Ochel H-J, Schulte TW, Nguyen P, Trepel J, Neckers L (1999) The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase. Mol Genet Metab 66:24?30","journal-title":"Mol Genet Metab"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1007\/PL00012491","volume":"59","author":"Picard","year":"2002","unstructured":"Picard D (2002) Heat-shock protein 90, a chaperone for folding and regulation. Cell Mol Life Sci 59:1640?1648","journal-title":"Cell Mol Life Sci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jcp.1131","volume":"188","author":"Richter","year":"2001","unstructured":"Richter K, Buchner J (2001) Hsp90: chaperoning signal transduction. J Cell Physiol 188:281?290","journal-title":"J Cell Physiol"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1128\/MCB.16.10.5839","volume":"16","author":"Schulte","year":"1996","unstructured":"Schulte TW, Blagosklonny MV, Romanova L, Mushinski JF, Monia BP, Johnston JF, Nguyen P, Trepel J, Neckers LM (1996) Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. Mol Cell Biol 16:5839?5845","journal-title":"Mol Cell Biol"},{"key":"CR16","first-page":"986","volume":"8","author":"Solit","year":"2002","unstructured":"Solit DB, Zheng FF, Drobnjak M, M\u00fcnster PN, Higgins B, Verbel D, Heller G, Tong W, Cordon-Cardo C, Agus DB, Scher HI, Rosen N (2002) 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2\/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res 8:986?993","journal-title":"Clin Cancer Res"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0022-2836(87)90380-9","volume":"194","author":"Sorger","year":"1987","unstructured":"Sorger PK, Pelham HRB (1987) The glucose-regulated protein grp94 is related to heat-shock protein hsp90. J Mol Biol 194:341?344","journal-title":"J Mol Biol"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"14949","DOI":"10.1016\/S0021-9258(18)33376-3","volume":"257","author":"Welch","year":"1982","unstructured":"Welch WJ, Feramisco JR (1982) Purification of the major mammalian heat shock proteins. J Biol Chem 257:14949?14959","journal-title":"J Biol Chem"},{"key":"CR19","first-page":"1721","volume":"52","author":"Whitesell","year":"1992","unstructured":"Whitesell L, Shifrin SD, Schwab G, Neckers LM (1992) Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition. Cancer Res 52:1721?1728","journal-title":"Cancer Res"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"8324","DOI":"10.1073\/pnas.91.18.8324","volume":"91","author":"Whitesell","year":"1994","unstructured":"Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM (1994) Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 91:8324?8328","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-004-0639-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-004-0639-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-004-0639-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T15:59:43Z","timestamp":1625068783000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-004-0639-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,8]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["639"],"URL":"https:\/\/doi.org\/10.1007\/s00432-004-0639-7","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,8]]}}}