{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:57:13Z","timestamp":1769741833346,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T00:00:00Z","timestamp":1245974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1007\/s00432-009-0628-y","type":"journal-article","created":{"date-parts":[[2009,6,25]],"date-time":"2009-06-25T08:31:55Z","timestamp":1245918715000},"page":"1799-1807","source":"Crossref","is-referenced-by-count":29,"title":["A predicted functional single-nucleotide polymorphism of bone morphogenetic protein-4 gene affects mRNA expression and shows a significant association with cutaneous melanoma in Southern Italian population"],"prefix":"10.1007","volume":"135","author":[{"given":"Mario","family":"Capasso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Anna","family":"Avvisati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Asci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Iolascon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,26]]},"reference":[{"key":"628_CR1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10549-006-9362-1","volume":"103","author":"EL Alarmo","year":"2007","unstructured":"Alarmo EL, Kuukasjarvi T, Karhu R, Kallioniemi A (2007) A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat 103:239\u2013246","journal-title":"Breast Cancer Res Treat"},{"key":"628_CR2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaad.2007.07.003","volume":"57","author":"N Balato","year":"2007","unstructured":"Balato N, Gaudiello F, Balato A, Monfrecola G (2007) Sun habits in the children of Southern Italy. J Am Acad Dermatol 57:883\u2013887","journal-title":"J Am Acad Dermatol"},{"key":"628_CR3","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1200\/JCO.2001.19.16.3635","volume":"19","author":"CM Balch","year":"2001","unstructured":"Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A Jr, Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, Thompson JA, Thompson JF (2001) Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19:3635\u20133648","journal-title":"J Clin Oncol"},{"key":"628_CR4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1203\/pdr.0b013e318030d108","volume":"61","author":"M Capasso","year":"2007","unstructured":"Capasso M, Avvisati RA, Piscopo C, Laforgia N, Raimondi F, de Angelis F, Iolascon A (2007) Cytokine gene polymorphisms in Italian preterm infants: association between interleukin-10 -1082 G\/A polymorphism and respiratory distress syndrome. Pediatr Res 61:313\u2013317","journal-title":"Pediatr Res"},{"key":"628_CR5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ijc.10629","volume":"101","author":"P Carli","year":"2002","unstructured":"Carli P, Naldi L, Lovati S, La Vecchia C (2002) The density of melanocytic nevi correlates with constitutional variables and history of sunburns: a prevalence study among Italian schoolchildren. Int J Cancer 101:375\u2013379","journal-title":"Int J Cancer"},{"key":"628_CR6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuroscience.2008.05.050","volume":"155","author":"GL Chen","year":"2008","unstructured":"Chen GL, Miller GM (2008) Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. Neuroscience 155:485\u2013491","journal-title":"Neuroscience"},{"key":"628_CR7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00223-005-0139-z","volume":"78","author":"JY Choi","year":"2006","unstructured":"Choi JY, Shin CS, Hong YC, Kang D (2006) Single-nucleotide polymorphisms and haplotypes of bone morphogenetic protein genes and peripheral bone mineral density in young Korean men and women. Calcif Tissue Int 78:203\u2013211","journal-title":"Calcif Tissue Int"},{"key":"628_CR8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10238-004-0040-5","volume":"4","author":"ES Chung","year":"2004","unstructured":"Chung ES, Sabel MS, Sondak VK (2004) Current state of treatment for primary cutaneous melanoma. Clin Exp Med 4:65\u201377","journal-title":"Clin Exp Med"},{"key":"628_CR9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.yexcr.2006.12.020","volume":"313","author":"H Deng","year":"2007","unstructured":"Deng H, Makizumi R, Ravikumar TS, Dong H, Yang W, Yang WL (2007) Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp Cell Res 313:1033\u20131044","journal-title":"Exp Cell Res"},{"key":"628_CR10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2007.12.002","volume":"366","author":"J Dong","year":"2008","unstructured":"Dong J, Ishimori N, Paigen B, Tsutsui H, Fujii S (2008) Role of modulator recognition factor 2 in adipogenesis and leptin expression in 3T3-L1 cells. Biochem Biophys Res Commun 366:551\u2013555","journal-title":"Biochem Biophys Res Commun"},{"key":"628_CR11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0140-6736(05)67531-9","volume":"366","author":"AT Hattersley","year":"2005","unstructured":"Hattersley AT, McCarthy MI (2005) What makes a good genetic association study? Lancet 366:1315\u20131323","journal-title":"Lancet"},{"key":"628_CR12","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0959-437X(96)80064-5","volume":"6","author":"BL Hogan","year":"1996","unstructured":"Hogan BL (1996) Bone morphogenetic proteins in development. Curr Opin Genet Dev 6:432\u2013438","journal-title":"Curr Opin Genet Dev"},{"key":"628_CR13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1368-8375(00)00087-7","volume":"37","author":"Y Jin","year":"2001","unstructured":"Jin Y, Tipoe GL, Liong EC, Lau TY, Fung PC, Leung KM (2001) Overexpression of BMP-2\/4, -5 and BMPR-IA associated with malignancy of oral epithelium. Oral Oncol 37:225\u2013233","journal-title":"Oral Oncol"},{"key":"628_CR14","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1038\/sj.onc.1209700","volume":"25","author":"M Kiyono","year":"2006","unstructured":"Kiyono M, Shibuya M (2006) Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene 25:7131\u20137137","journal-title":"Oncogene"},{"key":"628_CR15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/dna.2008.0777","volume":"27","author":"JY Lin","year":"2008","unstructured":"Lin JY, Chen YJ, Huang YL, Tang GP, Zhang L, Deng B, Li M, Ma H, Luan RS (2008) Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children. DNA Cell Biol 27:601\u2013605","journal-title":"DNA Cell Biol"},{"key":"628_CR16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"628_CR17","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1126\/science.1131262","volume":"314","author":"AG Nackley","year":"2006","unstructured":"Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O, Makarov SS, Maixner W, Diatchenko L (2006) Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314:1930\u20131933","journal-title":"Science"},{"key":"628_CR18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4161\/cbt.3.7.965","volume":"3","author":"TG Nishanian","year":"2004","unstructured":"Nishanian TG, Kim JS, Foxworth A, Waldman T (2004) Suppression of tumorigenesis and activation of Wnt signaling by bone morphogenetic protein 4 in human cancer cells. Cancer Biol Ther 3:667\u2013675","journal-title":"Cancer Biol Ther"},{"key":"628_CR19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1040-8428(02)00080-X","volume":"45","author":"TM Pawlik","year":"2003","unstructured":"Pawlik TM, Sondak VK (2003) Malignant melanoma: current state of primary and adjuvant treatment. Crit Rev Oncol Hematol 45:245\u2013264","journal-title":"Crit Rev Oncol Hematol"},{"key":"628_CR20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature05349","volume":"444","author":"SG Piccirillo","year":"2006","unstructured":"Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444:761\u2013765","journal-title":"Nature"},{"key":"628_CR21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bone.2004.12.005","volume":"36","author":"L Ramesh Babu","year":"2005","unstructured":"Ramesh Babu L, Wilson SG, Dick IM, Islam FM, Devine A, Prince RL (2005) Bone mass effects of a BMP4 gene polymorphism in postmenopausal women. Bone 36:555\u2013561","journal-title":"Bone"},{"key":"628_CR22","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","volume":"65","author":"T Rothhammer","year":"2005","unstructured":"Rothhammer T, Poser I, Soncin F, Bataille F, Moser M, Bosserhoff AK (2005) Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Cancer Res 65:448\u2013456","journal-title":"Cancer Res"},{"key":"628_CR23","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/sj.onc.1210182","volume":"26","author":"T Rothhammer","year":"2007","unstructured":"Rothhammer T, Bataille F, Spruss T, Eissner G, Bosserhoff AK (2007) Functional implication of BMP4 expression on angiogenesis in malignant melanoma. Oncogene 26:4158\u20134170","journal-title":"Oncogene"},{"key":"628_CR24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1359\/jbmr.071112","volume":"23","author":"I Schrauwen","year":"2008","unstructured":"Schrauwen I, Thys M, Vanderstraeten K, Fransen E, Dieltjens N, Huyghe JR, Ealy M, Claustres M, Cremers CR, Dhooge I, Declau F, Van de Heyning P, Vincent R, Somers T, Offeciers E, Smith RJ, Van Camp G (2008) Association of bone morphogenetic proteins with otosclerosis. J Bone Miner Res 23:507\u2013516","journal-title":"J Bone Miner Res"},{"key":"628_CR25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","volume":"39","author":"BE Stranger","year":"2007","unstructured":"Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavare S, Deloukas P, Dermitzakis ET (2007) Population genomics of human gene expression. Nat Genet 39:1217\u20131224","journal-title":"Nat Genet"},{"key":"628_CR26","first-page":"63","volume":"30","author":"JW van Baal","year":"2008","unstructured":"van Baal JW, Milana F, Rygiel AM, Sondermeijer CM, Spek CA, Bergman JJ, Peppelenbosch MP, Krishnadath KK (2008) A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma. Cell Oncol 30:63\u201375","journal-title":"Cell Oncol"},{"key":"628_CR27","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1398-9995.2007.01350.x","volume":"62","author":"Y Vasilopoulos","year":"2007","unstructured":"Vasilopoulos Y, Cork MJ, Teare D, Marinou I, Ward SJ, Duff GW, Tazi-Ahnini R (2007) A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis. Allergy 62:514\u2013519","journal-title":"Allergy"},{"key":"628_CR28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/01.RES.0000033593.05545.7B","volume":"91","author":"M Watanabe","year":"2002","unstructured":"Watanabe M, Layne MD, Hsieh CM, Maemura K, Gray S, Lee ME, Jain MK (2002) Regulation of smooth muscle cell differentiation by AT-rich interaction domain transcription factors Mrf2alpha and Mrf2beta. Circ Res 91:382\u2013389","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"628_CR29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0722.1998.tb02170.x","volume":"106","author":"JM Wozney","year":"1998","unstructured":"Wozney JM (1998) The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. Eur J Oral Sci 106(Suppl 1):160\u2013166","journal-title":"Eur J Oral Sci"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-009-0628-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-009-0628-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-009-0628-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T19:55:47Z","timestamp":1685044547000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-009-0628-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,26]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["628"],"URL":"https:\/\/doi.org\/10.1007\/s00432-009-0628-y","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,26]]}}}