{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:35:43Z","timestamp":1772105743672,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T00:00:00Z","timestamp":1265155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s00432-010-0787-x","type":"journal-article","created":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T09:26:19Z","timestamp":1265102779000},"page":"1359-1367","source":"Crossref","is-referenced-by-count":18,"title":["Immunization with two recombinant Bacillus Calmette-Gu\u00e9rin vaccines that combine the expression of multiple tandem repeats of mucin-1 and colony stimulating-factor suppress breast tumor growth in mice"],"prefix":"10.1007","volume":"136","author":[{"given":"Shifang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,2,3]]},"reference":[{"key":"787_CR1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/PL00006677","volume":"48","author":"B Acres","year":"2000","unstructured":"Acres B, Apostolopoulos V, Balloul JM et al (2000) MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines. Cancer Immunol Immunother 48:588\u2013594. doi: 10.1007\/PL00006677","journal-title":"Cancer Immunol Immunother"},{"key":"787_CR2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/intimm\/13.7.897","volume":"13","author":"JD Ahlers","year":"2001","unstructured":"Ahlers JD, Belyakov IM, Matsui S et al (2001) Mechanisms of cytokine synergy essential for vaccine protection against viral challenge. Int Immunol 13:897\u2013908. doi: 10.1093\/intimm\/13.7.897","journal-title":"Int Immunol"},{"key":"787_CR3","doi-asserted-by":"crossref","unstructured":"Apostolopoulos V, Pietersz GA, Tsibanis A et al. (2006) Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1. Breast Cancer Res 8:R27. doi: 10.1186\/bcr1505","DOI":"10.1186\/bcr1505"},{"key":"787_CR4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/10408360490452040","volume":"41","author":"SE Baldus","year":"2004","unstructured":"Baldus SE, Engelmann K, Hanisch FG (2004) MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Crit Rev Clin Lab Sci 41:189\u2013231. doi: 10.1080\/10408360490452040","journal-title":"Crit Rev Clin Lab Sci"},{"key":"787_CR5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0923-2508(90)90132-A","volume":"141","author":"RG Barletta","year":"1990","unstructured":"Barletta RG, Snapper B, Cirillo JD et al (1990) Recombinant BCG as a candidate oral vaccine vector. Res Microbiol 141:931\u2013939. doi: 10.1016\/0923-2508(90)90132-A","journal-title":"Res Microbiol"},{"key":"787_CR6","first-page":"1280","volume":"63","author":"MA Chung","year":"2003","unstructured":"Chung MA, Luo Y, O\u2019Donnell M et al (2003) Development and preclinical evaluation of a Bacillus Calmette-Guerin-MUC1-based novel breast cancer vaccine. Cancer Res 63:1280\u20131287","journal-title":"Cancer Res"},{"key":"787_CR7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1182\/blood.V88.1.202.202","volume":"81","author":"ML Disis","year":"1996","unstructured":"Disis ML, Bernhard H, Shiota FM et al (1996) Granulocyte\u2013macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood 81:202\u2013210","journal-title":"Blood"},{"key":"787_CR8","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/ijc.2910430620","volume":"43","author":"A Girling","year":"1989","unstructured":"Girling A, Bartkova J, Burchell J et al (1989) A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int J Cancer 43:1072\u20131076. doi: 10.1002\/ijc.2910430620","journal-title":"Int J Cancer"},{"key":"787_CR9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nm0597-558","volume":"3","author":"J Gong","year":"1997","unstructured":"Gong J, Chen D, Kashiwaba M et al (1997) Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med 3:558\u2013561. doi: 10.1038\/nm0597-558","journal-title":"Nat Med"},{"key":"787_CR10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/canjclin.50.1.7","volume":"50","author":"RT Greenlee","year":"2000","unstructured":"Greenlee RT, Murray T, Bolden S et al (2000) Cancer statistics. Cancer J. Clin 50:7\u201333. doi: 10.3322\/canjclin.50.1.7","journal-title":"Cancer J. Clin"},{"key":"787_CR11","first-page":"229","volume":"84","author":"MS Hanson","year":"1995","unstructured":"Hanson MS, Bansal GP, Langermann S et al (1995) Efficacy and safety of live recombinant BCG vaccines. Dev Biol Stand 84:229\u2013236","journal-title":"Dev Biol Stand"},{"key":"787_CR12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0952-7915(00)00110-2","volume":"12","author":"CA Hunter","year":"2000","unstructured":"Hunter CA, Reiner SL (2000) Cytokines and T cells in host defense. Curr Opin Immunol 12:413\u2013418. doi: 10.1016\/S0952-7915(00)00110-2","journal-title":"Curr Opin Immunol"},{"key":"787_CR13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yrtph.2007.05.005","volume":"49","author":"Y Huo","year":"2007","unstructured":"Huo Y, Li B, Zhang YQ et al (2007) Pre-clinical safety evaluation of heat shock protein 65-MUC1 peptide fusion protein. Regul Toxicol Pharmacol 49:63\u201374. doi: 10.1016\/j.yrtph.2007.05.005","journal-title":"Regul Toxicol Pharmacol"},{"key":"787_CR14","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.4049\/jimmunol.158.10.4591","volume":"158","author":"A Iwasaki","year":"1997","unstructured":"Iwasaki A, Stiernholm BJ, Chan AK et al (1997) Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 158:4591\u20134601","journal-title":"J Immunol"},{"key":"787_CR15","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1007\/s00262-004-0557-1","volume":"53","author":"KG Kohlgraf","year":"2004","unstructured":"Kohlgraf KG, Gawron AJ, Higashi M et al (2004) Tumor-specific immunity in MUC1.Tg mice induced by immunization with peptide vaccines from the cytoplasmic tail of CD227 (MUC1). Cancer Immunol Immunother 53:1068\u20131084. doi: 10.1007\/s00262-004-0557-1","journal-title":"Cancer Immunol Immunother"},{"key":"787_CR16","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.4049\/jimmunol.165.10.5713","volume":"165","author":"S Koido","year":"2000","unstructured":"Koido S, Kashiwaba M, Chen D et al (2000) Induction of antitumor immunity by vaccination of dendritic cells transfected with MUC1 RNA. J Immunol 165:5713\u20135719","journal-title":"J Immunol"},{"key":"787_CR17","first-page":"2856","volume":"54","author":"Y Kotera","year":"1994","unstructured":"Kotera Y, Fontenot JD, Pecher G et al (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 54:2856\u20132860","journal-title":"Cancer Res"},{"key":"787_CR18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1586\/14760584.4.3.249","volume":"4","author":"S North","year":"2005","unstructured":"North S, Butts C (2005) Vaccination with BLP25 liposome vaccine to treat non-small cell lung and prostate cancers. Expert Rev Vaccines 4:249\u2013257. doi: 10.1586\/14760584.4.3.249","journal-title":"Expert Rev Vaccines"},{"key":"787_CR19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s00262-004-0581-1","volume":"54","author":"RK Ramanathan","year":"2005","unstructured":"Ramanathan RK, Lee KM, McKolanis J et al (2005) Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer. Cancer Immunol Immunother 54:254\u2013264. doi: 10.1007\/s00262-004-0581-1","journal-title":"Cancer Immunol Immunother"},{"key":"787_CR20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/jgm.397","volume":"5","author":"C Rochlitz","year":"2003","unstructured":"Rochlitz C, Figlin R, Squiban P (2003) Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer. J Gene Med 5:690\u2013699. doi: 10.1002\/jgm.397","journal-title":"J Gene Med"},{"key":"787_CR21","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.4049\/jimmunol.166.11.6555","volume":"166","author":"MM Soares","year":"2001","unstructured":"Soares MM, Mehta V, Finn OJ (2001) Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J Immunol 166:6555\u20136563","journal-title":"J Immunol"},{"key":"787_CR22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/351456a0","volume":"351","author":"CK Stover","year":"1991","unstructured":"Stover CK, de la Cruz VF, Fuerst TR et al (1991) New use of BCG for recombinant vaccines. Nature 351:456\u2013460. doi: 10.1038\/351456a0","journal-title":"Nature"},{"key":"787_CR23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1020360121451","volume":"7","author":"J Taylor-P","year":"2002","unstructured":"Taylor-P J, Burchell JM, Plunkett T et al (2002) MUC1 and the immunobiology of cancer. J Mammary Gland Biol Neoplasia 7:209\u2013221. doi: 10.1023\/A:1020360121451","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"787_CR24","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.4049\/jimmunol.161.10.5500","volume":"161","author":"RM Tempero","year":"1989","unstructured":"Tempero RM, VanLith ML, Morikane K et al (1989) CD4+ lymphocytes provide MUC1-specific tumor immunity in vivo that is undetectable in vitro and is absent in MUC1 transgenic mice. J Immunol 161:5500\u20135506","journal-title":"J Immunol"},{"key":"787_CR25","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.4049\/jimmunol.161.5.2325","volume":"161","author":"WR Weiss","year":"1998","unstructured":"Weiss WR, Ishii KJ, Hedstrom RC et al (1998) A plasmid encoding murine granulocyte\u2013macrophage colony-stimulating factor increases protection conferred by a malaria DNA vaccine. J Immunol 161:2325\u20132332","journal-title":"J Immunol"},{"key":"787_CR26","first-page":"3575","volume":"25","author":"K Yamamoto","year":"2005","unstructured":"Yamamoto K, Ueno T, Kawaoka T et al (2005) MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer. Anticancer Res 25:3575\u20133579","journal-title":"Anticancer Res"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-010-0787-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-010-0787-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-010-0787-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T22:02:20Z","timestamp":1685397740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-010-0787-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,3]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["787"],"URL":"https:\/\/doi.org\/10.1007\/s00432-010-0787-x","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,3]]}}}