{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:05:51Z","timestamp":1782320751771,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,10]],"date-time":"2010-03-10T00:00:00Z","timestamp":1268179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s00432-010-0857-0","type":"journal-article","created":{"date-parts":[[2010,3,9]],"date-time":"2010-03-09T11:06:44Z","timestamp":1268132804000},"page":"41-47","source":"Crossref","is-referenced-by-count":18,"title":["Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells"],"prefix":"10.1007","volume":"137","author":[{"given":"\u00c7\u0131\u011f\u0131r Biray","family":"Avc\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumhur","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahri","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunde","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Ozlem","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcray","family":"Saydam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,10]]},"reference":[{"key":"857_CR1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/oxfordjournals.jbchem.a021455","volume":"120","author":"S Asoh","year":"1996","unstructured":"Asoh S, Mori T, Hayashi J, Ohta S (1996) Expression of the apoptosis-mediator Fas is enhanced by dysfunctional mitochondria. J Biochem 120:600\u2013607","journal-title":"J Biochem"},{"issue":"15","key":"857_CR2","doi-asserted-by":"crossref","first-page":"10922","DOI":"10.1074\/jbc.M610157200","volume":"282","author":"Y Baran","year":"2007","unstructured":"Baran Y, Salas A, Senkal CE, Bielawski J, Gunduz U, Obeid LM, Ogretmen B (2007a) Alterations of human longevity assurance gene 1 (LASS1)\/sphingosine kinase-1-dependent ceramide generation and metabolism involve in the regulation of imatinib-induced apoptosis and resistance in K562 human chronic myeloid leukemia (CML) cells. J Biol Chem 282(15):10922\u201310934","journal-title":"J Biol Chem"},{"issue":"6","key":"857_CR3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/10245330701562535","volume":"12","author":"Y Baran","year":"2007","unstructured":"Baran Y, Gur B, Ural AU, Avcu F, Gunduz U (2007b) Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogenous leukemia cells and reversal of the resistance. Hematology 12(6):511\u2013517","journal-title":"Hematology"},{"issue":"6","key":"857_CR4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/10245330701384179","volume":"12","author":"Y Baran","year":"2007","unstructured":"Baran Y, Ural AU, Gunduz U (2007c) Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells. Hematology 12(6):497\u2013503","journal-title":"Hematology"},{"key":"857_CR5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1207\/s15327914nc5101_13","volume":"51","author":"DM Baxa","year":"2005","unstructured":"Baxa DM, Luo X, Yoshimura FK (2005) Genistein Induces apoptosis in T lymphoma cells via mitochondrial damage. Nutr Cancer 51:93\u2013101","journal-title":"Nutr Cancer"},{"key":"857_CR6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.exphem.2007.07.006","volume":"35","author":"N Berger","year":"1992","unstructured":"Berger N, Ben Bassat H, Klein BY, Laskov R (1992) Cytotoxicity of NF-kappaB inhibitors Bay 11\u20137085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines. Exp Hematol 35:1495\u20131450","journal-title":"Exp Hematol"},{"key":"857_CR7","first-page":"4528","volume":"53","author":"RS Bhimani","year":"1993","unstructured":"Bhimani RS, Troll W, Grunberger D, Frenkel K (1993) Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res 53:4528\u20134533","journal-title":"Cancer Res"},{"key":"857_CR8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0367-326X(02)00189-2","volume":"73","author":"F Borrelli","year":"2002","unstructured":"Borrelli F, Izzo AA, Di Carlo G, Maffia P, Russo A, Maiello FM, Capasso F, Mascolo N (2002) Effect of a propolis extract and cafeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia 73:38\u201343","journal-title":"Fitoterapia"},{"key":"857_CR9","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1021\/jm00021a006","volume":"38","author":"TR Burke","year":"1995","unstructured":"Burke TR, Fesen MR, Mazumder A, Wang J, Carothers AM, Grunberger D, Driscoll J, Kohn K, Pommier Y (1995) Hydroxylated aromatic inhibitors of HIV-1 integrase. J Med Chem 38:4171\u20134178","journal-title":"J Med Chem"},{"issue":"2\u20133","key":"857_CR10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11864-008-0061-5","volume":"9","author":"B Cassileth","year":"2008","unstructured":"Cassileth B, Yeung KS, Gubili J (2008) Herbs and other botanicals in cancer patient care. Curr Treat Options Oncol 9(2\u20133):109\u2013116","journal-title":"Curr Treat Options Oncol"},{"issue":"2","key":"857_CR11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0304-3835(96)04425-4","volume":"108","author":"JH Chen","year":"1996","unstructured":"Chen JH, Shao Y, Huang MT, Chin CK, Ho CT (1996) Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells. Cancer Lett 108(2):211\u2013214","journal-title":"Cancer Lett"},{"key":"857_CR12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00001813-200102000-00008","volume":"12","author":"Y Chen","year":"2001","unstructured":"Chen Y, Shiao M, Wang SY (2001) The antioxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anti Cancer Drugs 12:143\u2013149","journal-title":"Anti Cancer Drugs"},{"key":"857_CR13","first-page":"458","volume":"34","author":"JC Chen","year":"2004","unstructured":"Chen JC, Zhang X, Singleton TP, Kiechle FL (2004) Mitochondrial membrane potential change induced by Hoechst 33342 in myelogenous leukemia cell line HL-60. Ann Clin Lab Sci 34:458\u2013466","journal-title":"Ann Clin Lab Sci"},{"key":"857_CR14","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.ijrobp.2005.08.001","volume":"63","author":"YJ Chen","year":"2005","unstructured":"Chen YJ, Liao HF, Tsai TH, Wang SY, Shiao MS (2005) Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int J Radiat Oncol Biol Phys 63:1252\u20131261","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"857_CR15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1159\/000159843","volume":"8","author":"MJ Chen","year":"2008","unstructured":"Chen MJ, Chang WH, Lin CC, Liu CY, Wang TE, Chu CH, Shih SC, Chen YJ (2008) Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction. Pancreatology 8:566\u2013576","journal-title":"Pancreatology"},{"key":"857_CR16","first-page":"3576","volume":"55","author":"C Chiao","year":"1995","unstructured":"Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Barrett JC (1995) Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res 55:3576\u20133583","journal-title":"Cancer Res"},{"key":"857_CR17","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1096\/fj.04-2126com","volume":"18","author":"TW Chung","year":"2004","unstructured":"Chung TW, Moon SK, Chang YC, Ko JH, Lee YC, Cho G, Kim SH, Kim JG, Kim CH (2004) Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J 18:1670\u20131681","journal-title":"FASEB J"},{"key":"857_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/bbrc.1993.2438","volume":"197","author":"A Cossarizza","year":"1993","unstructured":"Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C (1993) A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5, 50, 6, 60-tetrachloro-1, 10, 3, 30 tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun 197:40\u201345","journal-title":"Biochem Biophys Res Commun"},{"key":"857_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/156800909787314057","volume":"9","author":"R Crazzolara","year":"1999","unstructured":"Crazzolara R, Bendall L (1999) Emerging treatments in acute lymphoblastic leukemia. Curr Cancer Drug Targets 9:19\u201331","journal-title":"Curr Cancer Drug Targets"},{"key":"857_CR20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ptr.2594","volume":"23","author":"M Demestre","year":"2009","unstructured":"Demestre M, Messerli SM, Celli N, Shahhossini M, Kluwe L, Mautner V, Maruta H (2009) CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytother Res 23:226\u2013230","journal-title":"Phytother Res"},{"key":"857_CR21","first-page":"4731","volume":"61","author":"J D\u00f6rrie","year":"2001","unstructured":"D\u00f6rrie J, Gerauer H, Wachter Y, Zunino SJ (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61:4731\u20134739","journal-title":"Cancer Res"},{"issue":"1","key":"857_CR22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1534735408330202","volume":"8","author":"S Engdal","year":"2009","unstructured":"Engdal S, Klepp O, Nilsen OG (2009) Identification and exploration of herb-drug combinations used by cancer patients. Integr Cancer Ther 8(1):29\u201336","journal-title":"Integr Cancer Ther"},{"key":"857_CR23","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0006-2952(94)90291-7","volume":"48","author":"MR Fesen","year":"1994","unstructured":"Fesen MR, Pommier Y, Leteurtre F, Hiroguchi S, Yung J, Kohn KW (1994) Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochem Pharmacol 48:595\u2013608","journal-title":"Biochem Pharmacol"},{"key":"857_CR24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbabio.2006.03.016","volume":"1757","author":"V Gogvadze","year":"2006","unstructured":"Gogvadze V, Orrenius S, Zhivotovsky B (2006) Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta 1757:639\u2013647","journal-title":"Biochim Biophys Acta"},{"key":"857_CR25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2008.01.006","volume":"18","author":"V Gogvadze","year":"2008","unstructured":"Gogvadze V, Orrenius S, Zhivotovsky B (2008) Mitochondria in cancer cells: what is so special about them? Trends Cell Biol 18:165\u2013173","journal-title":"Trends Cell Biol"},{"key":"857_CR26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/BF01941717","volume":"44","author":"D Grunberger","year":"1998","unstructured":"Grunberger D, Banerjee R, Eisinger K, Oltz EM, Efros L, Caldwell M, Estevez V, Nakanishi K (1998) Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44:230\u2013232","journal-title":"Experientia"},{"key":"857_CR27","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.3748\/wjg.v12.i31.4981","volume":"12","author":"YJ He","year":"2006","unstructured":"He YJ, Liu BH, Xiang DB, Qiao ZY, Fu T, He YH (2006) Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway downregulation. World J Gastroenterol 12:4981\u20134985","journal-title":"World J Gastroenterol"},{"key":"857_CR28","first-page":"4773","volume":"23","author":"MW Hung","year":"2003","unstructured":"Hung MW, Shiao MS, Tsai LC, Chang GG, Chang TC (2003) Apoptotic effect of caffeic acid phenethyl ester and its ester and amide analogues in human cervical cancer ME180 cells. Anticancer Res 23:4773\u20134780","journal-title":"Anticancer Res"},{"key":"857_CR29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0304-3835(00)00389-X","volume":"153","author":"YJ Lee","year":"2000","unstructured":"Lee YJ, Liao PH, Chen WK, Yang CY (2000) Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Cancer Lett 153:51\u201356","journal-title":"Cancer Lett"},{"key":"857_CR30","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.bcp.2003.07.014","volume":"66","author":"YJ Lee","year":"2003","unstructured":"Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, Tseng TH (2003) Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol 66:2281\u20132289","journal-title":"Biochem Pharmacol"},{"key":"857_CR31","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1161\/01.CIR.102.16.1970","volume":"102","author":"D Li","year":"2000","unstructured":"Li D, Saldeen T, Romeo F, Mehta JL (2000) Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: the potential role of transcription factor NF-kappaB. Circulation 102:1970\u20131976","journal-title":"Circulation"},{"key":"857_CR32","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1021\/jf034729d","volume":"51","author":"H Liao","year":"1999","unstructured":"Liao H, Chen Y, Liu J (1999) Inhibitory effect of caffeic acid phenyl ester on angiogenesis, tumor invasion, and metastasis. J Agric Food Chem 51:7907\u20137912","journal-title":"J Agric Food Chem"},{"key":"857_CR33","first-page":"2347","volume":"59","author":"P Michaluart","year":"1999","unstructured":"Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ (1999) Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59:2347\u20132352","journal-title":"Cancer Res"},{"issue":"1","key":"857_CR34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1054\/bjoc.2000.1559","volume":"84","author":"J Neuzil","year":"2001","unstructured":"Neuzil J, Weber T, Gellert N, Weber C (2001) Selective cancer cell killing by alpha-tocopheryl succinate. Br J Cancer 84(1):87\u201389","journal-title":"Br J Cancer"},{"issue":"22","key":"857_CR35","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1016\/j.febslet.2006.05.072","volume":"5","author":"J Neuzil","year":"2006","unstructured":"Neuzil J, Wang XF, Dong LF, Low P, Ralph SJ (2006) Molecular mechanism of \u2018mitocan\u2019-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett 5(22):5125\u20135129","journal-title":"FEBS Lett"},{"key":"857_CR36","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1007\/s10863-006-9060-z","volume":"39","author":"J Neuzil","year":"2007","unstructured":"Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ (2007) Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr 39:7265\u20137282","journal-title":"J Bioenerg Biomembr"},{"key":"857_CR37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000026427","volume":"7","author":"Z Orban","year":"2000","unstructured":"Orban Z, Mitsiades N, Burke TR Jr, Tsokos M, Chrousos GP (2000) Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 7:99\u2013105","journal-title":"Neuroimmunomodulation"},{"issue":"3","key":"857_CR38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0009-2797(92)90129-9","volume":"84","author":"CV Rao","year":"1992","unstructured":"Rao CV, Desai D, Kaul B, Amin S, Reddy BS (1992) Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth. Chem Biol Interact 84(3):277\u2013290","journal-title":"Chem Biol Interact"},{"key":"857_CR39","first-page":"102","volume":"24","author":"F Sahin","year":"2007","unstructured":"Sahin F, Avci CB, Avcu F, Ural AU, Sarper M, Omay SB, Saydam G (2007) Red grape seed extract and its compound resveratrol exert cytotoxic effect to various human cancer lines. Turk J Hematolol 24:102\u2013109","journal-title":"Turk J Hematolol"},{"key":"857_CR40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(97)00669-8","volume":"411","author":"S Salvioli","year":"1997","unstructured":"Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A (1997) JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess Dc changes in intact cells:Implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 411:77\u201382","journal-title":"FEBS Lett"},{"key":"857_CR41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/sj.cdd.4401715","volume":"13","author":"J Schmidt-Mende","year":"2006","unstructured":"Schmidt-Mende J, Gogvadze V, Hellstr\u00f6m-Lindberg E, Zhivotovsky B (2006) Early mitochondrial alterations in ATRA-induced cell death. Cell Death Differ 13:119\u2013128","journal-title":"Cell Death Differ"},{"key":"857_CR42","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/jf010830b","volume":"50","author":"S Son","year":"2002","unstructured":"Son S, Lewis BA (2002) Free radical scavenging and antioxidative activity of cafeic acid amide and ester analogues: structure activity relationship. J Agric Food Chem 50:468\u2013472","journal-title":"J Agric Food Chem"},{"key":"857_CR43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-5793(93)80184-V","volume":"329","author":"GF Sud\u2019ina","year":"1993","unstructured":"Sud\u2019ina GF, Mirzoeva OK, Pushkareva MA, Korshunova GA, Sumbatyan NV, Varfolomeev SD (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 329:21\u201324","journal-title":"FEBS Lett"},{"issue":"11","key":"857_CR44","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1080\/10428190412331272767","volume":"45","author":"K Swerts","year":"2004","unstructured":"Swerts K, de Moerloose B, Dhooge C, Noens L, Laureys G, Benoit Y, Philipp\u00e9 J (2004) Comparison of two functional flow cytometric assays to assess P-gp activity in acute leukemia. Leuk Lymphoma 45(11):2221\u20132228","journal-title":"Leuk Lymphoma"},{"key":"857_CR45","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.3748\/wjg.v11.i26.4008","volume":"11","author":"D Wang","year":"2005","unstructured":"Wang D, Xiang DB, He YJ, Li ZP, Wu XH, Mou JH, Xiao HL, Zhang QH (2005) Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro. World J Gastroenterol 11:4008\u20134012","journal-title":"World J Gastroenterol"},{"key":"857_CR46","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1074\/jbc.M306040200","volume":"279","author":"M Watabe","year":"2004","unstructured":"Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279:6017\u20136026","journal-title":"J Biol Chem"},{"key":"857_CR47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0014-5793(94)80380-3","volume":"339","author":"EJ Wolvetang","year":"1994","unstructured":"Wolvetang EJ, Johnson KL, Krauer K, Ralph SJ, Linnane AW (1994) Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett 339:40\u201344","journal-title":"FEBS Lett"},{"issue":"10","key":"857_CR48","first-page":"2483","volume":"63","author":"W Yu","year":"2003","unstructured":"Yu W, Sanders BG, Kline K (2003) RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res 63(10):2483\u20132491","journal-title":"Cancer Res"},{"key":"857_CR49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.canlet.2005.09.001","volume":"240","author":"SJ Zunino","year":"2006","unstructured":"Zunino SJ, Storms DH (2006) Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. Cancer Lett 240:123\u2013134","journal-title":"Cancer Lett"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-010-0857-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-010-0857-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-010-0857-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:39:59Z","timestamp":1559083199000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-010-0857-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,10]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["857"],"URL":"https:\/\/doi.org\/10.1007\/s00432-010-0857-0","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,10]]}}}