{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:07:55Z","timestamp":1777633675745,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T00:00:00Z","timestamp":1308614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00432-011-0992-2","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T06:51:32Z","timestamp":1308552692000},"page":"1229-1238","source":"Crossref","is-referenced-by-count":34,"title":["Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer"],"prefix":"10.1007","volume":"137","author":[{"given":"Jeong Youp","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-A","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungmin","family":"Bang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ki","family":"Paik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"issue":"11","key":"992_CR1","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s11605-009-1001-9","volume":"13","author":"D Bausch","year":"2009","unstructured":"Bausch D, Mino-Kenudson M, Castillo CF-D, Warshaw AL, Kelly KA, Thayer SP (2009) Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms. J Gastrointest Surg 13(11):1948\u20131954","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"992_CR2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.7326\/0003-4819-123-3-199508010-00005","volume":"123","author":"P Berthelemy","year":"1995","unstructured":"Berthelemy P, Bouisson M, Escourrou J, Vaysse N, Rumeau JL, Pradayrol L (1995) Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer. Ann Intern Med 123(3):188\u2013191","journal-title":"Ann Intern Med"},{"issue":"28","key":"992_CR3","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.3748\/wjg.v12.i28.4511","volume":"12","author":"MH Bluth","year":"2006","unstructured":"Bluth MH, Patel SA, Dieckgraefe BK, Okamoto H, Zenilman ME (2006) Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. World J Gastroenterol 12(28):4511\u20134516","journal-title":"World J Gastroenterol"},{"issue":"52","key":"992_CR4","doi-asserted-by":"crossref","first-page":"36425","DOI":"10.1074\/jbc.M803603200","volume":"283","author":"PL Boulay","year":"2008","unstructured":"Boulay PL, Cotton M, Melancon P, Claing A (2008) ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. J Biol Chem 283(52):36425\u201336434","journal-title":"J Biol Chem"},{"issue":"4","key":"992_CR5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1074\/mcp.R500004-MCP200","volume":"4","author":"R Chen","year":"2005","unstructured":"Chen R, Pan S, Brentnall TA, Aebersold R (2005) Proteomic profiling of pancreatic cancer for biomarker discovery. Mol Cell Proteomics 4(4):523\u2013533","journal-title":"Mol Cell Proteomics"},{"issue":"6","key":"992_CR6","first-page":"1683","volume":"23","author":"J Gao","year":"2010","unstructured":"Gao J, Zhu F, Lv S, Li Z, Ling Z, Gong Y, Jie C, Ma L (2010) Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. Oncol Rep 23(6):1683\u20131692","journal-title":"Oncol Rep"},{"issue":"5","key":"992_CR7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1021\/pr0499085","volume":"3","author":"M Gronborg","year":"2004","unstructured":"Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A (2004) Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 3(5):1042\u20131055","journal-title":"J Proteome Res"},{"issue":"5","key":"992_CR8","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1053\/jhep.2001.24168","volume":"33","author":"K Harada","year":"2001","unstructured":"Harada K, Zen Y, Kanemori Y, Chen TC, Chen MF, Yeh TS, Jan YY, Masuda S, Nimura Y, Takasawa S, Okamoto H, Nakanuma Y (2001) Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Hepatology 33(5):1036\u20131042","journal-title":"Hepatology"},{"issue":"2","key":"992_CR9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF02786077","volume":"13","author":"T Hayakawa","year":"1993","unstructured":"Hayakawa T, Kondo T, Shibata T, Kitagawa M, Sakai Y, Sobajima H, Tanikawa M, Nakae Y, Hayakawa S, Katsuzaki T et al (1993) Serum pancreatic stone protein in pancreatic diseases. Int J Pancreatol 13(2):97\u2013103","journal-title":"Int J Pancreatol"},{"issue":"9","key":"992_CR10","first-page":"3418","volume":"9","author":"P Karihtala","year":"2003","unstructured":"Karihtala P, Mantyniemi A, Kang SW, Kinnula VL, Soini Y (2003) Peroxiredoxins in breast carcinoma. Clin Cancer Res 9(9):3418\u20133424","journal-title":"Clin Cancer Res"},{"issue":"2","key":"992_CR11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/archsurg.139.2.188","volume":"139","author":"M Kawai","year":"2004","unstructured":"Kawai M, Uchiyama K, Tani M, Onishi H, Kinoshita H, Ueno M, Hama T, Yamaue H (2004) Clinicopathological features of malignant intraductal papillary mucinous tumors of the pancreas: the differential diagnosis from benign entities. Arch Surg 139(2):188\u2013192","journal-title":"Arch Surg"},{"issue":"4","key":"992_CR12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1046\/j.1365-2133.2002.46845.x","volume":"146","author":"JB Lee","year":"2002","unstructured":"Lee JB, Yun SJ, Chae HZ, Won YH, Kim YP, Lee SC (2002) Expression of peroxiredoxin and thioredoxin in dermatological disorders. Br J Dermatol 146(4):710\u2013712","journal-title":"Br J Dermatol"},{"issue":"1\u20136","key":"992_CR13","first-page":"141","volume":"35","author":"KY Lee","year":"2004","unstructured":"Lee KY, Liu YH, Ho CC, Pei RJ, Yeh KT, Cheng CC, Lai YS (2004) An early evaluation of malignant tendency with plectin expression in human colorectal adenoma and adenocarcinoma. J Med 35(1\u20136):141\u2013149","journal-title":"J Med"},{"issue":"6","key":"992_CR14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10059-009-0152-6","volume":"28","author":"SB Lee","year":"2009","unstructured":"Lee SB, Ho JN, Yoon SH, Kang GY, Hwang SG, Um HD (2009) Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt. Mol Cells 28(6):583\u2013588","journal-title":"Mol Cells"},{"issue":"10","key":"992_CR15","doi-asserted-by":"crossref","first-page":"e7495","DOI":"10.1371\/journal.pone.0007495","volume":"4","author":"A Legoffic","year":"2009","unstructured":"Legoffic A, Calvo E, Cano C, Folch-Puy E, Barthet M, Delpero JR, Ferres-Maso M, Dagorn JC, Closa D, Iovanna J (2009) The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target. PLoS One 4(10):e7495","journal-title":"PLoS One"},{"issue":"4","key":"992_CR16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/ijc.20294","volume":"111","author":"ST Lehtonen","year":"2004","unstructured":"Lehtonen ST, Svensk AM, Soini Y, Paakko P, Hirvikoski P, Kang SW, Saily M, Kinnula VL (2004) Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer 111(4):514\u2013521","journal-title":"Int J Cancer"},{"issue":"16","key":"992_CR17","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1002\/pmic.200900105","volume":"9","author":"K Na","year":"2009","unstructured":"Na K, Lee EY, Lee HJ, Kim KY, Lee H, Jeong SK, Jeong AS, Cho SY, Kim SA, Song SY, Kim KS, Cho SW, Kim H, Paik YK (2009) Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma. Proteomics 9(16):3989\u20133999","journal-title":"Proteomics"},{"issue":"1","key":"992_CR18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s001090050305","volume":"77","author":"H Okamoto","year":"1999","unstructured":"Okamoto H (1999) Cyclic ADP-ribose-mediated insulin secretion and Reg, regenerating gene. J Mol Med 77(1):74\u201378","journal-title":"J Mol Med"},{"issue":"1","key":"992_CR19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/07357907.2010.535056","volume":"29","author":"JH Pak","year":"2010","unstructured":"Pak JH, Choi WH, Lee HM, Joo WD, Kim JH, Kim YT, Kim YM, Nam JH (2010) Peroxiredoxin 6 overexpression attenuates cisplatin-induced apoptosis in human ovarian cancer cells. Cancer Invest 29(1):21\u201328","journal-title":"Cancer Invest"},{"issue":"6","key":"992_CR20","first-page":"1868","volume":"62","author":"C Rosty","year":"2002","unstructured":"Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M (2002) Identification of hepatocarcinoma-intestine-pancreas\/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res 62(6):1868\u20131875","journal-title":"Cancer Res"},{"issue":"5","key":"992_CR21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/MPA.0b013e3181a1d9f9","volume":"38","author":"D Sanchez","year":"2009","unstructured":"Sanchez D, Mueller CM, Zenilman ME (2009) Pancreatic regenerating gene I and acinar cell differentiation: influence on cellular lineage. Pancreas 38(5):572\u2013577","journal-title":"Pancreas"},{"issue":"3","key":"992_CR22","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.gastro.2004.12.045","volume":"128","author":"A Sekikawa","year":"2005","unstructured":"Sekikawa A, Fukui H, Fujii S, Takeda J, Nanakin A, Hisatsune H, Seno H, Takasawa S, Okamoto H, Fujimori T, Chiba T (2005) REG Ialpha protein may function as a trophic and\/or anti-apoptotic factor in the development of gastric cancer. Gastroenterology 128(3):642\u2013653","journal-title":"Gastroenterology"},{"issue":"6","key":"992_CR23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/13651820600747907","volume":"8","author":"P Shamamian","year":"2006","unstructured":"Shamamian P, Goldberg JD, Ye XY, Stewart JD, White PJ, Gilvarg C (2006) Evaluation of pro-carboxypeptidase A and carboxypeptidase A as serologic markers for adenocarcinoma of the pancreas. HPB (Oxford) 8(6):451\u2013457","journal-title":"HPB (Oxford)"},{"issue":"24","key":"992_CR24","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1158\/0008-5472.CAN-04-3262","volume":"64","author":"J Shen","year":"2004","unstructured":"Shen J, Person MD, Zhu J, Abbruzzese JL, Li D (2004) Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 64(24):9018\u20139026","journal-title":"Cancer Res"},{"issue":"1","key":"992_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0888-7543(88)90102-4","volume":"2","author":"H Stedman","year":"1988","unstructured":"Stedman H, Browning K, Oliver N, Oronzi-Scott M, Fischbeck K, Sarkar S, Sylvester J, Schmickel R, Wang K (1988) Nebulin cDNAs detect a 25-kilobase transcript in skeletal muscle and localize to human chromosome 2. Genomics 2(1):1\u20137","journal-title":"Genomics"},{"issue":"1","key":"992_CR26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00535-009-0114-y","volume":"45","author":"R Takayama","year":"2010","unstructured":"Takayama R, Nakagawa H, Sawaki A, Mizuno N, Kawai H, Tajika M, Yatabe Y, Matsuo K, Uehara R, Ono K, Nakamura Y, Yamao K (2010) Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma. J Gastroenterol 45(1):52\u201359","journal-title":"J Gastroenterol"},{"key":"992_CR27","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-59745-432-2","volume-title":"Proteomics of human body fluids: principles, methods, and applications","author":"V Thongboonkerd","year":"2007","unstructured":"Thongboonkerd V (2007) Proteomics of human body fluids: principles, methods, and applications. Humana Press, Totowa"},{"key":"992_CR28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1471-2407-8-241","volume":"8","author":"M Tian","year":"2008","unstructured":"Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX (2008) Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer 8:241","journal-title":"BMC Cancer"},{"issue":"6","key":"992_CR29","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1073\/pnas.97.6.2567","volume":"97","author":"R Yamaji","year":"2000","unstructured":"Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (2000) Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc Natl Acad Sci USA 97(6):2567\u20132572","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7\u20138","key":"992_CR30","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/1522-2683(200204)23:7\/8<1185::AID-ELPS1185>3.0.CO;2-G","volume":"23","author":"X Yuan","year":"2002","unstructured":"Yuan X, Russell T, Wood G, Desiderio DM (2002) Analysis of the human lumbar cerebrospinal fluid proteome. Electrophoresis 23(7\u20138):1185\u20131196","journal-title":"Electrophoresis"},{"issue":"8","key":"992_CR31","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/pmic.200600086","volume":"7","author":"L Zhou","year":"2007","unstructured":"Zhou L, Lu Z, Yang A, Deng R, Mai C, Sang X, Faber KN, Lu X (2007) Comparative proteomic analysis of human pancreatic juice: methodological study. Proteomics 7(8):1345\u20131355","journal-title":"Proteomics"},{"issue":"8","key":"992_CR32","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/ijc.25188","volume":"127","author":"L Zhou","year":"2010","unstructured":"Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y (2010) Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer 127(8):1795\u20131803","journal-title":"Int J Cancer"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-011-0992-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-011-0992-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-011-0992-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T23:21:11Z","timestamp":1637882471000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-011-0992-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,21]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["992"],"URL":"https:\/\/doi.org\/10.1007\/s00432-011-0992-2","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,21]]}}}