{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:41:25Z","timestamp":1773679285504,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,4,6]],"date-time":"2012-04-06T00:00:00Z","timestamp":1333670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1007\/s00432-012-1203-5","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T09:43:31Z","timestamp":1333619011000},"page":"1347-1354","source":"Crossref","is-referenced-by-count":15,"title":["Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy"],"prefix":"10.1007","volume":"138","author":[{"given":"Francisco das Chagas Abreu","family":"da Silveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno de Almeida","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clovis Orlando","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thereza","family":"Quirico-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabel Christina Nunes","family":"de Palmer Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia Maria da Fonte","family":"de Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,4,6]]},"reference":[{"issue":"1","key":"1203_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2010.04.015","volume":"128","author":"L Arko","year":"2010","unstructured":"Arko L, Katsyv I, Park GE, Luan WP, Park JK (2010) Experimental approaches for the treatment of malignant gliomas. Pharmacol Ther 128(1):1\u201336. doi: 10.1016\/j.pharmthera.2010.04.015","journal-title":"Pharmacol Ther"},{"issue":"5","key":"1203_CR2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1177\/147323001003800509","volume":"38","author":"G Bao","year":"2010","unstructured":"Bao G, Wang M, Guo S, Han Y, Xu G (2010) Association between epidermal growth factor +61G\/A polymorphism and glioma risk in a Chinese Han population. J Int Med Res 38(5):1645\u20131652","journal-title":"J Int Med Res"},{"issue":"5 Suppl","key":"1203_CR3","first-page":"314","volume":"104","author":"U Bartels","year":"2006","unstructured":"Bartels U, Hawkins C, Jing M, Ho M, Dirks P, Rutka J, Stephens D, Bouffet E (2006) Vascularity and angiogenesis as predictors of growth in optic pathway\/hypothalamic gliomas. J Neurosurg 104(5 Suppl):314\u2013320. doi: 10.3171\/ped.2006.104.5.314","journal-title":"J Neurosurg"},{"issue":"4","key":"1203_CR4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1158\/0008-5472.CAN-03-3137","volume":"64","author":"DA Bhowmick","year":"2004","unstructured":"Bhowmick DA, Zhuang Z, Wait SD, Weil RJ (2004) A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. Cancer Res 64(4):1220\u20131223. doi: 10.1158\/0008-5472.CAN-03-3137","journal-title":"Cancer Res"},{"issue":"1","key":"1203_CR5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/316931","volume":"68","author":"DR Carvalho-Silva","year":"2001","unstructured":"Carvalho-Silva DR, Santos FR, Rocha J, Pena SD (2001) The phylogeography of Brazilian Y-chromosome lineages. Am J Hum Genet 68(1):281\u2013286. doi: 10.1086\/316931","journal-title":"Am J Hum Genet"},{"issue":"8","key":"1203_CR6","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1200\/JCO.2005.04.7522","volume":"24","author":"SM Chang","year":"2006","unstructured":"Chang SM, Butowski NA, Sneed PK (2006) Diagnosis and treatment of recurrent high-grade astrocytoma. J Clin Oncol 24(8):1273\u20131280. doi: 10.1200\/Jco.2005.04.7522","journal-title":"J Clin Oncol"},{"issue":"2\u20133","key":"1203_CR7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cbi.2008.12.016","volume":"179","author":"SC Chaudhary","year":"2009","unstructured":"Chaudhary SC, Alam MS, Siddiqui MS, Athar M (2009) Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. Chem Biol Interact 179(2\u20133):145\u2013153. doi: 10.1016\/j.cbi.2008.12.016","journal-title":"Chem Biol Interact"},{"issue":"9","key":"1203_CR8","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1158\/1078-0432.CCR-06-2606","volume":"13","author":"BM Costa","year":"2007","unstructured":"Costa BM, Ferreira P, Costa S, Canedo P, Oliveira P, Silva A, Pardal F, Suriano G, Machado JC, Lopes JM, Reis RM (2007) Association between functional EGF+61 polymorphism and glioma risk. Clin Cancer Res 13(9):2621\u20132626. doi: 10.1158\/1078-0432.Ccr-06-2606","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1203_CR9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.surneu.2007.07.040","volume":"70","author":"CO Fonseca da","year":"2008","unstructured":"da Fonseca CO, Schwartsmann G, Fischer J, Nagel J, Futuro D, Quirico-Santos T, Gattass CR (2008) Preliminary results from a phase I\/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. Surg Neurol 70(3):259\u2013267. doi: 10.1016\/j.surneu.2007.07.040","journal-title":"Surg Neurol"},{"key":"1203_CR10","author":"CO Fonseca da","year":"2009","unstructured":"da Fonseca CO, Silva JT, Lins IR, Simao M, Arnobio A, Futuro D, Quirico-Santos T (2009) Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. Invest New Drugs. doi: 10.1007\/s10637-008-9215-3","journal-title":"Invest New Drugs"},{"issue":"2","key":"1203_CR11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00432-010-0873-0","volume":"137","author":"CO Fonseca da","year":"2011","unstructured":"da Fonseca CO, Simao M, Lins IR, Caetano RO, Futuro D, Quirico-Santos T (2011) Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. J Cancer Res Clin Oncol 137(2):287\u2013293. doi: 10.1007\/s00432-010-0873-0","journal-title":"J Cancer Res Clin Oncol"},{"key":"1203_CR12","doi-asserted-by":"crossref","unstructured":"de Saldanha da Gama Fischer J, Costa Carvalho P, da Fonseca CO, Liao L, Degrave WM, da Gloria da Costa Carvalho M, Yates JR, Domont GB (2011) Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. J Proteome Res 10(1):153\u2013160. doi: 10.1021\/pr100677g","DOI":"10.1021\/pr100677g"},{"issue":"4","key":"1203_CR13","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1158\/1078-0432.CCR-04-1737","volume":"11","author":"AB Heimberger","year":"2005","unstructured":"Heimberger AB, Hlatky R, Suki D, Yang D, Weinberg J, Gilbert M, Sawaya R, Aldape K (2005) Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin Cancer Res 11(4):1462\u20131466. doi: 10.1158\/1078-0432.CCR-04-1737","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1203_CR14","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3171\/jns.1993.79.3.0408","volume":"79","author":"H Kanno","year":"1993","unstructured":"Kanno H, Chiba Y, Kyuma Y, Hayashi A, Abe H, Takada H, Kim I, Yamamoto I (1993) Urinary epidermal growth factor in patients with gliomas: significance of the factor as a glial tumor marker. J Neurosurg 79(3):408\u2013413. doi: 10.3171\/jns.1993.79.3.0408","journal-title":"J Neurosurg"},{"issue":"10","key":"1203_CR15","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3109\/07357907.2010.512596","volume":"28","author":"M Katakowski","year":"2010","unstructured":"Katakowski M, Zheng X, Jiang F, Rogers T, Szalad A, Chopp M (2010) MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest 28(10):1024\u20131030. doi: 10.3109\/07357907.2010.512596","journal-title":"Cancer Invest"},{"issue":"5322","key":"1203_CR16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.277.5322.109","volume":"277","author":"E Ktistaki","year":"1997","unstructured":"Ktistaki E, Talianidis I (1997) Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science 277(5322):109\u2013112","journal-title":"Science"},{"issue":"10","key":"1203_CR17","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1158\/1078-0432.CCR-07-4932","volume":"14","author":"M Lanuti","year":"2008","unstructured":"Lanuti M, Liu G, Goodwin JM, Zhai R, Fuchs BC, Asomaning K, Su L, Nishioka NS, Tanabe KK, Christiani DC (2008) A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Clin Cancer Res 14(10):3216\u20133222. doi: 10.1158\/1078-0432.Ccr-07-4932","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1203_CR18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1478-3231.2009.02134.x","volume":"30","author":"YJ Li","year":"2010","unstructured":"Li YJ, Xie Q, Lu FM, Zhao JM, Mao PY, Li Z, Liu S, Zhuang H (2010) Association between epidermal growth factor 61A\/G polymorphism and hepatocellular carcinoma susceptibility in Chinese patients. Liver Int 30(1):112\u2013118. doi: 10.1111\/j.1478-3231.2009.02134.x","journal-title":"Liver Int"},{"issue":"2","key":"1203_CR19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5301\/JBM.2009.8","volume":"24","author":"XQ Liu","year":"2009","unstructured":"Liu XQ, Li L, Chen XM, Wang XF, Mu LY, Li YJ, Xu Q, Xie Q, Lu FM (2009) No association between EGF+61A\/G polymorphism and increased risk of glioma. Int J Biol Markers 24(2):77\u201382","journal-title":"Int J Biol Markers"},{"issue":"2","key":"1203_CR20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114(2):97\u2013109. doi: 10.1007\/s00401-007-0243-4","journal-title":"Acta Neuropathol"},{"issue":"2","key":"1203_CR21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1124\/jpet.104.070516","volume":"311","author":"H Loutrari","year":"2004","unstructured":"Loutrari H, Hatziapostolou M, Skouridou V, Papadimitriou E, Roussos C, Kolisis FN, Papapetropoulos A (2004) Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther 311(2):568\u2013575. doi: 10.1124\/jpet.104.070516","journal-title":"J Pharmacol Exp Ther"},{"issue":"18","key":"1203_CR22","first-page":"6039","volume":"50","author":"M Lund-Johansen","year":"1990","unstructured":"Lund-Johansen M, Bjerkvig R, Humphrey PA, Bigner SH, Bigner DD, Laerum OD (1990) Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro. Cancer Res 50(18):6039\u20136044","journal-title":"Cancer Res"},{"issue":"3","key":"1203_CR23","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1203_CR24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1023\/A:1005766511385","volume":"15","author":"M Nguyen","year":"1997","unstructured":"Nguyen M (1997) Angiogenic factors as tumor markers. Invest New Drugs 15(1):29\u201337. doi: 10.1023\/A:1005766511385","journal-title":"Invest New Drugs"},{"issue":"3","key":"1203_CR25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10014-011-0029-1","volume":"28","author":"H Ohgaki","year":"2011","unstructured":"Ohgaki H, Kleihues P (2011) Genetic profile of astrocytic and oligodendroglial gliomas. Brain Tumor Pathol 28(3):177\u2013183. doi: 10.1007\/s10014-011-0029-1","journal-title":"Brain Tumor Pathol"},{"issue":"4","key":"1203_CR26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.5301\/JBM.2009.5517","volume":"24","author":"GR Pinto","year":"2009","unstructured":"Pinto GR, Yoshioka FK, Clara CA, Santos MJ, Almeida JR, Burbano RR, Rey JA, Casartelli C (2009) Association study of an epidermal growth factor gene functional polymorphism with the risk and prognosis of gliomas in Brazil. Int J Biol Markers 24(4):277\u2013281. doi: A6881898-2FD2-40A8-B33D-B8FA98818E11","journal-title":"Int J Biol Markers"},{"key":"1203_CR27","volume-title":"O povo brasileiro: a forma\u00e7\u00e3o e o sentido do Brasil","author":"D Ribeiro","year":"1995","unstructured":"Ribeiro D (1995) O povo brasileiro: a forma\u00e7\u00e3o e o sentido do Brasil. Estudos de antropologia da civiliza\u00e7\u00e3o, Companhia das Letras, S\u00e3o Paulo, Brazil"},{"issue":"9304","key":"1203_CR28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(02)07600-6","volume":"359","author":"M Shahbazi","year":"2002","unstructured":"Shahbazi M, Pravica V, Nasreen N, Fakhoury H, Fryer AA, Strange RC, Hutchinson PE, Osborne JE, Lear JT, Smith AG, Hutchinson IV (2002) Association between functional polymorphism in EGF gene and malignant melanoma. Lancet 359(9304):397\u2013401. doi: 10.1016\/S0140-6736(02)07600-6","journal-title":"Lancet"},{"issue":"4","key":"1203_CR29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1620\/tjem.222.229","volume":"222","author":"DH Tan","year":"2010","unstructured":"Tan DH, Xu JC, Li Y, Lai RL (2010) Association between +61G polymorphism of the EGF gene and glioma risk in different ethnicities: a meta-analysis. Tohoku J Exp Med 222(4):229\u2013235. doi: 10.1620\/Tjem.222.229","journal-title":"Tohoku J Exp Med"},{"key":"1203_CR30","doi-asserted-by":"crossref","unstructured":"Teruszkin Balassiano I, Alves de Paulo S, Henriques Silva N, Curie Cabral M, Gibaldi D, Bozza M, Orlando da Fonseca C, Da Gloria da Costa Carvalho M (2002) Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. Int J Mol Med 10(6):785\u2013788","DOI":"10.3892\/ijmm.10.6.785"},{"issue":"1","key":"1203_CR31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cancergencyto.2006.07.013","volume":"172","author":"E Vauleon","year":"2007","unstructured":"Vauleon E, Auger N, Benouaich-Amiel A, Laigle-Donadey F, Kaloshi G, Lejeune J, Delattre JY, Thillet J, Sanson M (2007) The 61 A\/G EGF polymorphism is functional but is neither a prognostic marker nor a risk factor for glioblastoma. Cancer Genet Cytogenet 172(1):33\u201337. doi: 10.1016\/j.cancergencyto.2006.07.013","journal-title":"Cancer Genet Cytogenet"},{"issue":"2","key":"1203_CR32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10549-007-9784-4","volume":"111","author":"Y Wang","year":"2008","unstructured":"Wang Y, Tian T, Hu Z, Tang J, Wang S, Wang X, Qin J, Huo X, Gao J, Ke Q, Jin G, Ma H, Shen H (2008) EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women. Breast Cancer Res Treat 111(2):321\u2013327. doi: 10.1007\/s10549-007-9784-4","journal-title":"Breast Cancer Res Treat"},{"key":"1203_CR33","doi-asserted-by":"crossref","unstructured":"Wang SJ, Zhao Y, Ruan ZC, Chen HY, Fan WW, Chen JX, Wu QH, Qian J, Zhang TB, Huang Y, Lu DR (2010) Association between EGF+61G\/A and glioma risk in a Chinese population. Bmc Cancer 10. doi: 10.1186\/1471-2407-10-221","DOI":"10.1186\/1471-2407-10-221"},{"issue":"4","key":"1203_CR34","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s12032-009-9392-8","volume":"27","author":"W Xu","year":"2010","unstructured":"Xu W, Li Y, Wang XL, Chen B, Liu S, Wang Y, Zhao WH, Wu JQ (2010) Association between EGF promoter polymorphisms and cancer risk: a meta-analysis. Med Oncol 27(4):1389\u20131397. doi: 10.1007\/s12032-009-9392-8","journal-title":"Med Oncol"},{"issue":"2","key":"1203_CR35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.canep.2010.02.004","volume":"34","author":"YM Zhang","year":"2010","unstructured":"Zhang YM, Cao C, Liang K (2010) Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: a meta-analysis. Cancer Epidemiol 34(2):150\u2013156. doi: 10.1016\/j.canep.2010.02.004","journal-title":"Cancer Epidemiol"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-012-1203-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-012-1203-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-012-1203-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:40:37Z","timestamp":1559083237000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-012-1203-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,6]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["1203"],"URL":"https:\/\/doi.org\/10.1007\/s00432-012-1203-5","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,6]]}}}