{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:04:21Z","timestamp":1774710261386,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s00432-014-1588-4","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T01:41:49Z","timestamp":1390786909000},"page":"487-493","source":"Crossref","is-referenced-by-count":15,"title":["Does regular zoledronic acid change the bone turnover of the jaw in men with metastatic prostate cancer: A possible clue to the pathogenesis of bisphosphonate related osteonecrosis of the jaw?"],"prefix":"10.1007","volume":"140","author":[{"given":"Oliver","family":"Ristow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Gerngro\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Schwaiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Hohlweg-Majert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Ristow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Koerdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roswitha","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Pautke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"issue":"2","key":"1588_CR1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jcms.2007.06.008","volume":"36","author":"MH Abu-Id","year":"2008","unstructured":"Abu-Id MH, Warnke PH, Gottschalk J, Springer I, Wiltfang J, Acil Y, Russo PA, Kreusch T (2008) \u201cBis-phossy jaws\u201d\u2014high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg 36(2):95\u2013103. doi: 10.1016\/j.jcms.2007.06.008","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"1588_CR2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0001-2998(97)80049-9","volume":"27","author":"L Ackerman","year":"1997","unstructured":"Ackerman L, Shirazi P (1997) Abnormal skull uptake on bone scan. Semin Nucl Med 27(2):190\u2013193","journal-title":"Semin Nucl Med"},{"issue":"5","key":"1588_CR3","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joms.2009.10.010","volume":"68","author":"TL Aghaloo","year":"2010","unstructured":"Aghaloo TL, Felsenfeld AL, Tetradis S (2010) Osteonecrosis of the jaw in a patient on Denosumab. J Oral Maxillofac Surg 68(5):959\u2013963. doi: 10.1016\/j.joms.2009.10.010","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"1588_CR4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/annonc\/mdl408","volume":"18","author":"D Aguiar Bujanda","year":"2007","unstructured":"Aguiar Bujanda D, Bohn Sarmiento U, Cabrera Suarez MA, Aguiar Morales J (2007) Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis. Ann Oncol 18(3):556\u2013560. doi: 10.1093\/annonc\/mdl408","journal-title":"Ann Oncol"},{"issue":"5 Suppl","key":"1588_CR5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","volume":"67","author":"MR Allen","year":"2009","unstructured":"Allen MR, Burr DB (2009) The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data. J Oral Maxillofac Surg 67(5 Suppl):61\u201370. doi: 10.1016\/j.joms.2009.01.007","journal-title":"J Oral Maxillofac Surg"},{"issue":"34","key":"1588_CR6","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","volume":"23","author":"A Bamias","year":"2005","unstructured":"Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, Koutsoukou V, Gika D, Anagnostopoulos A, Papadimitriou C, Terpos E, Dimopoulos MA (2005) Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol 23(34):8580\u20138587. doi: 10.1200\/JCO.2005.02.8670","journal-title":"J Clin Oncol"},{"issue":"4","key":"1588_CR7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s00774-007-0837-x","volume":"26","author":"F Bauss","year":"2008","unstructured":"Bauss F, Pfister T, Papapoulos S (2008) Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner Metab 26(4):406\u2013408. doi: 10.1007\/s00774-007-0837-x","journal-title":"J Bone Miner Metab"},{"issue":"6937","key":"1588_CR8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423(6937):337\u2013342. doi: 10.1038\/nature01658","journal-title":"Nature"},{"issue":"5","key":"1588_CR9","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1053\/hp.2000.6698","volume":"31","author":"L Bubendorf","year":"2000","unstructured":"Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, Gasser TC, Mihatsch MJ (2000) Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients. Hum Pathol 31(5):578\u2013583","journal-title":"Hum Pathol"},{"key":"1588_CR10","volume-title":"Bridging the gap between dental and orthopaedic implants","author":"LP Garetto","year":"1998","unstructured":"Garetto LP, Tricker ND (1998) Remodeling of bone surrounding the implant interface. In: Garetto LP, Turner CH, Duncan RL, Burr DB (eds) Bridging the gap between dental and orthopaedic implants. Indianapolis, IN"},{"issue":"4","key":"1588_CR11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1359\/jbmr.1997.12.4.498","volume":"12","author":"ZH Han","year":"1997","unstructured":"Han ZH, Palnitkar S, Rao DS, Nelson D, Parfitt AM (1997) Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Min Res 12(4):498\u2013508. doi: 10.1359\/jbmr.1997.12.4.498","journal-title":"J Bone Min Res"},{"key":"1588_CR12","author":"PJ Hansen","year":"2012","unstructured":"Hansen PJ, Knitschke M, Draenert FG, Irle S, Neff A (2012) Incidence of bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients taking bisphosphonates for osteoporosis treatment-a grossly underestimated risk? Clin Oral Invest. doi: 10.1007\/s00784-012-0873-3","journal-title":"Clin Oral Invest"},{"issue":"1","key":"1588_CR13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.eururo.2007.09.002","volume":"53","author":"A Heidenreich","year":"2008","unstructured":"Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP, Zattoni F (2008) EAU guidelines on prostate cancer. Eur Urol 53(1):68\u201380. doi: 10.1016\/j.eururo.2007.09.002","journal-title":"Eur Urol"},{"issue":"6","key":"1588_CR14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1359\/jbmr.080205","volume":"23","author":"AO Hoff","year":"2008","unstructured":"Hoff AO, Toth BB, Altundag K, Johnson MM, Warneke CL, Hu M, Nooka A, Sayegh G, Guarneri V, Desrouleaux K, Cui J, Adamus A, Gagel RF, Hortobagyi GN (2008) Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Mineral Res 23(6):826\u2013836. doi: 10.1359\/jbmr.080205","journal-title":"J Bone Mineral Res"},{"issue":"12","key":"1588_CR15","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ar.a.20396","volume":"288","author":"SS Huja","year":"2006","unstructured":"Huja SS, Fernandez SA, Hill KJ, Li Y (2006) Remodeling dynamics in the alveolar process in skeletally mature dogs. Anat Rec A Discov Mol Cell Evol Biol 288(12):1243\u20131249. doi: 10.1002\/ar.a.20396","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"issue":"5","key":"1588_CR16","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.eururo.2007.02.033","volume":"52","author":"M Lein","year":"2007","unstructured":"Lein M, Wirth M, Miller K, Eickenberg HU, Weissbach L, Schmidt K, Haus U, Stephan C, Meissner S, Loening SA, Jung K (2007) Serial markers of bone turnover in men with metastatic prostate cancer treated with zoledronic Acid for detection of bone metastases progression. Eur Urol 52(5):1381\u20131387. doi: 10.1016\/j.eururo.2007.02.033","journal-title":"Eur Urol"},{"issue":"9","key":"1588_CR17","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61(9):1115\u20131117","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"1588_CR18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3816\/CBC.2010.n.004","volume":"10","author":"PG Morris","year":"2010","unstructured":"Morris PG, Poznak CV, Modi S, Mak AF, Patil S, Larson S, Hudis CA, Divgi C, Grewal RK (2010) Intravenous bisphosphonate therapy does not acutely alter nuclear bone scan results. Clin Breast Cancer 10(1):33\u201339. doi: 10.3816\/CBC.2010.n.004","journal-title":"Clin Breast Cancer"},{"issue":"3","key":"1588_CR19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.joms.2008.09.028","volume":"67","author":"S Otto","year":"2009","unstructured":"Otto S, Hafner S, Grotz KA (2009) The role of inferior alveolar nerve involvement in bisphosphonate-related osteonecrosis of the jaw. J Oral Maxillofac Surg 67(3):589\u2013592. doi: 10.1016\/j.joms.2008.09.028","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"1588_CR20","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.joms.2009.07.079","volume":"68","author":"S Otto","year":"2010","unstructured":"Otto S, Hafner S, Mast G, Tischer T, Volkmer E, Schieker M, Sturzenbaum SR, von Tresckow E, Kolk A, Ehrenfeld M, Pautke C (2010) Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle? J Oral Maxillofac Surg 68(5):1158\u20131161. doi: 10.1016\/j.joms.2009.07.079","journal-title":"J Oral Maxillofac Surg"},{"issue":"4","key":"1588_CR21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcms.2011.05.003","volume":"40","author":"S Otto","year":"2012","unstructured":"Otto S, Schreyer C, Hafner S, Mast G, Ehrenfeld M, Sturzenbaum S, Pautke C (2012) Bisphosphonate-related osteonecrosis of the jaws\u2014characteristics, risk factors, clinical features, localization and impact on oncological treatment. J Craniomaxillofac Surg 40(4):303\u2013309. doi: 10.1016\/j.jcms.2011.05.003","journal-title":"J Craniomaxillofac Surg"},{"issue":"1","key":"1588_CR22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","volume":"44","author":"IR Reid","year":"2009","unstructured":"Reid IR (2009) Osteonecrosis of the jaw: who gets it, and why? Bone 44(1):4\u201310. doi: 10.1016\/j.bone.2008.09.012","journal-title":"Bone"},{"issue":"3","key":"1588_CR23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bone.2007.04.196","volume":"41","author":"IR Reid","year":"2007","unstructured":"Reid IR, Bolland MJ, Grey AB (2007) Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 41(3):318\u2013320. doi: 10.1016\/j.bone.2007.04.196","journal-title":"Bone"},{"key":"1588_CR24","doi-asserted-by":"crossref","unstructured":"Ristow O, Gerngro\u00df C, Schwaiger M, Hohlweg-Majert B, Kehl V, Jansen H, Hahnefeld L, Otto S, Pautke C (2013) Is the bone turnover of the jawbone and its possible oversuppression by bisphosphonates of etiological importance for the pathogenesis of the bisphosphonate-related osteonecrosis? J Oral Maxillofac Surg. doi: 10.1016\/j.joms.2013.11.005","DOI":"10.1016\/j.joms.2013.11.005"},{"issue":"12 Pt 1","key":"1588_CR25","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1158\/1535-7163.MCT-07-0311","volume":"6","author":"C Scavelli","year":"2007","unstructured":"Scavelli C, Di Pietro G, Cirulli T, Coluccia M, Boccarelli A, Giannini T, Mangialardi G, Bertieri R, Coluccia AM, Ribatti D, Dammacco F, Vacca A (2007) Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma. Mol Cancer Ther 6(12 Pt 1):3256\u20133262. doi: 10.1158\/1535-7163.MCT-07-0311","journal-title":"Mol Cancer Ther"},{"issue":"11","key":"1588_CR26","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1159\/000343950","volume":"35","author":"C Then","year":"2012","unstructured":"Then C, Horauf N, Otto S, Pautke C, von Tresckow E, Rohnisch T, Baumann P, Schmidmaier R, Bumeder I, Oduncu FS (2012) Incidence and risk factors of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients having undergone autologous stem cell transplantation. Onkologie 35(11):658\u2013664. doi: 10.1159\/000343950","journal-title":"Onkologie"},{"issue":"3","key":"1588_CR27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.oraloncology.2010.01.001","volume":"46","author":"T Wyngaert Van den","year":"2010","unstructured":"Van den Wyngaert T, Huizing MT, Fossion E, Vermorken JB (2010) Scintigraphic evaluation of mandibular bone turnover in patients with solid tumors receiving zoledronic acid. Oral Oncol 46(3):214\u2013218. doi: 10.1016\/j.oraloncology.2010.01.001","journal-title":"Oral Oncol"},{"issue":"5","key":"1588_CR28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.eururo.2008.06.070","volume":"54","author":"C Walter","year":"2008","unstructured":"Walter C, Al-Nawas B, Grotz KA, Thomas C, Thuroff JW, Zinser V, Gamm H, Beck J, Wagner W (2008) Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate. Eur Urol 54(5):1066\u20131072. doi: 10.1016\/j.eururo.2008.06.070","journal-title":"Eur Urol"},{"issue":"1","key":"1588_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00784-009-0266-4","volume":"14","author":"C Walter","year":"2010","unstructured":"Walter C, Klein MO, Pabst A, Al-Nawas B, Duschner H, Ziebart T (2010) Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells. Clin Oral Invest 14(1):35\u201341. doi: 10.1007\/s00784-009-0266-4","journal-title":"Clin Oral Invest"},{"issue":"9","key":"1588_CR30","first-page":"1165","volume":"91","author":"AM Wolf","year":"2006","unstructured":"Wolf AM, Rumpold H, Tilg H, Gastl G, Gunsilius E, Wolf D (2006) The effect of zoledronic acid on the function and differentiation of myeloid cells. Haematologica 91(9):1165\u20131171","journal-title":"Haematologica"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-014-1588-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-014-1588-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-014-1588-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:40:45Z","timestamp":1559068845000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-014-1588-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["1588"],"URL":"https:\/\/doi.org\/10.1007\/s00432-014-1588-4","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]}}}