{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:41:17Z","timestamp":1792597277321,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T00:00:00Z","timestamp":1423008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00432-015-1930-5","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T22:49:16Z","timestamp":1422917356000},"page":"1593-1601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["DNA methylation analysis of benign and atypical meningiomas: correlation between RUNX3 methylation and WHO grade"],"prefix":"10.1007","volume":"141","author":[{"given":"Aleksandra","family":"Majchrzak-Celi\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Paluszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlena","family":"Szalata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Barciszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Baer-Dubowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,4]]},"reference":[{"key":"1930_CR1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/modpathol.3800111","volume":"17","author":"VJ Amatya","year":"2004","unstructured":"Amatya VJ, Takeshima Y, Inai K (2004) Methylation of p14(ARF) gene in meningiomas and its correlation to the p53 expression and mutation. Mod Pathol 17:705\u2013710","journal-title":"Mod Pathol"},{"key":"1930_CR2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11845-013-1001-3","volume":"183","author":"CB Avci","year":"2014","unstructured":"Avci CB, Dodurga Y, Susluer SY, S\u0131gva ZO, Yucebas M, Caglar HO, Akalin T, Dalbasti T, Oktar N, Gunduz C (2014) Promoter hypermethylation-mediated down-regulation of RUNX3 gene in human brain tumors. Ir J Med Sci 183:259\u2013264","journal-title":"Ir J Med Sci"},{"key":"1930_CR3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1089\/gtmb.2011.0245","volume":"16","author":"F Aydemir","year":"2012","unstructured":"Aydemir F, Yurtcu E, Balci TB, Sahin FI, Gulsen S, Altinors N (2012) Identification of promoter region methylation patterns of MGMT, CDKN2A, GSTP1, and THBS1 genes in intracranial meningioma patients. Genet Test Mol Biomarkers 16:335\u2013340","journal-title":"Genet Test Mol Biomarkers"},{"key":"1930_CR4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1750-3639.2009.00340.x","volume":"20","author":"D Barski","year":"2010","unstructured":"Barski D, Wolter M, Reifenberger G, Riemenschneider MJ (2010) Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas. Brain Pathol 20:623\u2013631","journal-title":"Brain Pathol"},{"key":"1930_CR5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrc1607","volume":"5","author":"K Blyth","year":"2005","unstructured":"Blyth K, Cameron ER, Neil JC (2005) The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 5:376\u2013387","journal-title":"Nat Rev Cancer"},{"key":"1930_CR6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0002-9440(10)61737-3","volume":"159","author":"J Bostr\u00f6m","year":"2001","unstructured":"Bostr\u00f6m J, Meyer-Puttlitz B, Wolter M, Blaschke B, Weber RG, Lichter P, Ichimura K, Collins VP, Reifenberger G (2001) Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Am J Pathol 159:661\u2013669","journal-title":"Am J Pathol"},{"key":"1930_CR7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3171\/2011.3.JNS101748","volume":"115","author":"KS Cahill","year":"2011","unstructured":"Cahill KS, Claus EB (2011) Treatment and survival of patients with nonmalignant intracranial meningioma: results from the surveillance, epidemiology, and end results program of the National Cancer Institute. Clinical article. J Neurosurg 115:259\u2013267","journal-title":"J Neurosurg"},{"key":"1930_CR8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10571-011-9753-7","volume":"32","author":"G Cecener","year":"2012","unstructured":"Cecener G, Tunca B, Egeli U, Bekar A, Tezcan G, Erturk E, Bayram N, Tolunay S (2012) The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma. Cell Mol Neurobiol 32:237\u2013244","journal-title":"Cell Mol Neurobiol"},{"key":"1930_CR9","author":"PC Chen","year":"2011","unstructured":"Chen PC, Tsai MH, Yip SK, Jou YC, Ng CF, Chen Y, Wang X, Huang W, Tung CL, Chen GC, Huang MM, Tong JH, Song EJ, Chang DC, Hsu CD, To KF, Shen CH, Chan MW (2011) Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine. BMC Med Genomics. doi: 10.1186\/1755-8794-4-45","journal-title":"BMC Med Genomics"},{"key":"1930_CR10","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/ijc.27964","volume":"132","author":"LS Chuang","year":"2013","unstructured":"Chuang LS, Ito K, Ito Y (2013) RUNX family: regulation and diversification of roles through interacting proteins. Int J Cancer 132:1260\u20131271","journal-title":"Int J Cancer"},{"key":"1930_CR11","author":"TA Dolecek","year":"2012","unstructured":"Dolecek TA, Propp JM, Stroup NE, Kruchko C (2012) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005\u20132009. Neuro Oncol. doi: 10.1093\/neuonc\/nos218","journal-title":"Neuro Oncol"},{"key":"1930_CR12","author":"XY Fan","year":"2011","unstructured":"Fan XY, Hu XL, Han TM, Wang NN, Zhu YM, Hu W, Ma ZH, Zhang CJ, Xu X, Ye ZY, Han CM, Pan WS (2011) Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis. BMC Gastroenterol. doi: 10.1186\/1471-230X-11-92","journal-title":"BMC Gastroenterol"},{"key":"1930_CR13","author":"F Gao","year":"2013","unstructured":"Gao F, Shi L, Russin J, Zeng L, Chang X, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Mack WJ, Wang K (2013) DNA methylation in the malignant transformation of meningiomas. PLoS One. doi: 10.1371\/journal.pone.0054114","journal-title":"PLoS One"},{"key":"1930_CR14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1479-5876-10-36","volume":"10","author":"AB H\u00e5vik","year":"2012","unstructured":"H\u00e5vik AB, Brandal P, Honne H, Dahlback HS, Scheie D, Hektoen M, Meling TR, Helseth E, Heim S, Lothe RA, Lind GE (2012) MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR. J Transl Med 10:36","journal-title":"J Transl Med"},{"key":"1930_CR15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/carcin\/bgr260","volume":"33","author":"Y Kishida","year":"2012","unstructured":"Kishida Y, Natsume A, Kondo Y, Takeuchi I, An B, Okamoto Y, Shinjo K, Saito K, Ando H, Ohka F, Sekido Y, Wakabayashi T (2012) Epigenetic subclassification of meningiomas based on genome-wide DNA methylation analyses. Carcinogenesis 33:436\u2013441","journal-title":"Carcinogenesis"},{"key":"1930_CR16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF01366952","volume":"122","author":"AG Knudson","year":"1996","unstructured":"Knudson AG (1996) Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 122:135\u2013140","journal-title":"J Cancer Res Clin Oncol"},{"key":"1930_CR17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jnen\/63.4.275","volume":"63","author":"K Lamszus","year":"2004","unstructured":"Lamszus K (2004) Meningioma pathology, genetics, and biology. J Neuropathol Exp Neurol 63:275\u2013286","journal-title":"J Neuropathol Exp Neurol"},{"key":"1930_CR18","author":"S Linsler","year":"2014","unstructured":"Linsler S, Kraemer D, Driess C, Oertel J, Kammers K, Rahnenf\u00fchrer J, Ketter R, Urbschat S (2014) Molecular biological determinations of meningioma progression and recurrence. PLoS One. doi: 10.1371\/journal.pone.0094987","journal-title":"PLoS One"},{"key":"1930_CR19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.humpath.2005.02.006","volume":"36","author":"Y Liu","year":"2005","unstructured":"Liu Y, Pang JC, Dong S, Mao B, Poon WS, Ng HK (2005) Aberrant CpG island hypermethylation profile is associated with atypical and anaplastic meningiomas. Hum Pathol 36:416\u2013425","journal-title":"Hum Pathol"},{"key":"1930_CR20","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1158\/0008-5472.CAN-05-0043","volume":"65","author":"EA Lusis","year":"2005","unstructured":"Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A (2005) Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res 65:7121\u20137126","journal-title":"Cancer Res"},{"key":"1930_CR21","author":"A Majchrzak-Celi\u0144ska","year":"2015","unstructured":"Majchrzak-Celi\u0144ska A, Paluszczak J, Szalata M, Barciszewska AM, Nowak S, Kleszcz R, Sherba A, Baer-Dubowska W (2015) The methylation of a panel of genes differentiates low-grade from high-grade gliomas. Tumour Biol. doi: 10.1007\/s13277-014-3025-3","journal-title":"Tumour Biol"},{"key":"1930_CR22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4161\/epi.9130","volume":"4","author":"R Martinez","year":"2009","unstructured":"Martinez R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S, Schackert G, Esteller M (2009) A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics 4:255\u2013264","journal-title":"Epigenetics"},{"key":"1930_CR23","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3171\/JNS-07\/08\/0398","volume":"107","author":"Y Nakane","year":"2007","unstructured":"Nakane Y, Natsume A, Wakabayashi T, Oi S, Ito M, Inao S, Saito K, Yoshida J (2007) Malignant transformation-related genes in meningiomas: allelic loss on 1p36 and methylation status of p73 and RASSF1A. J Neurosurg 107:398\u2013404","journal-title":"J Neurosurg"},{"key":"1930_CR24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF03194647","volume":"47","author":"J Paluszczak","year":"2006","unstructured":"Paluszczak J, Baer-Dubowska W (2006) Epigenetic diagnostics of cancer\u2014the application of DNA methylation markers. J Appl Genet 47:365\u2013375","journal-title":"J Appl Genet"},{"key":"1930_CR25","author":"A Piepoli","year":"2009","unstructured":"Piepoli A, Cotugno R, Merla G, Gentile A, Augello B, Quitadamo M, Merla A, Panza A, Carella M, Maglietta R, D\u2019Addabbo A, Ancona N, Fusilli S, Perri F, Andriulli A (2009) Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour. BMC Med Genomics. doi: 10.1186\/1755-8794-2-11","journal-title":"BMC Med Genomics"},{"key":"1930_CR26","first-page":"114","volume":"1796","author":"AM Richter","year":"2009","unstructured":"Richter AM, Pfeifer GP, Dammann RH (2009) The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta 1796:114\u2013128","journal-title":"Biochim Biophys Acta"},{"key":"1930_CR27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11060-010-0291-9","volume":"102","author":"D Skiriute","year":"2011","unstructured":"Skiriute D, Tamasauskas S, Asmoniene V, Saferis V, Skauminas K, Deltuva V, Tamasauskas A (2011) Tumor grade-related NDRG2 gene expression in primary and recurrent intracranial meningiomas. J Neurooncol 102:89\u201394. doi: 10.1007\/s11060-010-0291-9","journal-title":"J Neurooncol"},{"key":"1930_CR28","author":"D Skiriute","year":"2012","unstructured":"Skiriute D, Vaitkiene P, Saferis V, Asmoniene V, Skauminas K, Deltuva VP, Tamasauskas A (2012) MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma. BMC Cancer. doi: 10.1186\/1471-2407-12-218","journal-title":"BMC Cancer"},{"key":"1930_CR29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3171\/2013.7.JNS13311","volume":"119","author":"J Vengoechea","year":"2013","unstructured":"Vengoechea J, Sloan AE, Chen Y, Guan X, Ostrom QT, Kerstetter A, Capella D, Cohen ML, Wolinsky Y, Devine K, Selman W, Barnett GH, Warnick RE, McPherson C, Chiocca EA, Elder JB, Barnholtz-Sloan JS (2013) Methylation markers of malignant potential in meningiomas. J Neurosurg 119:899\u2013906","journal-title":"J Neurosurg"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-015-1930-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-015-1930-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-015-1930-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T14:15:26Z","timestamp":1551190526000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-015-1930-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,4]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["1930"],"URL":"https:\/\/doi.org\/10.1007\/s00432-015-1930-5","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,4]]}}}