{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:12:44Z","timestamp":1775819564880,"version":"3.50.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00432-016-2319-9","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T05:18:35Z","timestamp":1482556715000},"page":"913-931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Values of molecular markers in the differential diagnosis of thyroid abnormalities"],"prefix":"10.1007","volume":"143","author":[{"given":"T. M. P. B.","family":"Tennakoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rushdhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D. C. U.","family":"Ranasinghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Dassanayake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"2319_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.mgene.2014.05.004","volume":"2","author":"S Ahlawat","year":"2014","unstructured":"Ahlawat S, Sharma R, Maitra A et al (2014) Designing, optimization and validation of tetra-primer ARMS PCR protocol for genotyping mutations in caprine Fec genes. Meta Gene 2:439\u2013449. doi: 10.1016\/j.mgene.2014.05.004","journal-title":"Meta Gene"},{"key":"2319_CR2","volume-title":"Hashimoto\u2019s thyroiditis","author":"T Akamizu","year":"2013","unstructured":"Akamizu T, Amino N, DeGroot LJ (2013) Hashimoto\u2019s thyroiditis. MDText.com Inc, South Dartmouth"},{"key":"2319_CR3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1159\/000363377","volume":"7","author":"SM Ali","year":"2014","unstructured":"Ali SM, He J, Carson W et al (2014) Extended antitumor response of a BRAF V600E papillary thyroid carcinoma to vemurafenib. Case Rep Oncol 7:343\u2013348. doi: 10.1159\/000363377","journal-title":"Case Rep Oncol"},{"key":"2319_CR4","volume-title":"Surgical Treatment: Evidence-Based and Problem-Oriented","author":"S Al-Sobhi","year":"2001","unstructured":"Al-Sobhi S, Clark O (2001) Thyroid carcinosarcoma and undifferentiated thyroid carcinoma. In: Holzheimer RG, Mannick JA (eds) Surgical Treatment: Evidence-Based and Problem-Oriented. Zuckschwerdt, Munich"},{"key":"2319_CR5","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1182\/blood-2011-08-368209","volume":"119","author":"L Arcaini","year":"2012","unstructured":"Arcaini L, Zibellini S, Boveri E et al (2012) The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms. Blood 119:188\u2013191. doi: 10.1182\/blood-2011-08-368209","journal-title":"Blood"},{"key":"2319_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1046\/j.1365-2559.2002.01467.x","volume":"41","author":"S Arif","year":"2002","unstructured":"Arif S, Blanes A, Diaz-Cano SJ (2002) Hashimoto\u2019s thyroiditis shares features with early papillary thyroid carcinoma. Histopathology 41:357\u2013362. doi: 10.1046\/j.1365-2559.2002.01467.x","journal-title":"Histopathology"},{"key":"2319_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-016-0976-y","author":"A Ashida","year":"2016","unstructured":"Ashida A, Sakaizawa K, Mikoshiba A et al (2016) Quantitative analysis of the BRAF V600E mutation in circulating tumor-derived DNA in melanoma patients using competitive allele-specific TaqMan PCR. Int J Clin Oncol. doi: 10.1007\/s10147-016-0976-y","journal-title":"Int J Clin Oncol"},{"key":"2319_CR8","doi-asserted-by":"publisher","first-page":"289834","DOI":"10.1155\/2014\/289834","volume":"2014","author":"J-S Bae","year":"2014","unstructured":"Bae J-S, Choi SK, Jeon S et al (2014) Impact of NRAS mutations on the diagnosis of follicular neoplasm of the thyroid. Int J Endocrinol 2014:289834. doi: 10.1155\/2014\/289834","journal-title":"Int J Endocrinol"},{"key":"2319_CR9","doi-asserted-by":"publisher","first-page":"18592","DOI":"10.1038\/srep18592","volume":"5","author":"R Barbano","year":"2015","unstructured":"Barbano R, Pasculli B, Coco M et al (2015) Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients. Sci Rep 5:18592. doi: 10.1038\/srep18592","journal-title":"Sci Rep"},{"key":"2319_CR10","doi-asserted-by":"publisher","first-page":"S127","DOI":"10.1016\/S0959-8049(16)61452-1","volume":"61","author":"R Barbano","year":"2016","unstructured":"Barbano R, Pasculli B, Coco M et al (2016) Evaluation of pre-analytical procedures for the detection of BRAF V600 mutations in melanoma patients: comparison between Sanger sequencing and Competitive allele-specific TaqMan PCR (Cast-PCR). Eur J Cancer 61:S127\u2013S128. doi: 10.1016\/S0959-8049(16)61452-1","journal-title":"Eur J Cancer"},{"key":"2319_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4137\/BIC.S25248","volume":"7","author":"D Barras","year":"2015","unstructured":"Barras D (2015) BRAF mutation in colorectal cancer: an update. Biomark Cancer 7:9\u201312. doi: 10.4137\/BIC.S25248","journal-title":"Biomark Cancer"},{"key":"2319_CR12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.2353\/jmoldx.2006.060070","volume":"8","author":"S Benlloch","year":"2006","unstructured":"Benlloch S, Pay\u00e1 A, Alenda C et al (2006) Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. J Mol Diagn 8:540\u2013543. doi: 10.2353\/jmoldx.2006.060070","journal-title":"J Mol Diagn"},{"key":"2319_CR13","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.ejso.2012.06.045","volume":"38","author":"B Brahma","year":"2012","unstructured":"Brahma B, Yulian ED, Ramli M et al (2012) 44. Surgical perspective of T1799a BRAF mutation diagnostic value in papillary thyroid carcinoma. Eur J Surg Oncol 38:745. doi: 10.1016\/j.ejso.2012.06.045","journal-title":"Eur J Surg Oncol"},{"key":"2319_CR14","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1158\/1535-7163.MCT-10-0799","volume":"10","author":"ER Cantwell-Dorris","year":"2011","unstructured":"Cantwell-Dorris ER, O\u2019Leary JJ, Sheils OM (2011) BRAFV600E: implications for carcinogenesis and molecular therapy. Mol Cancer Ther 10:385\u2013394. doi: 10.1158\/1535-7163.MCT-10-0799","journal-title":"Mol Cancer Ther"},{"issue":"Suppl 4","key":"2319_CR15","doi-asserted-by":"publisher","first-page":"S619","DOI":"10.1245\/s10434-014-3723-5","volume":"21","author":"S-P Cheng","year":"2014","unstructured":"Cheng S-P, Hsu Y-C, Liu C-L et al (2014) Significance of allelic percentage of BRAF c.1799T>A (V600E) mutation in papillary thyroid carcinoma. Ann Surg Oncol 21(Suppl 4):S619\u2013S626. doi: 10.1245\/s10434-014-3723-5","journal-title":"Ann Surg Oncol"},{"key":"2319_CR16","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/modpathol.3880312","volume":"14","author":"CC Cheung","year":"2001","unstructured":"Cheung CC, Ezzat S, Freeman JL et al (2001) Immunohistochemical diagnosis of papillary thyroid carcinoma. Mod Pathol 14:338\u2013342. doi: 10.1038\/modpathol.3880312","journal-title":"Mod Pathol"},{"key":"2319_CR17","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1365-2265.2006.02646.x","volume":"65","author":"K Chung","year":"2006","unstructured":"Chung K, Yang SK, Lee GK et al (2006) Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-prevalent area. Clin Endocrinol 65:660\u2013666. doi: 10.1111\/j.1365-2265.2006.02646.x","journal-title":"Clin Endocrinol"},{"key":"2319_CR18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1530\/EJE-14-0930","volume":"172","author":"C Colato","year":"2015","unstructured":"Colato C, Vicentini C, Cantara S et al (2015) Break-apart interphase fluorescence in situ hybridization assay in papillary thyroid carcinoma: on the road to optimizing the cut-off level for RET\/PTC rearrangements. Eur J Endocrinol 172:571\u2013582. doi: 10.1530\/EJE-14-0930","journal-title":"Eur J Endocrinol"},{"key":"2319_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1001\/archsurg.1955.01270080137023","volume":"70","author":"ME Dailey","year":"1955","unstructured":"Dailey ME, Lindsay S, Skahen R (1955) Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland. AMA Arch Surg 70:291\u2013297. doi: 10.1001\/archsurg.1955.01270080137023","journal-title":"AMA Arch Surg"},{"key":"2319_CR20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.yexmp.2012.03.001","volume":"92","author":"A Didelot","year":"2012","unstructured":"Didelot A, Le Corre D, Luscan A et al (2012) Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples. Exp Mol Pathol 92:275\u2013280. doi: 10.1016\/j.yexmp.2012.03.001","journal-title":"Exp Mol Pathol"},{"key":"2319_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1756-0500-4-263","volume":"4","author":"AC Eischeid","year":"2011","unstructured":"Eischeid AC (2011) SYTO dyes and EvaGreen outperform SYBR Green in real-time PCR. BMC Res Notes 4:263. doi: 10.1186\/1756-0500-4-263","journal-title":"BMC Res Notes"},{"key":"2319_CR22","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1210\/jcem.86.7.7678","volume":"86","author":"R Elisei","year":"2001","unstructured":"Elisei R, Romei C, Vorontsova T et al (2001) RET\/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86:3211\u20133216. doi: 10.1210\/jcem.86.7.7678","journal-title":"J Clin Endocrinol Metab"},{"key":"2319_CR23","first-page":"259","volume":"116","author":"JA Fagin","year":"2005","unstructured":"Fagin JA (2005) Genetics of papillary thyroid cancer initiation: implications for therapy. Trans Am Clin Climatol Assoc 116:259\u2013269 (discussion 269\u2013271)","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2319_CR24","doi-asserted-by":"crossref","first-page":"622","DOI":"10.5858\/2008-132-622-TTGRPI","volume":"132","author":"WC Faquin","year":"2008","unstructured":"Faquin WC (2008) Recurring problems in histologic and cytologic evaluation. Arch Pathol Lab Med 132:622\u2013632","journal-title":"Arch Pathol Lab Med"},{"key":"2319_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1177\/1947601911411084","volume":"2","author":"A Fern\u00e1ndez-Medarde","year":"2011","unstructured":"Fern\u00e1ndez-Medarde A, Santos E (2011) Ras in cancer and developmental diseases. Genes Cancer 2:344\u2013358. doi: 10.1177\/1947601911411084","journal-title":"Genes Cancer"},{"key":"2319_CR26","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/S0002-9440(10)65731-8","volume":"153","author":"AH Fischer","year":"1998","unstructured":"Fischer AH, Bond JA, Taysavang P et al (1998) Papillary thyroid carcinoma oncogene (RET\/PTC) alters the nuclear envelope and chromatin structure. Am J Pathol 153:1443\u20131450. doi: 10.1016\/S0002-9440(10)65731-8","journal-title":"Am J Pathol"},{"key":"2319_CR27","doi-asserted-by":"publisher","first-page":"597","DOI":"10.2174\/138920211798120826","volume":"12","author":"JM G\u00f3mez S\u00e1ez","year":"2011","unstructured":"G\u00f3mez S\u00e1ez JM (2011) Diagnostic and prognostic markers in differentiated thyroid cancer. Curr Genom 12:597\u2013608. doi: 10.2174\/138920211798120826","journal-title":"Curr Genom"},{"key":"2319_CR28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1634\/theoncologist.4-3-263","volume":"4","author":"DS Goodsell","year":"1999","unstructured":"Goodsell DS (1999) The molecular perspective: the ras oncogene. Oncologist 4:263\u2013264","journal-title":"Oncologist"},{"key":"2319_CR29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1530\/eje-11-0499","volume":"165","author":"A Guerra","year":"2011","unstructured":"Guerra A, Marotta V, Sapio MR, Vitale M (2011a) RET\/PTC rearrangement in benign and malignant thyroid diseases: a clinical standpoint. Eur J Endocrinol 165:499\u2013507. doi: 10.1530\/eje-11-0499","journal-title":"Eur J Endocrinol"},{"key":"2319_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1507\/endocrj.K10E-260","volume":"58","author":"A Guerra","year":"2011","unstructured":"Guerra A, Sapio MR, Marotta V et al (2011b) Prevalence of RET\/PTC rearrangement in benign and malignant thyroid nodules and its clinical application. Endocr J 58:31\u201338. doi: 10.1507\/endocrj.K10E-260","journal-title":"Endocr J"},{"key":"2319_CR31","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1634\/theoncologist.2013-0072","volume":"18","author":"GM Howell","year":"2013","unstructured":"Howell GM, Hodak SP, Yip L (2013) RAS mutations in thyroid cancer. Oncologist 18:926\u2013932. doi: 10.1634\/theoncologist.2013-0072","journal-title":"Oncologist"},{"key":"2319_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2050-7771-1-3","volume":"1","author":"T Huang","year":"2013","unstructured":"Huang T, Zhuge J, Zhang WW (2013) Sensitive detection of BRAF V600E mutation by amplification refractory mutation system (ARMS)-PCR. Biomark Res 1:3. doi: 10.1186\/2050-7771-1-3","journal-title":"Biomark Res"},{"key":"2319_CR33","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1089\/thy.2013.0302","volume":"24","author":"MI Ilie","year":"2014","unstructured":"Ilie MI, Lassalle S, Long-Mira E et al (2014) Diagnostic value of immunohistochemistry for the detection of the BRAF(V600E) mutation in papillary thyroid carcinoma: comparative analysis with three DNA-based assays. Thyroid 24:858\u2013866. doi: 10.1089\/thy.2013.0302","journal-title":"Thyroid"},{"key":"2319_CR34","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1210\/jc.2012-2978","volume":"98","author":"B Jankovic","year":"2013","unstructured":"Jankovic B, Le KT, Hershman JM (2013) Clinical Review: Hashimoto\u2019s thyroiditis and papillary thyroid carcinoma: is there a correlation? J Clin Endocrinol Metab 98:474\u2013482. doi: 10.1210\/jc.2012-2978","journal-title":"J Clin Endocrinol Metab"},{"key":"2319_CR35","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/SLA.0b013e318148563d","volume":"246","author":"E Kebebew","year":"2007","unstructured":"Kebebew E, Weng J, Bauer J et al (2007) The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg 246:466\u2013470. doi: 10.1097\/SLA.0b013e318148563d (discussion 470\u2013471)","journal-title":"Ann Surg"},{"key":"2319_CR36","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/cr.2012.27","volume":"22","author":"F Li","year":"2012","unstructured":"Li F, Feng Y, Fang R et al (2012a) Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res 22:928\u2013931. doi: 10.1038\/cr.2012.27","journal-title":"Cell Res"},{"key":"2319_CR37","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/modpathol.2012.68","volume":"25","author":"Y Li","year":"2012","unstructured":"Li Y, Zhou G, Ozaki T et al (2012b) Distinct histopathological features of Hashimoto\u2019s thyroiditis with respect to IgG4-related disease. Mod Pathol 25:1086\u20131097. doi: 10.1038\/modpathol.2012.68","journal-title":"Mod Pathol"},{"key":"2319_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5858\/arpa.2014-0056-RA","volume":"139","author":"H Liu","year":"2015","unstructured":"Liu H, Lin F (2015) Application of immunohistochemistry in thyroid pathology. Arch Pathol Lab Med 139:67\u201382. doi: 10.5858\/arpa.2014-0056-RA","journal-title":"Arch Pathol Lab Med"},{"issue":"Suppl 2","key":"2319_CR39","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/modpathol.2010.129","volume":"24","author":"VA LiVolsi","year":"2011","unstructured":"LiVolsi VA (2011) Papillary thyroid carcinoma: an update. Mod Pathol 24(Suppl 2):S1\u2013S9. doi: 10.1038\/modpathol.2010.129","journal-title":"Mod Pathol"},{"key":"2319_CR40","volume-title":"Molecular cell biology","author":"H Lodish","year":"2013","unstructured":"Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J (2013) Molecular cell biology, 7th edn. Freeman & Co, New York","edition":"7"},{"key":"2319_CR41","first-page":"375","volume":"23","author":"N Mahdieh","year":"2013","unstructured":"Mahdieh N, Rabbani B (2013) An overview of mutation detection methods in genetic disorders. Iran J Pediatr 23:375\u2013388","journal-title":"Iran J Pediatr"},{"key":"2319_CR42","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1634\/theoncologist.2010-0405","volume":"16","author":"CR McHenry","year":"2011","unstructured":"McHenry CR, Phitayakorn R (2011) Follicular adenoma and carcinoma of the thyroid gland. Oncologist 16:585\u2013593. doi: 10.1634\/theoncologist.2010-0405","journal-title":"Oncologist"},{"key":"2319_CR43","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12033-014-9734-4","volume":"56","author":"RFV Medrano","year":"2014","unstructured":"Medrano RFV, de Oliveira CA (2014) Guidelines for the tetra-primer ARMS-PCR technique development. Mol Biotechnol 56:599\u2013608. doi: 10.1007\/s12033-014-9734-4","journal-title":"Mol Biotechnol"},{"key":"2319_CR44","first-page":"67","volume-title":"Education Guide: Immunohistochemical Staining Methods","author":"S M\u00fcller","year":"2009","unstructured":"M\u00fcller S, Matthiesen SH, Nielsen KV (2009) Preparation of FFPE tissue slides for solid tumor FISH analysis. In: Kumar GL, Rudbeck L (eds) Education Guide: Immunohistochemical Staining Methods. 5th edn. Dako North America, Carpinteria, CA, pp 67\u201373","edition":"5"},{"key":"2319_CR45","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/gbe\/evr028","volume":"3","author":"M Nei","year":"2011","unstructured":"Nei M, Nozawa M (2011) Roles of mutation and selection in speciation: from Hugo de Vries to the modern genomic era. Genom Biol Evol 3:812\u2013829. doi: 10.1093\/gbe\/evr028","journal-title":"Genom Biol Evol"},{"key":"2319_CR46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1385\/EP:13:1:03","volume":"13","author":"YE Nikiforov","year":"2002","unstructured":"Nikiforov YE (2002) RET\/PTC rearrangement in thyroid tumors. Endocr Pathol 13:3\u201316. doi: 10.1385\/EP:13:1:03","journal-title":"Endocr Pathol"},{"key":"2319_CR47","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1038\/modpathol.2010.167","volume":"24","author":"YE Nikiforov","year":"2011","unstructured":"Nikiforov YE (2011) Molecular analysis of thyroid tumors. Mod Pathol 24:S34\u2013S43. doi: 10.1038\/modpathol.2010.167","journal-title":"Mod Pathol"},{"key":"2319_CR48","doi-asserted-by":"publisher","first-page":"6330","DOI":"10.1038\/sj.onc.1203019","volume":"18","author":"YE Nikiforov","year":"1999","unstructured":"Nikiforov YE, Koshoffer A, Nikiforova M et al (1999) Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas. Oncogene 18:6330\u20136334. doi: 10.1038\/sj.onc.1203019","journal-title":"Oncogene"},{"key":"2319_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/106689690201000104","volume":"10","author":"MN Nikiforova","year":"2002","unstructured":"Nikiforova MN, Caudill CM, Biddinger P, Nikiforov YE (2002) Prevalence of RET\/PTC rearrangements in Hashimoto\u2019s thyroiditis and papillary thyroid carcinomas. Int J Surg Pathol 10:15\u201322. doi: 10.1177\/106689690201000104","journal-title":"Int J Surg Pathol"},{"key":"2319_CR50","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/clinchem\/43.7.1114","volume":"43","author":"P Nollau","year":"1997","unstructured":"Nollau P, Wagener C (1997) Methods for detection of point mutations: performance and quality assessment. Clin Chem 43:1114\u20131128","journal-title":"Clin Chem"},{"issue":"Suppl 5","key":"2319_CR51","doi-asserted-by":"publisher","first-page":"v214","DOI":"10.1093\/annonc\/mdq190","volume":"21","author":"F Pacini","year":"2010","unstructured":"Pacini F, Castagna MG, Brilli L, Pentheroudakis G (2010) Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Suppl 5):v214\u2013v219. doi: 10.1093\/annonc\/mdq190","journal-title":"Ann Oncol"},{"key":"2319_CR52","doi-asserted-by":"publisher","first-page":"965212","DOI":"10.1155\/2013\/965212","volume":"2013","author":"G Pellegriti","year":"2013","unstructured":"Pellegriti G, Frasca F, Regalbuto C et al (2013) Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol 2013:965212. doi: 10.1155\/2013\/965212","journal-title":"J Cancer Epidemiol"},{"key":"2319_CR53","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1089\/thy.1998.8.133","volume":"8","author":"AV Pisarchik","year":"1998","unstructured":"Pisarchik AV, Ermak G, Fomicheva V et al (1998) The ret\/PTC1 rearrangement is a common feature of Chernobyl-associated papillary thyroid carcinomas from Belarus. Thyroid 8:133\u2013139. doi: 10.1089\/thy.1998.8.133","journal-title":"Thyroid"},{"key":"2319_CR54","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-11-2612","volume":"72","author":"IA Prior","year":"2012","unstructured":"Prior IA, Lewis PD, Mattos C (2012) A comprehensive survey of Ras mutations in cancer. Cancer Res 72:2457\u20132467. doi: 10.1158\/0008-5472.CAN-11-2612","journal-title":"Cancer Res"},{"key":"2319_CR55","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1086\/519259","volume":"45","author":"GW Procop","year":"2007","unstructured":"Procop GW (2007) Molecular diagnostics for the detection and characterization of microbial pathogens. Clin Infect Dis 45:S99\u2013S111. doi: 10.1086\/519259","journal-title":"Clin Infect Dis"},{"key":"2319_CR56","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/mpo.1133","volume":"36","author":"HM Rabes","year":"2001","unstructured":"Rabes HM (2001) Gene rearrangements in radiation-induced thyroid carcinogenesis. Med Pediatr Oncol 36:574\u2013582. doi: 10.1002\/mpo.1133","journal-title":"Med Pediatr Oncol"},{"key":"2319_CR57","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.bbamcr.2007.01.012","volume":"1773","author":"K Rajalingam","year":"2007","unstructured":"Rajalingam K, Schreck R, Rapp UR, Albert \u0160 (2007) Ras oncogenes and their downstream targets. Biochim Biophys Acta Mol Cell Res 1773:1177\u20131195. doi: 10.1016\/j.bbamcr.2007.01.012","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"2319_CR58","doi-asserted-by":"publisher","DOI":"10.5772\/37724","author":"HB Rasmussen","year":"2012","unstructured":"Rasmussen HB (2012) Restriction fragment length polymorphism analysis of PCR-amplified fragments (PCR-RFLP) and gel electrophoresis\u2014valuable tool for genotyping and genetic fingerprinting. Gel Electrophor Princ Basics. doi: 10.5772\/37724","journal-title":"Gel Electrophor Princ Basics"},{"key":"2319_CR59","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jss.2007.09.020","volume":"150","author":"D Repplinger","year":"2008","unstructured":"Repplinger D, Bargren A, Zhang Y-W et al (2008) Is Hashimoto\u2019s thyroiditis a risk factor for papillary thyroid cancer? J Surg Res 150:49\u201352. doi: 10.1016\/j.jss.2007.09.020","journal-title":"J Surg Res"},{"key":"2319_CR60","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1038\/labinvest.3700198","volume":"84","author":"KJ Rhoden","year":"2004","unstructured":"Rhoden KJ, Johnson C, Brandao G et al (2004) Real-time quantitative RT-PCR identifies distinct c-RET, RET\/PTC1 and RET\/PTC3 expression patterns in papillary thyroid carcinoma. Lab Invest 84:1557\u20131570. doi: 10.1038\/labinvest.3700198","journal-title":"Lab Invest"},{"key":"2319_CR61","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/modpathol.2010.112","volume":"23","author":"M Rivera","year":"2010","unstructured":"Rivera M, Ricarte-Filho J, Knauf J et al (2010) Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Mod Pathol 23:1191\u20131200. doi: 10.1038\/modpathol.2010.112","journal-title":"Mod Pathol"},{"key":"2319_CR62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fendo.2012.00054","volume":"3","author":"C Romei","year":"2012","unstructured":"Romei C, Elisei R (2012) RET\/PTC translocations and clinico-pathological features in human papillary thyroid carcinoma. Front Endocrinol 3:54. doi: 10.3389\/fendo.2012.00054","journal-title":"Front Endocrinol"},{"key":"2319_CR63","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1677\/ERC-07-0130","volume":"15","author":"C Romei","year":"2008","unstructured":"Romei C, Ciampi R, Faviana P et al (2008) BRAFV600E mutation, but not RET\/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer. Endocr Relat Cancer 15:511\u2013520. doi: 10.1677\/ERC-07-0130","journal-title":"Endocr Relat Cancer"},{"key":"2319_CR64","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12022-009-9101-3","volume":"21","author":"PM Sadow","year":"2010","unstructured":"Sadow PM, Heinrich MC, Corless CL et al (2010) Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET\/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas. Endocr Pathol 21:73\u201379. doi: 10.1007\/s12022-009-9101-3","journal-title":"Endocr Pathol"},{"key":"2319_CR65","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1530\/eje.1.02289","volume":"155","author":"M Santoro","year":"2006","unstructured":"Santoro M, Melillo RM, Fusco A (2006) RET\/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture. Eur J Endocrinol 155:645\u2013653. doi: 10.1530\/eje.1.02289","journal-title":"Eur J Endocrinol"},{"key":"2319_CR66","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1242\/jcs.00786","volume":"116","author":"H Sariola","year":"2003","unstructured":"Sariola H, Saarma M (2003) Novel functions and signalling pathways for GDNF. J Cell Sci 116:3855\u20133862. doi: 10.1242\/jcs.00786","journal-title":"J Cell Sci"},{"key":"2319_CR67","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4103\/2277-9175.127998","volume":"3","author":"M Tajadini","year":"2014","unstructured":"Tajadini M, Panjehpour M, Javanmard SH (2014) Comparison of SYBR Green and TaqMan methods in quantitative real-time polymerase chain reaction analysis of four adenosine receptor subtypes. Adv Biomed Res 3:85. doi: 10.4103\/2277-9175.127998","journal-title":"Adv Biomed Res"},{"key":"2319_CR68","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1582-4934.2004.tb00278.x","volume":"8","author":"R Talmaci","year":"2004","unstructured":"Talmaci R, Traeger-Synodinos J, Kanavakis E et al (2004) Scanning of \u03b2-globin gene for identification of \u03b2-thalassemia mutation in Romanian population. J Cell Mol Med 8:232\u2013240. doi: 10.1111\/j.1582-4934.2004.tb00278.x","journal-title":"J Cell Mol Med"},{"key":"2319_CR69","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.molonc.2014.07.014","volume":"9","author":"S Tomei","year":"2015","unstructured":"Tomei S, Bedognetti D, De Giorgi V et al (2015) The immune-related role of BRAF in melanoma. Mol Oncol 9:93\u2013104. doi: 10.1016\/j.molonc.2014.07.014","journal-title":"Mol Oncol"},{"key":"2319_CR70","first-page":"21","volume":"47","author":"M Troggio","year":"2008","unstructured":"Troggio M, Malacarne G, Vezzulli S et al (2008) Comparison of different methods for SNP detection in grapevine. Vitis - J Grapevine Res 47:21\u201330","journal-title":"Vitis - J Grapevine Res"},{"key":"2319_CR71","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1530\/eje.0.1510779","volume":"151","author":"VV Vasko","year":"2004","unstructured":"Vasko VV, Gaudart J, Allasia C et al (2004) Thyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma. Eur J Endocrinol 151:779\u2013786. doi: 10.1530\/eje.0.1510779","journal-title":"Eur J Endocrinol"},{"key":"2319_CR72","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/1758834014548188","volume":"6","author":"F Worden","year":"2014","unstructured":"Worden F (2014) Treatment strategies for radioactive iodine-refractory differentiated thyroid cancer. Ther Adv Med Oncol 6:267\u2013279. doi: 10.1177\/1758834014548188","journal-title":"Ther Adv Med Oncol"},{"key":"2319_CR73","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.1210\/jc.2005-0987","volume":"90","author":"M Xing","year":"2005","unstructured":"Xing M, Westra WH, Tufano RP et al (2005) BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 90:6373\u20136379. doi: 10.1210\/jc.2005-0987","journal-title":"J Clin Endocrinol Metab"},{"key":"2319_CR74","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1586\/1744666X.3.2.217","volume":"3","author":"K Zaletel","year":"2007","unstructured":"Zaletel K (2007) Determinants of thyroid autoantibody production in Hashimoto\u2019s thyroiditis. Expert Rev Clin Immunol 3:217\u2013223. doi: 10.1586\/1744666X.3.2.217","journal-title":"Expert Rev Clin Immunol"},{"key":"2319_CR75","doi-asserted-by":"publisher","first-page":"576","DOI":"10.2174\/138920211798120763","volume":"12","author":"K Zaletel","year":"2011","unstructured":"Zaletel K, Gaber\u0161\u010dek S (2011) Hashimoto\u2019s thyroiditis: from genes to the disease. Curr Genomics 12:576\u2013588. doi: 10.2174\/138920211798120763","journal-title":"Curr Genomics"},{"key":"2319_CR76","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1530\/EJE-09-0353","volume":"161","author":"MC Zatelli","year":"2009","unstructured":"Zatelli MC, Trasforini G, Leoni S et al (2009) BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies. Eur J Endocrinol 161:467\u2013473. doi: 10.1530\/EJE-09-0353","journal-title":"Eur J Endocrinol"},{"issue":"Suppl 1","key":"2319_CR77","doi-asserted-by":"publisher","first-page":"E1019","DOI":"10.1002\/hed.24149","volume":"38","author":"R-C Zeng","year":"2016","unstructured":"Zeng R-C, Jin L-P, Chen E-D et al (2016) Potential relationship between Hashimoto\u2019s thyroiditis and BRAF(V600E) mutation status in papillary thyroid cancer. Head Neck 38(Suppl 1):E1019\u2013E1025. doi: 10.1002\/hed.24149","journal-title":"Head Neck"},{"key":"2319_CR78","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1210\/jc.2006-1006","volume":"91","author":"Z Zhu","year":"2006","unstructured":"Zhu Z, Ciampi R, Nikiforova MN et al (2006) Prevalence of RET\/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity. J Clin Endocrinol Metab 91:3603\u20133610. doi: 10.1210\/jc.2006-1006","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-016-2319-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-016-2319-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-016-2319-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T21:30:34Z","timestamp":1658266234000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-016-2319-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["2319"],"URL":"https:\/\/doi.org\/10.1007\/s00432-016-2319-9","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}