{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:08:25Z","timestamp":1790082505212,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00432-017-2461-z","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T02:20:41Z","timestamp":1497925241000},"page":"2113-2121","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Safety and efficacy of chemosaturation in patients with primary and secondary liver tumors"],"prefix":"10.1007","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-4083","authenticated-orcid":false,"given":"Martha M.","family":"Kirstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Marquardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Jedicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Marhenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Koppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Wacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"2461_CR1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1245\/ASO.2005.05.003","volume":"12","author":"HR Alexander Jr","year":"2005","unstructured":"Alexander HR Jr, Libutti SK, Pingpank JF, Bartlett DL, Helsabeck C, Beresneva T (2005) Isolated hepatic perfusion for the treatment of patients with colorectal cancer liver metastases after irinotecan-based therapy. Ann Surg Oncol 12:138\u2013144","journal-title":"Ann Surg Oncol"},{"key":"2461_CR2","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1245\/s10434-009-0482-9","volume":"16","author":"HR Alexander Jr","year":"2009","unstructured":"Alexander HR Jr, Bartlett DL, Libutti SK, Pingpank JF, Fraker DL, Royal R, Steinberg SM et al (2009) Analysis of factors associated with outcome in patients undergoing isolated hepatic perfusion for unresectable liver metastases from colorectal center. Ann Surg Oncol 16:1852\u20131859","journal-title":"Ann Surg Oncol"},{"key":"2461_CR3","first-page":"6913","volume":"35","author":"N BacalbaSa","year":"2015","unstructured":"BacalbaSa N, Balescu I, Dima S, Popescu I (2015) Long-term survivors after liver resection for breast cancer liver metastases. Anticancer Res 35:6913\u20136917","journal-title":"Anticancer Res"},{"key":"2461_CR4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cld.2007.11.003","volume":"12","author":"BR Blechacz","year":"2008","unstructured":"Blechacz BR, Gores GJ (2008) Cholangiocarcinoma. Clin Liver Dis 12:131\u2013150, ix","journal-title":"Clin Liver Dis"},{"key":"2461_CR5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40336-016-0172-0","volume":"4","author":"MN Braat","year":"2016","unstructured":"Braat MN, Samim M, van den Bosch MA, Lam MG (2016) The role of 90Y-radioembolization in downstaging primary and secondary hepatic malignancies: a systematic review. Clin Transl Imaging 4:283\u2013295","journal-title":"Clin Transl Imaging"},{"key":"2461_CR6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000441802","volume":"33","author":"JA Ridder de","year":"2016","unstructured":"de Ridder JA, Lemmens VE, Overbeek LI, Nagtegaal ID, de Wilt JH, Dutch Liver Surgery G (2016) Liver resection for metastatic disease; a population-based analysis of trends. Dig Surg 33:104\u2013113","journal-title":"Dig Surg"},{"key":"2461_CR7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0039-6257(88)90173-7","volume":"32","author":"KM Egan","year":"1988","unstructured":"Egan KM, Seddon JM, Glynn RJ, Gragoudas ES, Albert DM (1988) Epidemiologic aspects of uveal melanoma. Surv Ophthalmol 32:239\u2013251","journal-title":"Surv Ophthalmol"},{"key":"2461_CR8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1245\/ASO.2004.07.004","volume":"11","author":"ED Feldman","year":"2004","unstructured":"Feldman ED, Pingpank JF, Alexander HR Jr (2004a) Regional treatment options for patients with ocular melanoma metastatic to the liver. Ann Surg Oncol 11:290\u2013297","journal-title":"Ann Surg Oncol"},{"key":"2461_CR9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.gassur.2003.11.005","volume":"8","author":"ED Feldman","year":"2004","unstructured":"Feldman ED, Wu PC, Beresneva T, Helsabeck C, Rodriguez M, Bartlett DL, Libutti SK et al (2004b) Treatment of patients with unresectable primary hepatic malignancies using hyperthermic isolated hepatic perfusion. J Gastrointest Surg 8:200\u2013207","journal-title":"J Gastrointest Surg"},{"key":"2461_CR10","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.surg.2004.06.044","volume":"136","author":"AC Grover","year":"2004","unstructured":"Grover AC, Libutti SK, Pingpank JF, Helsabeck C, Beresnev T, Alexander HR Jr (2004) Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal neuroendocrine neoplasms. Surgery 136:1176\u20131182","journal-title":"Surgery"},{"key":"2461_CR11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrclinonc.2015.78","volume":"12","author":"A Habib","year":"2015","unstructured":"Habib A, Desai K, Hickey R, Thornburg B, Lewandowski R, Salem R (2015) Transarterial approaches to primary and secondary hepatic malignancies. Nat Rev Clin Oncol 12:481\u2013489","journal-title":"Nat Rev Clin Oncol"},{"key":"2461_CR12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1245\/s10434-015-4968-3","volume":"23","author":"MS Hughes","year":"2016","unstructured":"Hughes MS, Zager J, Faries M, Alexander HR, Royal RE, Wood B, Choi J et al (2016) Results of a randomized controlled multicenter phase III trial of percutaneous hepatic perfusion compared with best available care for patients with melanoma liver metastases. Ann Surg Oncol 23:1309\u20131319","journal-title":"Ann Surg Oncol"},{"key":"2461_CR13","first-page":"1230","volume":"6","author":"P Jovanovic","year":"2013","unstructured":"Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V (2013) Ocular melanoma: an overview of the current status. Int J Clin Exp Pathol 6:1230\u20131244","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"2461_CR14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/00365521.2016.1233579","volume":"52","author":"MM Kirstein","year":"2017","unstructured":"Kirstein MM, Schweitzer N, Ay N, Boeck C, Lappas K, Hinrichs JB, Voigtlander T et al (2017a) Experience from a real-life cohort: outcome of 606 patients with hepatocellular carcinoma following transarterial chemoembolization. Scand J Gastroenterol 52(1):116\u2013124","journal-title":"Scand J Gastroenterol"},{"key":"2461_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13761","author":"MM Kirstein","year":"2017","unstructured":"Kirstein MM, Schweitzer N, Winter T, Lappas K, Graen N, Kunstmann I, Voigtlander T et al (2017b) Patterns and challenges of treatment sequencing in patients with hepatocellular carcinoma -experience from a referral center. J Gastroenterol Hepatol. doi:\n                        10.1111\/jgh.13761","journal-title":"J Gastroenterol Hepatol"},{"key":"2461_CR16","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/annonc\/mdu162","volume":"25","author":"A Lamarca","year":"2014","unstructured":"Lamarca A, Hubner RA, David Ryder W, Valle JW (2014) Second-line chemotherapy in advanced biliary cancer: a systematic review. Ann Oncol 25:2328\u20132338","journal-title":"Ann Oncol"},{"key":"2461_CR17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"JM Llovet","year":"2008","unstructured":"Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378\u2013390","journal-title":"N Engl J Med"},{"key":"2461_CR18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00270-013-0826-5","volume":"37","author":"FM Moeslein","year":"2014","unstructured":"Moeslein FM, McAndrew EG, Appling WM, Hryniewich NE, Jarvis KD, Markos SM, Sheets TP et al (2014) Evaluation of Delcath Systems\u2019 Generation 2 (GEN 2) melphalan hemofiltration system in a porcine model of percutaneous hepatic perfusion. Cardiovasc Intervent Radiol 37:763\u2013769","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2461_CR19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1091-255X(97)80126-6","volume":"1","author":"J Norstein","year":"1997","unstructured":"Norstein J, Silen W (1997) Natural history of liver metastases from colorectal carcinoma. J Gastrointest Surg 1:398\u2013407","journal-title":"J Gastrointest Surg"},{"key":"2461_CR20","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0002-9610(99)00234-2","volume":"178","author":"AS Pearson","year":"1999","unstructured":"Pearson AS, Izzo F, Fleming RY, Ellis LM, Delrio P, Roh MS, Granchi J et al (1999) Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am J Surg 178:592\u2013599","journal-title":"Am J Surg"},{"key":"2461_CR21","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/cam4.459","volume":"4","author":"RD Peixoto","year":"2015","unstructured":"Peixoto RD, Speers C, McGahan CE, Renouf DJ, Schaeffer DF, Kennecke HF (2015) Prognostic factors and sites of metastasis in unresectable locally advanced pancreatic cancer. Cancer Med 4:1171\u20131177","journal-title":"Cancer Med"},{"key":"2461_CR22","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1200\/JCO.2005.00.927","volume":"23","author":"JF Pingpank","year":"2005","unstructured":"Pingpank JF, Libutti SK, Chang R, Wood BJ, Neeman Z, Kam AW, Figg WD et al (2005) Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies. J Clin Oncol 23:3465\u20133474","journal-title":"J Clin Oncol"},{"key":"2461_CR23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/annonc\/mdt540","volume":"25","author":"JW Valle","year":"2014","unstructured":"Valle JW, Furuse J, Jitlal M, Beare S, Mizuno N, Wasan H, Bridgewater J et al (2014) Cisplatin and gemcitabine for advanced biliary tract cancer: a meta-analysis of two randomised trials. Ann Oncol 25:391\u2013398","journal-title":"Ann Oncol"},{"key":"2461_CR24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/annonc\/mdn032","volume":"19","author":"LB Iersel van","year":"2008","unstructured":"van Iersel LB, Gelderblom H, Vahrmeijer AL, van Persijn van Meerten EL, Tijl FG, Putter H, Hartgrink HH et al (2008) Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients. Ann Oncol 19:1127\u20131134","journal-title":"Ann Oncol"},{"key":"2461_CR25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1055\/s-0034-1366081","volume":"186","author":"TJ Vogl","year":"2014","unstructured":"Vogl TJ, Zangos S, Scholtz JE, Schmitt F, Paetzold S, Trojan J, Orsi F et al (2014) Chemosaturation with percutaneous hepatic perfusions of melphalan for hepatic metastases: experience from two European centers. Rofo 186:937\u2013944","journal-title":"Rofo"},{"key":"2461_CR26","first-page":"688","volume":"62","author":"T Ye","year":"2015","unstructured":"Ye T, Yang B, Tong H, Zhang Y, Xia J (2015) Long-term outcomes of surgical resection for liver metastasis from breast cancer. Hepatogastroenterology 62:688\u2013692","journal-title":"Hepatogastroenterology"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-017-2461-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2461-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2461-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T10:04:44Z","timestamp":1505383484000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-017-2461-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["2461"],"URL":"https:\/\/doi.org\/10.1007\/s00432-017-2461-z","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]}}}