{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:53:48Z","timestamp":1793912028406,"version":"4.8.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00432-017-2462-y","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T07:18:08Z","timestamp":1498202288000},"page":"2131-2141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hepatic arterial infusion chemotherapy for extensive liver metastases of breast cancer: efficacy, safety and prognostic parameters"],"prefix":"10.1007","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-8329","authenticated-orcid":false,"given":"Mitra","family":"Tewes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Wilhelm","family":"Peis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bogner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens M.","family":"Theysohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Paul","family":"Reinboldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Welt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"issue":"1","key":"2462_CR1","first-page":"419","volume":"36","author":"K Almstest","year":"2016","unstructured":"Almstest K, Fasching PA, Scharl A, Rauh C, Rack B, Hein A, Hack CC, Bayer CM, Jud SM, Schrauder MG, Beckmann MW, Lux MP (2016) Mitomycin C and Capecitabine (MiX Trial) for therapy of patients with metastasized breast cancer pretreated with anthracycline. Anticancer Res 36(1):419\u2013425","journal-title":"Anticancer Res"},{"issue":"17","key":"2462_CR3","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/S0959-8049(03)00601-4","volume":"39","author":"G Atalay","year":"2003","unstructured":"Atalay G, Biganzoli L, Renard F, Paridaens R, Cufer T, Coleman R, Calvert AH, Gamucci R, Minisini A, Therasse P, Piccart MJ, EORTC Breast Cancer and Early Clinical Studies Groups (2003) Clinical outcome of breast cancer patients with liver metastases alone in the anthracycline-taxane era: a retrospective analysis of two prospective, randomised metastatic breast cancer trials. Eur J Cancer 39(17):2439\u20132449","journal-title":"Eur J Cancer"},{"key":"2462_CR4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/MDER.S4036","volume":"2","author":"S Bacchetti","year":"2009","unstructured":"Bacchetti S, Pasqual E, Crozzolo E, Pellarin A, Cagol PP (2009) Intra-arterial hepatic chemotherapy for unresectable colorectal liver metastases: a review of medical devices complications in 3172 patients. Med Devices (Auckl) 2:31\u201340","journal-title":"Med Devices (Auckl)"},{"issue":"6","key":"2462_CR5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/030089169908500609","volume":"85","author":"M Bertuccelli","year":"1999","unstructured":"Bertuccelli M, Falcone A, Campoccia S, Conti M, Brunetti I, Caramella D, Giulianotti PC, Mosca F, Bartolozzi C, Conte PF (1999) Intrahepatic chemotherapy with floxuridine, leucovorin and dexamethasone in continuous infusion and mitomycin-C bolus in unresectable hepatic metastases from colorectal cancer: a phase II study. Tumori 85(6):473\u2013477","journal-title":"Tumori"},{"issue":"6","key":"2462_CR6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/00000658-198712000-00001","volume":"206","author":"AE Chang","year":"1987","unstructured":"Chang AE, Schneider PD, Sugarbaker PH, Simpson C, Culnane M, Steinberg SM (1987) A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg 206(6):685\u2013693","journal-title":"Ann Surg"},{"issue":"5","key":"2462_CR7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/cncr.22867","volume":"110","author":"SK Chia","year":"2007","unstructured":"Chia SK, Speers CH, Dyachkova Y, Kang A, Malfair-Taylor S, Barnett J, Coldman A, Gelmon KA, Oreilly SE, Olivotto IA (2007) The impact of new chemotherapeutic and hormone agents on survival in a population-based cohort of women with metastatic breast cancer. Cancer 110(5):973\u2013979","journal-title":"Cancer"},{"issue":"5","key":"2462_CR8","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1200\/JCO.1984.2.5.498","volume":"2","author":"JM Collins","year":"1984","unstructured":"Collins JM (1984) Pharmacologic rationale for regional drug delivery. J Clin Oncol 2(5):498\u2013504","journal-title":"J Clin Oncol"},{"issue":"3","key":"2462_CR9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10549-009-0630-8","volume":"119","author":"U Dafni","year":"2010","unstructured":"Dafni U, Grimani I, Xyrafas A, Eleftheraki AG, Fountzilas G (2010) Fifteen-year trends in metastatic breast cancer survival in Greece. Breast Cancer Res Treat 119(3):621\u2013631","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"2462_CR11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1158\/1055-9965.EPI-15-0535","volume":"24","author":"CE DeSantis","year":"2015","unstructured":"DeSantis CE, Bray F, Ferlay J, Lortet-Tieulent J, Anderson BO, Jemal A (2015) International variation in female breast cancer incidence and mortality rates. [Hrsg.] AACR. Cancer Epidemiol Biomark Prev 24(10):1495\u20131506","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"1","key":"2462_CR12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10147-011-0336-x","volume":"18","author":"XE Duan","year":"2013","unstructured":"Duan XE, Dong NN, Zhang T, Li Q (2013) The prognostic analysis of clinical breast cancer subrypes among patients with liver metastases from breast cancer. Int J Clin Oncol 18(1):26\u201332","journal-title":"Int J Clin Oncol"},{"issue":"2","key":"2462_CR13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.coc.0000251935.51345.10","volume":"30","author":"MH Eichbaum","year":"2007","unstructured":"Eichbaum MH, Gast AS, Schneeweiss A, Bruckner T, Sohn C (2007) Activity and tolerability of a combined palliative chemotherapy with mitomycin C, folinate, and 5-Fluorouracil in patients with advanced breast cancer after intensive pretreatment: a retrospective analysis. Am J Clin Oncol 30(2):139\u2013145","journal-title":"Am J Clin Oncol"},{"issue":"2","key":"2462_CR14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, Rubinstein L, Shankar L, Dodd L, Kaplan R, Lacombe D, Verweij J (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228\u2013247","journal-title":"Eur J Cancer"},{"key":"2462_CR15","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359\u2013E386","journal-title":"Int J Cancer"},{"issue":"1","key":"2462_CR16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cncr.11859","volume":"100","author":"SH Giordano","year":"2004","unstructured":"Giordano SH, Buzdar AU, Smith TL, Kau SW, Yang Y, Hortobagyi GN (2004) Is breast cancer survival improving? Cancer 100(1):44\u201352","journal-title":"Cancer"},{"issue":"4 Suppl","key":"2462_CR17","first-page":"171","volume":"22","author":"M Grosso","year":"2003","unstructured":"Grosso M, Scarrone A, Pedrazzini F, Priotto R, Testa F, Lingua G, Mondino I, Zanon C (2003) Intra-arterial hepatic chemotherapy: management of liver tumors by percutaneous port-a-cath positioning. J Exp Clin Cancer Res 22(4 Suppl):171\u2013175","journal-title":"J Exp Clin Cancer Res"},{"issue":"12","key":"2462_CR18","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1055\/s-0031-1281743","volume":"183","author":"TA Heusner","year":"2011","unstructured":"Heusner TA, Antoch G, Wittkowski-Sterczewski A, Ladd SC, Forsting M, Verhagen R, Scheulen M (2011) Transarterial hepatic chemoperfusion of uveal melanoma metastases: survival and response to treatment. Rofo 183(12):1151\u20131160","journal-title":"Rofo"},{"issue":"3","key":"2462_CR19","first-page":"255","volume":"25","author":"RD Hofheinz","year":"2002","unstructured":"Hofheinz RD, Hartung G, Samel S, Hochhaus A, Pichlmeier U, Post S, Hehlmann R, Queisser W (2002) High-dose 5-fluorouracil\/folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer. A phase II study. Onkologie 25(3):255\u2013260","journal-title":"Onkologie"},{"issue":"1","key":"2462_CR20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/jjco\/29.1.23","volume":"29","author":"T Ikeda","year":"1999","unstructured":"Ikeda T, Adachi I, Takashima S, Ogita M, Aoyama H, Sano M, Ando J, Tabei T, Tominaga T, Enomoto K, Kanda K, Fukutomi T, Shimoyama M (1999) A phase I\/II study of continuous intra-arterial chemotherapy using an implantable reservoir for the treatment of liver metastases from breast cancer: a Japan Clinical Oncology Group (JCOG) study 9113. JCOG Breast Cancer Study Group. Jpn J Clin Oncol 29(1):23\u201327","journal-title":"Jpn J Clin Oncol"},{"issue":"9","key":"2462_CR21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.clon.2010.08.004","volume":"22","author":"R Illing","year":"2010","unstructured":"Illing R, Gillams A (2010) Radiofrequency ablation in the treatment of breast cancer liver metastases. Clin Oncol (R Coll Radiol) 22(9):781\u2013784","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"4","key":"2462_CR22","doi-asserted-by":"crossref","first-page":"459","DOI":"10.7326\/0003-4819-107-4-459","volume":"107","author":"N Kemeny","year":"1987","unstructured":"Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma: a randomized trial. Ann Intern Med 107(4):459\u2013465","journal-title":"Ann Intern Med"},{"issue":"9","key":"2462_CR23","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1200\/JCO.2005.03.8166","volume":"24","author":"NE Kemeny","year":"2006","unstructured":"Kemeny NE, Niedzwiecki D, Hollis DR et al (2006) Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life and molecular markers (CALGB 9481). J Clin Oncol 24(9):1395\u20131403","journal-title":"J Clin Oncol"},{"issue":"9355","key":"2462_CR24","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0140-6736(03)12388-4","volume":"361","author":"DJ Kerr","year":"2003","unstructured":"Kerr DJ, McArdle CS, Ledermann J, Taylor I, Sherlock DJ, Schlag PM, Buckels J, Mayer D, Cain D, Stephens RJ, Medical Research Council\u2019s colorectal cancer study group; European Organisation for Research and Treatment of Cancer colorectal cancer study group (2003) Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal caner liver metastases: a multicenter randomised trial. Lancet 361(9355):368\u2013373","journal-title":"Lancet"},{"issue":"2","key":"2462_CR25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4048\/jbc.2013.16.2.184","volume":"16","author":"DV Kostov","year":"2013","unstructured":"Kostov DV, Kobakov GL, Yankov DV (2013) Prognostic factors related to surgical outcome of liver metastases of breast cancer. J Breast Cancer 16(2):184\u2013192","journal-title":"J Breast Cancer"},{"issue":"5","key":"2462_CR26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/tbj.12170","volume":"19","author":"HY Lee","year":"2013","unstructured":"Lee HY, Ko HK, Kim SH, Lee KS, Ro J, Park IH (2013) Percutaneous radiofrequency ablation for liver metastases in breast cancer patients. Breast J 19(5):563\u2013565","journal-title":"Breast J"},{"issue":"3","key":"2462_CR27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1148\/radiol.11081489","volume":"259","author":"RJ Lewandowski","year":"2011","unstructured":"Lewandowski RJ, Geschwind JF, Llapi E, Salem R (2011) Transcatheter intraarterial therapies: rationale and overview. Radiology 259(3):641\u2013657","journal-title":"Radiology"},{"key":"2462_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10549-007-9707-4","volume":"110","author":"T Maes","year":"2008","unstructured":"Maes T, Wildiers H, Heye S, Demey W, Maleux G, Neven P, Von Oosterom AT, Paridaens R (2008) Intra-hepatic Mitomycin C bolus infusion in the treatment of extensive liver metastases of breast cancer. Breast Cancer Res Treat 110:135\u2013142","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"2462_CR29","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1093\/annonc\/mds024","volume":"23","author":"M Malvezzi","year":"2012","unstructured":"Malvezzi M, Bertuccio P, Levi F, La VC, Negri E (2012) European cancer mortality predictions for the year 2012. Ann Oncol 23(4):1044\u20131052","journal-title":"Ann Oncol"},{"issue":"1","key":"2462_CR34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10585-016-9824-8","volume":"34","author":"AG Ording","year":"2017","unstructured":"Ording AG, Heide-J\u00f8rgensen U, Christiansen CF, N\u00f8rgaard M, Acquavella J, S\u00f8rensen HT (2017) Site of metastasis and breast cancer mortality: a Danish nationwide registry-based cohort study. Clin Exp Metastasis 34(1):93\u2013101","journal-title":"Clin Exp Metastasis"},{"issue":"4\u20135","key":"2462_CR35","first-page":"276","volume":"55","author":"EH Overbosch","year":"1986","unstructured":"Overbosch EH, Kuijpers TJ (1986) Hepatic artery bolus infusion chemotherapy with mitomycin C. Angiographic results and complications. Diagn Imaging Clin Med 55(4\u20135):276\u2013281","journal-title":"Diagn Imaging Clin Med"},{"key":"2462_CR37","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10549-015-3352-0","volume":"150","author":"CD Savci-Heijink","year":"2015","unstructured":"Savci-Heijink CD, Halfwerk H, Hooiker GKJ, Horlings HM, Wesseling J, van de Vijver MJ (2015) Retrospective analysis of metastatic behaviour of breast cancer subtypes. Breast Cancer Res Treat 150:547\u2013557","journal-title":"Breast Cancer Res Treat"},{"key":"2462_CR38","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1126\/science.343.6178.1452","volume":"343","author":"K Servick","year":"2014","unstructured":"Servick K (2014) Breast cancer: a world of differences. Science 343:1452\u20131453","journal-title":"Science"},{"key":"2462_CR39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1309\/AJCPYO5FSV3UPEXS","volume":"143","author":"A Soni","year":"2015","unstructured":"Soni A, Ren Z, Hameed O, Chanda D, Morgan CJ, Siegal GP, Wei S (2015) Breast cancer subtypes predispose the site of distant metastases. Am J Clin Pathol 143:471\u2013478","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"2462_CR41","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000238992","volume":"39","author":"R Torra","year":"1993","unstructured":"Torra R, Poch E, Torras A, Bomb\u00ed JA, Revert L (1993) Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy. Chemotherapy 39(6):453\u2013456","journal-title":"Chemotherapy"},{"issue":"127","key":"2462_CR42","first-page":"1611","volume":"60","author":"AM Tsimberidou","year":"2013","unstructured":"Tsimberidou AM, Vaklavas C, Fu S, Wen S, Lim JA, Hong D, Wheler J, Naing A, Uehara C, Wallace M, Kurzrock R (2013) Hepatic arterial infusion therapy in advanced cancer and liver-predominant disease: the MD Anderson experience. Hepatogastroenterology 60(127):1611\u20131623","journal-title":"Hepatogastroenterology"},{"issue":"10","key":"2462_CR44","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.ejso.2012.04.015","volume":"38","author":"GA Walsum van","year":"2012","unstructured":"van Walsum GA, de Ridder JA, Verhoef C, Bosscha K, van Gulik TM, Hesselink EJ, Ruers TJ, van den Tol MP, Nagtegaal ID, Brouwer M, van Hillegersberg R, Porte RJ, Rijken AM, Strobbe LJ, de Wilt JH, Dutch Liver Surgeons Group (2012) Resection of liver metastases in patients with breast cancer: survival and prognostic factors. Eur J Surg Oncol 38(10):910\u2013917","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"2462_CR45","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00330-007-0781-0","volume":"18","author":"TJ Vogl","year":"2008","unstructured":"Vogl TJ, Zangos S, Eichler K, Selby JB, Bauer RW (2008) Palliative hepatic intraarterial chemotherapy (HIC) using a novel combination of gemcitabine and mitomycin C: results in hepatic metastases. Eur Radiol 18(3):468\u2013476","journal-title":"Eur Radiol"},{"issue":"10 Suppl","key":"2462_CR46","first-page":"1515","volume":"19","author":"T Watanabe","year":"1992","unstructured":"Watanabe T, Sawada T, Kubota Y, Ooya M, Masaki T, Sameshima S, Shinozaki M, Tsuno N, Uchiyama M, Sakaguchi M et al (1992) Continuous intra-arterial infusion chemotherapy in colorectal cancer patients with nonresectable metastatic liver cance. Gan To Kagaku Ryoho 19(10 Suppl):1515\u20131518","journal-title":"Gan To Kagaku Ryoho"},{"issue":"2","key":"2462_CR47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/sj.bjc.6601038","volume":"89","author":"L Wyld","year":"2003","unstructured":"Wyld L, Gutteridge E, Pinder SE, James JJ, Chan SY, Cheung KL, Robertson JF, Evans AJ (2003) Prognostic factors for patients with hepatic metastases from breast cancer. Br J Cancer 89(2):284\u2013290","journal-title":"Br J Cancer"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-017-2462-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2462-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2462-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T14:54:15Z","timestamp":1569509655000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-017-2462-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["2462"],"URL":"https:\/\/doi.org\/10.1007\/s00432-017-2462-y","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,23]]}}}