{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:15:45Z","timestamp":1789661745175,"version":"4.0.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00432-017-2487-2","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T03:58:25Z","timestamp":1502078305000},"page":"2147-2157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Role of autophagy in regulating the radiosensitivity of tumor cells"],"prefix":"10.1007","volume":"143","author":[{"given":"Yong","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0705-2386","authenticated-orcid":false,"given":"Guan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"issue":"10","key":"2487_CR1","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1158\/1078-0432.CCR-06-2872","volume":"13","author":"JM Albert","year":"2007","unstructured":"Albert JM, Cao C, Kim KW et al (2007) Inhibition of poly (ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res 13(10):3033\u20133042","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2487_CR2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1667\/RR14202.1","volume":"185","author":"M Alotaibi","year":"2016","unstructured":"Alotaibi M, Sharma K, Saleh T et al (2016) Radiosensitization by PARP inhibition in DNA repair proficient and Deficient tumor cells: proliferative recovery in senescent cells. Radiat Res 185(3):229\u2013245","journal-title":"Radiat Res"},{"issue":"4","key":"2487_CR3","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3892\/ijo.2012.1583","volume":"41","author":"A Altmeyer","year":"2012","unstructured":"Altmeyer A, Josset E, Denis JM et al (2012) The mTOR inhibitor RAD001 augments radiation-induced growth inhibition in a hepatocellular carcinoma cell line by increasing autophagy. Int J Oncol 41(4):1381\u20131386","journal-title":"Int J Oncol"},{"issue":"3","key":"2487_CR4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.radonc.2012.04.001","volume":"103","author":"S Anbalagan","year":"2012","unstructured":"Anbalagan S, Pires IM, Blick C et al (2012) Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiother Oncol 103(3):388\u2013393","journal-title":"Radiother Oncol"},{"issue":"5","key":"2487_CR5","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1158\/0008-5472.CAN-07-0562","volume":"68","author":"A Apel","year":"2008","unstructured":"Apel A, Herr I, Schwarz H et al (2008) Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Can Res 68(5):1485\u20131494","journal-title":"Can Res"},{"issue":"3","key":"2487_CR6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/ijms.3635","volume":"9","author":"R Baskar","year":"2012","unstructured":"Baskar R, Lee KA, Yeo R et al (2012) Cancer and radiation therapy: current advances and future directions. Int J Med Sci 9(3):193\u2013199","journal-title":"Int J Med Sci"},{"issue":"3","key":"2487_CR7","first-page":"286","volume":"34","author":"DM Benbrook","year":"2012","unstructured":"Benbrook DM, Long A (2012) Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis. Exp Oncol 34(3):286\u2013297","journal-title":"Exp Oncol"},{"issue":"3","key":"2487_CR8","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1124\/jpet.112.199802","volume":"344","author":"ML Bristol","year":"2013","unstructured":"Bristol ML, Emery SM, Maycotte P et al (2013) Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 344(3):544\u2013552","journal-title":"J Pharmacol Exp Ther"},{"issue":"20","key":"2487_CR9","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1158\/0008-5472.CAN-06-0802","volume":"66","author":"C Cao","year":"2006","unstructured":"Cao C, Subhawong T, Albert JM et al (2006) Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Can Res 66(20):10040\u201310047","journal-title":"Can Res"},{"issue":"3","key":"2487_CR10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.radonc.2011.06.002","volume":"99","author":"H Chaachouay","year":"2011","unstructured":"Chaachouay H, Ohneseit P, Toulany M et al (2011) Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother Oncol 99(3):287\u2013292","journal-title":"Radiother Oncol"},{"issue":"10","key":"2487_CR12","doi-asserted-by":"crossref","first-page":"e1437","DOI":"10.1038\/cddis.2014.415","volume":"5","author":"L Chang","year":"2014","unstructured":"Chang L, Graham PH, Hao J et al (2014) PI3K\/Akt\/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways. Cell Death Dis 5(10):e1437","journal-title":"Cell Death Dis"},{"issue":"9","key":"2487_CR13","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.bbamcr.2008.12.013","volume":"1793","author":"N Chen","year":"2009","unstructured":"Chen N, Karantza-Wadsworth V (2009) Role and regulation of autophagy in cancer. Biochimica et Biophysica Acta (BBA)-Mol Cell Res 1793(9):1516\u20131523","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol Cell Res"},{"issue":"2","key":"2487_CR14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbcan.2010.07.003","volume":"1806","author":"S Chen","year":"2010","unstructured":"Chen S, Rehman SK, Zhang W et al (2010) Autophagy is a therapeutic target in anticancer drug resistance. Biochimica et Biophysica Acta (BBA)-Rev Cancer 1806(2):220\u2013229","journal-title":"Biochimica et Biophysica Acta (BBA)-Rev Cancer"},{"issue":"6","key":"2487_CR15","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1442-2050.2010.01156.x","volume":"24","author":"YS Chen","year":"2011","unstructured":"Chen YS, Song HX, Lu Y et al (2011) Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells. Dis Esophagus 24(6):437\u2013443","journal-title":"Dis Esophagus"},{"issue":"8","key":"2487_CR16","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s10495-014-0999-7","volume":"19","author":"Y Chen","year":"2014","unstructured":"Chen Y, Fu LL, Wen X et al (2014a) Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy. Apoptosis 19(8):1177\u20131189","journal-title":"Apoptosis"},{"issue":"7","key":"2487_CR17","doi-asserted-by":"crossref","first-page":"833","DOI":"10.7150\/ijbs.10564","volume":"11","author":"N Chen","year":"2014","unstructured":"Chen N, Wu L, Yuan H et al (2014b) ROS\/Autophagy\/Nrf2 pathway mediated low-dose radiation induced radio-resistance in human lung adenocarcinoma A549 cell. Int J Biol Sci 11(7):833\u2013844","journal-title":"Int J Biol Sci"},{"issue":"2","key":"2487_CR18","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3892\/mmr.2015.3623","volume":"12","author":"Y Chen","year":"2015","unstructured":"Chen Y, Li X, Guo L et al (2015) Combining radiation with autophagy inhibition enhances suppression of tumor growth and angiogenesis in esophageal cancer. Mol Med Rep 12(2):1645\u20131652","journal-title":"Mol Med Rep"},{"issue":"8","key":"2487_CR19","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.2174\/15665240113139990060","volume":"13","author":"H Cheng","year":"2013","unstructured":"Cheng H, Li J, Liu C et al (2013) Profilin1 sensitizes pancreatic cancer cells to irradiation by inducing apoptosis and reducing autophagy. Curr Mol Med 13(8):1368\u20131375","journal-title":"Curr Mol Med"},{"issue":"2","key":"2487_CR20","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bcp.2009.08.022","volume":"79","author":"PC Chiang","year":"2010","unstructured":"Chiang PC, Lin SC, Pan SL et al (2010) Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol 79(2):162\u2013171","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"2487_CR21","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4161\/auto.5.4.7759","volume":"5","author":"HW Chiu","year":"2009","unstructured":"Chiu HW, Ho SY, Guo HR et al (2009) Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K\/Akt and ERK1\/2 signaling pathways. Autophagy 5(4):472\u2013483","journal-title":"Autophagy"},{"issue":"3","key":"2487_CR22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4161\/auto.6.3.11229","volume":"6","author":"HW Chiu","year":"2010","unstructured":"Chiu HW, Lin JH, Chen YA et al (2010) Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy 6(3):353\u2013365","journal-title":"Autophagy"},{"issue":"2","key":"2487_CR23","doi-asserted-by":"crossref","first-page":"e31579","DOI":"10.1371\/journal.pone.0031579","volume":"7","author":"HW Chiu","year":"2012","unstructured":"Chiu HW, Chen YA, Ho SY et al (2012a) Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and-independent human prostate cancer cells. PLoS One 7(2):e31579","journal-title":"PLoS One"},{"issue":"7","key":"2487_CR24","doi-asserted-by":"crossref","first-page":"e40462","DOI":"10.1371\/journal.pone.0040462","volume":"7","author":"HW Chiu","year":"2012","unstructured":"Chiu HW, Fang WH, Chen YL et al (2012b) Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. PLoS One 7(7):e40462","journal-title":"PLoS One"},{"issue":"10","key":"2487_CR25","doi-asserted-by":"crossref","first-page":"e76340","DOI":"10.1371\/journal.pone.0076340","volume":"8","author":"HW Chiu","year":"2013","unstructured":"Chiu HW, Yeh YL, Wang YC et al (2013) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, enhances radiosensitivity and suppresses lung metastasis in breast cancer in vitro and in vivo. PLoS One 8(10):e76340","journal-title":"PLoS One"},{"issue":"2","key":"2487_CR26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.canlet.2015.05.025","volume":"365","author":"HW Chiu","year":"2015","unstructured":"Chiu HW, Lin SW, Lin LC et al (2015) Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6. Cancer Lett 365(2):229\u2013239","journal-title":"Cancer Lett"},{"issue":"7","key":"2487_CR27","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1158\/1541-7786.MCR-09-0507","volume":"8","author":"EJ Choi","year":"2010","unstructured":"Choi EJ, Ryu YK, Kim SY et al (2010) Targeting epidermal growth factor receptor\u2013associated signaling pathways in non\u2013small cell lung cancer cells: implication in radiation response. Mol Cancer Res 8(7):1027\u20131036","journal-title":"Mol Cancer Res"},{"issue":"10","key":"2487_CR28","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1158\/0008-5472.CAN-04-4202","volume":"65","author":"S Daido","year":"2005","unstructured":"Daido S, Yamamoto A, Fujiwara K et al (2005) Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy. Can Res 65(10):4368\u20134375","journal-title":"Can Res"},{"issue":"8","key":"2487_CR29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2174\/156800912803251243","volume":"12","author":"FJ Dumont","year":"2012","unstructured":"Dumont FJ, Bischoff P (2012) Disrupting the mTOR signaling network as a potential strategy for the enhancement of cancer radiotherapy. Curr Cancer Drug Targets 12(8):899\u2013924","journal-title":"Curr Cancer Drug Targets"},{"issue":"2","key":"2487_CR30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1124\/jpet.113.205120","volume":"348","author":"SM Emery","year":"2014","unstructured":"Emery SM, Alotaibi MR, Tao Q et al (2014) Combined antiproliferative effects of the aminoalkylindole WIN55, 212-2 and radiation in breast cancer cells. J Pharmacol Exp Ther 348(2):293\u2013302","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"2487_CR31","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/carcin\/bgs266","volume":"33","author":"LB Frankel","year":"2012","unstructured":"Frankel LB, Lund AH (2012) MicroRNA regulation of autophagy. Carcinogenesis 33(11):2018\u20132025","journal-title":"Carcinogenesis"},{"issue":"3","key":"2487_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4161\/auto.3723","volume":"3","author":"DA Gewirtz","year":"2007","unstructured":"Gewirtz DA (2007) Autophagy as a mechanism of radiation sensitization in breast tumor cells. Autophagy 3(3):249\u2013250","journal-title":"Autophagy"},{"issue":"3","key":"2487_CR33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.radonc.2009.05.022","volume":"92","author":"DA Gewirtz","year":"2009","unstructured":"Gewirtz DA, Hilliker ML, Wilson EN (2009) Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells. Radiother Oncol 92(3):323\u2013328","journal-title":"Radiother Oncol"},{"issue":"16","key":"2487_CR34","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1038\/sj.onc.1207521","volume":"23","author":"D Gozuacik","year":"2004","unstructured":"Gozuacik D, Kimchi A (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23(16):2891\u20132906","journal-title":"Oncogene"},{"issue":"8","key":"2487_CR35","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/pros.22804","volume":"74","author":"GL Gravina","year":"2014","unstructured":"Gravina GL, Marampon F, Sherris D et al (2014) Torc1\/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models. Prostate 74(8):852\u2013868","journal-title":"Prostate"},{"issue":"3","key":"2487_CR36","first-page":"1449","volume":"34","author":"MW Han","year":"2014","unstructured":"Han MW, Lee JC, Choi JY et al (2014) Autophagy inhibition can overcome radioresistance in breast cancer cells through suppression of TAK1 activation. Anticancer Res 34(3):1449\u20131455","journal-title":"Anticancer Res"},{"issue":"3","key":"2487_CR37","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3892\/ijo.2014.2497","volume":"45","author":"JH He","year":"2014","unstructured":"He JH, Liao XL, Wang W et al (2014a) Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy. Int J Oncol 45(3):1099\u20131108","journal-title":"Int J Oncol"},{"issue":"2","key":"2487_CR38","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s13277-013-1134-z","volume":"35","author":"G He","year":"2014","unstructured":"He G, Wang Y, Pang X et al (2014b) Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation. Tumor Biology 35(2):1003\u20131011","journal-title":"Tumor Biology"},{"key":"2487_CR39","first-page":"1401","volume":"26","author":"SD Hideakiito","year":"2005","unstructured":"Hideakiito SD, Kanzawa T, Kondo S et al (2005) Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 26:1401\u20131410","journal-title":"Int J Oncol"},{"issue":"5","key":"2487_CR40","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4161\/auto.5921","volume":"4","author":"M H\u00f8yer-Hansen","year":"2008","unstructured":"H\u00f8yer-Hansen M, J\u00e4\u00e4ttel\u00e4 M (2008) Autophagy: an emerging target for cancer therapy. Autophagy 4(5):574\u2013580","journal-title":"Autophagy"},{"key":"2487_CR41","doi-asserted-by":"publisher","unstructured":"Jin X, Li F, Zheng X et al (2015) Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Sci Rep 5:13815. doi: 10.1038\/srep13815","DOI":"10.1038\/srep13815"},{"issue":"3","key":"2487_CR42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/bjc.2016.202","volume":"115","author":"IV Karagounis","year":"2016","unstructured":"Karagounis IV, Kalamida D, Mitrakas A et al (2016) Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy. Br J Cancer 115(3):312\u2013321","journal-title":"Br J Cancer"},{"issue":"5","key":"2487_CR43","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4161\/auto.6058","volume":"4","author":"KW Kim","year":"2008","unstructured":"Kim KW, Hwang M, Moretti L et al (2008a) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4(5):659\u2013668","journal-title":"Autophagy"},{"issue":"5","key":"2487_CR44","doi-asserted-by":"crossref","first-page":"e2275","DOI":"10.1371\/journal.pone.0002275","volume":"3","author":"KW Kim","year":"2008","unstructured":"Kim KW, Moretti L, Lu B (2008b) M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models. PLoS One 3(5):e2275","journal-title":"PLoS One"},{"issue":"6","key":"2487_CR45","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/jcb.24465","volume":"114","author":"EJ Kim","year":"2013","unstructured":"Kim EJ, Jeong JH, Bae S et al (2013) mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy. J Cell Biochem 114(6):1248\u20131256","journal-title":"J Cell Biochem"},{"issue":"1","key":"2487_CR46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/cdd.2013.124","volume":"21","author":"A Ko","year":"2014","unstructured":"Ko A, Kanehisa A, Martins I et al (2014) Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling. Cell Death Differ 21(1):92\u201399","journal-title":"Cell Death Differ"},{"issue":"2","key":"2487_CR47","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bbrc.2015.04.014","volume":"461","author":"MI Koukourakis","year":"2015","unstructured":"Koukourakis MI, Kalamida D, Mitrakas A et al (2015) Intensified autophagy compromises the efficacy of radiotherapy against prostate cancer. Biochem Biophys Res Commun 461(2):268\u2013274","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2487_CR48","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1158\/1535-7163.MCT-09-0700","volume":"9","author":"BYK Law","year":"2010","unstructured":"Law BYK, Wang M, Ma DL et al (2010) Alisol B, a novel inhibitor of the sarcoplasmic\/endoplasmic reticulum Ca2+ ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther 9(3):718\u2013730","journal-title":"Mol Cancer Ther"},{"key":"2487_CR49","doi-asserted-by":"crossref","first-page":"27104","DOI":"10.1038\/srep27104","volume":"6","author":"X Li","year":"2016","unstructured":"Li X, Cen Y, Cai Y et al (2016) TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells. Sci Rep 6:27104","journal-title":"Sci Rep"},{"issue":"1","key":"2487_CR50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1748-717X-7-213","volume":"7","author":"B Liang","year":"2012","unstructured":"Liang B, Kong D, Liu Y et al (2012) Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells. Radiat Oncol 7(1):213","journal-title":"Radiat Oncol"},{"key":"2487_CR51","doi-asserted-by":"publisher","unstructured":"Liang DH, El-Zein R, Dave B (2015) Autophagy inhibition to increase radiosensitization in breast cancer. J Nucl Med Radiat Therapy 6(5):254. doi: 10.4172\/2155-9619.1000254","DOI":"10.4172\/2155-9619.1000254"},{"issue":"6","key":"2487_CR52","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.3892\/ol.2014.2049","volume":"7","author":"M Liu","year":"2014","unstructured":"Liu M, Ma S, Liu M et al (2014) Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis. Oncol Lett 7(6):1903\u20131910","journal-title":"Oncol Lett"},{"issue":"7","key":"2487_CR53","doi-asserted-by":"crossref","first-page":"663","DOI":"10.2174\/1566524015666150831141112","volume":"15","author":"C Liu","year":"2015","unstructured":"Liu C, He W, Jin M et al (2015) Blockage of autophagy in C6 glioma cells enhanced radiosensitivity possibly by attenuating DNA-PK-dependent DSB due to limited ku nuclear translocation and DNA binding. Curr Mol Med 15(7):663\u2013673","journal-title":"Curr Mol Med"},{"issue":"5","key":"2487_CR54","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.3892\/ol.2016.5036","volume":"12","author":"S Liu","year":"2016","unstructured":"Liu S, Wang X, Lu J et al (2016) Ubenimex enhances the radiosensitivity of renal cell carcinoma cells by inducing autophagic cell death. Oncol Lett 12(5):3403\u20133410","journal-title":"Oncol Lett"},{"issue":"2","key":"2487_CR55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","volume":"121","author":"L Ma","year":"2005","unstructured":"Ma L, Chen Z, Erdjument-Bromage H et al (2005) Phosphorylation and functional inactivation of TSC2 by Erk: implications for tuberous sclerosis and cancer pathogenesis. Cell 121(2):179\u2013193","journal-title":"Cell"},{"issue":"2","key":"2487_CR56","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.canlet.2014.11.016","volume":"356","author":"MB Meng","year":"2015","unstructured":"Meng MB, Wang HH, Guo WH et al (2015) Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo. Cancer Lett 356(2):985\u2013993","journal-title":"Cancer Lett"},{"issue":"5","key":"2487_CR57","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3892\/or.2014.3427","volume":"32","author":"N Mo","year":"2014","unstructured":"Mo N, Lu YK, Xie WM et al (2014) Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression. Oncol Rep 32(5):1905\u20131912","journal-title":"Oncol Rep"},{"issue":"4","key":"2487_CR58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.drup.2007.05.001","volume":"10","author":"L Moretti","year":"2007","unstructured":"Moretti L, Yang ES, Kim KW et al (2007) Autophagy signaling in cancer and its potential as novel target to improve anticancer therapy. Drug Resist Updates 10(4):135\u2013143","journal-title":"Drug Resist Updates"},{"issue":"4","key":"2487_CR59","first-page":"821","volume":"37","author":"H Mukubou","year":"2010","unstructured":"Mukubou H, Tsujimura T, Sasaki R et al (2010) The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. Int J Oncol 37(4):821","journal-title":"Int J Oncol"},{"issue":"24","key":"2487_CR60","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.4161\/cbt.8.24.10131","volume":"8","author":"M No","year":"2009","unstructured":"No M, Choi EJ, Kim IA (2009) Targeting HER2 signaling pathway for radiosensitization: alternative strategy for therapeutic resistance. Cancer Biol Ther 8(24):2351\u20132361","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"2487_CR61","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.radonc.2016.02.028","volume":"119","author":"M Ondrej","year":"2016","unstructured":"Ondrej M, Cechakova L, Durisova K et al (2016) To live or let die: unclear task of autophagy in the radiosensitization battle. Radiother Oncol 119(2):265\u2013275","journal-title":"Radiother Oncol"},{"issue":"4","key":"2487_CR62","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4161\/auto.2835","volume":"2","author":"S Paglin","year":"2006","unstructured":"Paglin S, Yahalom J (2006) Pathways that regulate autophagy and their role in mediating tumor response to treatment. Autophagy 2(4):291\u2013293","journal-title":"Autophagy"},{"issue":"1","key":"2487_CR63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.24118","volume":"228","author":"S Palumbo","year":"2013","unstructured":"Palumbo S, Comincini S (2013) Autophagy and ionizing radiation in tumors: the \u201csurvive or not survive\u201d dilemma. J Cell Physiol 228(1):1\u20138","journal-title":"J Cell Physiol"},{"issue":"7","key":"2487_CR64","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1002\/jcb.24102","volume":"113","author":"S Palumbo","year":"2012","unstructured":"Palumbo S, Pirtoli L, Tini P et al (2012) Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments. J Cell Biochem 113(7):2308\u20132318","journal-title":"J Cell Biochem"},{"issue":"3","key":"2487_CR65","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.radonc.2015.02.019","volume":"114","author":"MBE Schaaf","year":"2015","unstructured":"Schaaf MBE, Jutten B, Keulers TG et al (2015) Canonical autophagy does not contribute to cellular radioresistance. Radiother Oncol 114(3):406\u2013412","journal-title":"Radiother Oncol"},{"issue":"24","key":"2487_CR66","first-page":"4338","volume":"125","author":"CJ Shao","year":"2012","unstructured":"Shao CJ, Wu MW, Chen FR et al (2012) Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell lines in vitro. Chin Med J 125(24):4338\u20134343","journal-title":"Chin Med J"},{"issue":"12","key":"2487_CR67","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.4161\/15548627.2014.993283","volume":"10","author":"K Sharma","year":"2014","unstructured":"Sharma K, Goehe RW, Di X et al (2014) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy 10(12):2346\u20132361","journal-title":"Autophagy"},{"issue":"3","key":"2487_CR68","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1158\/1535-7163.MCT-15-0581","volume":"15","author":"S Shrivastava","year":"2016","unstructured":"Shrivastava S, Mansure JJ, Almajed W et al (2016) The role of HMGB1 in radioresistance of bladder cancer. Mol Cancer Ther 15(3):471\u2013479","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"2487_CR69","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/1535370214525315","volume":"239","author":"H Song","year":"2014","unstructured":"Song H, Pan B, Yi J et al (2014) Autophagic activation with Nimotuzumab enhanced chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma. Exp Biol Med 239(5):529\u2013541","journal-title":"Exp Biol Med"},{"issue":"5","key":"2487_CR70","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3892\/ijmm.2014.1927","volume":"34","author":"YC Su","year":"2014","unstructured":"Su YC, Yu CC, Hsu FT et al (2014) Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway. Int J Mol Med 34(5):1417\u20131422","journal-title":"Int J Mol Med"},{"issue":"5","key":"2487_CR71","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/ijc.29065","volume":"136","author":"Q Sun","year":"2015","unstructured":"Sun Q, Liu T, Yuan Y et al (2015a) MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1. Int J Cancer 136(5):1003\u20131012","journal-title":"Int J Cancer"},{"issue":"5","key":"2487_CR72","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.3892\/mmr.2015.3221","volume":"11","author":"Q Sun","year":"2015","unstructured":"Sun Q, Liu T, Zhang T et al (2015b) MiR-101 sensitizes human nasopharyngeal carcinoma cells to radiation by targeting stathmin 1. Mol Med Rep 11(5):3330\u20133336","journal-title":"Mol Med Rep"},{"issue":"11","key":"2487_CR73","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.febslet.2007.01.096","volume":"581","author":"K Suzuki","year":"2007","unstructured":"Suzuki K, Ohsumi Y (2007) Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 581(11):2156\u20132161","journal-title":"FEBS Lett"},{"issue":"11","key":"2487_CR74","first-page":"937","volume":"47","author":"ZP Tang","year":"2012","unstructured":"Tang ZP, Xu YD, Peng JR et al (2012) Mechanism of radiosensitization of 3-methyladenine in human hypopharynx cancer cells. Zhonghua er bi yan hou tou jing wai ke za zhi = Chin J Otorhinolaryngol Head Neck Surg 47(11):937\u2013941","journal-title":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chin J Otorhinolaryngol Head Neck Surg"},{"issue":"5","key":"2487_CR75","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/aps.2013.22","volume":"34","author":"W Wang","year":"2013","unstructured":"Wang W, Long L, Yang N et al (2013a) NVP-BEZ235, a novel dual PI3K\/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro. Acta Pharmacol Sin 34(5):681\u2013690","journal-title":"Acta Pharmacol Sin"},{"issue":"12","key":"2487_CR76","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.4161\/auto.26463","volume":"9","author":"P Wang","year":"2013","unstructured":"Wang P, Zhang L, Chen Z et al (2013b) MicroRNA targets autophagy in pancreatic cancer cells during cancer therapy. Autophagy 9(12):2171\u20132172","journal-title":"Autophagy"},{"issue":"1","key":"2487_CR77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/00016489.2013.844365","volume":"134","author":"Y Wang","year":"2014","unstructured":"Wang Y, Yin W, Zhu X (2014a) Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro. Acta Otolaryngol 134(1):105\u2013110","journal-title":"Acta Otolaryngol"},{"issue":"9","key":"2487_CR78","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10495-014-1010-3","volume":"19","author":"FZ Wang","year":"2014","unstructured":"Wang FZ, Fei H, Cui YJ et al (2014b) The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 19(9):1389\u20131398","journal-title":"Apoptosis"},{"issue":"5","key":"2487_CR79","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s12672-011-0081-7","volume":"2","author":"EN Wilson","year":"2011","unstructured":"Wilson EN, Bristol ML, Di X et al (2011) A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer 2(5):272\u2013285","journal-title":"Horm Cancer"},{"issue":"2","key":"2487_CR80","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","volume":"22","author":"Z Yang","year":"2010","unstructured":"Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22(2):124\u2013131","journal-title":"Curr Opin Cell Biol"},{"issue":"6","key":"2487_CR81","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1007\/s13277-015-3496-x","volume":"36","author":"Y Yang","year":"2015","unstructured":"Yang Y, Yang Y, Yang X et al (2015) Autophagy and its function in radiosensitivity. Tumor Biol 36(6):4079\u20134087","journal-title":"Tumor Biol"},{"issue":"2","key":"2487_CR82","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s13277-015-3974-1","volume":"37","author":"Y Yang","year":"2016","unstructured":"Yang Y, Sun X, Yang Y et al (2016) Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt\/mTOR pathway. Tumor Biol 37(2):1853\u20131862","journal-title":"Tumor Biol"},{"issue":"2","key":"2487_CR83","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3171\/jns.2003.98.2.0378","volume":"98","author":"KC Yao","year":"2003","unstructured":"Yao KC, Komata T, Kondo Y et al (2003) Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 98(2):378\u2013384","journal-title":"J Neurosurg"},{"issue":"12","key":"2487_CR85","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1593\/neo.121310","volume":"14","author":"L Yu","year":"2012","unstructured":"Yu L, Tumati V, Tseng SF et al (2012) DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor. Neoplasia 14(12):1203\u20131236","journal-title":"Neoplasia"},{"issue":"6","key":"2487_CR86","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.18632\/oncotarget.2975","volume":"6","author":"L Yu","year":"2015","unstructured":"Yu L, Shang ZF, Hsu FM et al (2015) NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor. Oncotarget 6(6):3848\u20133860","journal-title":"Oncotarget"},{"issue":"2","key":"2487_CR87","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yexcr.2014.09.006","volume":"330","author":"X Yuan","year":"2015","unstructured":"Yuan X, Du J, Hua S et al (2015) Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells. Exp Cell Res 330(2):267\u2013276","journal-title":"Exp Cell Res"},{"key":"2487_CR88","doi-asserted-by":"publisher","unstructured":"Zarzynska JM (2014) The importance of autophagy regulation in breast cancer development and treatment. BioMed Res Int 2014:9. doi: 10.1155\/2014\/710345","DOI":"10.1155\/2014\/710345"},{"issue":"11","key":"2487_CR89","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1007\/s13277-015-3578-9","volume":"36","author":"C Zhang","year":"2015","unstructured":"Zhang C, Qiu X (2015) Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy. Tumor Biol 36(11):8359\u20138365","journal-title":"Tumor Biol"},{"issue":"3","key":"2487_CR90","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.3892\/or.2015.4078","volume":"34","author":"X Zhang","year":"2015","unstructured":"Zhang X, Shi H, Lin S et al (2015) MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy. Oncol Rep 34(3):1557\u20131564","journal-title":"Oncol Rep"},{"issue":"5","key":"2487_CR91","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/abbs\/gmp028","volume":"41","author":"W Zhuang","year":"2009","unstructured":"Zhuang W, Qin Z, Liang Z (2009) The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta Biochim Biophys Sin 41(5):341\u2013351","journal-title":"Acta Biochim Biophys Sin"},{"key":"2487_CR92","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brainres.2010.11.044","volume":"1371","author":"W Zhuang","year":"2011","unstructured":"Zhuang W, Li B, Long L et al (2011) Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res 1371:7\u201315","journal-title":"Brain Res"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-017-2487-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2487-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-017-2487-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T22:46:29Z","timestamp":1569969989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-017-2487-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":90,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["2487"],"URL":"https:\/\/doi.org\/10.1007\/s00432-017-2487-2","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}