{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:51:58Z","timestamp":1789707118907,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100009794","name":"Breast Cancer Now","doi-asserted-by":"publisher","award":["2011MayPr35"],"award-info":[{"award-number":["2011MayPr35"]}],"id":[{"id":"10.13039\/100009794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00432-018-2579-7","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T15:49:11Z","timestamp":1515685751000},"page":"509-517","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High nuclear MSK1 is associated with longer survival in breast cancer patients"],"prefix":"10.1007","volume":"144","author":[{"given":"Xuan","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Storr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narmeen S.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Rakha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-2338","authenticated-orcid":false,"given":"Stewart G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"issue":"3","key":"2579_CR1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.21004","volume":"116","author":"DM Abd El Rehim","year":"2005","unstructured":"Abd El Rehim DM, Ball G, Pinder SE, Rakha E, Paish C, Robertson JF, Macmillan D, Blamey RW, Ellis IO (2005) High throughput protein expression analysis using tissue microarray technology of a large well characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 116(3):340\u2013350","journal-title":"Int J Cancer"},{"issue":"4","key":"2579_CR2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/path.2663","volume":"220","author":"TM Abdel Fatah","year":"2010","unstructured":"Abdel Fatah TM, Powe DG, Agboola J, Adamowicz Brice M, Blamey RW, Lopez Garcia MA, Green AR, Reis Filho JS, Ellis IO (2010) The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers. J Pathol 220(4):419\u2013434","journal-title":"J Pathol"},{"issue":"21","key":"2579_CR3","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","volume":"10","author":"RL Camp","year":"2004","unstructured":"Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10(21):7252\u20137259","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2579_CR4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"M Cargnello","year":"2011","unstructured":"Cargnello M, Roux PP (2011) Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev 75(1):50\u201383","journal-title":"Microbiol Mol Biol Rev"},{"issue":"15","key":"2579_CR5","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1093\/emboj\/17.15.4426","volume":"17","author":"M Deak","year":"1998","unstructured":"Deak M, Clifton AD, Lucocq JM, Alessi DR (1998) Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2\/p38, and may mediate activation of CREB. EMBO J 17(15):4426\u20134441","journal-title":"EMBO J"},{"issue":"37","key":"2579_CR6","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1038\/onc.2012.444","volume":"32","author":"Y Hsu","year":"2013","unstructured":"Hsu Y, Hou M, Kuo P, Huang Y, Tsai E (2013) Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK\/MSK1\/Elk-1\/snail signaling pathway. Oncogene 32(37):4436\u20134447","journal-title":"Oncogene"},{"issue":"3","key":"2579_CR7","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1074\/jbc.M109.083808","volume":"285","author":"KA Jacks","year":"2010","unstructured":"Jacks KA, Koch CA (2010) Differential regulation of mitogen-and stress-activated protein kinase-1 and-2 (MSK1 and MSK2) by CK2 following UV radiation. J Biol Chem 285(3):1661\u20131670","journal-title":"J Biol Chem"},{"issue":"5","key":"2579_CR8","doi-asserted-by":"crossref","first-page":"e63189","DOI":"10.1371\/journal.pone.0063189","volume":"8","author":"P Khan","year":"2013","unstructured":"Khan P, Drobic B, P\u00e9rez-Cadah\u00eda B, Healy S, He S, Davie JR (2013) Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. PLoS One 8(5):e63189","journal-title":"PLoS One"},{"issue":"3","key":"2579_CR9","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3892\/or.2012.2209","volume":"29","author":"HT Lee","year":"2013","unstructured":"Lee HT, Kim SK, Choi MR, Park JH, Jung KH, Chai YG (2013) Effects of the activated mitogen-activated protein kinase pathway via the c-ros receptor tyrosine kinase on the T47D breast cancer cell line following alcohol exposure. Oncol Rep 29(3):868\u2013874","journal-title":"Oncol Rep"},{"issue":"1","key":"2579_CR10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s12885-015-1398-3","volume":"15","author":"B Li","year":"2015","unstructured":"Li B, Wan Z, Huang G, Huang Z, Zhang X, Liao D, Luo S, He Z (2015) Mitogen-and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes. BMC Cancer 15(1):390","journal-title":"BMC Cancer"},{"issue":"2","key":"2579_CR11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1042\/BJ20041501","volume":"387","author":"CE McCOY","year":"2005","unstructured":"McCOY CE, Campbell DG, Maria D, Bloomberg GB, Arthur JSC (2005) MSK1 activity is controlled by multiple phosphorylation sites. Biochem J 387(2):507\u2013517","journal-title":"Biochem J"},{"issue":"4","key":"2579_CR12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/sj.bjc.6602678","volume":"93","author":"LM McShane","year":"2005","unstructured":"McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer 93(4):387\u2013391","journal-title":"Br J Cancer"},{"issue":"18","key":"2579_CR13","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.ejca.2006.08.015","volume":"42","author":"EA Rakha","year":"2006","unstructured":"Rakha EA, El-Rehim DA, Paish C, Green AR, Lee AH, Robertson JF, Blamey RW, Macmillan D, Ellis IO (2006) Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer 42(18):3149\u20133156","journal-title":"Eur J Cancer"},{"issue":"12","key":"2579_CR14","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/onc.2013.95","volume":"33","author":"D Reyes","year":"2014","unstructured":"Reyes D, Ballar\u00e9 C, Castellano G, Soronellas D, Bag\u00f3 J, Blanco J, Beato M (2014) Activation of mitogen-and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins. Oncogene 33(12):1570\u20131580","journal-title":"Oncogene"},{"issue":"11","key":"2579_CR15","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1093\/emboj\/cdg273","volume":"22","author":"A Soloaga","year":"2003","unstructured":"Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JSC (2003) MSK2 and MSK1 mediate the mitogen-and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J 22(11):2788\u20132797","journal-title":"EMBO J"},{"issue":"6","key":"2579_CR16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tibs.2009.02.007","volume":"34","author":"L Vermeulen","year":"2009","unstructured":"Vermeulen L, Berghe WV, Beck IM, De Bosscher K, Haegeman G (2009) The versatile role of MSKs in transcriptional regulation. Trends Biochem Sci 34(6):311\u2013318","journal-title":"Trends Biochem Sci"},{"issue":"9","key":"2579_CR17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/mc.20413","volume":"47","author":"Y Wei","year":"2008","unstructured":"Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB (2008) Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog 47(9):701\u2013706","journal-title":"Mol Carcinog"},{"issue":"8","key":"2579_CR18","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1128\/MCB.22.8.2871-2881.2002","volume":"22","author":"GR Wiggin","year":"2002","unstructured":"Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JSC (2002) MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol 22(8):2871\u20132881","journal-title":"Mol Cell Biol"},{"issue":"5","key":"2579_CR19","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.ijrobp.2010.11.002","volume":"79","author":"CM Woolston","year":"2011","unstructured":"Woolston CM, Al-Attar A, Storr SJ, Ellis IO, Morgan DAL, Martin SG (2011a) Redox protein expression predicts radiotherapeutic response in early-stage invasive breast cancer patients. Int J Radiat Oncol Biol Phys 79(5):1532\u20131540","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"2579_CR20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.radonc.2011.05.029","volume":"100","author":"CM Woolston","year":"2011","unstructured":"Woolston CM, Storr SJ, Ellis IO, Morgan DAL, Martin SG (2011b) Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer. Radiother Oncol 100(2):308\u2013313","journal-title":"Radiother Oncol"},{"issue":"9","key":"2579_CR21","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1158\/1940-6207.CAPR-14-0126","volume":"7","author":"K Yao","year":"2014","unstructured":"Yao K, Chen H, Liu K, Langfald A, Yang G, Zhang Y, Yu DH, Kim MO, Lee M-H, Li H (2014) Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prev Res 7(9):958\u2013967","journal-title":"Cancer Prev Res"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-018-2579-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-018-2579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-018-2579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T13:53:40Z","timestamp":1603634020000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-018-2579-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["2579"],"URL":"https:\/\/doi.org\/10.1007\/s00432-018-2579-7","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}