{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:29:15Z","timestamp":1793089755794,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201612023"],"award-info":[{"award-number":["SZSM201612023"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00432-018-2770-x","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T04:58:07Z","timestamp":1539752287000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A novel prognostic signature of seven genes for the prediction in patients with thymoma"],"prefix":"10.1007","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-7606","authenticated-orcid":false,"given":"Qiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"issue":"3","key":"2770_CR1","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1093\/icvts\/ivs263","volume":"15","author":"S Attaran","year":"2012","unstructured":"Attaran S et al (2012) Does surgical debulking for advanced stages of thymoma improve survival? Interact Cardiovasc Thorac Surg 15(3):494\u2013497","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"8","key":"2770_CR2","doi-asserted-by":"publisher","first-page":"e42669","DOI":"10.1371\/journal.pone.0042669","volume":"7","author":"S Badve","year":"2012","unstructured":"Badve S et al (2012) Molecular analysis of thymoma. PLoS One 7(8):e42669","journal-title":"PLoS One"},{"issue":"9","key":"2770_CR3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1093\/jnci\/dji112","volume":"97","author":"F Cappuzzo","year":"2005","unstructured":"Cappuzzo F et al (2005) Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97(9):643\u2013655","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"2770_CR4","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1056\/NEJMra0707704","volume":"358","author":"F Ciardiello","year":"2008","unstructured":"Ciardiello F, Tortora G (2008) EGFR antagonists in cancer treatment. N Engl J Med 358(11):1160\u20131174","journal-title":"N Engl J Med"},{"issue":"2","key":"2770_CR5","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1016\/j.jtcvs.2010.10.022","volume":"141","author":"CP Erkmen","year":"2011","unstructured":"Erkmen CP et al (2011) Thymoma-associated paraneoplastic encephalitis (TAPE): diagnosis and treatment of a potentially fatal condition. J Thorac Cardiovasc Surg 141(2):e17\u2013e20","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"7","key":"2770_CR6","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1097\/JTO.0b013e3181a4b8e0","volume":"4","author":"CB Falkson","year":"2009","unstructured":"Falkson CB et al (2009) The management of thymoma: a systematic review and practice guideline. J Thorac Oncol 4(7):911\u2013919","journal-title":"J Thorac Oncol"},{"key":"2770_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2156-8-17","volume":"8","author":"S Friedel","year":"2007","unstructured":"Friedel S et al (2007) Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13. BMC Genet 8:17","journal-title":"BMC Genet"},{"issue":"1","key":"2770_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/JTO.0b013e31818e105c","volume":"4","author":"N Girard","year":"2009","unstructured":"Girard N et al (2009) Thymoma: a focus on current therapeutic management. J Thorac Oncol 4(1):119\u2013126","journal-title":"J Thorac Oncol"},{"issue":"2","key":"2770_CR9","first-page":"17","volume":"7","author":"S Gumustas","year":"2013","unstructured":"Gumustas S et al (2013) Characterization of malignant thrombus in an invasive thymoma with intravascular growth. J Radiol Case Rep 7(2):17\u201323","journal-title":"J Radiol Case Rep"},{"issue":"3","key":"2770_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00432-001-0319-9","volume":"128","author":"JD Henley","year":"2002","unstructured":"Henley JD, Koukoulis GK, Loehrer PJ Sr. (2002) Epidermal growth factor receptor expression in invasive thymoma. J Cancer Res Clin Oncol 128(3):167\u2013170","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"2770_CR11","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s00432-004-0545-z","volume":"130","author":"JD Henley","year":"2004","unstructured":"Henley JD, Cummings OW, Loehrer PJ Sr. (2004) Tyrosine kinase receptor expression in thymomas. J Cancer Res Clin Oncol 130(4):222\u2013224","journal-title":"J Cancer Res Clin Oncol"},{"issue":"10","key":"2770_CR12","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1002\/ijc.21671","volume":"118","author":"KC Huang","year":"2006","unstructured":"Huang KC et al (2006) Selenium binding protein 1 in ovarian cancer. Int J Cancer 118(10):2433\u20132440","journal-title":"Int J Cancer"},{"issue":"1","key":"2770_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28(1):27\u201330","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2770_CR14","doi-asserted-by":"publisher","first-page":"577","DOI":"10.6004\/jnccn.2013.0073","volume":"11","author":"RJ Kelly","year":"2013","unstructured":"Kelly RJ (2013) Thymoma versus thymic carcinoma: differences in biology impacting treatment. J Natl Compr Canc Netw 11(5):577\u2013583","journal-title":"J Natl Compr Canc Netw"},{"issue":"6","key":"2770_CR15","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/onc.2011.272","volume":"31","author":"EW Law","year":"2012","unstructured":"Law EW et al (2012) Anti-angiogenic and tumor-suppressive roles of candidate tumor-suppressor gene, Fibulin-2, in nasopharyngeal carcinoma. Oncogene 31(6):728\u2013738","journal-title":"Oncogene"},{"issue":"1","key":"2770_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ejcts.2009.02.019","volume":"36","author":"CY Lee","year":"2009","unstructured":"Lee CY et al. (2009) Early Masaoka stage and complete resection is important for prognosis of thymic carcinoma: a 20-year experience at a single institution. Eur J Cardiothorac Surg 36(1):159\u201362 (discussion 163)","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"2770_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13019-016-0533-9","volume":"11","author":"T Luo","year":"2016","unstructured":"Luo T, Zhao H, Zhou X (2016) The clinical features, diagnosis and management of recurrent thymoma. J Cardiothorac Surg 11(1):140","journal-title":"J Cardiothorac Surg"},{"issue":"4","key":"2770_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1210\/mend.12.4.0084","volume":"12","author":"D Mao","year":"1998","unstructured":"Mao D et al (1998) Differential regulation and transcriptional control of immediate early gene expression in forskolin-treated WEHI7.2 thymoma cells. Mol Endocrinol 12(4):492\u2013503","journal-title":"Mol Endocrinol"},{"issue":"5","key":"2770_CR19","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/JTO.0000000000000154","volume":"9","author":"A Marx","year":"2014","unstructured":"Marx A et al (2014) ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting. J Thorac Oncol 9(5):596\u2013611","journal-title":"J Thorac Oncol"},{"issue":"3","key":"2770_CR20","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/cncr.10226","volume":"94","author":"M Okumura","year":"2002","unstructured":"Okumura M et al (2002) The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 94(3):624\u2013632","journal-title":"Cancer"},{"issue":"6","key":"2770_CR21","first-page":"617","volume":"85","author":"A Panarese","year":"2014","unstructured":"Panarese A et al (2014) Thymectomy and systemic lupus erythematosus (SLE). Ann Ital Chir 85(6):617\u2013618","journal-title":"Ann Ital Chir"},{"issue":"10 Suppl 4","key":"2770_CR22","doi-asserted-by":"publisher","first-page":"S323","DOI":"10.1097\/JTO.0b013e3181f20e90","volume":"5","author":"GJ Riely","year":"2010","unstructured":"Riely GJ, Huang J (2010) Induction therapy for locally advanced thymoma. J Thorac Oncol 5(10 Suppl 4):S323\u2013S326","journal-title":"J Thorac Oncol"},{"issue":"4","key":"2770_CR23","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/ijc.10624","volume":"101","author":"H Sasaki","year":"2002","unstructured":"Sasaki H et al (2002) Gene expression analysis of human thymoma correlates with tumor stage. Int J Cancer 101(4):342\u2013347","journal-title":"Int J Cancer"},{"issue":"3","key":"2770_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/cmi.2010.74","volume":"8","author":"S Shelly","year":"2011","unstructured":"Shelly S et al (2011) Thymoma and autoimmunity. Cell Mol Immunol 8(3):199\u2013202","journal-title":"Cell Mol Immunol"},{"issue":"10 Suppl 4","key":"2770_CR25","doi-asserted-by":"publisher","first-page":"S286","DOI":"10.1097\/JTO.0b013e3181f209a8","volume":"5","author":"P Strobel","year":"2010","unstructured":"Strobel P, Hohenberger P, Marx A (2010) Thymoma and thymic carcinoma: molecular pathology and targeted therapy. J Thorac Oncol 5(10 Suppl 4):S286\u2013S290","journal-title":"J Thorac Oncol"},{"issue":"3","key":"2770_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/0925-4439(93)90044-2","volume":"1180","author":"MP Thompson","year":"1993","unstructured":"Thompson MP et al (1993) Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. Biochim Biophys Acta 1180(3):236\u2013242","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2770_CR27","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/jcmm.12481","volume":"19","author":"I Valenca","year":"2015","unstructured":"Valenca I et al (2015) Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. J Cell Mol Med 19(4):723\u2013733","journal-title":"J Cell Mol Med"},{"issue":"4","key":"2770_CR28","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/S0006-291X(03)01097-0","volume":"306","author":"JJ Wenzel","year":"2003","unstructured":"Wenzel JJ et al (2003) ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. Biochem Biophys Res Commun 306(4):1089\u20131098","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"2770_CR29","first-page":"256","volume":"23","author":"Q Yao","year":"2017","unstructured":"Yao Q et al (2017) Clinicopathological features of thymoma with ring calcification: case reports. Thorac Cancer 23(5):256\u2013261","journal-title":"Thorac Cancer"},{"issue":"12","key":"2770_CR30","doi-asserted-by":"publisher","first-page":"9180","DOI":"10.1074\/jbc.M109.077958","volume":"285","author":"P Zhang","year":"2010","unstructured":"Zhang P et al (2010) Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem 285(12):9180\u20139189","journal-title":"J Biol Chem"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-018-2770-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-018-2770-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-018-2770-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T19:14:13Z","timestamp":1571253253000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-018-2770-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["2770"],"URL":"https:\/\/doi.org\/10.1007\/s00432-018-2770-x","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"value":"0171-5216","type":"print"},{"value":"1432-1335","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"assertion":[{"value":"3 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}