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The first Brazilian consensus provides support to improve penile cancer patients\u2019 outcomes, based on expert\u2019s opinion and evidence from medical literature.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Fifty-one Brazilian experts (clinical oncologists, radiation oncologists, urologists, and pathologists) assembled and voted 104 multiple-choice questions, confronted the results with the literature, and ranked the levels of evidence.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Healthcare professionals need to deliver more effective communication about the risk factors for penile cancer. Staging and follow-up of patients include physical examination, computed tomography, and magnetic resonance imaging. Close monitoring is crucial, because most recurrences occur in the first 2\u20135\u00a0years. Lymph-node involvement is the most important predictive factor for survival, and management depends on the location (inguinal or pelvic) and the number of lymph nodes involved. Conservative treatment may be helpful in selected patients without compromising oncological outcomes; however, surgery yields the lowest rate of local recurrence.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This consensus provides an essential decision-making orientation regarding this challenging disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00432-020-03417-1","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T10:02:45Z","timestamp":1603706565000},"page":"3281-3296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Penile cancer: a Brazilian consensus statement for low- and middle-income countries"],"prefix":"10.1007","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6729","authenticated-orcid":false,"given":"Andrey","family":"Soares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0607-7589","authenticated-orcid":false,"given":"Icaro Thiago","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alu\u00edzio Gon\u00e7alves","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Antonio Machado","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2161-0222","authenticated-orcid":false,"given":"Carlos Heli Bezerra","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Assed","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Paulo Holanda","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-7730","authenticated-orcid":false,"given":"Katia Ramos Moreira","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio Ronalsa Brand\u00e3o","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Wagner Pereira","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro Roberto de A.","family":"Cavallero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00eanio","family":"de Cassio Zequi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"de Ribamar Rodrigues Calixto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"3417_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.urolonc.2017.07.025","volume":"36","author":"M Albersen","year":"2018","unstructured":"Albersen M, Parnham A, Joniau S, Sahdev V, Christodoulidou M, Castiglione F et al (2018) Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. 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Andrey Soares: Speaker fee: Janssen, Pfizer, Bayer, Novartis, Astra Zeneca, Astellas, Pierre-Fabre, Merck-Serono, Sanofi, Lilly, Merck Sharp & Dohme, Roche, Bristol-Myers Squibb. Events Sponsorship: AstraZeneca, Pfizer, Astellas, Bristol-Myers Squibb, Merck Sharp & Dohme, Bayer, Roche, Janssen, Merck Serono, Sanofi, Ipsen. Advisory Board: Astellas, Janssen, Roche, Bayer, Lilly, AstraZeneca, Novartis, Merck Sharp & Dohme, Bristol-Myers Squibb, Pfizer. Research Funding: Bristol-Myers Squibb. Antonio Machado Alencar Jr.: None. Carlos Heli Bezerra Leite: None. Diogo Assed Bastos: Research funding: Janssen, Astellas, Pfizer, Merck Sharp & Dohme. Honouraria\/Advisory Board: Janssen, Astellas, Bristol-Myers Squibb, Merck Sharp & Dohme, Roche, Pfizer, Novartis, Bayer. Icaro Thiago de Carvalho: None. Jo\u00e3o Paulo Holanda Soares: Events sponsorship: Merck Sharp & Dome, Bayer. Research Funding: Merck Sharp & Dome, Beigene, Lilly, Nektar. Jos\u00e9 Ribamar Rodrigues Calixto: None. Katia Ramos Moreira Leite: None. M\u00e1rio Ronalsa Brand\u00e3o Filho: none. Ronald Wagner Pereira Coelho: Speaker fee: Roche. Sandro Roberto de A. Cavallero: Speaker fee: Janssen, Pfizer, Bayer, Novartis, AstraZeneca, Astellas, Amgen, Takeda, Merck Sharp & Dohme, Roche, Bristol-Myers Squibb. Events Sponsorship: AstraZeneca, Pfizer, Astellas, Bristol-Myers Squibb, Merck Sharp & Dohme, Bayer, Roche, Janssen. Advisory Board: Amgen, Janssen, Roche, Merck Sharp & Dohme, Pfizer. St\u00eanio de Cassio Zequi: Speaker fee: Bristol-Myers Squibb, Pfizer and AstraZeneca. Research funding: Merck Sharp & Dohme. Events sponsorship: Astellas.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}