{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:56:07Z","timestamp":1765486567059,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00432-021-03512-x","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T01:46:12Z","timestamp":1612835172000},"page":"1137-1144","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic and management challenges for MDM2-, CDK4-negative fatty tumors of the retroperitoneum"],"prefix":"10.1007","volume":"147","author":[{"given":"Max L.","family":"Silverstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra N.","family":"Kalof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn C.","family":"Kurchena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth P.","family":"Harlow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego F.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-5265","authenticated-orcid":false,"given":"Jessica A.","family":"Cintolo-Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"3512_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ijscr.2019.02.044","volume":"57","author":"MHM Al-Ali","year":"2019","unstructured":"Al-Ali MHM, Salih AM, Ahmed OF et al (2019) Retroperitoneal lipoma; a benign condition with frightening presentation. Int J Surg Case Rep 57:63\u201366","journal-title":"Int J Surg Case Rep"},{"issue":"4","key":"3512_CR2","first-page":"473","volume":"116","author":"ZK Arbiser","year":"2001","unstructured":"Arbiser ZK, Folpe AL, Weiss SW (2001) Consultative (expert) second opinions in soft tissue pathology. Analysis of problem-prone diagnostic situations. Am J ClinPathol 116(4):473\u2013476","journal-title":"Am J ClinPathol"},{"issue":"1","key":"3512_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1200\/JCO.2008.18.0802","volume":"27","author":"S Bonvalot","year":"2009","unstructured":"Bonvalot S, Rivoire M, Castaing M et al (2009) Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J ClinOncol 27(1):31\u201337","journal-title":"J ClinOncol"},{"issue":"9","key":"3512_CR4","first-page":"82","volume":"10","author":"JH Choi","year":"2020","unstructured":"Choi JH, Ro JY (2020) Retroperitoneal sarcomas: an update on the diagnostic pathology approach. Diagnostics (Basel) 10(9):82","journal-title":"Diagnostics (Basel)"},{"issue":"2","key":"3512_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0165-4608(93)90001-3","volume":"68","author":"P Dal Cin","year":"1993","unstructured":"Dal Cin P, Kools P, Sciot R et al (1993) Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 68(2):85\u201390","journal-title":"Cancer Genet Cytogenet"},{"key":"3512_CR6","unstructured":"Eble J, Sauter G, Epstein J, Sesterhenn I (2004) Pathology and genetics of tumours of the urinary system and male genital organs: World Health Organization classification of tumours. In: International Agency of Research on Cancer. 2004"},{"issue":"4","key":"3512_CR7","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/RCT.0b013e3181507534","volume":"32","author":"JJ Ellingson","year":"2008","unstructured":"Ellingson JJ, Coakley FV, Joe BN, Qayyum A, Westphalen AC, Yeh BM (2008) Computed tomographic distinction of perirenalliposarcoma from exophyticangiomyolipoma: a feature analysis study. J Comput Assist Tomogr 32(4):548\u2013552","journal-title":"J Comput Assist Tomogr"},{"key":"3512_CR8","first-page":"430","volume-title":"Urologic pathology","author":"GM Farrow","year":"1997","unstructured":"Farrow GM (1997) Disease of the kidney. In: Murphy WM (ed) Urologic pathology, 2nd edn. Sanders, Philadelphia, pp 430\u2013502","edition":"2"},{"issue":"4 Pt 1","key":"3512_CR9","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.juro.2015.07.126","volume":"195","author":"AS Flum","year":"2016","unstructured":"Flum AS, Hamoui N, Said MA et al (2016) Update on the diagnosis and management of renal angiomyolipoma. J Urol 195(4 Pt 1):834\u2013846","journal-title":"J Urol"},{"issue":"1","key":"3512_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humpath.2009.05.011","volume":"41","author":"AL Folpe","year":"2010","unstructured":"Folpe AL, Kwiatkowski DJ (2010) Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol 41(1):1\u201315","journal-title":"Hum Pathol"},{"issue":"4","key":"3512_CR11","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/annonc\/mdr323","volume":"23","author":"A Gronchi","year":"2012","unstructured":"Gronchi A, Miceli R, Colombo C et al (2012) Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas. Ann Oncol 23(4):1067\u20131073","journal-title":"Ann Oncol"},{"issue":"2","key":"3512_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1148\/radiology.188.2.8327691","volume":"188","author":"O Helenon","year":"1993","unstructured":"Helenon O, Chretien Y, Paraf F, Melki P, Denys A, Moreau JF (1993) Renal cell carcinoma containing fat: demonstration with CT. Radiology 188(2):429\u2013430","journal-title":"Radiology"},{"issue":"1","key":"3512_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1365-2559.2005.02316.x","volume":"48","author":"JL Hornick","year":"2006","unstructured":"Hornick JL, Fletcher CD (2006) PEComa: what do we know so far? Histopathology 48(1):75\u201382","journal-title":"Histopathology"},{"issue":"6","key":"3512_CR14","first-page":"1188","volume":"117","author":"N Ikoma","year":"2018","unstructured":"Ikoma N, Roland CL, Torres KE et al (2018) Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: a retrospective cohort study at a major sarcoma center. J SurgOncol 117(6):1188\u20131194","journal-title":"J SurgOncol"},{"issue":"3","key":"3512_CR15","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2214\/ajr.179.3.1790769","volume":"179","author":"GM Israel","year":"2002","unstructured":"Israel GM, Bosniak MA, Slywotzky CM, Rosen RJ (2002) CT differentiation of large exophytic renal angiomyolipomas and perirenalliposarcomas. AJR Am J Roentgenol 179(3):769\u2013773","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"3512_CR16","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s00261-014-0083-3","volume":"39","author":"M Jinzaki","year":"2014","unstructured":"Jinzaki M, Silverman SG, Akita H, Nagashima Y, Mikami S, Oya M (2014) Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management. Abdom Imaging 39(3):588\u2013604","journal-title":"Abdom Imaging"},{"issue":"3","key":"3512_CR17","doi-asserted-by":"crossref","first-page":"56","DOI":"10.59779\/jiomnepal.318","volume":"29","author":"P Kansakar","year":"2007","unstructured":"Kansakar P, Ghimire B, Rajbhandary A, Singh YP, Vaidya P (2007) Giant retroperitoneal lipoma. J Inst Med 29(3):56\u201358","journal-title":"J Inst Med"},{"issue":"4","key":"3512_CR18","first-page":"258","volume":"18","author":"L Laurino","year":"2001","unstructured":"Laurino L, Furlanetto A, Orvieto E, Dei Tos AP (2001) Well-differentiated liposarcoma (atypical lipomatoustumors). SeminDiagnPathol 18(4):258\u2013262","journal-title":"SeminDiagnPathol"},{"issue":"3","key":"3512_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/00000658-199809000-00008","volume":"228","author":"JJ Lewis","year":"1998","unstructured":"Lewis JJ, Leung D, Woodruff JM, Brennan MF (1998) Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg 228(3):355\u2013365","journal-title":"Ann Surg"},{"issue":"6","key":"3512_CR20","first-page":"445","volume":"46","author":"JS Liles","year":"2009","unstructured":"Liles JS, Tzeng CW, Short JJ, Kulesza P, Heslin MJ (2009) Retroperitoneal and intra-abdominal sarcoma. CurrProblSurg 46(6):445\u2013503","journal-title":"CurrProblSurg"},{"key":"3512_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fsurg.2015.00004","volume":"2","author":"LE Matthyssens","year":"2015","unstructured":"Matthyssens LE, Creytens D, Ceelen WP (2015) Retroperitoneal liposarcoma: current insights in diagnosis and treatment. Front Surg 2:4","journal-title":"Front Surg"},{"key":"3512_CR22","unstructured":"Patel S (2000) Retroperitoneal tumors and cysts. In: Pollack HM, McClennan BL (eds) Clinical urography, 2nd edn. Philadelphia: Saunders, pp 2823\u20132865"},{"issue":"6","key":"3512_CR23","first-page":"1481","volume":"17","author":"CP Raut","year":"2010","unstructured":"Raut CP, Swallow CJ (2010) Are radical compartmental resections for retroperitoneal sarcomas justified? Ann SurgOncol 17(6):1481\u20131484","journal-title":"Ann SurgOncol"},{"issue":"2","key":"3512_CR24","first-page":"206","volume":"70","author":"N Schieda","year":"2015","unstructured":"Schieda N, Kielar AZ, Al Dandan O, McInnes MD, Flood TA (2015) Ten uncommon and unusual variants of renal angiomyolipoma (AML): radiologic-pathologic correlation. ClinRadiol 70(2):206\u2013220","journal-title":"ClinRadiol"},{"issue":"5","key":"3512_CR25","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.urology.2008.07.049","volume":"72","author":"RM Seyam","year":"2008","unstructured":"Seyam RM, Bissada NK, Kattan SA et al (2008) Changing trends in presentation, diagnosis and management of renal angiomyolipoma: comparison of sporadic and tuberous sclerosis complex-associated forms. Urology 72(5):1077\u20131082","journal-title":"Urology"},{"issue":"2","key":"3512_CR26","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1148\/radiology.188.2.8327690","volume":"188","author":"M Strotzer","year":"1993","unstructured":"Strotzer M, Lehner KB, Becker K (1993) Detection of fat in a renal cell carcinoma mimicking angiomyolipoma. Radiology 188(2):427\u2013428","journal-title":"Radiology"},{"key":"3512_CR27","doi-asserted-by":"publisher","first-page":"741975","DOI":"10.1155\/2009\/741975","volume":"2009","author":"K Thway","year":"2009","unstructured":"Thway K, Fisher C (2009) Histopathological diagnostic discrepancies in soft tissue tumours referred to a specialist centre. Sarcoma 2009:741975","journal-title":"Sarcoma"},{"issue":"3","key":"3512_CR28","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/PAS.0b013e3182417330","volume":"36","author":"K Thway","year":"2012","unstructured":"Thway K, Flora R, Shah C, Olmos D, Fisher C (2012) Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytictumors. Am J SurgPathol 36(3):462\u2013469","journal-title":"Am J SurgPathol"},{"key":"3512_CR29","doi-asserted-by":"publisher","first-page":"812089","DOI":"10.1155\/2015\/812089","volume":"2015","author":"K Thway","year":"2015","unstructured":"Thway K, Wang J, Swansbury J, Min T, Fisher C (2015) Fluorescence in situ hybridization for MDM2 amplification as a routine ancillary diagnostic tool for suspected well-differentiated and dedifferentiated liposarcomas: experience at a tertiary center. Sarcoma 2015:812089","journal-title":"Sarcoma"},{"issue":"7","key":"3512_CR30","first-page":"2136","volume":"21","author":"WW Tseng","year":"2014","unstructured":"Tseng WW, Madewell JE, Wei W et al (2014) Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection? Ann SurgOncol 21(7):2136\u20132143","journal-title":"Ann SurgOncol"},{"issue":"8","key":"3512_CR31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1046\/j.1442-2042.2001.00344.x","volume":"8","author":"M Tsutsumi","year":"2001","unstructured":"Tsutsumi M, Yamauchi A, Tsukamoto S, Ishikawa S (2001) A case of angiomyolipoma presenting as a huge retroperitoneal mass. Int J Urol 8(8):470\u2013471","journal-title":"Int J Urol"},{"issue":"1","key":"3512_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1148\/radiographics.17.1.9017806","volume":"17","author":"BJ Wagner","year":"1997","unstructured":"Wagner BJ, Wong-You-Cheong JJ, Davis CJ Jr (1997) Adult renal hamartomas. Radiographics 17(1):155\u2013169","journal-title":"Radiographics"},{"key":"3512_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13104-015-1038-7","volume":"8","author":"M Weniger","year":"2015","unstructured":"Weniger M, D\u2019Haese JG, Kunz W et al (2015) En-bloc resection of a giant retroperitoneal lipoma: a case report and review of the literature. BMC Res Notes 8:75","journal-title":"BMC Res Notes"},{"issue":"3","key":"3512_CR34","first-page":"639","volume":"44","author":"ML Wroclawski","year":"2018","unstructured":"Wroclawski ML, Baccaglini W, Pazeto CL et al (2018) Extrarenalangiomyolipoma: differential diagnosis of retroperitoneal masses. IntBraz J Urol 44(3):639\u2013641","journal-title":"IntBraz J Urol"},{"issue":"Suppl 1","key":"3512_CR35","first-page":"66","volume":"62","author":"H Xiang","year":"2018","unstructured":"Xiang H, Han J, Ridley WE, Ridley LJ (2018) Claw sign: origin of a mass. J Med Imaging RadiatOncol 62(Suppl 1):66","journal-title":"J Med Imaging RadiatOncol"},{"issue":"5","key":"3512_CR36","first-page":"1821","volume":"32","author":"N Yamamoto","year":"2012","unstructured":"Yamamoto N, Hayashi K, Tanzawa Y et al (2012) Treatment strategies for well-differentiated liposarcomas and therapeutic outcomes. Anticancer Res 32(5):1821\u20131825","journal-title":"Anticancer Res"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03512-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-021-03512-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03512-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T21:27:54Z","timestamp":1724448474000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-021-03512-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,6]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3512"],"URL":"https:\/\/doi.org\/10.1007\/s00432-021-03512-x","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"type":"print","value":"0171-5216"},{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2021,2,6]]},"assertion":[{"value":"9 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}