{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:21:00Z","timestamp":1761582060819,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Cancer Res Clin Oncol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s00432-021-03538-1","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T05:01:34Z","timestamp":1613710894000},"page":"1335-1340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The potential of somatostatin receptor 2 as a novel therapeutic target in salivary gland malignant tumors"],"prefix":"10.1007","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-2926","authenticated-orcid":false,"given":"Amichay","family":"Meirovitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karny","family":"Shouchane-Blum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Maly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniya","family":"Bersudski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Hirshoren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Popovtzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Orevi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"3538_CR1","first-page":"347","volume":"14","author":"L Bodei","year":"2010","unstructured":"Bodei L, Pepe G, Paganelli G (2010) Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors with somatostatin analogues. Eur Rev Med Pharmacol Sci 14:347\u2013351","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3538_CR2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1177\/0194599815594789","volume":"153","author":"JW Chang","year":"2015","unstructured":"Chang JW, Hong HJ, Ban MJ, Shin YS, Kim WS, Koh YW, Choi EC (2015) Prognostic factors and treatment outcomes of parotid gland cancer: a 10-year single-center experience. Otolaryngol Head Neck Surg 153:981\u2013989","journal-title":"Otolaryngol Head Neck Surg"},{"key":"3538_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4103\/0973-029X.157206","volume":"19","author":"K Chatura","year":"2015","unstructured":"Chatura K (2015) Polymorphous low grade adenocarcinoma. J Oral Maxillofac Pathol 19:77","journal-title":"J Oral Maxillofac Pathol"},{"key":"3538_CR4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.2967\/jnumed.115.163865","volume":"57","author":"SA Deppen","year":"2016","unstructured":"Deppen SA, Liu E, Blume JD, Clanton J, Shi C, Jones-Jackson LB, Lakhani V, Baum RP, Berlin J, Smith GT (2016) Safety and efficacy of 68Ga-DOTATATE PET\/CT for diagnosis, staging, and treatment management of neuroendocrine tumors. J Nucl Med 57:708\u2013714","journal-title":"J Nucl Med"},{"key":"3538_CR5","volume-title":"WHO classification of head and neck tumours","author":"AK El-Naggar","year":"2017","unstructured":"El-Naggar AK, Chan JK, Grandis JR, Takata T, Slootweg PJ (2017) WHO classification of head and neck tumours. International Agency for Research on Cancer, France"},{"key":"3538_CR6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1177\/107327480601300406","volume":"13","author":"HA Gaissert","year":"2006","unstructured":"Gaissert HA, Mark EJ (2006) Tracheobronchial gland tumors. Cancer Control 13:286\u2013294","journal-title":"Cancer Control"},{"key":"3538_CR7","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.oooo.2015.02.481","volume":"119","author":"R Gupta","year":"2015","unstructured":"Gupta R, Balasubramanian D, Clark JR (2015) Salivary gland lesions: recent advances and evolving concepts. Oral Surg Oral Med Oral Pathol Oral Radiol 119:661\u2013674","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3538_CR8","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.critrevonc.2009.10.004","volume":"74","author":"M Guzzo","year":"2010","unstructured":"Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L (2010) Major and minor salivary gland tumors. Crit Rev Oncol Hematol 74:134\u2013148","journal-title":"Crit Rev Oncol Hematol"},{"key":"3538_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1758-3284-3-40","volume":"3","author":"K Ho","year":"2011","unstructured":"Ho K, Lin H, Ann DK, Chu PG, Yen Y (2011) An overview of the rare parotid gland cancer. Head Neck Oncol 3:40","journal-title":"Head Neck Oncol"},{"key":"3538_CR10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1210\/jcem.84.2.5497","volume":"84","author":"L Hofland","year":"1999","unstructured":"Hofland L, Liu Q, van Koetsveld P, Zuijderwijk J, van der Ham F, de Krijger R, Schonbrunn A, Lamberts S (1999) Immunohistochemical detection of somatostatin receptor subtypes sst1 and sst2A in human somatostatin receptor positive tumors. J Clin Endocrinol Metab 84:775\u2013780","journal-title":"J Clin Endocrinol Metab"},{"key":"3538_CR11","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.oraloncology.2012.05.004","volume":"48","author":"A Lagha","year":"2012","unstructured":"Lagha A, Chraiet N, Ayadi M, Krimi S, Allani B, Rifi H, Raies H, Mezlini A (2012) Systemic therapy in the management of metastatic or advanced salivary gland cancers. Oral Oncol 48:948\u2013957","journal-title":"Oral Oncol"},{"key":"3538_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0005-2736(03)00235-9","volume":"1616","author":"LN M\u00f8ller","year":"2003","unstructured":"M\u00f8ller LN, Stidsen CE, Hartmann B, Holst JJ (2003) Somatostatin receptors. Biochim Biophy Acta (BBA) Biomembr 1616:1\u201384","journal-title":"Biochim Biophy Acta (BBA) Biomembr"},{"key":"3538_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jobcr.2014.05.003","volume":"4","author":"PA Namboodiripad","year":"2014","unstructured":"Namboodiripad PA (2014) A review: immunological markers for malignant salivary gland tumors. J Oral Biol Craniofac Res 4:127\u2013134","journal-title":"J Oral Biol Craniofac Res"},{"key":"3538_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0960-0760(92)90184-K","volume":"43","author":"J Reubi","year":"1992","unstructured":"Reubi J, Laissue J, Krenning E, Lamberts S (1992) Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. J Steroid Biochem Mol Biol 43:27\u201335","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3538_CR15","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1097\/MNM.0b013e32833f635e","volume":"31","author":"M Shastry","year":"2010","unstructured":"Shastry M, Kayani I, Wild D, Caplin M, Visvikis D, Gacinovic S, Reubi JC, Bomanji JB (2010) Distribution pattern of 68Ga-DOTATATE in disease-free patients. Nucl Med Commun 31:1025\u20131032","journal-title":"Nucl Med Commun"},{"key":"3538_CR16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/hed.2890080309","volume":"8","author":"RH Spiro","year":"1986","unstructured":"Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8:177\u2013184","journal-title":"Head Neck Surg"},{"key":"3538_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S0002-9610(97)00153-0","volume":"174","author":"RH Spiro","year":"1997","unstructured":"Spiro RH (1997) Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg 174:495\u2013498","journal-title":"Am J Surg"},{"key":"3538_CR18","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00405-011-1663-2","volume":"269","author":"M Stenner","year":"2012","unstructured":"Stenner M, Molls C, Luers JC, Beutner D, Klussmann JP, Huettenbrink K-B (2012) Occurrence of lymph node metastasis in early-stage parotid gland cancer. Eur Arch Otorhinolaryngol 269:643\u2013648","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"3538_CR19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1507\/endocrj.52.605","volume":"52","author":"Y Taniyama","year":"2005","unstructured":"Taniyama Y, Suzuki T, Mikami Y, Moriya T, Satomi S, Sasano H (2005) Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study. Endocr J 52:605\u2013611","journal-title":"Endocr J"},{"key":"3538_CR20","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/hed.10400","volume":"26","author":"CH Terhaard","year":"2004","unstructured":"Terhaard CH, Lubsen H, van der Tweel I, Hilgers F, Eijkenboom W, Marres H, Tjho-Heslinga R, de Jong J, Roodenburg J (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck J Sci Special Head Neck 26:681\u2013693","journal-title":"Head Neck J Sci Special Head Neck"},{"key":"3538_CR21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.yfrne.2013.07.005","volume":"34","author":"M Theodoropoulou","year":"2013","unstructured":"Theodoropoulou M, Stalla GK (2013) Somatostatin receptors: from signaling to clinical practice. Front Neuroendocrinol 34:228\u2013252","journal-title":"Front Neuroendocrinol"},{"key":"3538_CR22","doi-asserted-by":"publisher","first-page":"S1806","DOI":"10.1590\/1807-3107BOR-2016.vol30.0002","volume":"30","author":"AC Vasconcelos","year":"2016","unstructured":"Vasconcelos AC, N\u00f6r F, Meurer L, Salvadori G, Souza LBD, Vargas PA, Martins MD (2016) Clinicopathological analysis of salivary gland tumors over a 15-year period. Brazilian Oral Research 30:S1806","journal-title":"Brazilian Oral Research"},{"key":"3538_CR23","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1038\/modpathol.3800954","volume":"20","author":"M Volante","year":"2007","unstructured":"Volante M, Brizzi MP, Faggiano A, la Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C (2007) Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol 20:1172\u20131182","journal-title":"Mod Pathol"},{"key":"3538_CR24","first-page":"102819","volume":"2013","author":"L Wang","year":"2013","unstructured":"Wang L, Tang K, Zhang Q, Li H, Wen Z, Zhang H, Zhang H (2013) Somatostatin receptor-based molecular imaging and therapy for neuroendocrine tumors. BioMed Res Int 2013:102819","journal-title":"BioMed Res Int"},{"key":"3538_CR25","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.18632\/oncotarget.13952","volume":"8","author":"X Wang","year":"2017","unstructured":"Wang X, Luo Y, Li M, Yan H, Sun M, Fan T (2017) Management of salivary gland carcinomas\u2014a review. Oncotarget 8:3946","journal-title":"Oncotarget"},{"key":"3538_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/0003489414542094","volume":"124","author":"K Watanabe","year":"2015","unstructured":"Watanabe K, Okumura Y, Hashimoto K, Suzuki T (2015) Clear cell carcinoma of the base of the tongue: case report and literature review. Ann Otol Rhinol Laryngol 124:55\u201361","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"3538_CR27","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/lary.25713","volume":"126","author":"KY Zhan","year":"2016","unstructured":"Zhan KY, Lentsch EJ (2016) Basal cell adenocarcinoma of the major salivary glands: a population-level study of 509 cases. Laryngoscope 126:1086\u20131090","journal-title":"Laryngoscope"}],"container-title":["Journal of Cancer Research and Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03538-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00432-021-03538-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00432-021-03538-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T18:06:12Z","timestamp":1617645972000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00432-021-03538-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["3538"],"URL":"https:\/\/doi.org\/10.1007\/s00432-021-03538-1","relation":{},"ISSN":["0171-5216","1432-1335"],"issn-type":[{"type":"print","value":"0171-5216"},{"type":"electronic","value":"1432-1335"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"1 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None of the authors have any conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Declaration of Helsinki approval: approval no. 0421-15-HMO.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Only non-identifying participant data will be published.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}