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The Initiative Geriatrische H\u00e4matologie und Onkologie (IN-GHO<jats:sup>\u00ae<\/jats:sup>) registry prospectively collected data on the comprehensive geriatric assessment (CGA), physician\u2019s and patient\u2019s-self assessment of fitness for treatment, and the course of treatment in patients within a treatment decision aged\u2009\u2265\u200970\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patients and methods<\/jats:title>\n                <jats:p>The registry included 3169 patients from 93 centres and evaluated clinical course and treatment outcomes 2\u20133 and 6\u00a0months after initial assessment. Fitness for treatment was classified as fit, compromised and frail according to results of a CGA, and in addition by an experienced physician\u2019s and by patient\u2019s itself. Feasibility of treatment (termed IN-GHO<jats:sup><jats:bold>\u00ae<\/jats:bold><\/jats:sup>-FIT) was defined as a composite endpoint, including willingness to undergo the same treatment again in retrospect, no modification or unplanned termination of treatment, and no early mortality (within 90\u00a0days).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>CGA classified 30.0% as fit, 35.8% as compromised, and 34.2% as frail. Physician\u2019s and patient\u2019s-self assessment classified 61.8%\/52.3% as fit, 34.2%\/42.4% as compromised, and 3.9%\/5.3%, as frail, respectively. Survival status at day\u00a0180 was available in 2072 patients, of which 625 (30.2%) had died. After 2\u20133\u00a0months, feasibility of treatment could be assessed in 1984 patients. 62.8% fulfilled IN-GHO<jats:bold>\u00ae<\/jats:bold>-FIT criteria. Multivariable analysis identified physician\u2019s assessment as the single most important item regarding feasibility of treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Geriatricians were involved in 2% of patients only. Classification of fitness for treatment by CGA, and physician\u2019s or patient\u2019s-self assessment showed marked discrepancies. For the prediction of feasibility of treatment no single item was superior to physician\u2019s assessment. 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